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ALKYLATING AGENTS. VI. Drug Examples of usual doses Toxicity Interactions, issues Direct DNA - interacting agents Alkylators Cisplatin 20 mg / m2 qd x 5 IV 1 q 3 - 4 vks or 100â200 mg / m2 / dose IV q3â4 vks Nausea Maintain high urine flow; Neuropathy osmotic diuresis, monitor Auditory intake / output K+, Mg2+ Marrow platelets > WBCs Emetogenic - prophylaxis Renal Mg2+, Ca2+ needed Full dose if CrCl > 60 mL / min and tolerate fluid push Carboplatin 365 mg / m2IV q 3 - 4 vks as adjusted for CrCl Marrow platelets > WBCs Reduce dose according to Nausea CrCl: to AUC of 5 â 7 mg / Renal (high dose) mL / min [AUC = dose / (CrCl + 25)] Oxaliplatin 130 mg / m2q 3wks over 2h or 85 mg / m2 q 2vks Nausea Anemia Acute reversible neurotoxicity; chronic sensory neurotox icity cumulative with dose; reversible laryngopharyngeal spasm CrCl, creatinine clearance; AUC, area under the curve
