Download BIOLOGICAL DYNAMICS OF ANTI-AGING

Signaling Energy
Revolutionizes Anti-Aging
Presenting two Experimental Studies
on the Ion Magnum
By Dr Xanya Sofra-Weiss
Signaling Technology views aging and desease as the result of faded or
missing signals that would otherwise give the instructions for the adequate
synthesis of hormones, antibodies, enzymes and other proteins such as
collagen, elastin, hemoglobin, actin, myosin, ATPace, etc
The proteins in each cell receive a complex combination of
signals which simultaneously trigger many different signaling
pathways which provide an opportunity for cross-talk
between different signals. The cell integrates information
from many different signaling pathways to initiate an
appropriate response. Missing signals leave the cell with
incoherent instructions hence leading to an inappropriate
response that may be deleterious to the cell.
Aging and Disease
Aging is the result of deteriorated protein signals
leaving the body with multiple deficiencies in terms
of hormones, antibodies, enzymes and other proteins
such as collagen, elastin, hemoglobin, actin, myosin,
ATPace, etc
Cancer is not the result of a number of “rebel” cells
that refuse to follow the rules of cellular
proliferation and differentiation but a number of
“obedient” cells who got the wrong instructions as a
result of Singaling deficiency
Some of the Functions of Proteins
 enzymatic catalysts

DNA repair
 transport molecules (hemoglobin transports oxygen)
 storage molecules
 they are used in movement --proteins are the major component of
muscles

needed for mechanical support (collagen)
 mediate cell migrations
 antibody proteins are needed for immune protection
 control of growth and cell differentiation uses proteins
 Collagen, Elastin are Proteins along with about 100,000 more types
of Proteins that exist in the human body
Among 4,087 different proteins identified with high
confidence by massspectrometry from 2,357 successful
purifications, our core dataset(median precision of 0.69)
comprises 7,123 proteinto protein interactions.
Investigating how such signaling pathways are organized
is relevant not only for understanding how normal cells
work, but also for appreciating the molecular basis for
aging and disease, since aging as well as many human
disorders result from breakdowns in signal transduction
Result of examing these comprises 7,123 protein to protein
interactions in aged vs young subjects demonstrated that
Aging is the result of the disorganization in the interactions
or communications between Protein to Protein interactions
Contrast of
Pixel
Intensities
Several studies have indicated an alteration in signal
transduction with ageing. Eg. T cells from aged have
decreased membrane fluidity. T cells activation and
proliferation is decreased as a result of decreased
recruitment of signaling proteins associated with the initial
complex of signal transduction
Diminished protein
signals from the
Champerone
proteins
during protein
synthesis leads to
decreased
synthesis
of proteins and a
subsequent deficiency in the aged.
EXAMPLES:
Less collagen and elastin (wrinkles);
Less actin and myosin (sagging muscles);
Less hormones (weight gain from decreased TSH, T3, muscular
hypotrophy from decreased IGF-1)
Less Atpace leading to decreased ATP synthesis, etc
Zhang et al (2002) showed that that human age-related cataract
is associated with decreased expression of L21 and other ribosomal
proteins.
Insulin Signaling
Ziv et al (2011) Mutations of genes
involved in the insulin/insulin-like
growth factor-1 (IGF-1) signaling
pathway affect lifespan in several model
organisms. decreased IGF-1 receptor
levels due to a single gene knockout
have been demonstrated to have
increased lifespan.
Bartke (2011) Longevity is associated to
insulin signaling and specifically to
reduced insulin levels and enhanced
sensitivity to insulin.
Insulin signaling alters gene expression
in the pancreas and in different
insulin/IGF-1 target organs (e.g. muscle,
liver, heart), and results in a slowing of
the aging process.
Insulin Code
Stem Cells Need Specific Signals
For Correct Differentiation
Researchers from Johns Hopkins have discovered the
presence of functional ion channels (that act like
electrical wires) in human embryonic stem cells (ESCs).
Li's lab (John Hopkins University) genetically engineered
heart cells derived from human ESCs, suggesting the
possibility of transplanting unlimited supplies of healthy,
specialized cells into damaged organs. A major concern
for human ESC-based therapies is the potential for
engineered grafts to go haywire after transplantation and
form tumors... “We therefore decided to explore the
existence of ION CHANNELS in pluripotent, or versatile,
human ESCs because ELECTRICAL ACTIVITY IS KNOWN
TO REGULATE CELL DIFFERENTIATION AND
PROLIFERATION," says Li.
Jan van Deursen (2002 -2011) studied study
a protein called BubR1, which helps ensure
that each cell has the correct number of
chromosomes during cell division
They found that a deficiency in protein
BubR1 causes premature aging. They also
found that BubR1 decreases with age.
Decreased BubR1 also correlated with
abnormal chromosome numbers in sperm
and eggs, associating this protein with
infertility. It is also associated with cataracts,
heart desease and other age related
diseases.
AGING iS THE RESULT OF INCREASING
IMBALANCES AS A RESULT OF:
1. Decreased Number of Proteins.
Underneath that there is a
2 . A decrease in the Champerone
proteins that help in the protein
folding.
3. A decrease or the absence of
signals initiating and completing the
process of protein synthesis
2011: Examination of a mechanism
involving the protein stromal-derived
factor-1 (SDF1), and its receptor CXCR4
provides proof that cancer is the result
of cells getting the wrong signals giving
them the wrong instructions.
A DNA mutation while it is unfolding to
copy itself during division or a mutation
anywhere in the signaling pathways of
the
series of proteins carrying the DNA info
means that the wrong order is sent.
Even when the right one arrives, our
cellular copiers can make mistakes,
leading to new genes that bark out
the wrong orders. Fortunately, our
bodies have patrols that constantly
neutralize most genetic mistakes,
but get enough of them and cancer
develops.
SINGALING TECHNOLOGY:
1. IDENTIFY THE SIGNALS THAT
REINSTATE THE SYNTHESIS
OF KEY PROTEINS ( research
started in Cambridge University)
2. INDENTIFY THE SIGNALS OF
PROTEIN INTERACTIONS DURING
IMPORTANT BIOLOGICAL
FUNCTIONS SUCH AS CELLULAR
PROLIFERATION AND DIFFERENTIATION
CONCEPTUALIZE SUCH PROTEIN
INTERACTIONS AS A DYNAMIC PROCESS
LIKE THE NOTES OF A MUSICAL PIECE OR THE
IMAGES FORMING A MOVING PICTURE
Signaling Energy Amplifies or
substitutes protein (antibodies,
hormones, enzymes, etc) signaling
that has diminished or paused with
age leading to a revival of
endogenous protein synthesis,
energy production while acting as a
MEGA
ANTI-OXIDANT
Fate and behavior of Cells is controlled
by signaling pathways
which deliver information from
1. Protein signals in surrounding tissue
2. Proteins signals emitted by
other cells.
Proteins and their signals are
transported by microtubules
We have been researching the aging process of
healthy individuals with a device built in Cambridge
on the basis of specifications that were researched in
Cambridge by comparing the signaling properties
of young vs aged cells and by artificially sending
the signals derived from a colony of young cells to
a colony of old cells and seeing it this “transfer” of
signals from the young to the old with in any way alter
the signaling pathways of the signaling properties
of the old colony of cells.
Results have shown a significant increase in a
number of proteins:
① Collagen Increase by 62%
② Actin Increase by 45%
③ Myosyn Increase by 38%
④ Hemoglobin Increase by 76%
⑤ ATPace Increase by 80%
⑥ Testosterone Increase by 46%
⑦ IGF-1 Increase by 62%
⑧ Insuline Increase by 23%
⑨ BubR1 by 18%
⑩ Cyclic Amp by 63%
⑪ G Proteins by 57%
⑫ Sitruins by 45%
Clinical Studies
Results have
revealed the
visibly dramatic
results that
persist from five
to nine months
with at least
three treatments
How are these waveforms composed?
First we record the signals of interacting cells by cell recording methods
that focus on cellular interactions, using advanced computer software that
were developed specifically for that reason. Then we go through thousands
of combinations of signals to recompose the biological decoded signals
THE IMPORTANCE OF TIMING
Combining
the signals
is like editing
a movie
or composing
a symphony
Timing is
Crucial
FACIAL REJUVENATION RESULTS
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