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f133 December 2, 2008 European Perspectives in Cardiology Spotlight: Manuel Antunes, MD, PhD, DSc An Expert on Mitral Valve Repair Who Took Inspiration From Christiaan Barnard, MD, and Whose Career Has Taken Him From Mozambique to South Africa and Thence to Portugal Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 Manuel Antunes, MD, PhD, DSc, head of the Department of Cardiothoracic Surgery, University Hospital, Coimbra, Portugal, and professor of cardiothoracic surgery, University of Coimbra, talks to Mark icholls. I n December 1967, when Christiaan Barnard, MD, performed the world’s first heart transplantation in Cape Town, South Africa, Manuel Antunes was studying at medical school in neighbouring Mozambique. Born in July 1948 in a small village close to Leiria, a town in the centre of Portugal, he had emigrated at the age of 5 with his family to Mozambique, where he pursued a career in medicine. Had I Been Able to Go Back to Mozambique, I Would Probably Have Become a General Surgeon Dr Barnard’s operation served not only as a watershed in cardiac surgery; Manuel Antunes, MD, PhD, DSc, says it also inspired him to become a cardiac surgeon. And the environment in which he studied proved pivotal to making this a reality. Professor Antunes explains, “I was probably touched by the world’s first heart transplantation. Unrelated to this, I moved to South Africa in 1975, which was to be for only 2 years, for a PhD. The independence of Mozambique and the civil war that followed, associated with closure of the borders between the 2 countries for political reasons, prevented me from going back and resulted in me following a career in Johannesburg [South Africa]. Had I been able to go back to Mozambique, I would probably have become a general surgeon, because cardiac surgery was not possible there.” Professor Antunes graduated from medical school at the University of Lourenço Marques, Lourenço Marques, Mozambique, in 1972, and he received specialist training in cardiothoracic surgery in South Africa. He started as a junior resident and progressively occupied the full range of positions (consultant, senior consultant, chief consultant, professor, and head of the department) in the Division of Cardiothoracic Surgery of the Johannesburg Hospital and the University of the Witwatersrand, Johannesburg. Several key figures influenced his career. He says, “I was most fortunate to work with Professor John Barlow [MD], one of the most important figures of the cardiology world during the whole of the 14 years I spent in South Africa. I was also influenced in my interest in valve surgery, and especially in mitral valve repair, which is one of my main interests, by Professor Alain Carpentier [MD], with whom I worked for a brief period in 1980.” Professor Antunes also cites the influence of Sir Magdi Yacoub, FRS, professor of cardiothoracic surgery, National Heart and Lung Institute, London, United Kingdom, and American cardiac surgeons Floyd Loop, MD, and Larry Bonchek, MD. “The Beginnings of Mitral Valve Repair in the Early 1980s Were Moments of Particular Excitement” Professor Antunes’ interests lie in valvular surgery, mitral valvuloplasty, and cardiac transplantation. Until September 2008, he served as chair of the Postgraduate Education On other pages... Spotlight: Carina Blomström-Lundqvist, MD, PhD, FESC Carina Blomström-Lundqvist, professor of cardiology, Department of Cardiology, University Hospital, University of Uppsala, Sweden, has been working on arrhythmogenic right ventricular cardiomyopathy for more than 20 years. Page f135 The Italian Heart Foundation Andrea Peracino, MD, vice president of the Italian Heart Foundation, and Emanuela Folco, PhD, secretary general, talk about how they are working to create a united political voice to fight cardiovascular disease in Italy. Page f137 Circulation: European Perspectives Circulation f134 Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 Circulation: European Perspectives Circulation December 2, 2008 Committee of the European Association for Cardiothoracic the European Association for Cardiothoracic Surgery. As Surgery and as chair of the Working Group of Valvular Heart chair of the European Society of Cardiology Working Group Disease of the European Society of Cardiology. He says that on Valvular Heart Disease, he participates in putting Professor Barlow honed these interests; he comments, “He together the programme of the Annual Congress of the European Society of Cardiology. [Professor Barlow] constantly supported me in the painful learning process of mitral repair, especially in the difficult “If You Do ot Have the Time, Don’t Attempt to setting of rheumatic valve disease in the very young black Become a Cardiac Surgeon” patients. I am also very keen on congenital heart surgery Professor Antunes would advise anyone who wants to folbecause of my love for children and because it constitutes a low a career in cardiology and cardiac surgery to study and more creative type of surgery.”1 Professor Antunes returned to Portugal in 1988 to his work hard. He adds, “If you want to be a doctor, make sure present posts at the hospital and the historic university, that you are prepared to dedicate your life to patients. Then, where he teaches at both the undergraduate and postgraduate study, study, study … work, work, work. If you do not have levels. His research has an entirely clinical focus and mostly the time, don’t attempt to become a cardiac surgeon.” relates to his preferred areas of surOf his work in Portugal, gical activity, particularly looking at Professor Antunes takes the most personal pride in having created a mitral valve repair. In South Africa, cardiac surgery department and he participated briefly in animal team, which he describes as “at least research (using baboons) on heart average European standard.” Now transplantation. age 60, he is working toward retireHe says, “I have always enjoyed ment, but he comments, “I need to all aspects of my work, but the consolidate my team to make sure beginnings of mitral valve repair in that I can retire with peace of the early 1980s were moments of mind.” Away from medicine, his particular excitement because of the interests include reading, music, pioneering aspect of its use in the gardening, and soccer, and he plans pure rheumatic population.” to write and travel more when he Professor Antunes has conducted retires. Married to Maria da Luz, he more than 600 communications and lectures at international congresses, Professor Antunes with Professor Sir Yacoub, during a lives in Coimbra, and they have 3 and he has published 230 articles. visit by Professor Sir Yacoub to Coimbra to celebrate children. The publications he considers his the heart transplantation programme in Portugal. Although Professor Antunes most important include his book Photograph courtesy of Professor Antunes. foresees significant developments Mitral Valve Repair,2 which until in cardiac surgery, he has concerns recently represented the only monograph on this type of surabout such rapid developments. He says, “The next decade gery, and several original articles on mitral valvuloplasty.3,4 will revolutionise the field of cardiac surgery. Minimally He has also participated in a number of international collabinvasive and robotic surgery will evolve, and hybrid proceorative studies. dures with interventional cardiology will constitute a good Professor Antunes’ work has received funding from state portion of our activity. But I am sceptical about many of institutions, hospitals, and universities, and he has won a these procedures that have taken off without solid scientific number of awards for his clinical, academic, and scientific foundations.” He believes the major breakthroughs will activities. These include the Merit Prize of the Southern come in genetic and tissue engineering for repair of the damAfrica Cardiac Society, 1980; Award for Most Outstanding aged myocardium and heart valves. Citizen, JCC, Johannesburg, 1987; Gold Medal, City of Leiria, 1999; Gold Medal, City of Coimbra, Portugal, 2006; References 1. Klass BG, Levin SE, Dansky R, Milner S, Colsen P, Antunes MJ, and Paul Harris Fellowship by Rotary International, 2007. Kinsley RH. Surgical correction of ventricular septal defects in black Professor Antunes also takes interest in the management and white children—an 11-year study. S Afr Med J. 1990;78:656–659. of clinical services and has written a book on the Portuguese 2. Antunes M. Mitral Valve Repair. Percha, Germany: RS Schulz; 1989. 3. Antunes MJ, Magalhaes MP, Colsen PR, Kinsley RH. Valvuloplasty National Health Service, published in 2001. He serves as for rheumatic mitral valve disease. A surgical challenge. J Thorac editor, associate editor, and reviewer for a number of jourCardiovasc Surg. 1987;94:44–56. nals, and he is a member of the American Association for 4. Butchart EG, Gohlke-Bärwolf C, Antunes MJ, Tornos P, De Caterina Thoracic Surgery, the Society of Thoracic Surgeons, the R, Cormier B, Prendergast B, Iung B, Bjornstad H, Leport C, Hall RJ, Vahanian A; Working Groups on Valvular Heart Disease, Thrombosis, European Association for Cardiothoracic Surgery, and the and Cardiac Rehabilitation and Exercise Physiology, European European Society of Cardiology. Currently president-elect Society of Cardiology. Recommendations for the management of of the Portuguese Cardiac Society, he will assume office for patients after heart valve surgery. Eur Heart J. 2005;26:2463–2471. a 2-year period in April 2009, and he also serves as coordinator of the postgraduate courses of the annual meeting of Mark icholls is a freelance medical journalist. f135 December 2, 2008 Spotlight: Carina Blomström-Lundqvist, MD, PhD, FESC “A Big Future in Arrhythmias—It’s Exploding! The Mechanisms of Atrial Fibrillation, Ventricular Fibrillation, and Sudden Death Are Still ot Solved” Carina Blomström-Lundqvist, professor of cardiology, Department of Cardiology, University Hospital, University of Uppsala, Sweden, talks to Barry Shurlock, MA, PhD. Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 B rought up in Stockholm, Sweden, by a father who worked as an engineer and had distinguished himself as a roundthe-world yachtsman, Carina Lundqvist first considered reading physics but found herself persuaded to study medicine, which many considered more appropriate for women. As the first physician in her family, she does not regret her change of direction, but she does admire the intellectual challenges of physics. After completing basic university medical training at the University of Uppsala, Uppsala, Sweden, and then at Linköping University Hospital, Linköping, Sweden, her interest in the basic sciences nudged her toward cardiovascular haemodynamics and then electrophysiology (in Swedish, “electrocardiology”), where the challenge of unravelling intracardiac electrocardiographic traces seemed as close to physics as she could get. and localising accessory pathways. Then I went on to work in the catheter lab, doing my own ablation procedures.” The research articles of which Professor BlomströmLundqvist feels particularly proud include an early one that “demonstrated for the first time that ARVC patients are at high risk of dying,” which she says led—after 15 years—to the recommendation of implantable cardioverter-defibrillators as first-line therapy for ventricular tacycardia.1 She also takes pride in having been a coauthor of a report of a European multicentre study that helped elucidate the mechanisms of sudden death in ARVC.2 More recent notable publications include studies with colleagues that have shown the benefits for atrial fibrillation (AF) of Cox Maze II surgery,3 and the finding from a Swedish trial that epicardial left atrial cryoablation for permanent AF has a more significant effect than mitral valve surgery.4,5 Working on Arrhythmogenic Right Ventricular Cardiomyopathy for More Than 20 Years After more than 20 years in the field, Carina BlomströmLundqvist, MD, PhD, FESC (her middle name comes from her physician husband) now hopes to focus on long-term follow-up studies of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), using genetic and clinical markers. She says, “The diagnosis of ARVC is frequently difficult to make in the absence of typical right ventricular morphological findings, which is a problem, especially in diagnosing relatives of patients with ARVC.” Professor Blomström-Lundqvist first tackled ARVC in her PhD, supervised by Professor Bertil S. Olssen, MD, at the University of Gothenburg, Sweden, where she trained in cardiology. She says, “I actually started my PhD studying dilated cardiomyopathy. But after 6 months I found it too ‘medical’ and not sufficiently challenging—too much like internal medicine. Some colleagues were studying arrhythmias, which I found much more interesting—interpreting electrocardiographic traces, working out the different mechanisms of such things as supraventricular tachycardia. It was a time when catheter ablation was being introduced and implantable cardioverter-defibrillators were being implanted for the first time. Electrophysiology was exploding in the mid-1980s, and it was all very exciting! My clinical work was devoted to ablation procedures—I had very good training at Gothenburg. We attended arrhythmia surgery procedures—measuring [the electrophysiological variables] “A Large umber of Original Ideas Are Taken From Europe and Implemented in the Rest of the World” Professor Blomström-Lundqvist strongly advocates the benefits of changing location from time to time. She says, “Moving place is a great challenge. You get to learn how other people do things.” Although early in her career she had some thoughts of working abroad, she has only done so once, in 1989, when she spent a period with paediatric cardiologist Jim Perry, MD, at the Texas Children’s Hospital, Houston, Tex, learning techniques for performing catheter ablation on small children. She then successfully introduced the procedure into Sweden at the University Hospital, Uppsala. In 1989, Professor Blomström-Lundqvist took a senior consultant post at the University Hospital, Lund; after 4 years there, she moved to Uppsala to head up the Electrophysiology Laboratory in the Department of Cardiology at the University Hospital. She now holds a chair of cardiology that allows her to spend 30% of her time in research and 70% in clinical work. Professor Blomström-Lundqvist names Michel Haissaguerre, MD, as someone she thinks has greatly influenced recent scientific developments in her field; in the 1990s, Dr Haissaguerre introduced radiofrequency catheter ablation for AF in his ground-breaking work at Haut Lévêque Heart Hospital, Bordeaux, France. One of Professor Blomström-Lundqvist’s own research interests involves developing these techniques further in the context Circulation: European Perspectives Circulation f 136 Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 Circulation: European Perspectives Circulation December 2, 2008 of off-pump thoracoscopic through the merging of Eurocatheter ablation surgery. She pean Society of Cardiology says, “Dr Haissaguerre is an working groups on cardiac extremely talented scientist pacing and arrhythmias; the and a good example of how a new association has a growing large number of original ideas membership of more than are taken from Europe and 2000. She says, “The most implemented in the rest of the important achievement is to world. In our ongoing studies of have created one strong organradiofrequency catheter ablaisation which, within the very tion for AF, we want to assess short time frame of 5 years, the role of vagal denervation in has become the leading organthe successful performance of isation in arrhythmology in the procedure.” Europe.” She knows, however, At Uppsala, Professor that this new organisation has Blomström-Lundqvist started a hard task to reach the same a long period of serving on a level as established and wellwide variety of committees resourced bodies such as the and boards—the Swedish US-based Heart Rhythm Society of Cardiology, the Society, founded in 1979, and Swedish Society of Medicine, now with a membership of Some members of the research team working with Professor the European Society of Blomstrom-Lundqvist at Uppsala University Hospital. From left nearly 5000 from more than Cardiology, the European to right: Anders Jonzon, senior consultant; Professor Blomstrom- 70 countries. Professor Heart Rhythm Association, the Lundqvist; Helena Malmborg, consultant; Stefan Lonnerholm, Blomström-Lundqvist says, American College of Cardio- senior consultant; Bozena Ostrowska, consultant; Leif ilsson, “There is a big future in logy, the North American senior consultant; Joanna Wessbergh, study nurse; Per arrhythmias—it’s exploding! Society of Pacing and Blomstrom, senior consultant. Photograph courtesy of Sevim The mechanisms of AF, Electrophysiology, and the Yildiz, Uppsala University Hospital. ventricular fibrillation, and International Coalition of Pacing and Electrophysiology sudden death are still not solved.” She would love to see Organisations. These appointments have involved a wide her students crack one of these great unknowns, but she variety of subjects—practice guidelines, education, science, says, “It’s very difficult to get younger doctors interested ethics, information, and linguistics. She says, “You can learn in research. It’s hard to motivate them. They ask, ‘What from the way organisations work, and you have a chance to will it give to me?’ Our politicians want people to be lead the organisation towards a common goal—to dissemigood at administration and finance rather than having nate knowledge, improve education, create opportunities for research competence. It’s the trend everywhere, and it’s research—whatever the aims are.” very dangerous.” Professor Blomström-Lundqvist has just finished organising the 200th anniversary of the Swedish Society of References 1. Blomström-Lundqvist C, Sabel KG, Olsson SB. A long term follow up Medicine, which claims to be the oldest general medical of 15 patients with arrhythmogenic right ventricular dysplasia. Br association in Europe (the British Medical Association did Heart J. 1987;58:477–488. not come into existence until 1832, and then under a differ2. Corrado D, Basso C, Thiene G, McKenna WJ, Davies MJ, Fontaliran F, Nava A, Silvestri F, Blomstrom-Lundqvist C, Wlodarska EK, Fontaine ent name). Along with holding a large number of Swedish G, Camerini F. Spectrum of clinicopathologic manifestations of Society of Medicine seminars, she has raised a large sum arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multiof money to fund future medical research. center study. J Am Coll Cardiol. 1997;30:1512–1520. “Politicians Want People to Be Good at Administration and Finance Rather Than Having Research Competence” Professor Blomström-Lundqvist now wants to spend more time on her research and has begun “learning to say no” to requests that do not have an international dimension. But she would still like to extend the influence of Europe in the world of pacing and electrophysiology. She points out that cultural differences between various parts of the developing world often require the tailoring of education and guidelines from advanced industrial nations for local application. One positive development has come with the European Heart Rhythm Association, which came into being in recent years 3. Lönnerholm S, Blomström P, Nilsson L, Oxelbark S, Jideus L, Blomström-Lundqvist C. Effects of the maze operation on health-related quality of life in patients with atrial fibrillation. Circulation. 2000;101:2607–2611. 4. Blomström-Lundqvist C, Johansson B, Berglin E, Nilsson L, Jensen SM, Thelin S, Holmgren A, Edvardsson N, Källner G, Blomström P. A randomized double-blind study of epicardial left atrial cryoablation for permanent atrial fibrillation in patients undergoing mitral valve surgery: the SWEDish Multicentre Atrial Fibrillation study (SWEDMAF). Eur Heart J. 2007;28:2902–2908. 5. Malmborg H, Lönnerholm S, Blomström-Lundqvist C. Acute and clinical effects of cryoballoon pulmonary vein isolation in patients with symptomatic paroxysmal and persistent atrial fibrillation. Europace. 2008;10:1277–1280. Barry Shurlock is a freelance medical journalist. f137 December 2, 2008 The Italian Heart Foundation Working to Create a United Political Voice to Fight Cardiovascular Disease in Italy Andrea Peracino, MD, vice president of the Italian Heart Foundation, and Emanuela Folco, PhD, secretary general, talk to Robert Short, BSc. T Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 he Italian Heart Foundation (Fondazione Italiana per il Cuore; IHF), the leading heart foundation in Italy, has worked with the many cardiology societies in Italy and sees itself as having a role in bringing these societies together politically (see www.fondazionecuore.it). Established in 1990, the IHF became a registered foundation in 2004. Health and Medicine; and the Italian Society of Gender Health and Medicine. The conference took place under the auspices of 42 learned societies including the International Atherosclerosis Society and the World Heart Federation. The IHF has played an active role in primary prevention for many years. Indeed, Dr Folco recognises the president of the IHF and the Giovanni Lorenzini Foundation, Rodolfo Paoletti, MD, PhD, as the first person in Italy to have promoted the concept of lowering cholesterol as a health target. Close Links With International Organisations The IHF has close links with the Giovanni Lorenzini Foundation, an international foundation that has wider interests than cardiovascular disease. Both organisations cooperate at the national and international levels. Indeed, Responsible for Promoting and Organising the Italian Andrea Peracino, MD, vice president of the IHF, also World Heart Day Since 2001 serves as vice president of the Giovanni Lorenzini Medical The IHF has a good reputation for working closely with Foundation. Dr Peracino trained as a cardiologists from the various cardiopathologist and has broad experience in logy groups, and it plays an important industry and in hospital administration, role in the difficult job of bringing the having served as scientific director of groups of cardiologists together. Dr one of the leading hospitals in Italy and Folco explains, “We are not a scientific as chief executive officer of an internasociety, so the cardiology societies tional pharmaceutical company. The Logo of the Italian Heart Foundation. don’t see us as a competitor. And we IHF also forms part of the World Heart Courtesy of the Italian Heart Foundation. have been in the field of primary preFederation and the European vention for many years, so we Heart Network, and it has links know them all, we like working Major Aims of the Italian Heart Foundation to the International Atherowith them, and we develop projsclerosis Society. ects together. We see ourselves ● To disseminate scientific information. as a glue to keep all these groups ● To develop relationships between specialists, general Organisation of Scientific together.” practitioners, and the general population ● To interact with government bodies to promote the Congresses to Promote Dr Peracino says, “We are prevention of cardiovascular diseases Primary Prevention trying as the IHF to enable these Emanuela Folco, PhD, secretary ● To carry out studies and research projects associations—and ourselves—to general for the IHF, says, “The speak with one single voice. IHF has as its main activity the promotion of primary preThat is our strategy. We currently use World Heart Day to vention through the education of physicians and provision build towards that aim. This event is an opportunity where of information to the lay public. These goals are achieved we put together, in working relationships toward a common through the organisation of scientific congresses, mainly purpose, many scientific societies, many national and local international, and through educational campaigns.” organisations, and many local activities.” ConaCuore, the A conference held in Venice in October 2008—the national confederation of patient associations, represents Seventh International Symposium on Multiple Risk one of the important national organisations. This powerful Factors in Cardiovascular Diseases: Prevention and patient group brings together about 119 local associations Intervention: Health Policy—served as one such event for and has the support of about 2 million people. doctors. The IHF sponsored this together with the The IHF has promoted and organised the Italian World Fondazione Giovanni Lorenzini Medical Science Heart Day since 2001. It does this in collaboration with the Foundation, Milan, Italy; the Giovanni Lorenzini Medical important institutions of the country, such as the Italian Foundation, Houston, Tex; the European Society of Gender Ministry for Health, the Ministry for University and Circulation: European Perspectives Circulation f 138 Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 Circulation: European Perspectives Circulation December 2, 2008 Research, and the Ministry for Agriculture. The Italian Red the public. It receives no government funding. Dr Folco Cross, the National Association of Carabinieri, the explains, “In Italy, there is very little culture for legacies National Sports Federations, the Union of European and door-to-door fund-raising, and the heart charities have Football Associations, ConaCuore, and the Italian to compete with cancer.” The cancer organisations do seem Federation of Cardiology also take part in the collaborato get most of the attention and most of the political help. tion, along with 20 scientific societies. During the World A law exists that allows an individual or institution to Heart Day ceremonies each year, a gold medal goes to a donate a percentage of earnings to a charity. Of the 4 celebrity for the distinction of “Health Champion” of the year. biggest beneficiaries of this law, 3 are cancer organisations. Although the IHF operates internationally and has powAbout 10% to 20% of the funds go to research through erful links and support, it remains a small organisation in scholarships to young investigators—either to study in itself. Dr Folco says, “Therefore, we focus on specific Italy or to go abroad, for a minimum of 6 months and a activities like the World Heart Day. Getting the major footmaximum of 2 years. The IHF awards about 3 or 4 such ball teams involved in the event was an important coup for awards each year. Dr Peracino says that research funding the IHF, because it was broadcast throughout the Arabic tends to go to specific projects that the IHF has an interest world through inviting Al in pursuing, rather than through Jazeera to cover the event.” grant applications. He comments, The IHF numbered among the “When we have a project, we earliest foundations in Europe to decide to direct funds to some run the “Go Red for Women” group of people or group of campaign (called “Red Dress young researchers.” Italia” in Italy). It has important links with the Italian Chamber of “othing Has Been Done to Fashion, Elizabeth Arden, and Launch the European Heart Vogue Italy, and it uses these Health Charter ationally” connections to get health mesPolitical influence through cultisages and information out to the vating the interest of politicians population using press events, in heart disease has proved an media contacts, television interelusive target. Says Dr Folco, views, and testimonials, and by “While we would like to have a distributing brochures and strategy for engagement with leaflets at grocery stores, superpoliticians, one issue is that, in markets, and shops. Italy, every 2 years the politicians Another major initiative has and the ‘system’ change. In Italy, come with the creation of the we now do not even have a health Italian and European Societies ministry.” for Gender Health and Medicine. Although many heart foundaDr Folco stresses that people tions say that the European Heart should not confuse “gender medHealth Charter has proved a useicine” with or limited it to ful political lever to engineer and “women’s health.” Both socispeed progress, the IHF reports eties cover all diseases and not The IHF has been responsible for promoting and organ- that, after a promising start in just heart disease. She says, “We ising the Italian World Heart Day since 2001. Image Milan, it has not seen wider are developing a Web site. For courtesy of the Italian Heart Foundation. application in Italy. Dr Folco each area, we are trying to define explains, “We launched it very the difference between genders. And, of course, cardiovassuccessfully in Milan. And we, of course, invited the politicular disease is one of the main areas.” cians. No one came from the central government. But, still, we wanted to launch it nationally. However, the Centre for Funding Comes Primarily From the Institutions Disease Control, responsible for prevention, has in the Linked With the IHF, and Also From Banks and meantime gone through a lot of restructuring, and nothing Insurance Companies has been done to launch the charter nationally.” The IHF raises funds primarily from its partner institutions, and from banks and insurance companies, rather than from Robert Short is a medical journalist. Editor: Thomas F. Lüscher, MD, FRCP, FACC Managing Editor: Lindy van den Berghe, BMedSci, BM, BS We welcome comments. E-mail [email protected] The opinions expressed in Circulation: European Perspectives in Cardiology are not necessarily those of the editors or of the American Heart Association. European Perspectives Circulation. 2008;118:f133-f138 doi: 10.1161/CIRCULATIONAHA.108.191139 Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2008 American Heart Association, Inc. All rights reserved. Print ISSN: 0009-7322. Online ISSN: 1524-4539 Downloaded from http://circ.ahajournals.org/ by guest on June 18, 2017 The online version of this article, along with updated information and services, is located on the World Wide Web at: http://circ.ahajournals.org/content/118/23/f133.citation Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published inCirculation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. 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