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35TH NORDIC CONGRESS IN CLINICAL BIOCHEMISTRY JUNE 14TH – 17TH 2016 Session 11 Lecture 1 Measurement of Cholecystokinin in Plasma Jens F. Rehfeld, Dept. of Clin. Biochemistry, Rigshospitalet, Copenhagen The gut hormone, cholecystokinin (CCK), was discovered in 1928 as a gallbladder contractor. In 1968 the structure was identified as a 33 amino acid peptide with a C-terminal “active site” sequence that revealed close homology with that of gastrin. Later the CCK gene has been shown to be expressed at high levels also in cerebral neurons and cardiac myocytes. CCK circulates in femtomolar to low picomolar concentrations. Due to the resemblance with gastrin that circulates in 20-fold higher concentrations, it has been unusually difficult to develop an assay specific for CCK in plasma. In 1998 we succeeded, however, and have now found diagnostic and prognostic use of measuring CCK peptides in patients with the newly described CCKoma syndrome, Ewing’s sarcoma and heart failure patients.