Download The DUODENAL HORMONE-CCK CCK or Cholecystokinin, the

The DUODENAL HORMONE-CCK
CCK or Cholecystokinin, the name coined by Ivy and Olberg in 1928, causes the
gallbladder to contract and behaves differently than Secretin in some respects.
CCK was prepared by Ivy, et al in 1929, isolated from the upper intestine of Hog,
Dog, Sheep and cattle. In 1930, Ivy, et al injected human subjects with CCK with
complete or partial evacuation of the gall bladder in 4out of 5 subjects. Use of
CCK as a therapeutics agent however was questioned since it apparently did
nothing more that egg yolk and cream and fatty meals. Mutt and then Jorpes and
Mutt in the 1950’s to 60’s researched the purification of CCK. In 1967, Jorpes and
Mutt delineated the structure of CCK consisting of 33 amino acids.
CCK was the defined name in 1964 and 1966 by Jorpes and Mutt when they
described both CCK and Pancrozymin activities and found essentially the same
substance. In 1968-70 Jorpes and Mutt indicated that the CCK-octapeptide (CCK8) showed full potency of total CCK, as did the synthetic and natural octapeptides.
The pancreozymin activity of extracts of the duodenal-jejunal mucosa has been
shown to be due to CCK.
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CHOLECYSTOKININ26-28 DESULFATED (ASP-TYR-MET)
CHOLECYSTOKININ26-29 DESULFATED
AC, CHOLECYSTOKININ26-32
CHOLECYSTOKININ26-32 PROTECTED, SULFATED S1
CHOLECYSTOKININ26-32
AC, CHOLECYSTOKININ26-33, SULFATED
CHOLECYSTOKININ-8 26-33, DESULFATED
CHOLECYSTOKININ-8 26-33, SULFATED
CHOLECYSTOKININ-8, SULFATED, DEAMINATED
BOCCHOLECYSTOKININ-8
CHOLECYSTOKININ "JMV180"
CHOLECYSTOKININ27-32 (NLE-28, 31)
CBZ CHOLECYSTOKININ 27-32
CAERULEIN 6-10
BOC CHOLECYSTOKININ 30-33
L-TRP-MET-ASP-PHE OH
L-TRP-MET-ASP-PHE NH2
C-TERM OFCHOLECYSTOKININ