Download Arrhythmia/Electrophysiology

Arrhythmia/Electrophysiology
Sports-Related Sudden Death in the General Population
Eloi Marijon, MD; Muriel Tafflet, PhD; David S. Celermajer, PhD, FRACP; Florence Dumas, MD;
Marie-Cécile Perier, MSc; Hazrije Mustafic, MD; Jean-François Toussaint, MD, PhD;
Michel Desnos, MD; Michel Rieu, MD; Nordine Benameur, MD; Jean-Yves Le Heuzey, MD;
Jean-Philippe Empana, MD, PhD; Xavier Jouven, MD, PhD
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Background—Although such data are available for young competitive athletes, the prevalence, characteristics, and
outcome of sports-related sudden death have not been assessed previously in the general population.
Methods and Results—A prospective and comprehensive national survey was performed throughout France from 2005 to
2010, involving subjects 10 to 75 years of age. Case detection for sports-related sudden death, including resuscitated
cardiac arrest, was undertaken via national ambulance service reporting and Web-based screening of media releases. The
overall burden of sports-related sudden death was 4.6 cases per million population per year, with 6% of cases occurring
in young competitive athletes. Sensitivity analyses used to address suspected underreporting demonstrated an incidence
ranging from 5 to 17 new cases per million population per year. More than 90% of cases occurred in the context of
recreational sports. The age of subjects was relatively young (mean⫾SD 46⫾15 years), with a predominance of men
(95%). Although most cases were witnessed (93%), bystander cardiopulmonary resuscitation was only commenced in
30.7% of cases. Bystander cardiopulmonary resuscitation (odds ratio 3.73, 95% confidence interval 2.19 to 6.39,
P⬍0.0001) and initial use of cardiac defibrillation (odds ratio 3.71, 95% confidence interval 2.07 to 6.64, P⬍0.0001)
were the strongest independent predictors for survival to hospital discharge (15.7%, 95% confidence interval 13.2% to
18.2%).
Conclusions—Sports-related sudden death in the general population is considerably more common than previously
suspected. Most cases are witnessed, yet bystander cardiopulmonary resuscitation was only initiated in one third of
cases. Given the often predictable setting of sports-related sudden death and that prompt interventions were significantly
associated with improved survival, these data have implications for health services planning. (Circulation. 2011;124:
672-681.)
Key Words: arrhythmia 䡲 cardiac arrest 䡲 athletes 䡲 cardiopulmonary resuscitation 䡲 defibrillation 䡲 bystander help
䡲 exercise, physical
A
lthough regular physical activity benefits cardiovascular
health,1 sport, particularly when practiced vigorously,
has been shown to increase the risk of dying suddenly during
or shortly after exercise.2,3 The devastating consequences of
unexpected sports-related sudden death (SD) and the recent
availability of public access defibrillation mandate a thorough
understanding of this phenomenon across the general population.4 – 6 To date, the large majority of data regarding
sports-related SD have focused on young competitive athletes,7,8 whereas literature on sports-related SD during recreational sports activities in the community remains sparse.9,10
No prospective evaluation of sports-related SD in the general
population, including young competitive athletes, has been
published to date.
Clinical Perspective on p 681
Sports-related SDs in young competitive athletes are
highly visible and usually attract considerable public and
media attention. On the basis of relatively large studies of
sports-related SDs in young athletes from the United States
and Italy,7,11 specific preventive measures have been suggested, and some have been introduced in those countries.7,11,12 Preparticipation screening and emergency response planning, for example, have been associated with a
significant decrease in the incidence and mortality of such
events in young athletes.7,11,13,14 Nevertheless, the relatively
low absolute number of such events occurring annually
among young competitive athletes (estimated at 50 to 75 per
Received November 22, 2010; accepted June 10, 2011.
From INSERM U970, Paris Cardiovascular Research Center PARCC, Paris, France (E.M., M.T., F.D., M.-C.P., H.M., J.-P.E., X.J.); Université Paris
Descartes, UMR-S970, Paris, France (E.M., M.T., F.D., M.-C.P., H.M., M.D., J.-P.E., X.J.); Assistance Publique–Hôpitaux de Paris, Hôpital Européen
Georges Pompidou, Département de Cardiologie, Paris, France (E.M., M.D., J.-Y.L., X.J.); IRMES, Institut de Recherche BioMédicale et
d’Épidémiologie du Sport, Paris, France (M.T., J.-F.T.); Sydney Medical School, University of Sydney, Australia (D.S.C.); Agence Française de Lutte
contre le Dopage, Paris, France (M.R.); and Lille 2 University Hospital, University of Lille, Emergency Department and SAMU 59, Lille, France (N.B.).
Correspondence to Eloi Marijon, MD, Paris Cardiovascular Research Center, INSERM U970, Hôpital européen Georges Pompidou, 56 rue Leblanc,
75737 Paris CEDEX 15, France. E-mail [email protected]
© 2011 American Heart Association, Inc.
Circulation is available at http://circ.ahajournals.org
DOI: 10.1161/CIRCULATIONAHA.110.008979
672
Marijon et al
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year in the United States) appears to have influenced authorities in other countries,8 such as France (Projet d’amendement
relatif à l’installationde défibrillateurs dans les installations
sportives de grande taille: Mission d’evaluation des politiques
publiques—République Française, Mai 2009), where comprehensive preventive strategies (eg, widespread access to
automatic external defibrillators) have not been instituted in
public sports arenas because of a perceived lack of
cost-effectiveness.
The extent to which data on sports-related SD based on
young competitive athletes are generalizable to the wider
community remains unknown. We hypothesized that sportsrelated SD would be more prevalent in the general population
and thus designed a prospective nationwide observational
study over a 5-year period to examine this issue. Our aims
were to determine the overall sports-related SD burden in the
community, to characterize the circumstances and features of
sports-related SD, and to identify the independent factors that
influence outcome.
Methods
Setting, Definitions, and Survey Methods
This prospective study was performed in France between April 2005
and April 2010. We included subjects 10 to 75 years old because the
context of physical activity can be difficult to assess in the very
young, and those older than 75 years only rarely participate in sports.
The project was commissioned in 2004 by the Ministère de la Santé
et des Sports and was performed by the Institut National de la Santé
et de la Recherche Médicale (INSERM). We obtained close collaboration from the French system of mobile intensive care units
(Service d’Aide Médicale Urgente [SAMU]). All of the 96 administrative districts throughout France were invited to participate, and
60 of these districts eventually participated (see Appendix for
participating centers).
A death was considered to be sudden if it occurred within 1 hour
of symptom onset.7,8,15 Sports-related SD was defined if death
occurred during sport or within 1 hour of cessation of sports activity.
In most cases, this resulted from an unexpected collapse during
physical exertion or immediately after, associated with a previously
uneventful clinical course. Sports-related SDs related to trauma (for
example, runner or cyclist hit by a car) were excluded, other than for
cases of commotio cordis. A “young competitive athlete” was
defined as any person 10 to 35 years old who participated in an
organized sports program (team or individual sport) that required
regular competition and training according to the National Registry
from the Ministère de la Santé et des Sports (individuals participating
in college-sponsored intramural sports were not considered young
competitive athletes).16 Sports-related SDs that occurred in competitive athletes outside the context of physical activity were not
included. Sports participants who survived cardiac arrest after
defibrillation and/or cardiopulmonary resuscitation (CPR) were considered to have experienced sports-related SD for the purpose of the
present analysis.
To maximize case detection, 2 complementary independent methods were instituted that have already been used by other groups for
young competitive athletes.8 We tested the efficacy of the following
case-detection methodology in France by performing a preliminary
6-month pilot study over 5 districts in 2004. First, a prospective case
reporting system was instituted via the mobile intensive care services
(SAMU); the French SAMU system is a nationwide emergency
medical service accessed via a well-known nationwide free call
number. Thus, SAMU is systematically called in cases of cardiac
arrest or sudden collapse. Emergency health technicians in SAMU
assess these subjects and start resuscitation where required, on site.
For each case of sports-related SD during the study period, a specific
Sports-Related Sudden Death
673
detailed report form was completed by SAMU and then transmitted
to the data collection center (INSERM U970, Paris, France) within
the following 3 months. In parallel, a media search program screened
for cases from continuous Web-based monitoring via Google Reader
using the Really Simple Syndication system for local, regional, and
national newspapers (n⫽275) with the key words “death,” “cardiac
arrest,” and “dizziness.” Manual checking of these reports was
performed to identify verifiable sports-related SDs in 10- to 75-yearolds, and these cases were followed up if we had not already been
notified of them via SAMU; complementary information was then
obtained from written accounts or telephone interviews with the local
emergency team of the SAMU.
A systematic review of all sports-related SD notifications was
undertaken by an independent events committee every 6 months.
Three experts in sports-related SD adjudicated cases to exclude SDs
unrelated to sports, nonfatal sports-related cardiovascular events, and
deaths that did not meet the SD definition, and finally to identify
incomplete files that required further information.
Collected Data
Data were collected and registered according to revised Utstein
guidelines, with an additional specific focus related to sports activity
information.17,18 Case report forms used by the emergency team of
the SAMU included (1) date of arrest, patient identifier, and district
of each event; (2) clinical and demographic information (age or date
of birth, sex, any personal history of known heart disease, and any
cardiovascular symptoms during the 4 preceding weeks); (3) data
regarding the setting (recreational or competitive) and level of
exercise at the time of the sports-related SD, as assessed by the
ambulance officers using a prospectively defined scale of 1 to 8
metabolic equivalents (MET), classified as light (⬍4 MET), moderate (4 to 6 MET), or vigorous (⬎6 MET),19,20 as well as the sports
activity being undertaken at the time of the event and the regular
training regimen of each subject; (4) circumstances of collapse,
location type (sports facility or other area), presence of witnesses,
and bystander CPR and defibrillation attempt; (5) detailed information regarding the resuscitation (time of collapse, SAMU call receipt,
time SAMU vehicle arrived, CPR initiation, time of first rhythm
analysis, and time of achieved return of spontaneous circulation), the
initial cardiac rhythm recorded, and the number and timing of
delivered defibrillator shocks; and (6) survival status to hospital
admission.
Complementary data on survival status and causes of death were
managed directly by INSERM U970 in collaboration with hospitals,
and in some cases after contact with the patient’s regular physician.
Status of the patients at hospital discharge was available in the great
majority of admitted cases (97.6%). Cause of death could only be
obtained in cases in which an autopsy was performed or clinical
features at the time of death permitted a confident diagnosis for those
who died on site. In France, the performance of an autopsy is at the
discretion of the physician certifying the death and is only mandated
when the death is regarded as potentially “suspicious.” For survivors,
neurological status at discharge was evaluated with the Cerebral
Performance Categories score.21
Importantly, no specific recommendations were specified in the
study design regarding emergency care modalities or documentation
of causes of death, because the objective of the investigators was to
offer a “real-life” descriptive picture of sports-related SD features in
France.
Statistical Methods
This report was prepared in compliance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology)
checklist for observational studies.22 The primary objective of the
study was to provide an estimate of the incidence of sports-related
SD in the general population of subjects 10 to 75 years of age.
Secondary objectives were to describe population characteristics and
identify variables associated with survival.
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August 9, 2011
Absence of Signs of Circulation
and/or Considered for Resuscitation
N=820
Resuscitation Not Attempted
N=15
Resuscitation Attempted
All cases, N=805
Any defibrillation attempt, N=494
Chest compressions, N=805
Assisted ventilation, N=523
Location of Arrest
Sports Facilities, N=426
Other public places, N=391
Home, N=3
First Monitored Rhythm
Shockable, N=377
VF, N=323
VT, N=54
Nonshockable, N=441
Asystole, N=343
PEA, N=87
Sinus rhythm, N=1
Unknown, N=12
Figure 1. Utstein reporting template for 820
sports-related sudden deaths enrolled in the
study. VF indicates ventricular fibrillation; VT,
ventricular tachycardia; PEA, pulseless electrical activity; CPR, cardiopulmonary arrest; EMS,
emergency medical services; ROSC, return of
spontaneous circulation; and CPC, Cerebral
Performance Categories score.
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Arrest Witnessed, N=756
By layperson/bystander, N=660
By Healthcare personnel, N=96
Arrest not Witnessed, N=64
CPR Before EMS Arrival, N=252
Outcome
Any ROSC
Yes, N=494
No, N=296
Unknown, N=15
Survived Event, N=253
Discharged Alive, N=128
Neurologic Outcome at Discharge
CPC 1 or 2, N= 103
CPC 3 or 4, N=23
Unknown, N=8
The overall incidence of sports-related SD in France was estimated by extrapolation of the incidence of sports-related SD in the
60 participating administrative districts (which represent approximately 70% [33 948 400] of the French population 10 to 75 years of
age) to the overall 96 French districts. We calculated the incidence in
each participating district by dividing the average number of sportsrelated SDs reported per year by the locally registered 10- to
75-year-old population.23 Because there is no evidence to support a
triggering effect of light exertion for SD, the primary result regarding
calculation of incidence only included cases that occurred during
moderate and vigorous exertion (n⫽780). Moreover, because our
estimated incidence of sports-related SD in the general population is
almost certainly an underestimate, in addition to providing the global
incidence with its 95% confidence interval (CI), 2 scenarios were
then calculated based on the 80th and 20th percentiles of the highest
reported incidences of sports-related SD across different districts in
France.
The specific incidence of sports-related SD among young competitive athletes was calculated according to data from the Ministère
de la Santé et des Sports.16 The participating number of 10- to
35-year-old athletes over the study period was 1 015 293, and this
figure was considered stable over time.16 Because of the constant
high level of media coverage of sports-related SDs in young sports
participants in France (that is, such reports were considered likely to
be comprehensive), we provided only 1 incidence rate calculation for
this population.
Two additional sensitivity analyses were performed: First, on
cases that occurred during vigorous exertion among the entire
population (n⫽322), and second, among all degrees of exertion
among the 10- to 60-year-old age group (n⫽667). The characteristics of sports-related SDs are described as mean⫾SD, proportions, or median and interquartile ranges, as appropriate. Qualitative variables were compared with the ␹2 test. All covariates
that reached a significance level of P⬍0.15 for survival were then
included in an initial multivariable regression model. Odds ratios
(ORs) and their 95% CIs were calculated. All tests were 2-tailed,
and P⬍0.05 was considered to indicate statistical significance.
All data were analyzed at INSERM, Unit 970, Cardiovascular
Epidemiology and Sudden Death, Paris, using STATA software
version 11.0.
The authors had full access to the data and take full responsibility
for its integrity. All authors have read and agree to the manuscript as
written.
Results
Incidence Rates of Sports-Related Sudden Death
After 5 years of observation, representing 169 742 000 agespecific person-years, a total of 820 sports-related SDs were
recorded (Figures 1 and 2); of these, 51% were first reported
by SAMU and 49% by press reports. The proportion of cases
reported first by SAMU varied between participating districts
(from 32% to 100%). The overall estimate of sports-related
SD was 4.6 (95% CI 3.9 to 5.3) per million population per
year.
Additional sensitivity analyses were performed to address
suspected underreporting of sports-related SD in each district;
considering the 80th and 20th highest percentiles of reporting
districts, the incidence of sports-related SD throughout
France was calculated to be 5.4 and 16.7 cases per million per
year, respectively (Table 1). Considering the 60- to 75-yearold population separately did not alter the nature of our
findings, because the calculated incidence when we excluded
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675
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Figure 2. Distribution by age of sports-related sudden deaths (SDs) in the overall population (blue) and among young competitive athletes (red).
Patient Characteristics and Sports-Related Sudden
Death Settings
the cases in the older age group was 15.9 (95% CI 13.2 to
18.6) per million per year (20th percentile).
Among the 820 reported sports-related SDs, only 50 cases
(6%) occurred in young competitive athletes, which yielded
an incidence in this group of approximately 10 cases per
million per year (Figure 2; Table 1). Compared with young
(10 to 35 years old) noncompetitive sports participants, young
competitive athletes had a higher risk of sports-related SD
(relative risk 4.5, 95% CI 2.3 to 8.7). There were 777 SDs in
males and 43 SDs in females (male/female ratio of 20:1),
equivalent to incidence rates (20th percentile) of 32.8 and 1.9
million persons per year, respectively (relative risk 17.3, 95%
CI 5.9 to 50.0).
The mean age of the sports-related SD subjects was 46⫾15
years (range 11 to 75 years; Table 2). Ninety-four subjects
(11.7%) had a known history of cardiovascular disease or
presented with more than 1 classic cardiovascular risk factor
for coronary heart disease. The majority (86.5%) of sportsrelated SD subjects performed regular sports and/or training.
Symptoms, mainly chest discomfort, were reported in the
days preceding the sports-related SD in 104 patients (12.7%).
These patients were more likely to have sports-related SD due
to ischemic heart disease than other participants (92.3%
versus 70.7%, P⫽0.005).
Table 1. Estimated Incidence Rates of Sports-Related Sudden Death in the General
Population, Amongst Young Competitive Athletes and Young Noncompetitive Sport Participants
Population
No. of
Districts
Incidence Rates, per Million
per Year (95% CI)
Estimated Absolute
per Year in France
Overall
33 948 400
60
4.6 (3.9–5.3)
226
Male
16 195 232
60
9.2 (7.7–10.7)
216
Female
17 753 168
60
0.4 (0.1–0.7)
10
7 239 500
12
16.7 (13.7–19.7)
814
Male
3 474 960
12
32.8 (26.8–38.8)
772
Female
3 764 540
12
1.9 (0.5–3.2)
42
General population (10 –75 y)
20th percentile
80th percentile
27 950 100
48
5.4 (4.5–6.3)
263
Male
13 116 500
48
10.6 (8.8–12.4)
250
Female
14 833 600
48
0.8 (0.4–1.3)
13
1 015 293
60
9.8 (3.7–16.0)
15
12 358 498
60
2.2 (1.4–3.0)
39
Young competitive athletes
Young noncompetitive participants
CI indicates confidence interval.
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Table 2. Characteristics of Patients and Selected Features of
820 Sports-Related Sudden Deaths Included in the Study
Value
Demographic data
Age, y
Mean
46.1⫾14.8
IQR
37–57
Males
777 (94.8)
Young competitive athlete
50 (6.1)
History of known heart disease*
66 (8.1)
Coronary heart disease
31
Paroxysmal atrial fibrillation
12
Ventricular arrhythmias considered as benign
6
Valvular heart disease
5
Pacemaker placement
5
Dilated cardiomyopathy
3
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Others†
Continued
Value
Delay, median (IQR), min
Collapse-to-call received
2.0 (0.5–4.5)
Collapse-to-start of CPR
4.8 (1.2–8.5)
Collapse-to-first defibrillator shock
12.5 (10.5–15.5)
IQR indicates interquartile range; SD, sudden death; and CPR, cardiopulmonary resuscitation.
Data are n (%), unless otherwise specified.
*Data were missing for history of known heart disease (for 8 subjects),
cardiovascular risk factors (11), intensity of exercise (8), presence of witness
(4), and monitored rhythm (12). Percentages were calculated on the basis of
the total number of known events.
†Others denote operated congenital heart disease (2), history of Kawasaki
disease (1), or Marfan syndrome (1).
‡Cardiovascular risk factor included known/treated diabetes mellitus, dyslipidemia, systemic hypertension, obesity, current smoker, and family history of
premature coronary heart disease.
4
⬎1 Cardiovascular risk factor*‡
49 (6.1)
Time of occurrence
Season
Winter
158 (19.3)
Spring
258 (31.5)
Summer
243 (29.6)
Autumn
161 (19.6)
Week
Weekend
336 (41.0)
Time of day
Morning (6
Table 2.
AM
to 12
Afternoon (12
PM
Evening (6
to 12
PM
PM)
to 6
PM)
AM)
287 (35.0)
359 (43.8)
174 (21.2)
Sport setting
Sport activities
Team sports
273 (33.3)
Individual sports
547 (66.7)
Sports-related SD actually occurred during sports activity
in 92%, immediately after (within 30 minutes) in 7.4%, and
only rarely more than 30 minutes after cessation of sports
activity. Most sports-related SDs were observed during cycling (30.6%), running (21.3%), or soccer (13.0%), the sport
activities most practiced in France (Figure 3). Sports-related
SDs during team sports activities occurred at a younger age
than during individual sports (33⫾11 versus 51⫾13 years,
P⬍0.0001). Half of the sports-related SDs (51.9%) occurred
in public sports facilities (such as a gymnasium or a stadium),
and 99.8% of these were witnessed. Bystanders in sports
facilities were slightly more likely to initiate CPR than were
bystanders outside these settings, but this difference was not
statistically significant (35.5% versus 30.8%, P⫽0.15).
Among cases outside these settings, 83.4% were witnessed.
There were more sports-related SDs on Sunday (P⬍0.0001,
asymptotic test for binomial proportions), but no significant
circadian variation was observed.
Location of occurrence
Sport facilities
426 (52.0)
Others
394 (48.0)
Intensity of exercise*
Light
32 (3.9)
Moderate
458 (56.4)
Vigorous
322 (39.7)
Management of sports-related SD
Sudden death witnessed*
756 (92.6)
Bystander CPR
252 (30.7)
First monitored rhythm*
Ventricular fibrillation or tachycardia
377 (46.7)
Asystole
343 (42.5)
Pulseless electrical activity
Sinus rhythm
Shock by external defibrillator
87 (10.8)
1 (0.1)
494 (61.1)
(Continued)
Bystander Cardiopulmonary Resuscitation,
Advanced Life Support, and Predictors of Survival
Bystander CPR was initiated in 252 cases (30.7%). Median
time from collapse to CPR initiation was 4.8 minutes (interquartile range 1.2 to 8.5 minutes). The initial cardiac rhythm
was ventricular fibrillation or pulseless fast ventricular
tachycardia in 377 cases (46.1%), with a mean number of
shocks in this group of 5.3⫾3.8 (range 1 to 19).
A total of 253 of the 820 subjects (30.8%; 95% CI 27.7%
to 34.0%) survived to hospital admission, and among them,
vital status at time of discharge was known for 247 (97.6%).
One hundred twenty-eight of these subjects survived to
hospital discharge, giving an overall survival rate to hospital
discharge of 15.7% (95% CI 13.2% to 18.2%). The majority
of these (103 of 126 for whom neurological assessment was
established) presented with a Cerebral Performance Categories
score of 1 or 2, good enough to allow normal life or part-time
work in a sheltered environment. The highest survival rates
(⬇50%) were in the Burgundy (Côte-d’Or) and Nord-Pas-de-
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677
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Figure 3. Sports engaged in at the time of sudden death (SD) in 820 sports participants. Shaded proportions of the bars represent the
female ratio.
Calais (Nord) districts, where bystanders initiated CPR in
more than 90% of cases.
Univariable analyses for factors associated with survival to
hospital discharge are shown in Table 3. According to
multiple logistic regression analysis, the following factors
were independently associated with survival to hospital discharge: Bystander CPR (OR 3.73, 95% CI 2.19 to 6.39,
P⬍0.0001), time from collapse to start of CPR (OR 1.32,
95% CI 1.08 to 1.61, P⫽0.006), and the initial use of cardiac
defibrillation (OR 3.71, 95% CI 2.07 to 6.64, P⬍0.0001).
Additional sensitivity analyses among cases of sports-related
SD associated with vigorous exertion and among the 10- to
60-year-old population did not demonstrate significant differences regarding predictors for survival compared with the
overall population.
Cardiovascular Abnormalities Associated With
Sports-Related Sudden Deaths
The proportion of cases with a clear diagnosis remained low
(24.7%), particularly among subjects who died on site
(5.1%). Cause-of-death analysis among young competitive
athletes and the general population is presented in Figure 4.
Although 64% of sports-related SDs among young competitive athletes had the cause elucidated, this was only available
for 22% of SDs among the general population.
Among the 203 cases in which it was possible to ascertain
the cause of death with clinical certainty or from anatomopathological investigations, causes were cardiac in origin
in all but 4 cases (98.0%). Acute coronary syndrome was the
principal cause of cardiac arrest during sports (152 subjects,
74.9%); other cardiovascular causes of death or pathological
findings included hypertrophic cardiomyopathy (7 subjects),
possible hypertrophic cardiomyopathy (6), congenital cardiac
abnormality (5, including 2 cases of aberrant coronary artery), dilated cardiomyopathy (5), myocarditis (5, including 1
case of sarcoidosis), arrhythmogenic right ventricular dysplasia (3), early repolarization syndrome (2), Wolff-Parkinsonwhite syndrome (1), familial long-QT syndrome (1), mitral
valve prolapse (2), and commotio cordis (1). Noncardiac
causes were found in 4 cases, ascribed to epilepsy, ruptured
cerebral artery, stroke, and ruptured ascending aorta, respectively. The remaining 9 cases were ascribed to idiopathic
ventricular fibrillation because no cardiac abnormality was
observed. Among the 820 patients, drugs or anabolic steroids
were reported to have been implicated in death in 2 cases.
Discussion
In this prospective study of 820 cases of sports-related SDs
and resuscitated cardiac arrests in a general population, we
have identified a higher burden of this event than previously
suspected from comprehensive surveys of sports-related SD
in young competitive athletes. We found that the majority of
such events were witnessed (93%), although bystander CPR
was initiated in fewer than one third of the cases. Given the
often predictable setting of sports-related SD and that prompt
interventions were significantly associated with improved
survival, these data have implications for health services
planning. In particular, education about CPR for sports
participants and availability of public access defibrillation in
sports facilities have the potential to achieve substantial
improvements in outcomes.
Previously published data on the incidence of sportsrelated SDs observed in competitive young athletes have
documented an incidence of 6 to 9 per million such competitors per year.7,8 The present data among young competitive
athletes are very consistent with these estimates. The largest
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August 9, 2011
Table 3. Univariate Analysis for Survival to Hospital Discharge
Predictors of Survival: Variables
Women vs men
OR
95% CI
P
1.59
0.76 –3.32
0.21
Age, y
⬍0.0001
10–30
1.00
31–50
0.60
0.36–0.99
51–75
0.26
0.15–0.44
0.56
0.28–1.12
Known CVD vs others
0.10
Seasons
Winter
1.00
Spring
1.61
0.92–2.84
0.18
Summer
1.13
0.62–2.04
Autumn
1.64
0.89–3.00
Weekend
1.60
1.10–2.32
0.01
Team sports
0.98
0.66–1.45
0.92
Intensity of exercise
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Light
1.00
Moderate
1.70
0.40–7.51
0.002
Vigorous
3.36
0.78–14.5
Sport facilities vs others
2.83
1.88–4.25
Competitive vs recreational setting
1.32
0.83–2.12
0.24
Young competitive athlete
1.62
0.82–3.18
0.16
Presence of witness
6.73
1.62–27.8
0.009
Bystander CPR
9.83
6.42–15.04
⬍0.0001
⬍0.0001
Collapse to start of CPR delay, min
⬍0.0001
0–2
1.00
3–4
0.44
0.22–0.91
5–10
0.13
0.06–0.28
11–20
0.10
0.05–0.23
9.60
5.88–15.70
Initial shockable rhythm
⬍0.0001
OR indicates odds ratio; CI, confidence interval; CVD, cardiovascular disease;
and CPR, cardiopulmonary resuscitation.
previous European study of sports-related SDs, from Veneto,
Italy, included 55 cases of sports-related SDs in young
competitive athletes documented over a 25-year period.7,24
Maron et al8 reported 1866 cases of SD in young competitive
athletes over a 27-year period in the United States, 50% of
which were traumatic, of noncardiac origin, or did not occur
during sporting activity. Taken together, these data suggest
that approximately 50 to 75 SDs in young competitive
athletes would occur annually in the United States, and
approximately 10 to 15 such events would occur in France
each year. The focus on this group of healthy young athletes
is highly understandable given the substantial social and
emotional impact of sudden and unexpected deaths in this
group.25
However, data showing relatively low absolute numbers of
events in young athletes per year have influenced health
authorities in many countries regarding the institution of
widespread early response measures. In France in May 2009,
for example, draft legislation proposing the installation of
automatic external defibrillators in sporting arenas was eventually rejected after evaluation by an economic expert com-
mittee that concluded that this would not be cost-effective
based on the 10 to 15 expected such cases yearly.
Data concerning the risk of sports-related SD among
recreational sports participants, who accounted for more than
90% of cases in the present study, are relatively sparse. These
data come from a limited number of retrospective studies that
involved small numbers of cases and most often were in
regard to only 1 sports activity.9,10,26 –32 To date, only 1 study
attempted to evaluate sports-related acute cardiovascular
events in the general population, with no specific focus on
SD.33 Other available data from autopsy series contribute
information on likely causes of SD; however, these are
associated with bias and do not allow calculation of the
population burden of sports-related SD.34 –38 Finally, to the
best of our knowledge, sports-related SD has never been
evaluated in the general population, including athletes and
recreational sports participants across a wide age range. The
present study revealed a much higher prevalence of sportsrelated SD in the general population than previously suspected (estimated at approximately 4250 cases in the United
States or 800 cases in France each year in the 10- to
75-year-old age group). The present data demonstrated that
although risk for sports-related SD remains higher in young
competitive athletes than in 10- to 35-year-old noncompetitive sports participants, the absolute risk appears to be higher
in the general population. In the present series, although the
survival rate to hospital discharge after sports-related SD
(approximately 16%) was substantially higher than the published rates of survival after SD in general, at approximately
7% to 8%,39 there may still be substantial room for improvement. For example, 90% of sports-related SDs in the present
series were witnessed, but bystander CPR was commenced in
only one third of these cases. The data from 2 French districts
where resuscitation rates of more than 90% were associated
with survival rates of approximately 50% support calls for
more extensive population-based CPR education. Because the
population is relatively young and such settings offer optimal
chances for survival, these data should prompt the development of preventive measures based on public education.
Moreover, these results also raise the question of systematic screening, especially for ischemic heart disease,
among male recreational sports participants with cardiovascular risk factors.
We note the striking male predominance in sports-related
SD in the present series. Based on sports participation rates in
France, this is not simply the reflection of a greater male
participation but likely the consequence of a higher risk
profile in men. The reasons for this sex difference is unclear,
but it could be related to the known higher prevalence of
coronary disease in young and middle-aged men than in
women. Differences in the mode of physical activity and
training between sexes may also be relevant.
We acknowledge that the present study has a number of
potential limitations. First, we observed important differences
in incidences among districts. One possible explanation is
that this may reflect real differences in incidences due to
subject characteristics or sports activities. However, the ratio
of emergency medical services cases to total cases varied
markedly among districts, which leads us to favor a different
Marijon et al
Sports-Related Sudden Death
679
Young Competitive Athletes
2%
2%
2%
2%
4%
8%
36%
2%
2%
2%
4%
4%
6%
6%
4%
4%
10%
Unexplained
Coronary heart disease
HCM
Possible HCM
ARVD
Congenital heart disease
Dilated cardiomyopathy
Myocarditis
Early repolarization syndrome
Wolff-Parkinson-White
Long QT syndrome
Primitive VF
Mitral-valve prolapse
Tunneled LAD coronary artery
Commotio cordis
Ruptured ascending aorta
Epilepsy
General Population
Downloaded from http://circ.ahajournals.org/ by guest on June 17, 2017
(except young competitive athletes)
19%
78%
Figure 4. Cardiovascular abnormalities associated
with sports-related sudden death in 820 subjects
among the young competitive group (n⫽50) and
the general population (n⫽770). HCM indicates
hypertrophic cardiomyopathy; ARVD, arrhythmogenic right ventricular dysplasia; VF, ventricular
fibrillation; and LAD, left anterior descending.
Unexplained
Coronary heart disease
HCM
Possible HCM
ARVD
Dilated cardiomyopathy
Myocarditis
Primitive VF
Stroke
Ruptured cerebral artery
Aortic valve stenosis
explanation, ie, that the variability of reported incidences
across different districts reflects a variable degree of underreporting. Our estimated incidence of sports-related SD in the
general population is also almost certainly an underestimate.
In addition to underreporting, this is also due in part to the
consideration of the entire 10- to 75-year-old population as
being potentially at risk of sports-related SD rather than
estimating the proportion who were actually participating in
sports (this is because there are no reliable data to estimate
actual recreational sports participation). This has been the
rationale for the use of sensitivity analyses to provide a range
of incidence of community-based sports-related SD. Second,
autopsy rates are very low in France, where they are performed at the discretion of the certifying physician rather than
mandated by law. The present results among young competitive athletes, including the rate of cases without precise
diagnosis, are consistent with the study of the largest cohort
to date performed by Maron and colleagues in the United
States.8 On the other hand, we offered a different view from
the general population with a majority of cases considered
ischemic cardiovascular events but that ultimately remained
without a precise diagnosis. Further efforts for better identification of cause of death, including postmortem molecular
analysis, are crucial in this context, in which early diagnosis
of familial cardiomyopathy or channelopathy may be vital for
relatives.40
In summary, we have documented a substantially higher
incidence of sports-related SD in the general population than
suspected previously from studies focused on competitive
young athletes. Depending on the degree of underreporting
present in our sample, we estimate from 5 to 17 cases of
sports-related SD occur per million individuals residing in
France per year. Most such events occur in previously healthy
men 35 to 65 years old, happen in a public area, and are
witnessed by bystanders. Given the often predictable setting
of sports-related SD and that prompt interventions including
bystander CPR and defibrillation were significantly associated with improved survival, these data have implications for
health services planning.
Appendix
Participating Centers
The investigators and coordinators participating in the study were as
follows (numbers given are French administrative division numbers):
02 Aisne, Dr F. Degrootte; 05 Hautes-Alpes, Dr M. Tashan; 06
Côte d’Azur, Dr D. Grimaud; 13 Bouches-du-Rhône, Dr V. Vig; 14
Calvados, Dr D. Bonnieux; 16 Charente, Dr R. Loyant; 17 CharenteMaritime, Dr A. Mounios; 18 Cher, Dr F. Bandaly; 21 Côte-d’Or, Dr
M. Freysz; 22 Côtes-d’Armor, Dr C. Hamon; 24 Dordogne, Dr M.
Gautron; 25 Doubs, Dr M.C. Maillot; 26 Drôme, Dr C. Zamour; 28
Eure-et-Loir, Dr N. Letellier; 29 Finistère, Dr D. Lazou; 31 HauteGaronne, Dr J.L. Ducasse; 32 Gers, Dr J.M. Guez; 33 Gironde, Dr
680
Circulation
August 9, 2011
M. Thicoipe; 34 Hérault, Dr P. Benatia; 36 Indre, Dr L. Soulat; 37
Indre-et-Loire, Dr A. Fusciardi; 38 Isère, Dr K. Berthelot; 39 Jura,
Dr A. Elisseeff; 40 Landes, Dr R. Ricard; 41 Loir-et-Cher Dr Solo
Randriamalala; 42 Loire, Dr T. Guerin; 44 Loire Atlantique, Dr V.
Debierre; 45 Loiret, Dr S. Narcisse; 48 Lozère, Dr M. Chassing; 51
Marne, Dr A. Léon; 52 Haute-Marne, Dr J. Milleron; 55 Meuse, Dr
M. Vedel; 56 Morbihan, Dr F. Charland; 59 Nord, Dr N. Benameur;
60 Oise, Dr T. Ramaherison; 62 Pas-de-Calais, Dr L. Hapka; 63
Puy-de-Dôme, Dr J. Meyrieux; 64 Pyrénées-Atlantiques, Dr I.
Pouyanne; 65 Hautes-Pyrénées, Dr J. Khazaka; 67 Bas Rhin, Dr J.C.
Bartier; 68 Haut-Rhin, Dr A. Goulesqueb; 69 Rhône, Dr P.Y.
Gueugniaud; 70 Haute-Sâone, Dr T. Elcadi; 71 Sâone-et-Loire, Dr B.
Girardet; 72 Sarthe, Dr C. Savio; 75 Paris, Dr D. Jannière; 76
Seine-Maritime, Dr B. Dureuil; 77 Seine et Marne, Dr J.Y. Le
Tarnec; 78 Yvelines, Dr S. Templer; 80 Somme, Dr C. Ammirati; 81
Tarn, Dr M.G. Vaissière; 83 Var, Dr J.J. Raymond; 84 Vaucluse, Dr
P. Olivier; 88 Vosges, Dr H. Tonnelier; 89 Yonne, Dr M. Duche; 90
Territoire-de-Belfort, Dr A. Kara; 92 Hauts-de-Seine, Dr M. Baer; 93
Seine-Saint-Denis, Dr F. Adnet; 94 Val-de-Marne, Dr C. Vallier; 95
Val-d’Oise, Dr C. Ramaut.
Downloaded from http://circ.ahajournals.org/ by guest on June 17, 2017
Acknowledgments
We would like to acknowledge the contributions of all participating
units of SAMU of France, as well as Dr Pénélope Troude for her
technical assistance.
Sources of Funding
This study was supported in part by INSERM (Institut National de la
Santé et de la Recherche Médicale) and IRMES (Institut de Recherche BioMédicale et d’Épidémiologie du Sport).
Disclosures
None.
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CLINICAL PERSPECTIVE
Downloaded from http://circ.ahajournals.org/ by guest on June 17, 2017
To date, the majority of data regarding sports-related sudden death (SD) have focused on young competitive athletes, and
few data concerning sports-related SD in the general population have been available. In this 5-year observational study of
SD occurring during sports in competitive and recreational participants 10 to 75 years of age, we have found that although
the risk for sports-related SD remains higher in young competitive athletes than in young noncompetitive sports
participants, the absolute risk is otherwise higher in the general population. The present study revealed approximately 800
cases in France each year compared with the 15 annual cases among young competitive athletes. Case subjects were
relatively young (46⫾15 years), predominantly males (95%), and without any prior history of heart disease. Half of the
observed cases occurred in sports facilities, and almost 90% of events were witnessed; however, the rate of bystander
cardiopulmonary resuscitation was low, initiated in fewer than one third of cases. Given the often predictable setting of
sports-related SD and that prompt interventions including bystander CPR and defibrillation were significantly associated
with improved survival in the present study, these data have implications for health services planning.
Sports-Related Sudden Death in the General Population
Eloi Marijon, Muriel Tafflet, David S. Celermajer, Florence Dumas, Marie-Cécile Perier,
Hazrije Mustafic, Jean-François Toussaint, Michel Desnos, Michel Rieu, Nordine Benameur,
Jean-Yves Le Heuzey, Jean-Philippe Empana and Xavier Jouven
Downloaded from http://circ.ahajournals.org/ by guest on June 17, 2017
Circulation. 2011;124:672-681; originally published online July 25, 2011;
doi: 10.1161/CIRCULATIONAHA.110.008979
Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231
Copyright © 2011 American Heart Association, Inc. All rights reserved.
Print ISSN: 0009-7322. Online ISSN: 1524-4539
The online version of this article, along with updated information and services, is located on the
World Wide Web at:
http://circ.ahajournals.org/content/124/6/672
Data Supplement (unedited) at:
http://circ.ahajournals.org/content/suppl/2013/10/14/CIRCULATIONAHA.110.008979.DC1
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48
일반 사람들이 운동하다 발생하는 급사, 생각보다 흔하다
최 기 준 교수 서울아산병원 심장내과
Summary
배경
젊은 경쟁적 운동선수들에게서 발생하는 운동 중 급사
였다. 발생 당시 연령은 평균 46세였고, 대부분이 남자였
에 대해서는 일부 보고된 적이 있지만, 일반인들에게서
다(95%). 93%의 예에서 목격자가 있었으나 목격자에 의
운동과 연관되어 생기는 급사의 빈도, 특성 및 결과에 대
한 심폐소생술은 겨우 30.7%에서만 시행되었다. 목격자
해서는 보고된 바는 없다.
심페소생술(OR, 3.73; P<0.0001)과 초기 제세동기의 사
용(OR, 3.71; P<0.0001)이 생존 퇴원율(15.7%; 95% CI,
방법 및 결과
13.2-18.2)의 가장 강력한 독립인자였다.
2005년부터 2010년에 걸쳐 프랑스에서 10-75세의 사람
들을 대상으로 전향적인 통합적 국가조사로 시행되었
결론
다. 운동과 연관된 급사는 심정지에서 소생된 예를 포함
일반인들에서 운동과 연관된 급사는 막연히 예측했던 것
하였고, 국가 구급서비스의 보고와 언론을 통해 보고된
보다는 흔하게 관찰되었다. 대부분의 예에서 목격자가
예들을 web을 근간으로 조사하여 취합하였다. 전체적
있었으나, 목격자에 의한 심폐소생술은 겨우 1/3정도에
인 운동 연관 급사는 일년에 백만 명 중 4.6예에서 발생
서만 시행되었다. 즉각적인 심폐소생술과 초기 제세동기
하였고, 이 중 6%는 젊은 경쟁적 운동선수들에게서 발
의 사용이 생존율의 증가와 연관성이 있었고, 이러한 결
생하였다. Sensitivity 분석을 통하여 예상된 과소보고 정
과는 향후 보건의료 계획에 영향을 줄 것이다.
도를 교정해 보면 이 발생률은 5명에서 17명이 새롭게
발생하는 것으로 분석된다. 운동과 연관된 급사의 예 중
에서 90% 이상이 레크레이션 운동과 연관되어 발생하
Arrhythmia
49
Commentary
일반적으로 규칙적인 운동이 심혈관계 질환에 좋은 영
흔하였는데, 이 종목들은 모두 프랑스에서 흔히 행해지
향을 미치나, 드물게 운동 중 혹은 운동 직후에 급사에
는 운동종목이다. 심정지가 발생한 환자들에서 원인질환
이르는 경우가 보고된다. 이제까지 이러한 운동과 연관
이 어느 정도 확인된 경우는 22% 정도였는데, 이 중 급
1
된 급사는 젊은 운동선수들에서는 보고된 바가 있지만,
성 관동맥 증후군이 152명(74.9%)으로 가장 많았고, 그
일반인들에서 사회체육이나 레크레이션 운동 중 발생하
외에 비후성심근증(의증 포함 13명), 선천성 심질환(5명),
는 급사에 대해서는 그 빈도나 특징이 보고된 연구가 드
확장성심근증(5명), 심근염(5명), 부정맥유발성 우심실이
물며, 특히 전향적인 연구는 이번 연구가 처음이다. 우리
형증(3명), 조기 재분극증후군(2명) 등이 진단되었다.
나라에서도 2000년 야구선수인 임수혁 선수와 올해 축
운동 중 심정지가 발생한 경우, 예후와 관계된 중요한 인
구선수인 신영록 선수가 경기 중 심정지가 발생하여 임
자는 목격자에 의한 심폐소생술과 초기의 제세동기 사
선수는 식물인간 상태로 지내다 10년 후 사망하였고 신
용이었다. 또한, 51.9%의 운동-연관 심정지가 공공 운동
선수는 소생하긴 하였지만 상당한 장애가 남아있는 상
장소(스포츠센터, 체육관, 운동장 등)에서 발생하였던 점
태이다. 일반인에서는 드물지 않게 마라톤 대회에서 사
을 감안하면 공공 운동장소에 자동제세동기(automatic
망하는 경우가 간혹 보고되고 있다.
external defibrillator)의 설치가 꼭 필요한 이유임을 강
본 연구는 일반인들에서 운동과 연관된 급사의 빈도와
조하게 된다. 젊은 운동선수에서의 급사는 운동선수
특성을 알아보기 위하여 2005년부터 2010년에 걸쳐 프
들에 대한 선수생활 시작 전의 검사(preparticipation
랑스에서 시행된 국가적인 관찰연구의 결과이다. 5년 동
screening)로 운동 중 급사를 줄였다는 보고도 있으나
안의 기간에 820명의 운동과 연관된 급사가 수집되었고,
일반인들에게 모두 이러한 검사를 시행하기에는 비용 대
이 중 51%는 국가 구급서비스를 통하여 보고된 예이고
비 효과가 떨어진다는 제한점이 있다.
2
나머지 49%는 언론을 통해 보고된 사례들이었다. 전체
820명 중 젊은 경쟁적 운동선수들에서 발생한 예는 50
예(6%)로 전체 운동과 연관된 급사 중 극히 일부였다. 보
고된 급사 환자 중 11.7%만이 심혈관계 질환의 병력이
있거나 심혈관계 질환의 중요한 위험인자를 갖고 있는
경우였고, 86.5%의 예에서는 정기적으로 운동을 하거나
트레이닝을 받는 경우여서, 위험인자가 없거나 정기적인
운동을 하였다고 해서 안심할 수 있는 것은 아니었다. 하
지만 12.7%의 환자들에서는 사건이 있기 전에 흉부 불
편감이나 흉통의 증상이 있었고, 이런 환자들은 허혈성
심질환과 연관된 급사를 경험한 경우가 많은 것으로 보
고되었다.
대부분의 심정지는 운동 중 발생하였고(92%), 운동 종류
로는 싸이클링(30.6%), 달리기(21.3%), 축구(13.0%) 등이
References
111 Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young
competitive athletes: analysis of 1866 deaths in the United States, 1980–2006.
Circulation . 2009;119:1085-1092.
222 Maron BJ, Haas TS, Doerer JJ, Thompson PD, Hodges JS. Comparison of U.S. and
Italian experiences with sudden cardiac deaths in young competitive athletes and
implications for preparticipation screening strategies. Am J Cardiol . 2009;104:276
-280.
Arrhythmia/Electrophysiology
Sports-Related Sudden Death in the General Population
Eloi Marijon, MD; Muriel Tafflet, PhD; David S. Celermajer, PhD, FRACP; Florence Dumas, MD;
Marie-Cécile Perier, MSc; Hazrije Mustafic, MD; Jean-François Toussaint, MD, PhD;
Michel Desnos, MD; Michel Rieu, MD; Nordine Benameur, MD; Jean-Yves Le Heuzey, MD;
Jean-Philippe Empana, MD, PhD; Xavier Jouven, MD, PhD
Background—Although such data are available for young competitive athletes, the prevalence, characteristics, and
outcome of sports-related sudden death have not been assessed previously in the general population.
Methods and Results—A prospective and comprehensive national survey was performed throughout France from 2005 to
2010, involving subjects 10 to 75 years of age. Case detection for sports-related sudden death, including resuscitated
cardiac arrest, was undertaken via national ambulance service reporting and Web-based screening of media releases. The
overall burden of sports-related sudden death was 4.6 cases per million population per year, with 6% of cases occurring
in young competitive athletes. Sensitivity analyses used to address suspected underreporting demonstrated an incidence
ranging from 5 to 17 new cases per million population per year. More than 90% of cases occurred in the context of
recreational sports. The age of subjects was relatively young (mean�SD 46�15 years), with a predominance of men
(95%). Although most cases were witnessed (93%), bystander cardiopulmonary resuscitation was only commenced in
30.7% of cases. Bystander cardiopulmonary resuscitation (odds ratio 3.73, 95% confidence interval 2.19 to 6.39,
P�0.0001) and initial use of cardiac defibrillation (odds ratio 3.71, 95% confidence interval 2.07 to 6.64, P�0.0001)
were the strongest independent predictors for survival to hospital discharge (15.7%, 95% confidence interval 13.2% to
18.2%).
Conclusions—Sports-related sudden death in the general population is considerably more common than previously
suspected. Most cases are witnessed, yet bystander cardiopulmonary resuscitation was only initiated in one third of
cases. Given the often predictable setting of sports-related sudden death and that prompt interventions were significantly
associated with improved survival, these data have implications for health services planning. (Circulation. 2011;124:
672-681.)
Key Words: arrhythmia � cardiac arrest � athletes � cardiopulmonary resuscitation � defibrillation � bystander help
� exercise, physical
A
lthough regular physical activity benefits cardiovascular
health,1 sport, particularly when practiced vigorously,
has been shown to increase the risk of dying suddenly during
or shortly after exercise.2,3 The devastating consequences of
unexpected sports-related sudden death (SD) and the recent
availability of public access defibrillation mandate a thorough
understanding of this phenomenon across the general population.4 – 6 To date, the large majority of data regarding
sports-related SD have focused on young competitive athletes,7,8 whereas literature on sports-related SD during recreational sports activities in the community remains sparse.9,10
No prospective evaluation of sports-related SD in the general
population, including young competitive athletes, has been
published to date.
Clinical Perspective on p 59
Sports-related SDs in young competitive athletes are
highly visible and usually attract considerable public and
media attention. On the basis of relatively large studies of
sports-related SDs in young athletes from the United States
and Italy,7,11 specific preventive measures have been suggested, and some have been introduced in those countries.7,11,12 Preparticipation screening and emergency response planning, for example, have been associated with a
significant decrease in the incidence and mortality of such
events in young athletes.7,11,13,14 Nevertheless, the relatively
low absolute number of such events occurring annually
among young competitive athletes (estimated at 50 to 75 per
Received November 22, 2010; accepted June 10, 2011.
From INSERM U970, Paris Cardiovascular Research Center PARCC, Paris, France (E.M., M.T., F.D., M.-C.P., H.M., J.-P.E., X.J.); Université Paris
Descartes, UMR-S970, Paris, France (E.M., M.T., F.D., M.-C.P., H.M., M.D., J.-P.E., X.J.); Assistance Publique–Hôpitaux de Paris, Hôpital Européen
Georges Pompidou, Département de Cardiologie, Paris, France (E.M., M.D., J.-Y.L., X.J.); IRMES, Institut de Recherche BioMédicale et
d’Épidémiologie du Sport, Paris, France (M.T., J.-F.T.); Sydney Medical School, University of Sydney, Australia (D.S.C.); Agence Française de Lutte
contre le Dopage, Paris, France (M.R.); and Lille 2 University Hospital, University of Lille, Emergency Department and SAMU 59, Lille, France (N.B.).
Correspondence to Eloi Marijon, MD, Paris Cardiovascular Research Center, INSERM U970, Hôpital européen Georges Pompidou, 56 rue Leblanc,
75737 Paris CEDEX 15, France. E-mail [email protected]
© 2011 American Heart Association, Inc.
Circulation is available at http://circ.ahajournals.org
DOI: 10.1161/CIRCULATIONAHA.110.008979
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672 by IMED Korea on November 13, 2011
50
Marijon et al
year in the United States) appears to have influenced authorities in other countries,8 such as France (Projet d’amendement
relatif à l’installationde défibrillateurs dans les installations
sportives de grande taille: Mission d’evaluation des politiques
publiques—République Française, Mai 2009), where comprehensive preventive strategies (eg, widespread access to
automatic external defibrillators) have not been instituted in
public sports arenas because of a perceived lack of
cost-effectiveness.
The extent to which data on sports-related SD based on
young competitive athletes are generalizable to the wider
community remains unknown. We hypothesized that sportsrelated SD would be more prevalent in the general population
and thus designed a prospective nationwide observational
study over a 5-year period to examine this issue. Our aims
were to determine the overall sports-related SD burden in the
community, to characterize the circumstances and features of
sports-related SD, and to identify the independent factors that
influence outcome.
Methods
Setting, Definitions, and Survey Methods
This prospective study was performed in France between April 2005
and April 2010. We included subjects 10 to 75 years old because the
context of physical activity can be difficult to assess in the very
young, and those older than 75 years only rarely participate in sports.
The project was commissioned in 2004 by the Ministère de la Santé
et des Sports and was performed by the Institut National de la Santé
et de la Recherche Médicale (INSERM). We obtained close collaboration from the French system of mobile intensive care units
(Service d’Aide Médicale Urgente [SAMU]). All of the 96 administrative districts throughout France were invited to participate, and
60 of these districts eventually participated (see Appendix for
participating centers).
A death was considered to be sudden if it occurred within 1 hour
of symptom onset.7,8,15 Sports-related SD was defined if death
occurred during sport or within 1 hour of cessation of sports activity.
In most cases, this resulted from an unexpected collapse during
physical exertion or immediately after, associated with a previously
uneventful clinical course. Sports-related SDs related to trauma (for
example, runner or cyclist hit by a car) were excluded, other than for
cases of commotio cordis. A “young competitive athlete” was
defined as any person 10 to 35 years old who participated in an
organized sports program (team or individual sport) that required
regular competition and training according to the National Registry
from the Ministère de la Santé et des Sports (individuals participating
in college-sponsored intramural sports were not considered young
competitive athletes).16 Sports-related SDs that occurred in competitive athletes outside the context of physical activity were not
included. Sports participants who survived cardiac arrest after
defibrillation and/or cardiopulmonary resuscitation (CPR) were considered to have experienced sports-related SD for the purpose of the
present analysis.
To maximize case detection, 2 complementary independent methods were instituted that have already been used by other groups for
young competitive athletes.8 We tested the efficacy of the following
case-detection methodology in France by performing a preliminary
6-month pilot study over 5 districts in 2004. First, a prospective case
reporting system was instituted via the mobile intensive care services
(SAMU); the French SAMU system is a nationwide emergency
medical service accessed via a well-known nationwide free call
number. Thus, SAMU is systematically called in cases of cardiac
arrest or sudden collapse. Emergency health technicians in SAMU
assess these subjects and start resuscitation where required, on site.
For each case of sports-related SD during the study period, a specific
Sports-Related Sudden Death
67351
detailed report form was completed by SAMU and then transmitted
to the data collection center (INSERM U970, Paris, France) within
the following 3 months. In parallel, a media search program screened
for cases from continuous Web-based monitoring via Google Reader
using the Really Simple Syndication system for local, regional, and
national newspapers (n�275) with the key words “death,” “cardiac
arrest,” and “dizziness.” Manual checking of these reports was
performed to identify verifiable sports-related SDs in 10- to 75-yearolds, and these cases were followed up if we had not already been
notified of them via SAMU; complementary information was then
obtained from written accounts or telephone interviews with the local
emergency team of the SAMU.
A systematic review of all sports-related SD notifications was
undertaken by an independent events committee every 6 months.
Three experts in sports-related SD adjudicated cases to exclude SDs
unrelated to sports, nonfatal sports-related cardiovascular events, and
deaths that did not meet the SD definition, and finally to identify
incomplete files that required further information.
Collected Data
Data were collected and registered according to revised Utstein
guidelines, with an additional specific focus related to sports activity
information.17,18 Case report forms used by the emergency team of
the SAMU included (1) date of arrest, patient identifier, and district
of each event; (2) clinical and demographic information (age or date
of birth, sex, any personal history of known heart disease, and any
cardiovascular symptoms during the 4 preceding weeks); (3) data
regarding the setting (recreational or competitive) and level of
exercise at the time of the sports-related SD, as assessed by the
ambulance officers using a prospectively defined scale of 1 to 8
metabolic equivalents (MET), classified as light (�4 MET), moderate (4 to 6 MET), or vigorous (�6 MET),19,20 as well as the sports
activity being undertaken at the time of the event and the regular
training regimen of each subject; (4) circumstances of collapse,
location type (sports facility or other area), presence of witnesses,
and bystander CPR and defibrillation attempt; (5) detailed information regarding the resuscitation (time of collapse, SAMU call receipt,
time SAMU vehicle arrived, CPR initiation, time of first rhythm
analysis, and time of achieved return of spontaneous circulation), the
initial cardiac rhythm recorded, and the number and timing of
delivered defibrillator shocks; and (6) survival status to hospital
admission.
Complementary data on survival status and causes of death were
managed directly by INSERM U970 in collaboration with hospitals,
and in some cases after contact with the patient’s regular physician.
Status of the patients at hospital discharge was available in the great
majority of admitted cases (97.6%). Cause of death could only be
obtained in cases in which an autopsy was performed or clinical
features at the time of death permitted a confident diagnosis for those
who died on site. In France, the performance of an autopsy is at the
discretion of the physician certifying the death and is only mandated
when the death is regarded as potentially “suspicious.” For survivors,
neurological status at discharge was evaluated with the Cerebral
Performance Categories score.21
Importantly, no specific recommendations were specified in the
study design regarding emergency care modalities or documentation
of causes of death, because the objective of the investigators was to
offer a “real-life” descriptive picture of sports-related SD features in
France.
Statistical Methods
This report was prepared in compliance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology)
checklist for observational studies.22 The primary objective of the
study was to provide an estimate of the incidence of sports-related
SD in the general population of subjects 10 to 75 years of age.
Secondary objectives were to describe population characteristics and
identify variables associated with survival.
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Circulation
Absence of Signs of Circulation
and/or Considered for Resuscitation
N=820
Resuscitation Not Attempted
N=15
Resuscitation Attempted
All cases, N=805
Any defibrillation attempt, N=494
Chest compressions, N=805
Assisted ventilation, N=523
Location of Arrest
Sports Facilities, N=426
Other public places, N=391
Home, N=3
First Monitored Rhythm
Shockable, N=377
VF, N=323
VT, N=54
Nonshockable, N=441
Asystole, N=343
PEA, N=87
Sinus rhythm, N=1
Unknown, N=12
Figure 1. Utstein reporting template for 820
sports-related sudden deaths enrolled in the
study. VF indicates ventricular fibrillation; VT,
ventricular tachycardia; PEA, pulseless electrical activity; CPR, cardiopulmonary arrest; EMS,
emergency medical services; ROSC, return of
spontaneous circulation; and CPC, Cerebral
Performance Categories score.
Arrest Witnessed, N=756
By layperson/bystander, N=660
By Healthcare personnel, N=96
Arrest not Witnessed, N=64
CPR Before EMS Arrival, N=252
Outcome
Any ROSC
Yes, N=494
No, N=296
Unknown, N=15
Survived Event, N=253
Discharged Alive, N=128
Neurologic Outcome at Discharge
CPC 1 or 2, N= 103
CPC 3 or 4, N=23
Unknown, N=8
The overall incidence of sports-related SD in France was estimated by extrapolation of the incidence of sports-related SD in the
60 participating administrative districts (which represent approximately 70% [33 948 400] of the French population 10 to 75 years of
age) to the overall 96 French districts. We calculated the incidence in
each participating district by dividing the average number of sportsrelated SDs reported per year by the locally registered 10- to
75-year-old population.23 Because there is no evidence to support a
triggering effect of light exertion for SD, the primary result regarding
calculation of incidence only included cases that occurred during
moderate and vigorous exertion (n�780). Moreover, because our
estimated incidence of sports-related SD in the general population is
almost certainly an underestimate, in addition to providing the global
incidence with its 95% confidence interval (CI), 2 scenarios were
then calculated based on the 80th and 20th percentiles of the highest
reported incidences of sports-related SD across different districts in
France.
The specific incidence of sports-related SD among young competitive athletes was calculated according to data from the Ministère
de la Santé et des Sports.16 The participating number of 10- to
35-year-old athletes over the study period was 1 015 293, and this
figure was considered stable over time.16 Because of the constant
high level of media coverage of sports-related SDs in young sports
participants in France (that is, such reports were considered likely to
be comprehensive), we provided only 1 incidence rate calculation for
this population.
Two additional sensitivity analyses were performed: First, on
cases that occurred during vigorous exertion among the entire
population (n�322), and second, among all degrees of exertion
among the 10- to 60-year-old age group (n�667). The characteristics of sports-related SDs are described as mean�SD, proportions, or median and interquartile ranges, as appropriate. Qualitative variables were compared with the �2 test. All covariates
that reached a significance level of P�0.15 for survival were then
included in an initial multivariable regression model. Odds ratios
(ORs) and their 95% CIs were calculated. All tests were 2-tailed,
and P�0.05 was considered to indicate statistical significance.
All data were analyzed at INSERM, Unit 970, Cardiovascular
Epidemiology and Sudden Death, Paris, using STATA software
version 11.0.
The authors had full access to the data and take full responsibility
for its integrity. All authors have read and agree to the manuscript as
written.
Results
Incidence Rates of Sports-Related Sudden Death
After 5 years of observation, representing 169 742 000 agespecific person-years, a total of 820 sports-related SDs were
recorded (Figures 1 and 2); of these, 51% were first reported
by SAMU and 49% by press reports. The proportion of cases
reported first by SAMU varied between participating districts
(from 32% to 100%). The overall estimate of sports-related
SD was 4.6 (95% CI 3.9 to 5.3) per million population per
year.
Additional sensitivity analyses were performed to address
suspected underreporting of sports-related SD in each district;
considering the 80th and 20th highest percentiles of reporting
districts, the incidence of sports-related SD throughout
France was calculated to be 5.4 and 16.7 cases per million per
year, respectively (Table 1). Considering the 60- to 75-yearold population separately did not alter the nature of our
findings, because the calculated incidence when we excluded
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Marijon et al
Sports-Related Sudden Death
67553
Figure 2. Distribution by age of sports-related sudden deaths (SDs) in the overall population (blue) and among young competitive athletes (red).
Patient Characteristics and Sports-Related Sudden
Death Settings
the cases in the older age group was 15.9 (95% CI 13.2 to
18.6) per million per year (20th percentile).
Among the 820 reported sports-related SDs, only 50 cases
(6%) occurred in young competitive athletes, which yielded
an incidence in this group of approximately 10 cases per
million per year (Figure 2; Table 1). Compared with young
(10 to 35 years old) noncompetitive sports participants, young
competitive athletes had a higher risk of sports-related SD
(relative risk 4.5, 95% CI 2.3 to 8.7). There were 777 SDs in
males and 43 SDs in females (male/female ratio of 20:1),
equivalent to incidence rates (20th percentile) of 32.8 and 1.9
million persons per year, respectively (relative risk 17.3, 95%
CI 5.9 to 50.0).
The mean age of the sports-related SD subjects was 46�15
years (range 11 to 75 years; Table 2). Ninety-four subjects
(11.7%) had a known history of cardiovascular disease or
presented with more than 1 classic cardiovascular risk factor
for coronary heart disease. The majority (86.5%) of sportsrelated SD subjects performed regular sports and/or training.
Symptoms, mainly chest discomfort, were reported in the
days preceding the sports-related SD in 104 patients (12.7%).
These patients were more likely to have sports-related SD due
to ischemic heart disease than other participants (92.3%
versus 70.7%, P�0.005).
Table 1. Estimated Incidence Rates of Sports-Related Sudden Death in the General
Population, Amongst Young Competitive Athletes and Young Noncompetitive Sport Participants
Population
No. of
Districts
Incidence Rates, per Million
per Year (95% CI)
Estimated Absolute
per Year in France
33 948 400
60
4.6 (3.9–5.3)
226
216
General population (10 –75 y)
Overall
Male
16 195 232
60
9.2 (7.7–10.7)
Female
17 753 168
60
0.4 (0.1–0.7)
10
7 239 500
12
16.7 (13.7–19.7)
814
3 474 960
12
32.8 (26.8–38.8)
772
20th percentile
Male
Female
3 764 540
12
1.9 (0.5–3.2)
42
27 950 100
48
5.4 (4.5–6.3)
263
Male
13 116 500
48
10.6 (8.8–12.4)
250
Female
14 833 600
48
0.8 (0.4–1.3)
13
1 015 293
60
9.8 (3.7–16.0)
15
12 358 498
60
2.2 (1.4–3.0)
39
80th percentile
Young competitive athletes
Young noncompetitive participants
CI indicates confidence interval.
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676
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Circulation
Table 2. Characteristics of Patients and Selected Features of
820 Sports-Related Sudden Deaths Included in the Study
Value
Demographic data
Continued
Value
Delay, median (IQR), min
Collapse-to-call received
Age, y
Collapse-to-start of CPR
Mean
46.1�14.8
IQR
37–57
Males
777 (94.8)
Young competitive athlete
50 (6.1)
History of known heart disease*
66 (8.1)
Coronary heart disease
31
Paroxysmal atrial fibrillation
12
Ventricular arrhythmias considered as benign
6
Valvular heart disease
5
Pacemaker placement
5
Dilated cardiomyopathy
3
Others†
4
�1 Cardiovascular risk factor*‡
49 (6.1)
Time of occurrence
Season
Winter
158 (19.3)
Spring
258 (31.5)
Summer
243 (29.6)
Autumn
161 (19.6)
Week
Weekend
336 (41.0)
Time of day
Morning (6
Table 2.
AM
to 12
Afternoon (12
PM
Evening (6
to 12
PM
PM)
to 6
287 (35.0)
PM)
AM)
359 (43.8)
174 (21.2)
Sport setting
Sport activities
Team sports
273 (33.3)
Individual sports
547 (66.7)
Location of occurrence
Sport facilities
426 (52.0)
Others
394 (48.0)
Intensity of exercise*
Light
32 (3.9)
Moderate
458 (56.4)
Vigorous
322 (39.7)
Management of sports-related SD
Sudden death witnessed*
756 (92.6)
Bystander CPR
252 (30.7)
First monitored rhythm*
Ventricular fibrillation or tachycardia
377 (46.7)
Asystole
343 (42.5)
Pulseless electrical activity
Sinus rhythm
87 (10.8)
1 (0.1)
Shock by external defibrillator
494 (61.1)
(Continued)
Collapse-to-first defibrillator shock
2.0 (0.5–4.5)
4.8 (1.2–8.5)
12.5 (10.5–15.5)
IQR indicates interquartile range; SD, sudden death; and CPR, cardiopulmonary resuscitation.
Data are n (%), unless otherwise specified.
*Data were missing for history of known heart disease (for 8 subjects),
cardiovascular risk factors (11), intensity of exercise (8), presence of witness
(4), and monitored rhythm (12). Percentages were calculated on the basis of
the total number of known events.
†Others denote operated congenital heart disease (2), history of Kawasaki
disease (1), or Marfan syndrome (1).
‡Cardiovascular risk factor included known/treated diabetes mellitus, dyslipidemia, systemic hypertension, obesity, current smoker, and family history of
premature coronary heart disease.
Sports-related SD actually occurred during sports activity
in 92%, immediately after (within 30 minutes) in 7.4%, and
only rarely more than 30 minutes after cessation of sports
activity. Most sports-related SDs were observed during cycling (30.6%), running (21.3%), or soccer (13.0%), the sport
activities most practiced in France (Figure 3). Sports-related
SDs during team sports activities occurred at a younger age
than during individual sports (33�11 versus 51�13 years,
P�0.0001). Half of the sports-related SDs (51.9%) occurred
in public sports facilities (such as a gymnasium or a stadium),
and 99.8% of these were witnessed. Bystanders in sports
facilities were slightly more likely to initiate CPR than were
bystanders outside these settings, but this difference was not
statistically significant (35.5% versus 30.8%, P�0.15).
Among cases outside these settings, 83.4% were witnessed.
There were more sports-related SDs on Sunday (P�0.0001,
asymptotic test for binomial proportions), but no significant
circadian variation was observed.
Bystander Cardiopulmonary Resuscitation,
Advanced Life Support, and Predictors of Survival
Bystander CPR was initiated in 252 cases (30.7%). Median
time from collapse to CPR initiation was 4.8 minutes (interquartile range 1.2 to 8.5 minutes). The initial cardiac rhythm
was ventricular fibrillation or pulseless fast ventricular
tachycardia in 377 cases (46.1%), with a mean number of
shocks in this group of 5.3�3.8 (range 1 to 19).
A total of 253 of the 820 subjects (30.8%; 95% CI 27.7%
to 34.0%) survived to hospital admission, and among them,
vital status at time of discharge was known for 247 (97.6%).
One hundred twenty-eight of these subjects survived to
hospital discharge, giving an overall survival rate to hospital
discharge of 15.7% (95% CI 13.2% to 18.2%). The majority
of these (103 of 126 for whom neurological assessment was
established) presented with a Cerebral Performance Categories
score of 1 or 2, good enough to allow normal life or part-time
work in a sheltered environment. The highest survival rates
(�50%) were in the Burgundy (Côte-d’Or) and Nord-Pas-de-
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Marijon et al
Sports-Related Sudden Death
67755
Figure 3. Sports engaged in at the time of sudden death (SD) in 820 sports participants. Shaded proportions of the bars represent the
female ratio.
Calais (Nord) districts, where bystanders initiated CPR in
more than 90% of cases.
Univariable analyses for factors associated with survival to
hospital discharge are shown in Table 3. According to
multiple logistic regression analysis, the following factors
were independently associated with survival to hospital discharge: Bystander CPR (OR 3.73, 95% CI 2.19 to 6.39,
P�0.0001), time from collapse to start of CPR (OR 1.32,
95% CI 1.08 to 1.61, P�0.006), and the initial use of cardiac
defibrillation (OR 3.71, 95% CI 2.07 to 6.64, P�0.0001).
Additional sensitivity analyses among cases of sports-related
SD associated with vigorous exertion and among the 10- to
60-year-old population did not demonstrate significant differences regarding predictors for survival compared with the
overall population.
Cardiovascular Abnormalities Associated With
Sports-Related Sudden Deaths
The proportion of cases with a clear diagnosis remained low
(24.7%), particularly among subjects who died on site
(5.1%). Cause-of-death analysis among young competitive
athletes and the general population is presented in Figure 4.
Although 64% of sports-related SDs among young competitive athletes had the cause elucidated, this was only available
for 22% of SDs among the general population.
Among the 203 cases in which it was possible to ascertain
the cause of death with clinical certainty or from anatomopathological investigations, causes were cardiac in origin
in all but 4 cases (98.0%). Acute coronary syndrome was the
principal cause of cardiac arrest during sports (152 subjects,
74.9%); other cardiovascular causes of death or pathological
findings included hypertrophic cardiomyopathy (7 subjects),
possible hypertrophic cardiomyopathy (6), congenital cardiac
abnormality (5, including 2 cases of aberrant coronary artery), dilated cardiomyopathy (5), myocarditis (5, including 1
case of sarcoidosis), arrhythmogenic right ventricular dysplasia (3), early repolarization syndrome (2), Wolff-Parkinsonwhite syndrome (1), familial long-QT syndrome (1), mitral
valve prolapse (2), and commotio cordis (1). Noncardiac
causes were found in 4 cases, ascribed to epilepsy, ruptured
cerebral artery, stroke, and ruptured ascending aorta, respectively. The remaining 9 cases were ascribed to idiopathic
ventricular fibrillation because no cardiac abnormality was
observed. Among the 820 patients, drugs or anabolic steroids
were reported to have been implicated in death in 2 cases.
Discussion
In this prospective study of 820 cases of sports-related SDs
and resuscitated cardiac arrests in a general population, we
have identified a higher burden of this event than previously
suspected from comprehensive surveys of sports-related SD
in young competitive athletes. We found that the majority of
such events were witnessed (93%), although bystander CPR
was initiated in fewer than one third of the cases. Given the
often predictable setting of sports-related SD and that prompt
interventions were significantly associated with improved
survival, these data have implications for health services
planning. In particular, education about CPR for sports
participants and availability of public access defibrillation in
sports facilities have the potential to achieve substantial
improvements in outcomes.
Previously published data on the incidence of sportsrelated SDs observed in competitive young athletes have
documented an incidence of 6 to 9 per million such competitors per year.7,8 The present data among young competitive
athletes are very consistent with these estimates. The largest
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August 9, 2011
Table 3. Univariate Analysis for Survival to Hospital Discharge
Predictors of Survival: Variables
OR
95% CI
P
Women vs men
1.59
0.76 –3.32
0.21
Age, y
�0.0001
10–30
1.00
31–50
0.60
0.36–0.99
51–75
0.26
0.15–0.44
0.56
0.28–1.12
Known CVD vs others
0.10
Seasons
Winter
1.00
Spring
1.61
0.92–2.84
0.18
Summer
1.13
0.62–2.04
Autumn
1.64
0.89–3.00
Weekend
1.60
1.10–2.32
0.01
Team sports
0.98
0.66–1.45
0.92
Intensity of exercise
Light
1.00
0.002
Moderate
1.70
0.40–7.51
Vigorous
3.36
0.78–14.5
Sport facilities vs others
2.83
1.88–4.25
�0.0001
Competitive vs recreational setting
1.32
0.83–2.12
0.24
Young competitive athlete
1.62
0.82–3.18
0.16
Presence of witness
6.73
1.62–27.8
0.009
Bystander CPR
9.83
6.42–15.04
�0.0001
Collapse to start of CPR delay, min
�0.0001
0–2
1.00
3–4
0.44
0.22–0.91
5–10
0.13
0.06–0.28
11–20
0.10
0.05–0.23
9.60
5.88–15.70
Initial shockable rhythm
�0.0001
OR indicates odds ratio; CI, confidence interval; CVD, cardiovascular disease;
and CPR, cardiopulmonary resuscitation.
previous European study of sports-related SDs, from Veneto,
Italy, included 55 cases of sports-related SDs in young
competitive athletes documented over a 25-year period.7,24
Maron et al8 reported 1866 cases of SD in young competitive
athletes over a 27-year period in the United States, 50% of
which were traumatic, of noncardiac origin, or did not occur
during sporting activity. Taken together, these data suggest
that approximately 50 to 75 SDs in young competitive
athletes would occur annually in the United States, and
approximately 10 to 15 such events would occur in France
each year. The focus on this group of healthy young athletes
is highly understandable given the substantial social and
emotional impact of sudden and unexpected deaths in this
group.25
However, data showing relatively low absolute numbers of
events in young athletes per year have influenced health
authorities in many countries regarding the institution of
widespread early response measures. In France in May 2009,
for example, draft legislation proposing the installation of
automatic external defibrillators in sporting arenas was eventually rejected after evaluation by an economic expert com-
mittee that concluded that this would not be cost-effective
based on the 10 to 15 expected such cases yearly.
Data concerning the risk of sports-related SD among
recreational sports participants, who accounted for more than
90% of cases in the present study, are relatively sparse. These
data come from a limited number of retrospective studies that
involved small numbers of cases and most often were in
regard to only 1 sports activity.9,10,26 –32 To date, only 1 study
attempted to evaluate sports-related acute cardiovascular
events in the general population, with no specific focus on
SD.33 Other available data from autopsy series contribute
information on likely causes of SD; however, these are
associated with bias and do not allow calculation of the
population burden of sports-related SD.34 –38 Finally, to the
best of our knowledge, sports-related SD has never been
evaluated in the general population, including athletes and
recreational sports participants across a wide age range. The
present study revealed a much higher prevalence of sportsrelated SD in the general population than previously suspected (estimated at approximately 4250 cases in the United
States or 800 cases in France each year in the 10- to
75-year-old age group). The present data demonstrated that
although risk for sports-related SD remains higher in young
competitive athletes than in 10- to 35-year-old noncompetitive sports participants, the absolute risk appears to be higher
in the general population. In the present series, although the
survival rate to hospital discharge after sports-related SD
(approximately 16%) was substantially higher than the published rates of survival after SD in general, at approximately
7% to 8%,39 there may still be substantial room for improvement. For example, 90% of sports-related SDs in the present
series were witnessed, but bystander CPR was commenced in
only one third of these cases. The data from 2 French districts
where resuscitation rates of more than 90% were associated
with survival rates of approximately 50% support calls for
more extensive population-based CPR education. Because the
population is relatively young and such settings offer optimal
chances for survival, these data should prompt the development of preventive measures based on public education.
Moreover, these results also raise the question of systematic screening, especially for ischemic heart disease,
among male recreational sports participants with cardiovascular risk factors.
We note the striking male predominance in sports-related
SD in the present series. Based on sports participation rates in
France, this is not simply the reflection of a greater male
participation but likely the consequence of a higher risk
profile in men. The reasons for this sex difference is unclear,
but it could be related to the known higher prevalence of
coronary disease in young and middle-aged men than in
women. Differences in the mode of physical activity and
training between sexes may also be relevant.
We acknowledge that the present study has a number of
potential limitations. First, we observed important differences
in incidences among districts. One possible explanation is
that this may reflect real differences in incidences due to
subject characteristics or sports activities. However, the ratio
of emergency medical services cases to total cases varied
markedly among districts, which leads us to favor a different
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Sports-Related Sudden Death
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57
Young Competitive Athletes
2%
2%
2%
2%
4%
8%
36%
2%
2%
2%
4%
4%
6%
4%
6%
4%
10%
Unexplained
Coronary heart disease
HCM
Possible HCM
ARVD
Congenital heart disease
Dilated cardiomyopathy
Myocarditis
Early repolarization syndrome
Wolff-Parkinson-White
Long QT syndrome
Primitive VF
Mitral-valve prolapse
Tunneled LAD coronary artery
Commotio cordis
Ruptured ascending aorta
Epilepsy
General Population
(except young competitive athletes)
19%
78%
Figure 4. Cardiovascular abnormalities associated
with sports-related sudden death in 820 subjects
among the young competitive group (n�50) and
the general population (n�770). HCM indicates
hypertrophic cardiomyopathy; ARVD, arrhythmogenic right ventricular dysplasia; VF, ventricular
fibrillation; and LAD, left anterior descending.
Unexplained
Coronary heart disease
HCM
Possible HCM
ARVD
Dilated cardiomyopathy
Myocarditis
Primitive VF
Stroke
Ruptured cerebral artery
Aortic valve stenosis
explanation, ie, that the variability of reported incidences
across different districts reflects a variable degree of underreporting. Our estimated incidence of sports-related SD in the
general population is also almost certainly an underestimate.
In addition to underreporting, this is also due in part to the
consideration of the entire 10- to 75-year-old population as
being potentially at risk of sports-related SD rather than
estimating the proportion who were actually participating in
sports (this is because there are no reliable data to estimate
actual recreational sports participation). This has been the
rationale for the use of sensitivity analyses to provide a range
of incidence of community-based sports-related SD. Second,
autopsy rates are very low in France, where they are performed at the discretion of the certifying physician rather than
mandated by law. The present results among young competitive athletes, including the rate of cases without precise
diagnosis, are consistent with the study of the largest cohort
to date performed by Maron and colleagues in the United
States.8 On the other hand, we offered a different view from
the general population with a majority of cases considered
ischemic cardiovascular events but that ultimately remained
without a precise diagnosis. Further efforts for better identification of cause of death, including postmortem molecular
analysis, are crucial in this context, in which early diagnosis
of familial cardiomyopathy or channelopathy may be vital for
relatives.40
In summary, we have documented a substantially higher
incidence of sports-related SD in the general population than
suspected previously from studies focused on competitive
young athletes. Depending on the degree of underreporting
present in our sample, we estimate from 5 to 17 cases of
sports-related SD occur per million individuals residing in
France per year. Most such events occur in previously healthy
men 35 to 65 years old, happen in a public area, and are
witnessed by bystanders. Given the often predictable setting
of sports-related SD and that prompt interventions including
bystander CPR and defibrillation were significantly associated with improved survival, these data have implications for
health services planning.
Appendix
Participating Centers
The investigators and coordinators participating in the study were as
follows (numbers given are French administrative division numbers):
02 Aisne, Dr F. Degrootte; 05 Hautes-Alpes, Dr M. Tashan; 06
Côte d’Azur, Dr D. Grimaud; 13 Bouches-du-Rhône, Dr V. Vig; 14
Calvados, Dr D. Bonnieux; 16 Charente, Dr R. Loyant; 17 CharenteMaritime, Dr A. Mounios; 18 Cher, Dr F. Bandaly; 21 Côte-d’Or, Dr
M. Freysz; 22 Côtes-d’Armor, Dr C. Hamon; 24 Dordogne, Dr M.
Gautron; 25 Doubs, Dr M.C. Maillot; 26 Drôme, Dr C. Zamour; 28
Eure-et-Loir, Dr N. Letellier; 29 Finistère, Dr D. Lazou; 31 HauteGaronne, Dr J.L. Ducasse; 32 Gers, Dr J.M. Guez; 33 Gironde, Dr
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August 9, 2011
M. Thicoipe; 34 Hérault, Dr P. Benatia; 36 Indre, Dr L. Soulat; 37
Indre-et-Loire, Dr A. Fusciardi; 38 Isère, Dr K. Berthelot; 39 Jura,
Dr A. Elisseeff; 40 Landes, Dr R. Ricard; 41 Loir-et-Cher Dr Solo
Randriamalala; 42 Loire, Dr T. Guerin; 44 Loire Atlantique, Dr V.
Debierre; 45 Loiret, Dr S. Narcisse; 48 Lozère, Dr M. Chassing; 51
Marne, Dr A. Léon; 52 Haute-Marne, Dr J. Milleron; 55 Meuse, Dr
M. Vedel; 56 Morbihan, Dr F. Charland; 59 Nord, Dr N. Benameur;
60 Oise, Dr T. Ramaherison; 62 Pas-de-Calais, Dr L. Hapka; 63
Puy-de-Dôme, Dr J. Meyrieux; 64 Pyrénées-Atlantiques, Dr I.
Pouyanne; 65 Hautes-Pyrénées, Dr J. Khazaka; 67 Bas Rhin, Dr J.C.
Bartier; 68 Haut-Rhin, Dr A. Goulesqueb; 69 Rhône, Dr P.Y.
Gueugniaud; 70 Haute-Sâone, Dr T. Elcadi; 71 Sâone-et-Loire, Dr B.
Girardet; 72 Sarthe, Dr C. Savio; 75 Paris, Dr D. Jannière; 76
Seine-Maritime, Dr B. Dureuil; 77 Seine et Marne, Dr J.Y. Le
Tarnec; 78 Yvelines, Dr S. Templer; 80 Somme, Dr C. Ammirati; 81
Tarn, Dr M.G. Vaissière; 83 Var, Dr J.J. Raymond; 84 Vaucluse, Dr
P. Olivier; 88 Vosges, Dr H. Tonnelier; 89 Yonne, Dr M. Duche; 90
Territoire-de-Belfort, Dr A. Kara; 92 Hauts-de-Seine, Dr M. Baer; 93
Seine-Saint-Denis, Dr F. Adnet; 94 Val-de-Marne, Dr C. Vallier; 95
Val-d’Oise, Dr C. Ramaut.
Acknowledgments
We would like to acknowledge the contributions of all participating
units of SAMU of France, as well as Dr Pénélope Troude for her
technical assistance.
Sources of Funding
This study was supported in part by INSERM (Institut National de la
Santé et de la Recherche Médicale) and IRMES (Institut de Recherche BioMédicale et d’Épidémiologie du Sport).
Disclosures
None.
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CLINICAL PERSPECTIVE
To date, the majority of data regarding sports-related sudden death (SD) have focused on young competitive athletes, and
few data concerning sports-related SD in the general population have been available. In this 5-year observational study of
SD occurring during sports in competitive and recreational participants 10 to 75 years of age, we have found that although
the risk for sports-related SD remains higher in young competitive athletes than in young noncompetitive sports
participants, the absolute risk is otherwise higher in the general population. The present study revealed approximately 800
cases in France each year compared with the 15 annual cases among young competitive athletes. Case subjects were
relatively young (46�15 years), predominantly males (95%), and without any prior history of heart disease. Half of the
observed cases occurred in sports facilities, and almost 90% of events were witnessed; however, the rate of bystander
cardiopulmonary resuscitation was low, initiated in fewer than one third of cases. Given the often predictable setting of
sports-related SD and that prompt interventions including bystander CPR and defibrillation were significantly associated
with improved survival in the present study, these data have implications for health services planning.
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