Multiscale characterization of cardiac remodeling induced by intrauterine growth restriction, at
... Cardiovascular diseases are the leading cause of mortality in developed countries, with an estimated 23% of all disease burdens and over 4 million deaths each year in Europe (European Heart Network). It has been historically thought that cardiovascular diseases are determined by genetic factors and ...
... Cardiovascular diseases are the leading cause of mortality in developed countries, with an estimated 23% of all disease burdens and over 4 million deaths each year in Europe (European Heart Network). It has been historically thought that cardiovascular diseases are determined by genetic factors and ...
Reviews - Circulation Research
... and is highly expressed in cardiac muscle and brain and to a lesser extent in many other tissues. NCX2 and NCX3 are not expressed in adult rat heart at the protein level, but an NCX2-specific transcript can be detected faintly by using reverse transcriptase–polymerase chain reaction.22 NCX2 and NCX3 ...
... and is highly expressed in cardiac muscle and brain and to a lesser extent in many other tissues. NCX2 and NCX3 are not expressed in adult rat heart at the protein level, but an NCX2-specific transcript can be detected faintly by using reverse transcriptase–polymerase chain reaction.22 NCX2 and NCX3 ...
Community Safety Programs
... Brampton, Caledon and Mississauga,. In Canada, 40,000 deaths occur from Sudden Cardiac Arrest each year which translates into one every 12 minutes. 90% of our population in Canada has at least one cardiac risk factor today. The need for PAD programs is becoming more apparent each year with the aging ...
... Brampton, Caledon and Mississauga,. In Canada, 40,000 deaths occur from Sudden Cardiac Arrest each year which translates into one every 12 minutes. 90% of our population in Canada has at least one cardiac risk factor today. The need for PAD programs is becoming more apparent each year with the aging ...
1 - Circulation Research
... rhythm such as bigeminy, ventricular extrasystoles, idioventricular rhythm, ventricular tachycardia, bradycardia, atrioventricular dissociation, etc. (fig. 3C), (4) severe changes of rhythm (fig. 4D) such as marked electrocardiographic deformations and ventricular rhythm lasting up to several minute ...
... rhythm such as bigeminy, ventricular extrasystoles, idioventricular rhythm, ventricular tachycardia, bradycardia, atrioventricular dissociation, etc. (fig. 3C), (4) severe changes of rhythm (fig. 4D) such as marked electrocardiographic deformations and ventricular rhythm lasting up to several minute ...
Coexpression of Cardiac titins
... sarcomeres from a range of species labeled with N2BC are shown in Fig. 2B. At a given SL, sarcomeres from myocardium that expresses predominately N2B titin contain a single epitope toward the A band (Fig. 2B, top) and sarcomeres from myocardium that expresses predominately N2BA titin contain a singl ...
... sarcomeres from a range of species labeled with N2BC are shown in Fig. 2B. At a given SL, sarcomeres from myocardium that expresses predominately N2B titin contain a single epitope toward the A band (Fig. 2B, top) and sarcomeres from myocardium that expresses predominately N2BA titin contain a singl ...
Stretch-mediated cardiac hypertrophy and extracellular matrix
... Cardiovascular diseases are one of the most frequent causes of death worldwide1 and are, in the Netherlands, responsible for approximately 30% of all deaths2. Heart failure accounts for 16% of all cardiac deaths3. Heart failure develops secondary to cardiac overload. This overload may originate from ...
... Cardiovascular diseases are one of the most frequent causes of death worldwide1 and are, in the Netherlands, responsible for approximately 30% of all deaths2. Heart failure accounts for 16% of all cardiac deaths3. Heart failure develops secondary to cardiac overload. This overload may originate from ...
Cardiac Thyrotropin-Releasing Hormone Mediates
... TRH-iRNA–treated SHR showed similar indices that were significantly lower compared to those of the Con-iRNA– treated SHR. These normal ratios found in the animals with the inhibition of the LV TRH were not caused by normalization of blood pressure or changes in the body weight, as we measured both v ...
... TRH-iRNA–treated SHR showed similar indices that were significantly lower compared to those of the Con-iRNA– treated SHR. These normal ratios found in the animals with the inhibition of the LV TRH were not caused by normalization of blood pressure or changes in the body weight, as we measured both v ...
Risk factors for sudden cardiac death from an acute ischemic event
... later, results from the Paris Prospective Study confirmed this finding but also indicated that even though a family history of SCD increased the risk for SCD it did not increase the risk for AMI. In opposite, for AMI, family history of AMI was an independent risk factor. (Jouven et al. 1999). This s ...
... later, results from the Paris Prospective Study confirmed this finding but also indicated that even though a family history of SCD increased the risk for SCD it did not increase the risk for AMI. In opposite, for AMI, family history of AMI was an independent risk factor. (Jouven et al. 1999). This s ...
Functional Comparison of Cardiac Troponin C from
... has favoured an overall decrease in myocyte Ca2+-sensitivity in endothermic species (Churcott et al., 1994). This is necessary in order to maintain a physiological Ca2+ affinity with increased temperatures, as with too high a Ca2+-sensitivity, the muscle would become locked in contraction when cytos ...
... has favoured an overall decrease in myocyte Ca2+-sensitivity in endothermic species (Churcott et al., 1994). This is necessary in order to maintain a physiological Ca2+ affinity with increased temperatures, as with too high a Ca2+-sensitivity, the muscle would become locked in contraction when cytos ...
The role of altered fatty acid metabolism in cardiomyopathy and
... The heart pumps blood to supply oxygen and nutrients to the tissues in our body. The importance of the heart was first recognized in the 4 th century BC, by the Greek philosopher Aristotle from his observation in chick embryos that the heart was formed first before the rest of the internal organs. H ...
... The heart pumps blood to supply oxygen and nutrients to the tissues in our body. The importance of the heart was first recognized in the 4 th century BC, by the Greek philosopher Aristotle from his observation in chick embryos that the heart was formed first before the rest of the internal organs. H ...
Comparison of Family History of Sudden Cardiac Death
... The causes of nonischemic SCD of the present study differ from those reported previously.11,12 In accordance with the present study, we recently reported in a larger sample size that obesity, alcoholic CMP, and idiopathic myocardial fibrosis were more prevalent causes of nonischemic SCD than causes ...
... The causes of nonischemic SCD of the present study differ from those reported previously.11,12 In accordance with the present study, we recently reported in a larger sample size that obesity, alcoholic CMP, and idiopathic myocardial fibrosis were more prevalent causes of nonischemic SCD than causes ...
Overexpression of microRNA-1 impairs cardiac
... Transgenic (Tg) mice (C57BL/6) for cardiac-specific overexpression of miR-1 driven by the a-myosin heavy chain proand results moter were generated and identified by real-time reverse-transcription polymerase chain reaction with left ventricular samples. We found an age-dependent decrease in the hear ...
... Transgenic (Tg) mice (C57BL/6) for cardiac-specific overexpression of miR-1 driven by the a-myosin heavy chain proand results moter were generated and identified by real-time reverse-transcription polymerase chain reaction with left ventricular samples. We found an age-dependent decrease in the hear ...
Molecular distinction between physiological and pathological
... 2004; Thom et al., 2006; Lloyd-Jones et al., 2009). Symptoms of heart failure patients include fatigue, insomnia, anxiety, depression, shortness of breath, edema, dizziness, and nausea, all of which contribute to a reduced quality of life for these patients (Blinderman et al., 2008). With an aging p ...
... 2004; Thom et al., 2006; Lloyd-Jones et al., 2009). Symptoms of heart failure patients include fatigue, insomnia, anxiety, depression, shortness of breath, edema, dizziness, and nausea, all of which contribute to a reduced quality of life for these patients (Blinderman et al., 2008). With an aging p ...
Cardioprotective Effect of Angiotensin
... ecent clinical and experimental studies have established the therapeutic benefits of ACE inhibitors, not only in treating hypertension and congestive heart failure, but also in reducing reinfarction, limiting infarct size, and preventing reperfusion arrhythmias.1–3 These cardioprotective effects of ...
... ecent clinical and experimental studies have established the therapeutic benefits of ACE inhibitors, not only in treating hypertension and congestive heart failure, but also in reducing reinfarction, limiting infarct size, and preventing reperfusion arrhythmias.1–3 These cardioprotective effects of ...
chronic congestive heart failure.
... preparations made from the combined right and Physiological studies of experimental animals. left ventricles of normal dogs. Myosin from sepaThe results are presented in Table I. The 11 dogs rate right and left ventricles of dogs with right with tricuspid insufficiency and pulmonic stenosis heart fa ...
... preparations made from the combined right and Physiological studies of experimental animals. left ventricles of normal dogs. Myosin from sepaThe results are presented in Table I. The 11 dogs rate right and left ventricles of dogs with right with tricuspid insufficiency and pulmonic stenosis heart fa ...
Community AED Toolkit Public Access to Defibrillation
... is a major cause of death in Manitoba. It can happen at any age. It can happen anywhere and anytime, but it usually happens in the home, workplace, or community, away from the advanced life support available in the hospital environment. In sudden cardiac arrest, the heart no longer pumps blood to th ...
... is a major cause of death in Manitoba. It can happen at any age. It can happen anywhere and anytime, but it usually happens in the home, workplace, or community, away from the advanced life support available in the hospital environment. In sudden cardiac arrest, the heart no longer pumps blood to th ...
Fiber tracking and fiber architecture description in cardiac DT
... and is a leading cause of death in the world. An estimated 17.3 million people died from CVDs in 2008, representing 30% of all global deaths. Over 80% of CVD deaths take place in low- and middle-income countries [Organization (2011)]. The number of people who die from CVDs, mainly from heart disease ...
... and is a leading cause of death in the world. An estimated 17.3 million people died from CVDs in 2008, representing 30% of all global deaths. Over 80% of CVD deaths take place in low- and middle-income countries [Organization (2011)]. The number of people who die from CVDs, mainly from heart disease ...
EARLY POSTNATAL CARDIAC DEVELOPMENT IN ATRIAL NATRIURETIC PEPTIDE GENE-DISRUPTED MICE
... Figure 10. Methodological images of polymer injection ............................................................... 41 Figure 11. Effect of proANP gene-disruption on heart weight to body weight ratios. .................. 45 Figure 12. Effect of proANP gene-disruption on hematocrit. ............... ...
... Figure 10. Methodological images of polymer injection ............................................................... 41 Figure 11. Effect of proANP gene-disruption on heart weight to body weight ratios. .................. 45 Figure 12. Effect of proANP gene-disruption on hematocrit. ............... ...
a biphasic role for the voltage
... This work would not have been possible without the assistance and support of many people and departments throughout the Vanderbilt community. I’d like to particularly thank Terry Dermody, and the leaders and administration of the Medical Scientist Training Program for years of support and encoura ...
... This work would not have been possible without the assistance and support of many people and departments throughout the Vanderbilt community. I’d like to particularly thank Terry Dermody, and the leaders and administration of the Medical Scientist Training Program for years of support and encoura ...
Initiation of cardiac differentiation occurs in the
... ectoderm. The top two layers were then peeled off together, leaving the ectoderm behind. For endodermless explants, the endoderm was first mechanically peeled away as an intact sheet from the underlying mesoderm and, in most cases, discarded. In some cases, the endodermal sheet was removed for cultu ...
... ectoderm. The top two layers were then peeled off together, leaving the ectoderm behind. For endodermless explants, the endoderm was first mechanically peeled away as an intact sheet from the underlying mesoderm and, in most cases, discarded. In some cases, the endodermal sheet was removed for cultu ...
cardiac arrest - isa kanyakumari
... The initial dose 1 to 1.5 mg/kg IV push If VF / pulseless VT persists additional doses 0.5 to 0.75 mg/kg IV push 5 to ...
... The initial dose 1 to 1.5 mg/kg IV push If VF / pulseless VT persists additional doses 0.5 to 0.75 mg/kg IV push 5 to ...
Inhibition of cyclooxygenase-2 improves cardiac - AJP
... tanoids produced by COX-2 affect a number of other biological processes, including angiogenesis, differentiation, and apoptosis (24, 46). HEK-293 cells overexpressing both COX-2 and PGE2 synthase release large quantities of PGE2, grow faster than normal cells, and also exhibit altered morphology (30 ...
... tanoids produced by COX-2 affect a number of other biological processes, including angiogenesis, differentiation, and apoptosis (24, 46). HEK-293 cells overexpressing both COX-2 and PGE2 synthase release large quantities of PGE2, grow faster than normal cells, and also exhibit altered morphology (30 ...
Characterization and Modeling of the Purkinje System for Biophysical Simulations
... the excitation-contraction function of the heart ventricles. The electrical impulse originates in the sino-atrial node (SAN), the natural pacemaker, located in the right atrium of the heart. From the SAN it advances to the atrio-ventricular node (AVN), which electrically delays the impulse and conne ...
... the excitation-contraction function of the heart ventricles. The electrical impulse originates in the sino-atrial node (SAN), the natural pacemaker, located in the right atrium of the heart. From the SAN it advances to the atrio-ventricular node (AVN), which electrically delays the impulse and conne ...
The distribution of the cardiac veins in the New Zealand White
... it was observed to open into the base of the left cranial vena cava as it was in Angora rabbit (Bahar et al., 2007) and beaver (Bisaillon, 1981). Moreover, in one (4%) cases the middle cardiac vein started from the base of the caudal vena cava, which was the same pattern described by Yadm and Gad (1 ...
... it was observed to open into the base of the left cranial vena cava as it was in Angora rabbit (Bahar et al., 2007) and beaver (Bisaillon, 1981). Moreover, in one (4%) cases the middle cardiac vein started from the base of the caudal vena cava, which was the same pattern described by Yadm and Gad (1 ...
Cardiac Pacing: Patient Management
... When epicardial pacing wires are not in use they should have their tips insulated. This is done by curling the wire, wrapping it in gauze and adhering to the chest wall with an ...
... When epicardial pacing wires are not in use they should have their tips insulated. This is done by curling the wire, wrapping it in gauze and adhering to the chest wall with an ...
Cardiac arrest
Cardiac arrest, also known as cardiopulmonary arrest or circulatory arrest, is a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all. Medical personnel may refer to an unexpected cardiac arrest as a sudden cardiac arrest (SCA).A cardiac arrest is different from (but may be caused by) a myocardial infarction (also known as a heart attack), where blood flow to the muscle of the heart is impaired. It is different from congestive heart failure, where circulation is substandard, but the heart is still pumping sufficient blood to sustain life.Arrested blood circulation prevents delivery of oxygen and glucose to the body. Lack of oxygen and glucose to the brain causes loss of consciousness, which then results in abnormal or absent breathing. Brain injury is likely to happen if cardiac arrest goes untreated for more than five minutes. For the best chance of survival and neurological recovery immediate treatment is important.Cardiac arrest is a medical emergency that, in certain situations, is potentially reversible if treated early. Unexpected cardiac arrest can lead to death within minutes: this is called sudden cardiac death (SCD). The treatment for cardiac arrest is immediate defibrillation if a ""shockable"" rhythm is present, while cardiopulmonary resuscitation (CPR) is used to provide circulatory support and/or to induce a ""shockable"" rhythm.A number of heart conditions and non-heart-related events can cause cardiac arrest; the most common cause is coronary artery disease.