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! Mistakes, Assumptions, Corruption, and Medical Arrogance! Why you should question vaccine policy and “settled science” Suzanne Humphries MD Aluminium and pregnancy “Aluminum is considered to be an essential metal with quantities fluctuating naturally during normal cellular activity. It is found in all tissues and is is also believed to play an important role in the development of a healthy fetus.” Reviewed by: Paul A. Offit, MD Date: April 2013 Aluminium knowledge: 2013 “Although traditional Al-based adjuvants have been used in humans since the 1930s, there is still not enough information about the manner of their actions.” Zivkovic 2013 PMID: 23161337 3 h"ps://www.youtube.com/watch?v=PWP6e2CYPo8 Amount in vaccines Per dose • • • • • • • • • • Pneumococcal vaccine 125 mcg Diphtheria-tetanus-pertussis (DTaP) vaccine– 170-625 mcg Haemophilus influenzae type b (Hib) vaccine– 225 mcg Hib/Hep B vaccine 225 mcg Hep A vaccine (for children) 225-250 mcg Hepatitis B vaccine (Hep B) 225-500 mcg Hep A/ Hep B vaccine 450 mcg DTaP/inactivated polio/ Hep B vaccine 850 mcg DTaP/inactivated polio/Hib vaccine 330 mcg Human Papillomavirus (HPV) vaccine 225 mcg-500 mcg Vaccine aluminium into brain: Every step proven: • Macrophages eat aluminum at injection site (Gherardi 2001 PMID: 11522584) • Travel and cross BBB (Khan 2013 PMID: 23557144) • Aluminum nanoparticles have been photographed in macrophages and detected in brain. (Khan 2013 PMID: 23557144) 7 Alawdietal2016 Kooletal,2008 Some Un-Settled Science Yesterday…. Louveau2015PMID:26030524 Today. h"p://neurosciencenews.com/lymphaPcsystem-brain-neurobiology-2080/ h"p://www.sciencealert.com/a-giant-neuron-has-been-found-wrapped-around-the-enPrecircumference-of-the-brain h"p://www.sciencealert.com/a-bug-in-fmri-soTware-could-invalidate-decades-ofbrain-research-scienPsts-discover h"p://news.stanford.edu/2017/03/20/scienPsts-find-previously-unknown-role-cerebellum/ Commonly Accepted Fallacy “Autism is not an immune-mediated disease. Unlike autoimmune diseases such as multiple sclerosis, there is no evidence of immune activation or inflammatory lesions in the CNS of people with autism.” Offit 2009. PMID: 19128068 Some Real Science “Aluminum is extremely proinflammatory, pathological and a genotoxic element that is particularly deleterious to the normal homeostatic operation of brain cells, especially at the level of normal cytoplasmic and genetic activities that utilize phosphate.” Bhattacharjee 2013 PMID: 23764827 Aluminium content of major arteries in human AD cadavers BBB Gliacells+++ 4 PCA 9 3.5 3 2 Bhattacharjee 2013 PMID: 23764827 FA 1 What things alter the BBB? • Premature birth • Formula via dysbiosis, LPS and cytokines? • Chastre 2014 PMID: 23910048 and Wu 2015 PMID: 26376205 • Dysbiosis and lack of SCFA • Braniste 2014 PMID: 25411471 • Cytokines, inflammation • Stamatovic 2008 PMID: 19506719 and Saija 1995 PMID: 7885193 • Infectious agents • Stamatovic 2008 PMID: 19506719 • Mitochondrial crisis • Doll 2015 PMID: 25922503 • Irradiation • Qin 2001 PMID: 11704317 • Complement • Mahajan 2015 PMID: 26059553 • Methamphetamine • Northrop 2015 PMID: 25788874 SuzanneHumphries,MDrisingfromthedead.com o We demonstrate an active neuroinflammatory process in the cerebral cortex, white matter, and cerebellum of autistic patients. o Immunocytochemical studies showed marked activation of microglia and astroglia. o CSF showed a pro-inflammatory profile Vargas 2005 PMID: 15546155 Conclusions • Immune activation in autistic brains and CSF is INTENSE compared to normal brains and CSF. • Microglia are consistently activated in all brain regions of autistic patients. • Neuroinflammatory activation prevalent in white matter, cerebral cortex, and cerebellum. • Inflammatory and anti-inflammatory cytokines in brain and CSF. • Evidence for brain inflammation is overwhelming. Vargas 2005 PMID 15546155 SuzukiJAMA2013PMID:23404112 Suzuki2013PMID:23404112 Developmentalwindowsofimmunematuration Appearance/expansion of astrocyte populations 16 wks-2 yrs Microglia cell appearance 5.5-7 wks Myelomonocytic cell emergence 4 wks Conception Emergence, seeding, expansion of T-reg populations 12-2yrs Nine windows Seeding/expansion microglia cerebral wall 12-24 wks Birth 2 yrs. seeding of thymus with thymocytes and selection against autoreactive T-cell clones 14-26 wks Alteration of macrophages and macrophage-related cells 16 wks 1 yr Emergence and expansion of intraepithelial lymphocytes contributing to the gastrointestine-associated lymphoid tissue (GALT) 14wk-1 yr maturation of dendritic cells to promote Th1 responses 36 wks -2 yrs Dietert 2008: PMID 18821424 25 Developmentalperiodsinbrain maximumgeneexpression ⎯⎯⎯cholecystokinin-positive neurons (satiety) spine density/pyramidal neurons. (ability to think) •⎯•⎯• chandelier neuron cartridges. (nerve excitation/muscle tone) ••••••••• dopamine axon terminals. (motivational/reward related) Brainin'lammationandvaccines • Evidenceoverwhelming • Mechanismsdescribedinbenchresearch • Epidemiologystudiescorrupted – DeStefano2004 – Thorsen2002,2003 Themercuryresearch PMID:12949291 TheMMRstudy “Thisstudyprovidesstrongevidenceagainstthehypothesisthat MMRvaccina;oncausesau;sm.” h"ps://oig.hhs.gov/fraud/fugiPves/index.asp Total Nonsense “Autism is not an immune-mediated disease. Unlike autoimmune diseases such as multiple sclerosis, there is no evidence of immune activation or inflammatory lesions in the CNS of people with autism.” Offit 2009. PMID: 19128068 Conclusions • Morehumilityneededinscienceinlightofongoing discoveries. • Vaccinated/unvaccinatedstudiesurgentlyneeded. • Re-evaluationofcurrentepidemiologystudies refutingautism/vaccinerelationship. • Closerlookatbenchresearchrefutingearlier studiesthatshowedpotentialvaccine/autism relationship.