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Download Bio 122 Study Guide 10 Objectives 1. Understand how DNA
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Bio 122 Study Guide 10 Objectives 1. Understand how DNA structure suggested the ‘semiconservative’ hypothesis for the mechanism for DNA replication to Watson and Crick. 2. Know the enzymes involved in DNA replication and their functions well enough to understand why DNA replication works in a complicated way. 3. Learn the major events that occur during initiation, elongation, and termination of DNA replication. 4. Understand why the leading strand at the replication fork on one side of a replication bubble is the lagging strand at the other replication fork. 5. Know the steps involved with elongation on the lagging strand. Terms semiconservative amino acid antiparallel initiators helicase single stranded binding protein primase DNA polymerase ligase replication fork replication bubble leading strand lagging strand Okazaki fragment ligation mutation Questions 1. Describe two differences between the appearance of a bacterial chromosome and a eukaryote chromosome during DNA replication. 2. Why does DNA replication involve a leading and a lagging strand (i.e. why can’t they both be leading strands)? 3. Why is primase required for DNA replication? 4. Describe the steps required to convert an Okazaki fragment to a uniform DNA strand. 5. Why is ligase needed to complete DNA replication?
