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Dr. Markus B Sikkel
MBBS (Hons), BSc (Hons), MRCP, MRCS
Last updated 03/03/2016
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21 Braintree Road, Ruislip, HA4 0EJ
[email protected]
08/01/80
Married
6104133
Current Appointment
Walport Academic Clinical Lecturer and Electrophysiology Fellow/Cardiology Specialist Registrar (now ST6),
Imperial College NHS Healthcare Trust, 04/2015 onward
Relevant Previous Appointments
Electrophysiogy and Devices Fellow and Cardiology Specialist Registrar (ST5), Imperial College NHS
Healthcare Trust, 10/2014 – 04/2015
Specialist Registrar in Cardiology (ST4), Northwick Park and Central Middlesex Hospitals 10/2013-10/2014
Wellcome Trust Clinical Research Training Fellow, Imperial College London 10/2010-10/2013
Specialist Registrar in Cardiology, Imperial College NHS Healthcare Trust 08/2009-10/2010
Walport Academic Clinical Fellow and Cardiology Specialist Registrar (ST3), Imperial College NHS
Healthcare Trust, 10/2009 – 10/2010
Education
2010-2013
1998-2004
1993-1998
Imperial College Wellcome Trust Clinical Research Training
Fellow
Imperial College School of Medicine
Reading Boys School, Reading
Qualifications
2015 – PhD
2008 – MRCP
2006 – MRCS
2004 – MBBS (Hons) with distinction and prizes
2002 – BSc. (Hons) in Medical Sciences with Pharmacology and Toxicology – First Class Honours
Selected Prizes and Honours
RESEARCH
1. NHLI Thesis Prize 2015, NHLI, Imperial College London, 13/6/2015
2. 3rd Place Poster Prize, European Cardiac Arrhythmia Society Annual Meeting 19/4/2015
3. Best Poster Prize, Basic Science Category (European Working Group on Cardiac Cellular
Electrophysiology) at EHRA/Europace Annual Meeting, Athens, 24/6/2013
4. Highly Commended Oral Presentation, National Heart and Lung Institute Postgraduate Research Day,
London, 21/6/2013
5. Best Poster Prize, Basic Science Category (BAS/BSCR), British Cardiovascular Society Annual
Meeting, London, 4/6/13
6. Best Poster Prize, Imperial College Academic Trainees Annual Event 9/5/2013
7. Travel awards to attend:
a. European Working Group on Cardiac Cellular Electrophysiology Meeting, Athens, 06/2013
b. Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Ventura, California,
02/2013
MEDICAL SCHOOL
1. Distinction in Clinical Practice 2004
2. Faculty of Medicine Award (one of eight) for best overall performance in finals 2004
3. Victor Ludorum Llewellyn Prize for clinical pharmacology 2004
4. Surgery, Medicine & Pharmacology Honours 2004
5. Duke Elder Prize Examination 03/2004: Ranked Second nationally.
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The A.H. Bygott Scholarship for Public Health Medicine – awarded by the trustees of the University of
London 2003
Third Year Examinations in Medicine and Surgery 06/2001 – Distinction
Second Year Examinations 06/2000 – Merit
First Year Examinations 06/1999 – Distinction
PRIOR NATIONAL AWARDS
1. OCEAC Prize for Biology – ranked first across three exam boards for best overall performance
nationally and internationally in A-Level Biology. 1998
2. OCEAC Certificate of Excellence for Chemistry – top 5 in A-Level Chemistry nationally and
internationally across three exam boards 1998
3. The Institute of Mechanical Engineers top 150 Award 07/1996 – presented to the 150 students with the
best GCSE results in the United Kingdom.
Grants Awarded
Primary Applicant
1. NIHR BRC Funding, Identification of Electrograms and Anatomical Locations that Correlate with
Responses to High Frequency Stimulation during AF Ablation - £4961 – Nov 2015
2. NIHR Walport Clinical Lecturer Post: Provides ~£45,000/year salary costs for up to 4 years - Apr 2015
onward – Apr 2019
3. Wellcome Trust Clinical Research Fellowship, Good and bad sparks - Identifying and targeting
arrhythmogenic calcium sparks in the failing heart. Oct 2010- Oct 2013 £265,544
4. Travel grants: ESC Congress 2012, Gordon Conference Arrhythmia 2013, EWGCCE Conference 2013
Total £1050
Co-Applicant
1. Boston Scientific Group, High Density Mapping for WACA Completion: Use of a High Density
Mapping System to Complete Wide Area Circumferential Ablation of the Pulmonary Veins and Avoid
Antral Segmental Ablation.Sept 2015 £63,443
Supervised Students
1. Mit Shah “Does flecainide alter sarcoplasmic reticulum calcium release events in normal and postmyocardial infarction cardiac myocytes?”, BSc Project 2011 (1st Class Honours)
2. Becker Al-Khayatt “Ranolazine Reduces Arrhythmogenic Calcium Waves in Ventricular
Cardiomyocytes”, BSc Project 2013 (2:1)
Publications
1. Miragoli M, Sanchez-Alonso JL, Bhargava A, Wright PT, Sikkel M, Schobesberger S, Diakonov I,
Novak P, Castaldi A, Cattaneo P, Lyon AR, Lab MJ, Gorelik J. Microtubule-Dependent Mitochondria
Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes.
Cell Rep. 2016 Jan 5;14(1):140-51.
2. Sikkel MB, Kumar S, Maioli V, Rowlands C, Gordon F, Harding SE, Lyon AR, Macleod KT, Dunsby
CW. High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in
cardiac myocytes. J Biophotonics. 2015 Oct 21. doi: 10.1002/jbio.201500193. [Epub ahead of print].
3. Glukhov AV, Balycheva M, Sanchez-Alonso JL, Ilkan Z, Alvarez-Laviada A, Bhogal N, Diakonov I,
Schobesberger S, Sikkel MB, Bhargava A, Faggian G, Punjabi PP, Houser SR, Gorelik J. Direct
Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium
Channels in Rat and Human Atrial Myocytes. Circulation. 2015 Dec 22;132(25):2372-84.
4. Roca-Alonso L, Castellano L, Mills A, Dabrowska AF, Sikkel MB, Pellegrino L, Jacob J, Frampton
AE, Krell J, Coombes RC, Harding SE, Lyon AR, Stebbing J. Myocardial MiR-30 downregulation
triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis. Cell
Death Dis. 2015 May 7;6:e1754.
5. Lagarto J, Dyer BT, Talbot C, Sikkel MB, Peters NS, French PM, Lyon AR, Dunsby C. Application of
time-resolved autofluorescence to label-free in vivo optical mapping of changes in tissue matrix and
metabolism associated with myocardial infarction and heart failure. Biomed Opt Express. 2015 Jan
7;6(2):324-46.
6. Bannister ML, Thomas NL, Sikkel MB, Mukherjee S, Maxwell C, MacLeod KT, George CH,
Williams AJ. The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on
RyR2. Circ Res. 2015 Apr 10;116(8):1324-35.
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Chahine MN, Mioulane M, Sikkel MB, O'Gara P, Dos Remedios CG, Pierce GN, Lyon AR, Földes G,
Harding SE. Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and
human failing hearts. Cardiovasc Res. 2015 Jan 1;105(1):31-43.
Land S, Niederer SA, Louch WE, Røe AT, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon
AR, Harding SE, Smith NP. Computational modeling of Takotsubo cardiomyopathy: effect of spatially
varying β-adrenergic stimulation in the rat left ventricle. Am J Physiol Heart Circ Physiol. 2014 Nov
15;307(10):H1487-96.
Shalhoub J, Sikkel MB, Davies KJ, Vorkas PA, Want EJ, Davies AH. Systems biology of human
atherosclerosis. Vasc Endovascular Surg. 2014 Jan;48(1):5-17.
Sikkel MB, Hayward C, Macleod KT, Harding SE, Lyon AR. SERCA2a gene therapy in heart failure:
an anti-arrhythmic positive inotrope. Br J Pharmacol. 2014 Jan;171(1):38-54.
Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk
AI, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J. Caveolin-3 regulates
compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. J Mol Cell
Cardiol. 2013 Dec 15;67:38-48.
Shah M, Sikkel MB. Coronary artery disease and age: beyond atherosclerosis. J Physiol. 2013 Dec
1;591(Pt 23):5807-8.
Sikkel MB, MacLeod KT, Gordon F. Letter by Sikkel et al regarding article, "Late sodium current
inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy".
Circulation. 2013 Sep 3;128(10):e156.
Tranter MH, Wright PT, Sikkel MB, Lyon AR. Takotsubo cardiomyopathy: the pathophysiology.
Heart Fail Clin. 2013 Apr;9(2):187-96.
Sikkel MB, Collins TP, Rowlands C, Shah M, O'Gara P, Williams AJ, Harding SE, Lyon AR, Macleod
KT. Triple mode of action of flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia:
Reply. Cardiovasc Res. 2013 May 1;98(2):327-8.
Toepfer C, Caorsi V, Kampourakis T, Sikkel MB, West TG, Leung MC, Al-Saud SA, Macleod KT,
Lyon AR, Marston SB, Sellers JR, Ferenczi MA. Myosin regulatory light chain (RLC) phosphorylation
change as a modulator of cardiac muscle contraction in disease. J Biol Chem. 2013 May
10;288(19):13446-54.
Caorsi V, Toepfer C, Sikkel MB, Lyon AR, MacLeod KT, Ferenczi MA. Non-Linear Optical
Microscopy Sheds Light on Cardiovascular Disease. PLOS One. 2013 Feb 7.
Sikkel MB, Collins TP, Rowlands C, Shah M, O'Gara P, Williams AJ, Harding SE, Lyon AR, Macleod
KT. Flecainide Reduces Ca2+ Spark and Wave Frequency Via Inhibition of The Sarcolemmal Sodium
Current. Cardiovasc Res. 2013 May 1;98(2):286-96.
Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO,
Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding
SE. High levels of circulating epinephrine trigger apical cardiodepression in a β(2)-adrenergic
receptor/G(i)-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 2012 Aug
7;126(6):697-706.
Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot JS, Kohlbrenner E, Hajjar
RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J. Plasticity of surface structures and
β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart
failure. Circ Heart Fail. 2012 May 1;5(3):357-65.
Kumar S, Wilding D, Sikkel MB, Lyon AR, MacLeod KT, Dunsby C, High-speed 2D and 3D
fluorescence microscopy of cardiac myocytes, Opt. Express 2011 19, 13839-13847
Shalhoub J, Sikkel MB. The attributes of a good medical trainee: how to build your portfolio. Br J
Hosp Med (Lond). 2009 Jun 10; 70(6):M92-M95.
Abbas A, Sikkel MB, Collins JP, Davies CW, Chen F. A cryptic diagnosis: disseminated cryptococcal
disease presenting as an asymptomatic pulmonary nodule and a skin lesion: a case report. Cases
Journal. 2008 Dec; 1(1):430.
Sikkel MB, Quint JK, Mallia P, Wedzicha JA, Johnston SL. Respiratory syncytial virus persistence in
chronic obstructive pulmonary disease. Pediatr Infectious Disease Journal. 2008 Oct;27(10
Suppl):S63-70.
Sikkel MB, Batrick N. Asystole and Apnoea as a Presentation of Diffuse Glioma. Resuscitation. 2007;
73(2):304-6.
How P, Sikkel MB, Shalhoub J, Law NW. Brachial Artery Mycotic Aneurysm Secondary to
Methicillin-Resistant Staphylococcus Epidermidis and Infective Endocarditis. Annals of Vascular
Surgery 2006; 20(5):684-620
Shalhoub J, Hamish M, Sikkel MB, Davies AH Pseudoaneurysm of the Superficial Temporal Artery:
Case Report and Review of the Literature. Grand Rounds 2006; 6:15-17
Selected Oral Presesentations
1. Sikkel MB, Shah M, Desplantez T, Collins TP, O'Gara P, Harding SE, Lyon AR, MacLeod KT.
Flecainide Induces a New Population of Calcium Sparks in Rat Cardiomyocytes. Presented at AHA
Scientific Sessions 2011, published: Circulation. 2011;124:A11948.
2. Sikkel MB, Abbas A, Langham T, McGown A. Adequacy of Sample Collection in Tuberculosis: Is it
Specialty Dependent? Presented at BTS Meeting 2008, published: Thorax 2008;63;A145.
Selected Poster Presentations
1. MB Sikkel, V Luther, J Harrison, L Malcolm-Lawes, S Hayat, FS Ng, Ian Wright, N Qureshi, K
Leong, N Linton, M Koa-Wing, D Lefroy, B Lim, Z Whinnett, NS Peters, P Kanagaratnam, DW
Davies. Early Clinical Experience with the Rhythmia 3D Mapping System: Rapid, Automatic,
Accurate, High Density Mapping of Complex Arrhythmias Facilitates Successful Ablation. Presented
at ECAS 19/4/2015
2. Sikkel MB, Collins TP, Rowlands C, Harding SE, Lyon AR, MacLeod KT. Modulation of The
Sarcolemmal Sodium Current Changes Spontaneous SR Ca2+ Release. Presented at Gordon
Conference: Cardiac Arrhythmia Mechanisms, Ventura CA, 18/2/2013.
3. Sikkel MB, Rowlands C, Harding S, Lyon A, MacLeod KT. Reducing Sarcolemmal Sodium Current
Decreases Spontaneous SR Ca2+ Release. Presented at BCS meeting 2013. Heart 2013;99:suppl 2
A120
4. Sikkel MB, Collins TP, O’Gara P, Harding SE, Lyon AR, Macleod KT. Elemental SR Ca2+ release in
failing human cardiomyocytes - a comparison with failing rat cardiomyocytes and inhibition by
flecainide. Presented at ESC Congress 2012. published: Eur Heart J (2012) 33 (suppl 1): 941-1105.
5. Sikkel MB, Shah M, Desplantez T, Collins TP, O'Gara P, Harding SE, Lyon AR, MacLeod KT. Post
Myocardial Infarction Hearts Exhibit Larger Calcium Sparks which are Not Modified by Flecainide.
Presented at AHA Scientific Sessions 2011, published: Circulation. 2011;124:A11969
6. Sikkel MB, Ruparelia N, Shirodaria C, McKenna CJ, Spyrou N, Swinburn J, Orr WP. Can aggressive
pharmacoinvasive therapy for ST elevation myocardial infarction achieve TIMI flow and survival
comparable to primary angioplasty? Presented at BCS Meeting 2009, published: Heart 2009; 95(Suppl
1); 73
Books/Chapters
1. Alazawi W, Byrne P, Sikkel MB, Shalhoub J. Questions & Answers in Medicine, Lulu Publishing,
2012.
2. Sikkel MB, Lyon AR. Chapter: Drugs and Other Causes, in Heart Failure: Principles and Clinical
Management. Chief editors William Abraham and Henry Krum, McGraw-Hill Publishing, In Press
2014.
Public Engagement
1. Appearance on Channel 4 News, 30/4/13 – interviewed regarding science behind CUPID2 gene
therapy trial.
2. School visits discussing maintaining cardiac health