Download Posters – Devices and Imaging NAME OF THE PROJECT

Posters –
Devices and Imaging
NAME OF THE PROJECT
NAME OF THE MAIN CONTACT
ORGANISATION NAME
Technology
Microdialysis probes for optogenetics (optodialysis)
Laetitia ROUX
Pulsalys
The principle of the optodialysis probe is the coupling of microdialysis sampling technique
and light delivering via an optical-fiber into a targeted brain area which has been
genetically modified for a specific light activation.
The optodialysis probe allows to collect neuroactive compounds in the extracellular
medium before, during, and after a targeted cell stimulation induced by the appropriate
wavelength.
Customers / Target market
Applications are huge :

Neuroscience

all cell types which are all genetically modified

high sampling rate monitoring.
This device is currently unique on the market, and has several advantages :
• Light stimulation in optogenetics is performed simultaneously to microdialysis sampling
Industry and competitors
• Drug application by reverse dialysis can modulate optogenetic stimulation
• High sampling rate for dialysis collection is compatible with short-lasting light
stimulations.
Financing need / Commercial
opportunity
Pulsalys looks for industrial partners to test the prototypes, make and sell the
optodialysis probes.
Know how
IP – Patent situation
Inventors : Sandrine PARROT / Claire BENETOLLO
University Lyon 1 – INSERM - Lyon
Future steps / Milestones
-Prototypes developed
-Proof of concept obtained in vivo in mice on a brain area genetically modified by viral
infection. The technique has been successfully used for the study of light effects on the
levels of the two major brain neurotransmitters, glutamate and GABA.
Further reading
Parrot S, Denoroy L, Renaud B, Benetollo C. (2015) Why Optogenetics Needs in Vivo
Neurochemistry. ACS Chemical Neuroscience. 2nd most read article in June 2015.
Contact person
Laetitia ROUX, Tech Transfer Officer – Medical devices, SATT Pulsalys,
[email protected] - +33 (0)4.26.23.56.65