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Posters – Devices and Imaging NAME OF THE PROJECT NAME OF THE MAIN CONTACT ORGANISATION NAME Technology Microdialysis probes for optogenetics (optodialysis) Laetitia ROUX Pulsalys The principle of the optodialysis probe is the coupling of microdialysis sampling technique and light delivering via an optical-fiber into a targeted brain area which has been genetically modified for a specific light activation. The optodialysis probe allows to collect neuroactive compounds in the extracellular medium before, during, and after a targeted cell stimulation induced by the appropriate wavelength. Customers / Target market Applications are huge : Neuroscience all cell types which are all genetically modified high sampling rate monitoring. This device is currently unique on the market, and has several advantages : • Light stimulation in optogenetics is performed simultaneously to microdialysis sampling Industry and competitors • Drug application by reverse dialysis can modulate optogenetic stimulation • High sampling rate for dialysis collection is compatible with short-lasting light stimulations. Financing need / Commercial opportunity Pulsalys looks for industrial partners to test the prototypes, make and sell the optodialysis probes. Know how IP – Patent situation Inventors : Sandrine PARROT / Claire BENETOLLO University Lyon 1 – INSERM - Lyon Future steps / Milestones -Prototypes developed -Proof of concept obtained in vivo in mice on a brain area genetically modified by viral infection. The technique has been successfully used for the study of light effects on the levels of the two major brain neurotransmitters, glutamate and GABA. Further reading Parrot S, Denoroy L, Renaud B, Benetollo C. (2015) Why Optogenetics Needs in Vivo Neurochemistry. ACS Chemical Neuroscience. 2nd most read article in June 2015. Contact person Laetitia ROUX, Tech Transfer Officer – Medical devices, SATT Pulsalys, [email protected] - +33 (0)4.26.23.56.65