Download Homework: Karyotyping Activity

Name:_________________________________
Homework: Karyotyping Activity
Date:_____
Answer the following:
1. What sex chromosome combination does a female have?_____________
2. What sex chromosome combination does a male have?______________
3. How many chromosomes are in normal human cells?_________
Use the internet to define karyotype:
Karyotype - ____________________________________________________
_____________________________________________________________
The pictures below show normal ( all 46 non-damaged chromosomes)
Female Karyotype (2 X chromosomes)
Male Karyotype (XY chromosomes)
Why would scientists use karyotypes?
Scientists use karyotypes to diagnose genetic disorders. A karyotype can show if
there are extra, missing, or structurally damaged chromosomes.
Predict: What could cause someone to have missing or damaged chromosomes?
The following are four case studies. Each karyotype is showing a certain genetic
disorder. Analyze the karyotypes below to determine how they are different from
normal human karyotypes and answer the questions that follow each.
Case Study #1 – Dr. Wilson runs some tests and analyzes his patient’s karyotype.
What he sees is shown below.
How is this karyotype different from a normal human karyotype?
Which chromosome is affected?
Disorder Name: Down Syndrome
Case Study # 2 – Dr. Smith noticed that his male patient was exhibiting female
characteristics. He took a look at his cells and discovered the following karyotype:
What is different between this karyotype and a normal male karyotype?
Why might his patient have been exhibiting female characteristics?
Disorder Name: Kleinfelter’s Syndrome
Case Study # 3 – Dr. Wong had a patient that suffered from mental retardation.
Upon a closer look at the karyotype this is what she saw:
Does this karyotype have a normal amount of chromosomes?_________
What is different between this karyotype and a normal human karyotype?
Disorder Name: Cri du Chat (Cry of the cat)
Case Study # 4 – Dr. Jones noticed that her patient was not maturing during
puberty, she decided to run some tests and saw this karyotype:
How many chromosomes does this karyotype have?_________________
What chromosome is missing?
Disorder Name:Turner’s Syndrome