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BIO212 MIDTERM #2, SECTION .11/1/04. ALL ANSWERS MUST GO ON THE ANSWER SHEET;
YOU ARE LIMITED TO THE SPACE PROVIDED FOR EACH ANSWER. YOU MAY USE THE BACKS
OF THE PAGES FOR SCRAP/CALCULATIONS. You have 60 .
1. [4 ] Match each disease listed on the answer sheet with its description, and its genetics. For each
disease, write the letter corresponding to the best description, and the number corresponding to the
appropriate inheritance. Each may only be used once. Answer any 4; you may skip any one.
DESCRIPTION
GENETICS
A). Dwarfism.
B). Dementia in late life. Beta-amyloid protein
buildup found in brain.
C) Blackening of urine upon standing in air.
D). Dementia; begins as jerky dance-like
motions
E). Children regress; become vegetative, and
die.
F). High risk for heart attack and stroke.
G). Nearly normal; often some breast and/or
hip development.
H). X linked recessive
I). X linked dominant
1). Autosomal dominant, but only about 5% of
cases are genetic.
2). Confined to wheelchair as children; often
fatal before adulthood.
3). Autosomal dominant; many are new
mutations.
4). Autosomal recessive
5). Autosomal dominant; shows anticipation.
6). Trisomy 21
7). Incomplete dominance.
8). XXY
9). XO
2. [2 ] Fill in the names on your answer sheet for each of the labels shown:
3.
[1 ] According to The Gay Gene Revisited , what kind of inheritance does Sykes believe that
homosexuality follows?
4. [2 ] What are SNP s, and what do we use them for?
5. [2 ] What is the effect or end result of unequal crossing over?
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6. [6 ] In the pedigree below: Within each generation, the people are numbered from left to right. So for
instance, the last symbol on line III would be referred to as person III-8.
A.
B.
C.
D.
What type of inheritance is most likely the cause of this condition?
Indicate by number (such as IV-2) all people you know to be carriers.
What s the chance that IV-11 is a carrier?
If IV-10 marries IV-1, what s the chance their first child will have the disorder?
7. [3 ] A. How many genetically distinct gametes would a person of genotype AaBBccDdEeFf create [be
careful with your math!!]?
B. If two people of that same genotype married, what would be the chance that their first child would be
phenotype ABcDEF?
8. [2 ] Cure or quest for perfection discusses a 17th century short story called The Birthmark . In a
sentence or two, summarize that short story. You needn t interpret the story; just tell me what it s
about.
9. [4 ] In one sentence each, tell me what each of the following experiments demonstrated [they re in
chronological order]. You needn t describe the experiment; just what the conclusion was for each:
A. Griffith
B. Avery
C. Hershey-Chase
D. Meselson-Stahl
10. [3 ] Based upon your sex, tell me how YOUR IGF2 genes [insulin-like growth factor gene; this growth
factor acts on the placenta] genes are imprinted [that is, what kind of imprint will each of your alleles
carry], and how the IGF2 genes of your gametes are imprinted.
11. [4 ] Define: B. Genetic anticipation
Leptin
Genetic heterogeneity
D. The Haylflick Limit
Histone/Nucleosome
12. [2 ] You re studying a pair of identical twins who have an unusual skin disorder. Each twin has
patches of normal skin, and patches of skin that completely lack hair or hair follicles. Yet the
pattern of patches is different between the two twins. What s the most likely explanation?
13. [1 ] For the most part, heterozygotes of sickle cell are perfectly normal. However, if they go to
environments with low oxygen, such as high altitudes, they can show some effects of the disease. What
do we call this phenomenon?
15. [1 ] When we performed PCR, how is it that only the ONE gene [with 1 or 2 alleles] we were
interested showed up on the gel?
14. [1 ] A mother of blood type AB gives birth to a baby of type O . How can genetics explain this?
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15. [2 ] What question was Sykes trying to answer about Neanderthal man, and what was the answer?
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16. [2 ] You re performing a cross in mice, examining two loci, A and B. The males you will be using are
the F1 offspring of two purebred mouse strains, one of the purebreds showing phenotype AB and
the other ab. The females for your cross show both recessive traits. The mouse textbook claims
that these loci are 6 map units apart. Given 230 offspring, how many would you have expected to
be in each class of offspring?
UP TO 3 POINTS EXTRA CREDIT [this IS A CHALLENGING QUESTION, I SUGGEST YOU LEAVE IT
FOR LAST]:
You do the cross described above using a number of males and females, and find the following
offspring:
113 ab
100 AB
10Ab
7 aB
B. What is the P value for your experiment (you can give a range surrounding your P value).
C. Are your results consistent with the idea that these loci are 6 map units apart?
You may need the following:
2
Degrees
of
freedom
(O E ) 2
E
1
2
3
4
P values:
0.995
0.99
----0.010
0.020
0.072
0.115
0.207
0.297
0.975
0.001
0.051
0.216
0.484
0.95
0.004
0.103
0.352
0.711
0.90
0.016
0.211
0.584
1.064
0.10
2.706
4.605
6.251
7.779
0.05
0.025
0.01
3.841
5.024
6.635
5.991
7.378
9.210
7.815
9.348 11.345
9.488 11.143 13.277
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MIDTERM EXAM #2: section A: 11/1/04
1. Achondroplasia__________
NAME:_________________________________________
Alcaptonuria__________
Familial Hypercholesterolemia__________ Klinefelter s__________
HD__________
Deuchene Muscular Dystrophy Alzheimer s__________
Tay Sachs
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