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CHAPTER 2, INTRODUCTION TO THE VERTEBRATE ENDOCRINE SYSTEM Today is last day to drop with no permission, no W, and full money return General characteristics Important job of endocrine – maintain a fairly stable internal environment Homeostasis – maintaining a set point Set points differ with age, sex, reproductive status, time in day or year, stage of development – Romero’s Reactive Scope Model Endotherms vs. ectotherms Ectotherms: using environment for temperature saves energy, but reliant on the environment Downside – if it’s cold so are you Upside – the values for homeostasis are quite flexible Endotherms: maintaining unique set points yourself (esp. temperature) takes lots of energy Upside – body (specifically enzymes) can always work at best capacity Downside – always on the lookout for food and restrictions in such can be severe Physiological roles of hormones Synthesis and secretion of cellular products Other hormones Regulating metabolic processes Contraction, relaxation, and metabolism of muscles Reproduction Cellular proliferation Excretion/retention of inorganic ions Permissive actions - Behaviors General Characteristics Endocrine glands Ductless – go directly into blood stream Secretory cells Well vascularized May be compact, discrete mass – thyroid gland May be small clumps of cells – Islets of Langerhans May be individual, diffuse cells – intestinal tract Usually permanent (exception: placenta) Area and activity can change over life – obvious one, gonads pre and post-puberty General endocrine glands of humans Plus some we don’t think of; whole brain, skeleton General Characteristics This can be a variety of distances NOTE: The difference, no going into general circulation General Characteristics Typically see hormones secreted in low concentrations Binding to high affinity receptors Release of hormones pulsatile – minutes to hours, makes for a low daily mean Seasonal release of hormones – makes for a low yearly mean Often more than one hormone produced by a single gland One hormone can have many actions Whole pituitary – 10+ Estradiol (estrogen) One function can have multiple hormone influences Fat metabolism Categories of hormones 3 general types of hormone Grouped based on structure or functional similarities Peptide hormones – peptide, polypeptide, protein Take home – they are made of amino acids Special cases Book has more classes, I do some grouping – follow what I do here Monoamine hormones – single amino acids Thyroid hormones Steroid hormones - cholesterol Lipid-based hormones – other than cholesterol Note some hormones can do double duty as neurotransmitters, depends on location Some unexpected neurotransmitters too Protein (aka, peptide) hormones Comprised of amino acids Storable, released by exocytosis No carriers needed, move freely in blood Often bound with plasma proteins (esp. albumin) for protection from degrading enzymes Receptors typically located in cell membrane Ca2+ dependent exocytosis Hydrophilic Transcription/translation Lots of modification! Hydrophilic nature means they cannot pass cell membranes Secondary messengers important for their actions Hormone modification Preprohormones and prohormones, very prevalent and easiest to see in the protein hormones. Other groups have preprohormone/prohormone characteristics. General Characteristics Example: Proopiomelanocortin (POMC) a classic preprohormone (prepropeptide) Special cases of peptide hormones Thyroid hormones Initially a single tyrosine, but multiple altered tyrosines together Iodinated hormone Fat soluble and need carrier Receptors found inside cell membrane Neurohormones Synthesized in the perikarya (cell body) moved to axon terminals Released as is upon stimulation from storage vesicles Monoamine hormones Made from single amino acid Special protein hormones - monoamines Epinephrine, produced mainly from adrenal gland tissue, is the biggie here. Do not get confused here, dopamine and norepinephrine are hormones and neurotransmitters. These are catecholamines Special protein hormones - monoamines The important one here, melatonin. This is made under specific environmental circumstances. This is an indoleamine Evolution of peptide hormones Substitutions/changes in amino acids can yield new hormones with new functions Oxytocin and vasopressin Both from posterior pituitary Very similar in sequence, 2 amino acid differences Oxytocin stimulates milk let-down and uterine contractions Vasopressin influences water retention Receptors similar – this leads to a interesting wrinkle in my mind Can lead to formation of hormone families Similar primary sequences different activities Insulin-like growth hormone family Steroid hormones Majority of hormones gonadal or adrenal in origin Adrenal glands- glucocorticoids, mineralocorticoids, weak androgens Gonads- androgens, estrogens, progestins Steroids derived from cholesterol Liver and dietary sources Steroids a series of carbon rings Groups typically identified by number of carbon atoms Cholesterol has 27 carbons, to produce steroids carbon atoms are removed Steroid hormones Steroids are hydrophobic Need carriers to move through blood Carriers can protect and extend half life Receptors for steroids located in cytoplasm or nucleus Sex steroids actions highly conserved in vertebrates Steroids move easily through cell membranes Strong impact on reproduction, selection tries not to mess with reproduction Minor structural differences yield major functional differences Chart outlines conversion of steroids, note all start with cholesterol. All conversions must be gone through to get the more derived forms Steroid hormones C21 steroids Have 21 carbon atoms in ring structure Progestins, Are glucocorticoids, mineralcorticoids considered prohormones Can act as hormones themselves, but are precursors for other hormones Steroid hormones C19 steroids Have 19 carbons in ring structure Androgens Important in males for primary and secondary sex characters, gamete production, and reproductive behavior Are considered prohormones – estradiol (estrogen) Steroid hormones C18 steroids Have 18 carbon atoms in ring structure Estrogens Produced from androgens by aromatase Important to female primary and secondary sex characteristics, gamete formation, and behavior Has influences on male behavior Aggressive behavior in male mice Song system development in male birds Lipid-based hormones: Eicosanoids Prostaglandins – discovered in 1930’s 1st finding – in seminal fluid & induce uterine contractions Have a 20 carbon atom fatty acid skeleton Arachidonic acid Cyclooxygnease – enzyme for modification Known to have direct effects on behavior in insects Involved in reproduction, smooth muscle contraction and relaxation, and cardiac function Other types: thromboxanes and leukotrienes Control of hormone release Electrical (nerve) or chemical stimulation Induces endocrine cell to produce or release product Induced by metabolic by-product One hormone can induce another to be released Hypothalamic hormones induce pituitary hormone release Regulation via positive or negative feedback General actions of hormones Hormones will act via receptors Peptide – in membrane (at right) Steroid – intracellular or intra-nuclear Secondary messengers important Modifications to transcription/translation Pathophysiology Classic Hypofunction Gland destruction Extraglandular disorder Hyperfunction Excess or deficient levels Gland destruction or growth Extraglandular sources Reduced sensitivity Genetic Acquired Abnormal levels