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Transcript
Appendix S1. Calculation of the reproductive numbe r using the next generation matrix.
In this section, we derive
, the reproductive number, using the next generation matrix method
[16-18]. It is easy to see that the scaled model system has exactly one disease- free equilibrium
and the equations for the infectious compartments of the linearized system of
the scaled model at
take the form:
We now introduce the following matrices:
These expressions give
Then
corresponds to the spectral radius of
:
This expression is also obtained when derived from the original (unscaled) system of ODEs (Eq.
1). Note that in the scaled equation, S0 = 1. If a proportion v of ducks is vaccinated at the
beginning of the infection, the total susceptible population reduces to (1-v)S0 assuming that the
vaccine provides perfect protection against BYDV. In this case, the effective reproductive
number under vaccination,
, is given by
Therefore the minimum vaccination proportion,
below one (i.e.
) is
, required to bring the reproductive number