CURRICULUM VITAE William Schaffner, MD
... CDC Honor Award. “For work on evidence-based modification of the vaccine schedule for rabies post-exposure prophylaxis”, ACIP Rabies Vaccine Workgroup, National Center for Emerging and Zoonotic Infectious Diseases, Co-awardee ...
... CDC Honor Award. “For work on evidence-based modification of the vaccine schedule for rabies post-exposure prophylaxis”, ACIP Rabies Vaccine Workgroup, National Center for Emerging and Zoonotic Infectious Diseases, Co-awardee ...
4-080816-Gnann-Parsippany
... • Skin manifestations can appear similar to other rashes – Zosteriform herpes simplex is the most frequent error in diagnosis2 • Can be linear, but heals more rapidly, is likely to have less pain, and may recur in same area2 • If indicated, only reliable way to distinguish between the two is with la ...
... • Skin manifestations can appear similar to other rashes – Zosteriform herpes simplex is the most frequent error in diagnosis2 • Can be linear, but heals more rapidly, is likely to have less pain, and may recur in same area2 • If indicated, only reliable way to distinguish between the two is with la ...
Chronic Hepatitis B Infection - National Medical Research Council
... HBsAg negative, anti-HBs < 10 IU/L, anti-HBc positive These individuals may have hepatitis B virus infection with low viral load and an undetectable level of HBsAg. Those who are tested positive for anti‑HBc alone may be in the ‘window’ phase of acute hepatitis B infection or they may have chronic h ...
... HBsAg negative, anti-HBs < 10 IU/L, anti-HBc positive These individuals may have hepatitis B virus infection with low viral load and an undetectable level of HBsAg. Those who are tested positive for anti‑HBc alone may be in the ‘window’ phase of acute hepatitis B infection or they may have chronic h ...
evaluation of quadrivalent HpV 6/11/16/18 vaccine efficacy against
... who were PCR and seronegative to vaccine HPV types at baseline. This is possibly due to the protective effect of acquired immunity in the seropositive subjects. This prior seropositivity would have led to a humoralresponse, and potentially had a better chance of preventing the development of a lesio ...
... who were PCR and seronegative to vaccine HPV types at baseline. This is possibly due to the protective effect of acquired immunity in the seropositive subjects. This prior seropositivity would have led to a humoralresponse, and potentially had a better chance of preventing the development of a lesio ...
Combining Human and Rat Sequences in Her
... by self pE2TM (124 ± 4, P < 0.001). Therefore, heterologous Her2 or neu DNA is superior in overcoming T-cell tolerance. All ELISPOT assays were performed with pooled PBL except in NeuT mice whose splenocytes were used because neu-reactive T cells were not detectable in their PBL. Induction of Her-2 ...
... by self pE2TM (124 ± 4, P < 0.001). Therefore, heterologous Her2 or neu DNA is superior in overcoming T-cell tolerance. All ELISPOT assays were performed with pooled PBL except in NeuT mice whose splenocytes were used because neu-reactive T cells were not detectable in their PBL. Induction of Her-2 ...
Common Features of Mucosal and Peripheral Antibody Responses
... (2). In addition, there was no difference between the breadth and depth of IgG binding to linear Env peptides between the mucosal and serum compartments (Fig. 4D). These results suggest that Env-specific mucosal and serum IgG generally share similar epitope specificities. HIV-1 infects humans primar ...
... (2). In addition, there was no difference between the breadth and depth of IgG binding to linear Env peptides between the mucosal and serum compartments (Fig. 4D). These results suggest that Env-specific mucosal and serum IgG generally share similar epitope specificities. HIV-1 infects humans primar ...
Our focus is on vaccines
... Chimigen ® WEEV vaccines shifted survival curve in a subset of the animals ...
... Chimigen ® WEEV vaccines shifted survival curve in a subset of the animals ...
Transmission-Blocking Immunity against Malaria: From Antigen
... After the ingestion, the gametocytes differentiate into gametes, fertilization occurs, and the zygote develops into an ookinete, that forms oocysts in the midgut epithelium. When the oocysts rupture, the sporozoites from the haemolymph invade the salivary glands to be injected into a new host. The t ...
... After the ingestion, the gametocytes differentiate into gametes, fertilization occurs, and the zygote develops into an ookinete, that forms oocysts in the midgut epithelium. When the oocysts rupture, the sporozoites from the haemolymph invade the salivary glands to be injected into a new host. The t ...
The effects of environmental mycobacteria on VLP and MVA based vaccines against tuberculosis
... has become since then the most widely administered vaccine globally. Later different local sub-strains of BCG evolved (by separate closed activity) such as BCG Connaught, Danish, Glaxo, Pasteur, and Tokyo, all of which contain differences in terms of genetic and antigenic composition (Behr, 2001, Oe ...
... has become since then the most widely administered vaccine globally. Later different local sub-strains of BCG evolved (by separate closed activity) such as BCG Connaught, Danish, Glaxo, Pasteur, and Tokyo, all of which contain differences in terms of genetic and antigenic composition (Behr, 2001, Oe ...
Mucosal Vaccines: Where Do We Stand?
... Mucosal immunization, especially via the intranasal and sublingual routes, also can induce substantial levels of IgA and IgG in serum [26] because mucosal DCs may migrate and carry antigen to systemic inductive sites (lymph nodes and spleen) [27,28] and a fraction of the B cells activated in the muc ...
... Mucosal immunization, especially via the intranasal and sublingual routes, also can induce substantial levels of IgA and IgG in serum [26] because mucosal DCs may migrate and carry antigen to systemic inductive sites (lymph nodes and spleen) [27,28] and a fraction of the B cells activated in the muc ...
Review - Antimicrobe.org
... The upper respiratory tract is the ecological niche for many bacterial species. In children, the nasopharyngeal flora become established during the first months of life.7,18 A broad variety of microorganisms including S pneumoniae, H influenzae, and M catarrhalis can colonise the nasopharyngeal nich ...
... The upper respiratory tract is the ecological niche for many bacterial species. In children, the nasopharyngeal flora become established during the first months of life.7,18 A broad variety of microorganisms including S pneumoniae, H influenzae, and M catarrhalis can colonise the nasopharyngeal nich ...
An Advisory Committee Statement (ACS)
... not been firmly established and previously reported incidence has varied based on the methods used and duration of follow-up. Recently, Yawn et al. examined medical records of 1669 Olmsted County (Minnesota) residents >22 years old and found a 5.7% (95% CI 4.46.9%) recurrence rate over eight years i ...
... not been firmly established and previously reported incidence has varied based on the methods used and duration of follow-up. Recently, Yawn et al. examined medical records of 1669 Olmsted County (Minnesota) residents >22 years old and found a 5.7% (95% CI 4.46.9%) recurrence rate over eight years i ...
Vaccines and Autism
... Cytokines from T cells regulate the full spectrum of antibody and cell-mediated response, the latter being particularly important in resistance to viral infections. Both numeric and functional Tcell deficiencies are demonstrated in autistic children. Autistic children have significantly reduced tota ...
... Cytokines from T cells regulate the full spectrum of antibody and cell-mediated response, the latter being particularly important in resistance to viral infections. Both numeric and functional Tcell deficiencies are demonstrated in autistic children. Autistic children have significantly reduced tota ...
Biological Feasibility of Measles Eradication
... Measles virus transmission can be interrupted by achieving high levels of population immunity with measles vaccines, such that the probability of an infected case coming in contact with a susceptible individual is low [22]. However, a 2-dose measles immunization schedule is necessary to achieve the ...
... Measles virus transmission can be interrupted by achieving high levels of population immunity with measles vaccines, such that the probability of an infected case coming in contact with a susceptible individual is low [22]. However, a 2-dose measles immunization schedule is necessary to achieve the ...
update on the use of quadrivalent conjugate meningococcal vaccines
... serogroup B disease in Canada. Rates of serogroup C meningococcal disease have decreased due to vaccination programs, and in 2007, the number of serogroup Y cases slightly exceeded the number of serogroup C cases (30 serogroup C cases and 35 serogroup Y cases). The median age for serogroup Y disease ...
... serogroup B disease in Canada. Rates of serogroup C meningococcal disease have decreased due to vaccination programs, and in 2007, the number of serogroup Y cases slightly exceeded the number of serogroup C cases (30 serogroup C cases and 35 serogroup Y cases). The median age for serogroup Y disease ...
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... and Dobson, 2002; Simonetti, 1995). Where this problem has been studied, the focus in disease ecology has been on disease dynamics in the absence of human impacts (e.g., McCallum and Dobson, 2002), while the focus in economics has been on optimal disease control (e.g., Horan et al., 2008). There has ...
... and Dobson, 2002; Simonetti, 1995). Where this problem has been studied, the focus in disease ecology has been on disease dynamics in the absence of human impacts (e.g., McCallum and Dobson, 2002), while the focus in economics has been on optimal disease control (e.g., Horan et al., 2008). There has ...
10276005
... few months following a two-dose regimen [24], but this efficacy falls toward baseline within 24 to 36 months of vaccination, especially in children who may not have had previous exposure like the adults [5]. In comparison, natural cholera induces protection that lasts for years or decades after infe ...
... few months following a two-dose regimen [24], but this efficacy falls toward baseline within 24 to 36 months of vaccination, especially in children who may not have had previous exposure like the adults [5]. In comparison, natural cholera induces protection that lasts for years or decades after infe ...
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... The main aim of vaccination is to incite a strong pathogenspecific immune response to confer life-long protection against subsequent exposure to the pathogen [1]. An ideal vaccine must be efficacious, non-toxic, cost-effective, and amenable to large scale manufacture [2]. Since its inception, vaccin ...
... The main aim of vaccination is to incite a strong pathogenspecific immune response to confer life-long protection against subsequent exposure to the pathogen [1]. An ideal vaccine must be efficacious, non-toxic, cost-effective, and amenable to large scale manufacture [2]. Since its inception, vaccin ...
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... are exogenous to human choices, we assume some parameters are endogenous functions of the supplemental feeding choice, f. Specifically, natural mortality is assumed to be declining in f. We model this as M ( f ) = m(1 − wf ) , where m is the natural mortality rate and w is a parameter that represent ...
... are exogenous to human choices, we assume some parameters are endogenous functions of the supplemental feeding choice, f. Specifically, natural mortality is assumed to be declining in f. We model this as M ( f ) = m(1 − wf ) , where m is the natural mortality rate and w is a parameter that represent ...
Recent Advances in Understanding Immunity
... The molecule MyD88, which is the adaptor molecule for several TLRs and some interleukin receptors, is clearly required for the control of Brucella replication in mice [2729], suggesting that signaling through receptors that use MyD88 is critical to control brucellosis. Our group has investigated the ...
... The molecule MyD88, which is the adaptor molecule for several TLRs and some interleukin receptors, is clearly required for the control of Brucella replication in mice [2729], suggesting that signaling through receptors that use MyD88 is critical to control brucellosis. Our group has investigated the ...
Kotzer,_Natalie
... parents and victims who believe that the vaccine is causing more harm than science knows or public authorities will admit. Because of conflicting reports as to the actual incidence of hepatitis B in the United States and because the vaccine was developed for those engaging in high risk behaviors, in ...
... parents and victims who believe that the vaccine is causing more harm than science knows or public authorities will admit. Because of conflicting reports as to the actual incidence of hepatitis B in the United States and because the vaccine was developed for those engaging in high risk behaviors, in ...
Shingles - Children`s Hospital of Philadelphia
... 1 million people. About one of every three people in the United States will get shingles during their lifetime. Approximately half of those who live to be 85 years old will have one or more encounters with shingles. ...
... 1 million people. About one of every three people in the United States will get shingles during their lifetime. Approximately half of those who live to be 85 years old will have one or more encounters with shingles. ...
Immunity against Mucosal Pathogens?
... A recent study found that mice who received two i.n. immunizations of H1N1 influenza virus-like particles (VLPs) were protected against a lethal challenge with both the 1918 H1N1 virus and the heterotypic H5N1 virus (60). In addition, mucosal immunization was able to induce a higher level of cross-r ...
... A recent study found that mice who received two i.n. immunizations of H1N1 influenza virus-like particles (VLPs) were protected against a lethal challenge with both the 1918 H1N1 virus and the heterotypic H5N1 virus (60). In addition, mucosal immunization was able to induce a higher level of cross-r ...
Vaccines Against Malaria - Oxford Academic
... before phase 2 field testing in the target population of children in malaria-endemic areas could finally be performed to determine vaccine efficacy. These steps included initial development of a candidate vaccine in the laboratory, testing for safety and proof-of-concept in animal models, and age de-es ...
... before phase 2 field testing in the target population of children in malaria-endemic areas could finally be performed to determine vaccine efficacy. These steps included initial development of a candidate vaccine in the laboratory, testing for safety and proof-of-concept in animal models, and age de-es ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... The three groups had a comparable ethnical/racial distribution, with an approximate 50% of the subjects in each group of East Asian heritage and an approximate 25% of Caucasian heritage. Demographic characteristics in the TVC were similar. ...
... The three groups had a comparable ethnical/racial distribution, with an approximate 50% of the subjects in each group of East Asian heritage and an approximate 25% of Caucasian heritage. Demographic characteristics in the TVC were similar. ...