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A Biology Engineering Design Challenge Topic: Mitosis: Making Duplicate Cells Scenario: While you were out feeding the horses in the barn, one of them got loose. You spent 45 minutes trying to corral it back into its stall. In the excitement, you cut your arm on some barbed wire. In the ER they gave you 8 stitches and told you that you have to keep the wound dry until the stitches come out in 4 weeks. During this time the damaged skin will need to be replaced by the surrounding healthy skin. Individual skin cells will spend the next few weeks making copies of themselves until the wound is completely healed. 1. What is the main concern after this accident? 2. What does our body have to do? 3. How can that happen? Engineering Design Challenge: Your challenge is to determine steps ( barriers) a cell must overcome to divide and produce an exact replica of itself. You will also develop models that suggest possible solutions for each barrier that the cell must address. Right – p. 1 Brainstorming 1. Research and write down the functions of the following parts of a cell. Cell membrane: Nucleus: Chromatin: Chromosomes: Ribosomes: Mitochondria: Cytoplasm: 2. In table #1, write down what steps (barriers) it takes for a cell to make an exact replica of itself. Don’t worry about what the “right” answer is. The purpose of this activity is problem-­‐solve. Any possible solution is a good answer. Right – p. 2 Table #1: Engineering Design Challenge Table #2: Engineering Design Challenge Descriptions of Barrier (Steps) 1 2 3 4 5 Cell Part Material you assigned to cell part Cell Membrane Nucleus Chromatin/ Chromosomes Ribosomes Mitochondria Cytoplasm Possible Solutions Left – p. 1 Left – p. 2 Playtime: Making Models 1. Gather available materials and assign objects a cell structure. Fill out Table #2. 2. Build a model of a cell. The chromosomes should be located in the _________________. Take a picture of your original cell. 3. Manipulate the pieces to design a solution for step one. (You cannot just build another cell. All new cells must come from existing cells.) a. Record your solution in the “possible solutions” column in the table. b. Take a picture of your solution. c. Repeat step three for steps (barriers) 2-­‐5. 4. Upload your SIX pictures into your Google drive. You can also email the picture to yourself (school email is [email protected]) and save them in your drive. 5. In Google Classroom, create a new document under the assignment and put all SIX photos in the doc. SHARE with your group. 6. Use Google Draw or another program to label your original cell. 7. Put your pictures in order and explain what design problem you solved in each phase. 8. Turn in via Google Classroom. Post Lab Reflection Watch the video showing how mitosis actually happens. Compare and contrast your model and problem solving to the video. Compare (what is the same) Going further: a) How does a cell know when to stop dividing? b) What happens if it divides indefinitely? c) How do the new cells know they are skin cells and not heart cells, eye, liver, or blood cells? d) Why is it important for DNA to condense from chromatin to chromosomes before mitosis? What could happen if it didn’t? Right – p. 3 Contrast (what is different) Left – p. 3