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CURRICULUM VITAE GENERAL INFORMATION NAME: Mousumi Moulik, MBBS PRESENT TITLE AND AFFILIATION: Assistant Professor Department of Pediatrics Division of Pediatric Cardiology University of Texas Medical School-Houston, TX 08/2007-current CITIZENSHIP: U.S. Citizen OFFICE ADDRESS: The University of Texas McGovern Medical School 6431 Fannin, MSB 3.128 Houston, TX 77030 Tel: 713-500-5738 Fax: 713-500-5751 e.mail: [email protected] EDUCATION Medical School Aug. 1985 - Dec. 1991 All India Institute of Medical Sciences, New Delhi, India Residency & Fellowship Jan. 1991 - Jun. 1992 Internship/Residency, Pediatrics, All India Institute of Medical Sciences, New Delhi, India (Chairman: Meharban Singh, MD) Jun. 1992 - Jun. 1993 Internship, Internal Medicine, Michael Reese Medical Center, University of Illinois, Chicago, IL (Chairman: William Chamberlin III, MD) Jun. 1993 – Jun. 1996 Residency, Pediatrics, Baylor College of Medicine, Houston, TX (Chairman: Ralph D. Feigin, MD) Aug. 2002- Jun. 2007 Fellowship, Pediatric Cardiology, Baylor College of Medicine, Houston, TX Mousumi Moulik, MD Page 1 CURRICULUM VITAE 3 years as Clinical Fellow, 2 years as Research Fellow (Division Chiefs: J. Timothy Bricker, MD; Jeffrey A. Towbin, MD) Research Jun. 2004- May. 2005 Certificate of Added Qualification in Clinical Investigation, Clinical Scientist Training Program, Baylor College of Medicine, Houston, TX (Course Director: Morey W. Haymond, MD) Oct. 2004- Jun. 2006 Post-Doctoral Research Fellow in the Phoebe Willingham Muzzy Pediatric Molecular Cardiology Laboratory (Mentor: Jeffrey A. Towbin, MD) Jun. 2006- Jun. 2007 Masters Candidate for Masters in Clinical Investigation, Graduate School, Baylor College of Medicine, Houston, TX (Course Director: Morey W. Haymond, MD) Nov. 2011- Feb. 2012 Clinical Trial Design Course (Honors), Center for Clinical Research and Evidence-Based Medicine, University of Texas Medical School, Houston (Course Director: Jon E. Tyson, MD) CREDENTIALS Board Certification General Pediatrics, American Board of Pediatrics, initial certification 1996, recertified in 2010 Pediatric Cardiology, American Board of Pediatrics, initial certification 2010 Licensure(s) Active Texas, K1576, 11/16/1996 Inactive Massachusetts, 151009, 5/15/1996 EXPERIENCE/SERVICE Academic Appointments Apr. 1997- Dec. 2000 Assistant Professor, Department of Pediatrics, Texas Tech University Health Science Center, El Paso, TX (Chairman: Gilbert Handal, MD) Mousumi Moulik, MD Page 2 CURRICULUM VITAE Aug. 2007- current Assistant Professor, Division of Pediatric Cardiology, Department of Pediatrics, University of Texas Medical School, Houston (Division Chiefs: P. Syamasundar Rao, MD; J. Timothy Bricker, MD, John P. Breinholt, MD) Academic Administrative Appointments/Responsibilities Jul. 2009-current Co-Director Research, Division of Pediatric Cardiology University of Texas Medical School, Houston Non-academic clinical experience Jan. 2000- Jul. 2002 Group Practice in General Pediatrics in Medically Underserved Area, Revere, MA (Revere Pediatrics) GAP IN WORK HISTORY Jul. 1996- Mar. 1997 Job search and work visa processing HOSPITAL AFFILIATIONS Aug. 2007- current Memorial Hermann Children’s Hospital, Houston, TX Aug. 2007- current Lyndon B. Johnson Hospital, Houston, TX Feb. 2000 – Jul. 2007 Melrose Wakefield Hospital, Melrose, MA Aug. 2001 – Jul. 2007 Children’s Hospital Boston, Boston, MA Nov. 1997– Dec. 1999 Sierra Provider Health Network, El Paso, TX Apr. 1997- Dec. 1999 Thomason General Hospital, El Paso, TX Jul. 1997- Dec. 1999 Columbia Medical Center East and West, El Paso, TX Jun. 1999- Dec. 1999 Southwestern General Hospital, El Paso, TX HONORS and AWARDS 1973-1985 First rank for academic excellence throughout elementary, middle and high school 1982-1983 Junior Science Talent Scholarship, India 1983 Winner of Team and Individual Category Awards, Ramanujan Society of Born Mathematicians Inter School Mathematics Talent Contest, 1983 1984 Winner of All India Science Exhibition Quiz Contest, 1984 1983-1992 National Talent Scholarship, National Council of Educational Research and Training, India Mousumi Moulik, MD Page 3 CURRICULUM VITAE 1987 Gold Medal in Pathology and Microbiology, 1987, All India Institute of Medical Sciences, 1993 Best Intern in Internal Medicine, Michael Reese Hospital and Medical Center, Chicago, IL 2005 Fellows Day Research Oral Presentation Award, Texas Children’s Hospital, Houston, TX (Mentor: Jeffrey A. Towbin, MD) 2005 Fellow Basic Research Award, Society for Pediatric Research, 2005 (Mentor: Jeffrey A. Towbin, MD) 2006 Fellows Day Research Poster Presentation Award, Texas Children’s Hospital, Houston, TX (Mentor: Jeffrey A. Towbin, MD) 2006 Women in Cardiology Trainee Award for Excellence, American Heart Association, 2006 2006 Young Investigator Travel Award, American Academy of Pediatrics (Section of Cardiology and Cardiac Surgery), 2006 (Mentor: Jeffrey A. Towbin, MD) 2006 Young Investigator Award, First Place, American Academy of Pediatrics (Section of Cardiology and Cardiac Surgery), 2006 (Mentor: Jeffrey A. Towbin, MD) RESEARCH Grants and Contracts Current Support None Pending Grants 1R01HL128548-01 (MPI) NIH/NHLBI Title: Tead1 Regulation of Cardiomyocyte Function and Survival Role: Co Principal Investigator Completed Support Mousumi Moulik, MD Page 4 CURRICULUM VITAE 5 K08 HL091176 2008-2014 NIH/NHLBI $571,776 Title: Inherited Dysfunction of Stretch Based Signaling in Dilated Cardiomyopathy Role: Principal Investigator Mentor: Jeffrey A. Towbin, MD 5T32HL007676-17 NHLBI T32 Training Grant PI: Susan Hamilton, PhD Title: ‘Molecular Excitability in the Cardiovascular System’ Role: Trainee Fellow Mentor: Jeffrey A. Towbin, M.D. 2005-2006 5T32HL007706-11 NHLBI T32 Training Grant PI: Michael Schneider, M.D. Title: ‘Training Grant in Molecular Cardiology’ Role: Trainee Fellow Mentor: Jeffrey A. Towbin, M.D. 2004-2005 UTHSC Institutional K Supplement Award 2009-2011 $21,000 Title: Inherited Dysfunction of Stretch Based Signaling in Dilated Cardiomyopathy Role: Principal Investigator Grant Reviewer Service American Heart Association- Immunology BSc1 Reviewers Panel, Oct 2012 PUBLICATIONS/ABSTRACTS a. Peer-Reviewed Publications 1. Joseph W. Rossano MD, Michelle A. Grenier MD, William J. Dreyer MD, Jeffrey J. Kim MD, Jack F. Price MD, John L. Jefferies MD, E. O’Brian Smith PhD, Sarah K. Clunie RN, Mousumi Moulik MD, Jamie A. Decker MD, John P. Breinholt MD, David L.S. Morales MD, E. Dean McKenzie MD, Jeffrey A. Towbin MD and Susan W. Denfield MD: Effect of Body Mass Index on Outcome in Pediatric Heart Transplant Patients. J Heart Lung Transplant 2007 Jul; 26(7):718-23. 2. Mousumi Moulik, Stephanie Witt, Anita Arola, Ross Murphy, William McKenna, Aladin Boriek, Kazuhiro Oka, Seigfried Labeit, Neil Bowles, Takeo Arimura, Akinori Kimura, Matteo Vatta, Mousumi Moulik, MD Page 5 CURRICULUM VITAE Jeffrey Towbin: Ankrd1, the gene encoding cardiac ankyrin repeat protein, is a novel DCM causing gene. J Am Coll Cardiol 2009 Jul 21;54(4):325-33 3. Takuro Arimura, Martin Bos, Akinori Sato, Toru Kubo, Hiroshi Okamoto, Hirofumi Nishi, Haruhito Harada, Yoshinori Koga, Mousumi Moulik, Yoshinori Doi, Jeffrey A. Towbin, Michael Ackerman, Akinori Kimura: Cardiac Ankyrin Repeat Protein Mutations in Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2009 Jul 21;54(4):334-42 4. John P. Breinholt, Mousumi Moulik, William J. Dreyer, Susan W. Denfield, Jeffrey J. Kim, John L. Jefferies, Joseph W. Rossano, Brandy Harbes, Corey Gates, Sarah K. Clunie, Karla R. Bowles, Debra L. Kearney, Neil E. Bowles, Jeffrey A. Towbin: Parvovirus B19 in the Myocardium of Pediatric Cardiac Transplant Patients is Associated with Transplant Coronary Artery Disease. J Heart Lung Transplant 2010 Apr 22 5. Mousumi Moulik, John P. Breinholt, William J. Dreyer, Debra L. Kearney, Jack Price, Sarah Clunie, Brady S. Moffett, Jeffrey J. Kim, Joseph W. Rossano, John Lynn Jefferies, Annie Thomas, Brandy A. Harbes, Karla R. Bowles, E. O Brian Smith, Neil E. Bowles, Susan W. Denfield, Jeffrey A. Towbin: Viral Endomyocardial Infection is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients. J Am Coll Cardiol 2010 Aug 10;56(7):582-92. 6. Agopian AJ, Moulik M, Gupta-Malhotra M, Marengo LK, Mitchell LE: Descriptive epidemiology of non-syndromic complete atrioventricular canal defects. Paediatr Perinat Epidemiol 2012 Nov;26(6):515-24. PMID: 23061687 7. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK: Bmal1 and β-cell clock are required for adaptation to circadian disruption and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol. 2013 Jun: 33(11):232738/MCB.01421-12. Epub 2013 Apr 1. PMID:23547261 8. Molina K, Denfield S, Fan Y, Moulik M, Towbin J, Dreyer W, Rossano J: Viral endomyocardial infection in the 1st year post transplant is associated with persistent inflammation in children who have undergone cardiac transplant. Cardiology Young. 2014 April; 24(2):331-6 PMID:23680495 9. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V.: PD-L1 driven Tolerance Protects Neurogenin3-induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes. 2014 Oct 20. pii: DB_131737. [Epub ahead of print] b. Abstract Presentations Mousumi Moulik, MD Page 6 CURRICULUM VITAE 1. Mousumi Moulik, Stephanie Witt, Anita Arola, Ross Murphy, William McKenna, Seigfried Labeit, Neil Bowles, Jeffrey Towbin : “Mutations in Cardiac Mechanosensory Units and Dilated Cardiomyopathy”, Presented at Society for Pediatric Research /Pediatric Academic Societies Meeting Washington DC, April 2005, Recipient : SPR Fellow’s Basic Research Award Recipient 2. Mousumi Moulik, Stephanie Witt, Anita Arola, Ross Murphy, William McKenna, Seigfried Labeit, Neil Bowles, Jeffrey Towbin : “Mutations in Cardiac Mechanosensory Units and Dilated Cardiomyopathy”, Presented at Japanese Pediatric Society Meeting Kanazawa, Japan, April 2006, Invited Abstract Presentation 3. Mousumi Moulik, John P. Breinholt, William J. Dreyer, Debra L. Kearney, Jack Price, Sarah Clunie, Brady S. Moffett, Jeffrey J. Kim, Joseph W. Rossano, John Lynn Jefferies, Annie Thomas, Brandy A. Harbes, Karla R. Bowles, E. O Brian Smith, Neil E. Bowles, Susan W. Denfield, Jeffrey A. Towbin : “ Viral Myocardial Infection is a Predictor of Graft Loss in Pediatric Cardiac Transplant Recipients”, Presented at Society for Pediatric Research /Pediatric Academic Societies Meeting Washington DC, San Fransisco, CA, April 2006 4. John P Breinholt, Mousumi Moulik, Corey M Gates, Karla R Bowles, Erin Blank, Jeathrina Bersola, Brandy Harbes, Sara K Clunie, Debra L Kearney, Neil E Bowles, Jeffrey A Towbin: “The epidemiologic Shift to Parvovirus B19 in Viral Myocardial Disease: What are the Implications to Heart Transplants ?”, Presented at Society for Pediatric Research /Pediatric Academic Societies Meeting, San Fransisco, CA, April 2006 5. Mousumi Moulik, John P. Breinholt, William J. Dreyer, Debra L. Kearney, Jack Price, Sarah Clunie, Brady S. Moffett, Jeffrey J. Kim, Joseph W. Rossano, John Lynn Jefferies, Annie Thomas, Brandy A. Harbes, Karla R. Bowles, E. O Brian Smith, Neil E. Bowles, Susan W. Denfield, Jeffrey A. Towbin : “Viral Endomyocardial Infection is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss in Pediatric Cardiac Transplant Recipients”, Presented at the American Academy of Pediatrics Meeting, Atlanta, GA, October 2006, Recipient : Young Investigator Award, First Position, Section of Cardiology and Cardiac Surgery 6. Mousumi Moulik, John P. Breinholt, William J. Dreyer, Debra L. Kearney, Jack Price, Sarah Clunie, Brady S. Moffett, Jeffrey J. Kim, Joseph W. Rossano, John Lynn Jefferies, Annie Thomas, Brandy A. Harbes, Karla R. Bowles, E. O Brian Smith, Neil E. Bowles, Susan W. Denfield, Jeffrey A. Towbin : “Viral Endomyocardial Infection is an Independent Predictor for Graft Loss in Pediatric Cardiac Transplant Recipients”, Presented at the American Heart Association Scientific Sessions Meeting, Chicago, IL, November 2006 7. John P Breinholt, Mousumi Moulik, Corey M Gates, Karla R Bowles, Erin Blank, Jeathrina Bersola, Brandy Harbes, Sara K Clunie, Debra L Kearney, Neil E Bowles, Jeffrey A Towbin: “Parvovirus B19 in the Myocardium of Pediatric Cardiac Transplant Patients is Associated with Transplant Coronary Artery Disease”, Presented at the American Heart Association Scientific Sessions Meeting, Chicago, IL, November 2006 Mousumi Moulik, MD Page 7 CURRICULUM VITAE 8. Unnati Doshi, Syed Shahrukh Hashmi, Lisa Marengo, Surabhi Kaul, Mousumi Moulik: “Incidence of and Risk Factors for Delayed Diagnosis of Critical Congenital Heart Defects: A Population Based Study”, Presented American Academy of Pediatrics National Conference and Exhibition, San Diego, CA, October 2014 9. Unnati Doshi, Syed Shahrukh Hashmi, Lisa Marengo, Surabhi Kaul, Mousumi Moulik: “Factors Associated With Delayed Diagnosis of Critical Congenital Heart Defects in Texas”, Accepted at the American Heart Association Scientific Sessions Meeting, Chicago, IL, November 2014 10. Arpan R. Doshi, Chandra Srinivasan, Hem H Desai, Heli P Bhatt, Mousumi Moulik: “Impact of 2007 American Heart Association Infective Endocarditis Prevention Guidelines on Endocarditis Related Pediatric Hospital Admissions: A U.S. Population-Based Study”, Accepted at the American Heart Association Scientific Sessions Meeting, Chicago, IL, November 2014 c. Book Chapters 1. Lee J, Moulik M, Yechoor V. Circadian control of islet function. In: The Islets of Langerhans 2 nd edition 2013. Md. Shahidul Islam (ed.) Springer Inc. 2. Moulik M. Neonatal Cardiomyopathies. In: Perinatal Cardiology. P.S.Rao and D. Vidyasagar (ed.) Cardiotext Publishing (in press) EDITORIAL AND REVIEW ACTIVITIES Journal Reviewer Reviewed manuscript for Lancet, 2012 PROFESSIONAL ACTIVITIES a. Teaching Lectures within UT Medical School Houston Aug. 2007-current Mousumi Moulik, MD Pediatric Cardiology Fellow/ Resident lectures: Bacterial Endocarditis in the Pediatric Age Group Hypertrophic Cardiomyopathy Dilated and Hypertrophic Cardiomyopathies: Clinical Evaluation Genetic and Metabolic Evaluation of Pediatric Cardiomyopathies Left Ventricular Non Compaction Acquired Heart Diseases in Pediatrics Page 8 CURRICULUM VITAE Aug. 2007-current Medical Student Lectures: Radiology In Cardiology Acquired Heart Disease in Pediatrics Clinical Fellow Training Aug. 2007-current Supervision of and formal/informal teaching activities for all PGY-4, 5 & 6 Clinical Pediatric Cardiology Fellows in both inpatient and outpatient settings at the Children’s Memorial Hermann Hospital, Lyndon B Johnson Hospital Houston and University of Texas Kids Place Specialty Clinics, Houston TX. I also actively participate in the fellowship training educational activities such as Journal Clubs, Board Review, Case management conferences and didactic teaching. Medical Students and Residents Aug. 2007-Present Supervision of and formal/informal teaching activities for medical students and residents rotating through the Pediatric Cardiology Division in both inpatient and outpatient settings at the Children’s Memorial Hermann Hospital, Lyndon B. Johnson Hospital Houston and University of Texas Kids Place Specialty Clinics, Houston TX College Student Mentoring May 2010 to Aug. 2011 Summer Practicum Mentor for Masters in Public Health Students from the School of Public Health, UTHSC Houston b. Invited Lectures 2006 ‘Mutations in Cardiac Mechanosensory Units and Dilated Cardiomyopathy’, Japanese Pediatric Society Meeting Kanazawa, Japan, April 2006, Invited Abstract Presentation 2007 ‘Pediatric Cardiomyopathies: From the Primary Care Perspective’, Third Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX 2008 ‘Pediatric Cardiomyopathies: An Update’, Pediatrics Grand Rounds, UT Medical School Houston, TX 2009 ‘Guidelines for Management of Cardiomyopathies’, Fifth Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX Mousumi Moulik, MD Page 9 CURRICULUM VITAE 2010 ‘Metabolic and Genetic Evaluation of Pediatric Cardiomyopathies’, Sixth Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX 2011 ‘Management of Heart Failure in Children: the Art and the Evidence’, Pediatrics Grand Rounds, UT Medical School Houston, TX 2011 ‘Outpatient Management of Heart Failure in Children’, Seventh Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX 2012 ‘Outpatient Management of Heart Failure in Children’, Eighth Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX 2013 ‘Myocarditis: State of the Art and Future Perspectives’, Ninth Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX 2013 ‘Genetics of Cardiomyopathies’, Adult Cardiology Grand Rounds, UT Medical School Houston, Houston, TX 2014 ‘Genetics of Cardiomyopathies: Clinical Applications’, Pediatrics Grand Rounds, UT Medical School-Houston, Houston, TX 2014 ‘Cardiomyopathies: For Genetic Counselors’, Invited lecture for UT Genetic Counseling Program, UTHSC-Houston. 2014 ‘Myocarditis: State of the Art and Future Perspectives’, Tenth Annual Pediatric Cardiology Symposium for the Primary Care Physician, UT Medical School Houston & Children’s Memorial Herman Hospital, Houston, TX c. Clinical Responsibilities Attending Physician, Division of Pediatric Cardiology, University of Texas Health Science Center, Houston, Inpatient and Outpatient Pediatric Cardiology Service Cardiomyopathy and general pediatric cardiology outpatient clinic, interpretation of transthoracic echocardiograms, EKGs and Holters, attending on pediatric cardiomyopathy service, general pediatric cardiology consult and primary service in Children’s Memorial Herman Hospital, including patients admitted in pediatric and neonatal care units, pediatric cardiology consult service and outpatient clinic in Lyndon B Johnson Hospital, participation in pediatric cardiology case Mousumi Moulik, MD Page 10 CURRICULUM VITAE management conferences, pediatric cardiology case discussion conferences and regular participation in the pediatric cardiology attending night call/ weekend call system in CMHH. d. Research Molecular Genetics of Cardiomyopathies Supported by an NIH funded K08 career development grant, a major focus of my current research has been on the molecular genetics of cardiomyopathies and involved screening of a dilated cardiomyopathy patient cohort for presence of deleterious disease associated mutations in candidate genes, encoding proteins involved in cardiac mechano-sensation and stretch based signaling. So far, I have finished screening a total of 10 genes as part of this project and identified novel DCM associated mutations in ANKRD1 (results published). In addition, I have identified a novel DCM associated mutation in one additional gene and further in-vitro analysis is underway. I have generated cardiac specific transgenic mice carrying the DCM associated mutations (Transgenic ANKRD1WT, ANKRD1P105S, ANKRD1M185I) identified in ANKRD1, the gene encoding Cardiac Ankyrin Repeat Protein. No phenotypic difference was seen between the transgenic and nontransgenic controls under resting conditions. Our preliminary results suggest an impairment of physiologic cardiac conditioning post exercise training in the ANKRD1 transgenic mice compared to wild type C57Bl mice, though no significant phenotypic difference with physiologic stress was detected between the ANKRD1 WT and mutant mice. Further biochemical molecular profiling including gene and protein expression in these mice is underway. Additional mice are being generated to detect any phenotypic difference between the wild type and mutant transgenic mice under conditions of pathologic stress such as aortic banding and isoproterenol injection. Biorepository for pediatric cardiomyopathy and congenital heart disease Access to a biorepository is key for human genomics research. To expand the ability to perform translational genomics research in cardiomyopathies and congenital heart disease in UT Houston, I am establishing a local bio-repository for human genomic DNA, patient sera and discarded surgical myocardial tissue, from patients and families with cardiomyopathies and various congenital heart defects. The biorepository will also have maternal nail samples and neonatal meconium collection to allow for future studies looking at association between environmental toxin exposure and congenital heart defects. Role of Tead1 - The Hippo Pathway Effector Transcription Factor - in Cardiomyocyte Survival and Function Tead1 is one of the four members of the Tead family of transcriptions factors, a key effector transcription factor of the Hippo tumor suppressor pathway. Tead proteins lack a DNA activating domain and are dependent on interaction with co-activators for transcriptional activity. The two Mousumi Moulik, MD Page 11 CURRICULUM VITAE key co-activators of Tead are YAP/TAZ which have been found to be at the center of at least four signaling pathways (Hippo, biophysical, Wnt, TGFβ/BMP) and also cross talk with several more key pathways such as IGF and PI(3)K/Akt. This positions the Tead family of transcription factors as a key effector family of transcription factors orchestrating the downstream effects of these multiple signaling pathways known to play important roles in physiologic and pathologic modelling of the heart. Tead 1 along with YAP/TAZ is highly expressed in the embryonic heart. While the expression of YAP/TAZ goes down in the postnatal heart, Tead1 continues to be robustly expressed in the terminally differentiated postnatal heart. However the role of Tead signaling in the post natal heart is not clear. Global inactivation of the Tead1 gene results in early embryonic lethality with cardiac hypoplasia, precluding the assessment of its role in the post natal heart. New data from our lab demonstrate that conditional deletion of Tead1 in the postnatal heart (cardiomyocyte specific, tamoxifen induced ‘Cre’-mediated inactivation of floxed Tead1/Tef1 gene using alphaMHCcre) in 512 weeks old mice results in a severe, lethal, acute dilated cardiomyopathy phenotype, supporting our general hypothesis that Tead1 plays an important, non-redundant role in maintenance of cardiomyocyte homeostasis, integrity and function in the post natal heart. My current research focus is to delineate the molecular pathways perturbed in and causally affecting the phenotype of acute cardiac dysfunction seen in the cardiac specific conditional Tead1 knockout mice, and delineate the role Tead1 plays in physiologic homeostasis of terminally differentiated post natal cardiomyocytes. I plan to apply for NIH funding (RO1) on this project. Incidence of and Risk Factors for Delayed Diagnosis of Critical Congenital Heart Defects Critical congenital heart defects (CCHD) are cardiac defects which require surgical and /or trans-catheter intervention in the neonatal period and account for around 30% of neonatal mortality in developed nations. They usually, but not always, have ductal dependent circulation. Timely diagnosis before ductal closure is important to reduce morbidity and mortality in this high risk group. Information on the true incidence and risk factors for delayed diagnosis of CCHD in United States is still sparse. I am the Principal Investigator in an ongoing retrospective, statewide, population-based, observational study using data from the active surveillance based Texas Birth Defects Registry (TBDR). This study involves all live born infants in Texas born between 2000 and 2009 with a definitive diagnosis of one of 13 CCHDs [HLHS, critical coarctation of aorta (COA), interrupted aortic arch, critical aortic stenosis, d-transposition of great arteries (dTGA) , doubleoutlet right ventricle, critical Ebsteins anomaly, pulmonary atresia, single ventricle, total anomalous pulmonary venous return (TAPVR), tetralogy of Fallot, tricuspid atresia, and truncus arteriosus], as identified in the TBDR. Our preliminary data show that one fourth of all neonates with CCHD have a delayed diagnosis in Texas (after DOL#3). Time of diagnosis varies by the type of CCHD with the highest rates of delayed diagnosis in critical COA (36.5%) and TAPVR (33.8%) and least in tricuspid atresia (13.6%) and dTGA (14.3%). Rate of prenatal diagnosis is low (13.6%). Timeliness of the diagnosis increased in the presence of other birth defects and isolated single CCHD had an overall delayed diagnosis rate as high as 47%. Further analysis to identify the demographic risk factors for delayed diagnosis of CCHD is underway. Mousumi Moulik, MD Page 12 CURRICULUM VITAE Impact of 2007 American Heart Association Infective Endocarditis Prevention Guidelines on Pediatric Hospital Admissions: A US Population-Based Study The 2007 American Heart Association (AHA) guidelines for the prevention of infective endocarditis (IE) called for a major change in indications for antibiotic prophylaxis. I am the Principal Investigator in a retrospective study examining the inpatient admissions (age <20 yrs) for infective endocarditis using the nationally representative Healthcare and Utilization Project’s Kids’ Inpatient Database (KID), for the years 2006 and 2009. Purpose of this study is to evaluate the national trends and mortality in IE, its associations with congenital heart disease (CHD), and the impact of 2007 AHA prevention guidelines on the hospitalization rates for IE. In our preliminary results we found no difference between the hospitalization rates with an IE diagnosis between the year 2006 (0.2 per 1000 hospitalizations, 95% CI 0.18-0.23) and year 2009 (0.18 per 1000 hospitalizations, 95% CI 0.16-0.2) (P = 0.07). We noted a statistically significant decline in IE admissions associated with a coexisting diagnosis of isolated ventricular septal defect (VSD) in 2009 compared to 2006 (P = 0.020). There was no significant change in the IE admissions with other associated diagnostic subgroups of CHD including isolated aortic valve disease, left ventricular outflow tract obstruction, right ventricular outflow tract obstruction or conotruncal defects. No significant change in overall mortality rate was seen in IE-related admissions between the years 2006 and 2009 (P = 0.44). Non-white race (OR 1.9; 95% CI 1.22-3.15) and CHD (OR 2.3; 95% CI 1.513.60) were significant factors associated with increased mortality in IE-related admissions. Among CHD associated with IE admissions, presence of isolated patent ductus arteriosus (OR 5.1; 95% CI 1.95-13.28), left ventricular outflow tract obstruction (OR 2.9; 95% CI 1.83-4.75) and right ventricular outflow tract obstruction (OR 2.7; 95% CI 1.17-6.05) were significantly associated with increased mortality on univariate analysis. Further analysis including multivariate logistic regression analysis is underway to identify demographic and diagnostic subgroups with a worse outcome in infective endocarditis. e. Professional Memberships American Academy of Pediatrics, Fellow American College of Cardiology American Heart Association Mousumi Moulik, MD Page 13 CURRICULUM VITAE Mousumi Moulik, MD Page 14