Download Negative Feedback

Calcitonin:
-Polypeptide type
hormone
-Produced by Ccells (aka
parafollicular cells)
within the thyroid.
The thyroid is
located
-Calcitonin prevents bones from
breaking down by inhibiting
osteoclasts, it also inhibits kidney
tubules which allows calcium to pass
out of the body in urine.
Negative
Feedback:
When calcium levels in the blood rise
above the 9-11 mg/100ml level, the
thyroid releases calcitonin, which then
inhibits osteoclasts, increases bone
calcium production, and stimulates
osteoblasts to created more bone, which
brings the blood calcium levels down.
-Human bodies can still maintain relatively normal calcium ion levels
without calcitonin. People whose calcitonin levels are changed through
changes to the thyroid (hypothyroidism, hyperthyroidism, thyroid cancer)
still have normal calcium concentrations. Calcitonin is actually used
medically to treat osteoporosis
Lets think of the body’s calcium levels as a
big family. Sometimes it’s stable and
functional, and sometimes it’s unbalanced
and full of drama. There is always that one
relative that stirs up the drama, lets call
her Penny Hannah Spencer. In addition,
there is always one level headed cousin
who calms things down when the drama
builds up: good ol cousin Cal C. Tonin
Sources
Bowen, R. “Calcitonin.” Colorado State. Colorado State University, 11 Oct. 2003.
Web. 11 Feb. 2014.
<http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/thyroid/calcitonin.html>.
Tucker, Kelli, ed. “Negative Feedback Mechanism of Regulating Blood.” Gateway CC.
Gateway Community College, 2000. Web. 11 Feb. 2014.
<http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/thyroid/calcitonin.html>
.