Download Calcitonin

By Taylor Kudirka
 Calcitonin
is a hormone known to participate in
calcium and phosphorus metabolism.
 In
mammals calcitonin is the C cells in the thyroid
gland.
 Calcitonin
was first purified in 1962 by Chopp and
Cheney.
 At first they believed it was a secretion of the
parathyroid glands and was later identified as the
secretion of the C-cells of the thyroid gland.
 This
hormone participates in calcium and
phosphorous metabolism.
 Calcitonin
counteracts the parathyroid gland.
 1.
Inhibits calcium absorption by the intestines.
 2.
Inhibits osteoclast activity in bones.
 3.
Inhibits renal tubular cell reabsorption of
calcium allowing it to be secreted into the urine.
 Calcitonin
is a polypeptide hormone of 32 amino
acids.
 It
weights about 3454.93 daltons.
 Its
structure comprises a single alpha helix.
 Calcitonin
can be used as a tumor maker for
medullary thyroid cancer.

It can also be used on biopsy samples to
establish whether they are metastasis of the
original cancer.
Calcitonin is secreted from the thyroid glands
 Calcitonin
is very important for women because it
helps protect against calcium loss during
pregnancy and lactation.
The End