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Bio102: Introduction to Cell Biology and Genetics Mendelian Genetics – Beyond Pea Plants Key Terms: Pedigree Carrier Key Questions: What does an allele that causes a recessive human genetic disorder usually do? (What do we suspect is true about the protein it encodes?) Why are fewer lethal human genetic diseases caused by dominant alleles than by recessive alleles? If we determine that a particular trait is recessive by looking at a pedigree, what do we automatically knowabout the genotypes of the individuals in the pedigree? If we determine that a particular trait is dominant by looking at a pedigree, what do we automatically know about the genotypes of the individuals in the pedigree? How can a pedigree be useful in counselling prospective parents who are concerned about their children inheriting genetic disorders that run in the family? Why is pedigree-based information sometimes incomplete? In analyzing a pedigree, why is it useful to know whether a trait is common or rare in the population? Lecture Outline: Human genetics offers unique challenges and opportunities no controlled matings, few offspring, long generation times, no true-breeding collected histories Pedigrees circles for females, squares for males filled symbol is affected (often means diseased) affected child of unaffected parents is strong evidence for recessive trait recessive traits are not always rare