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THE HUMAN BODY. 1. - THE WAY IN WHICH LIVING THINGS ARE ORGANISED. The material that forms the living organisms is structured in different levels: Subatomic level: made up of neutrons, protons and electrons. Atomic level: atoms (the smallest particle that conserves their properties). Molecular level: the union of several atoms forms molecules. The molecules that forms living beings are called bio-molecules. They can be organic molecules (glucids, lipids, proteins and nucleic acids) or inorganic molecules (water and mineral salts). Cells: the building blocks of all living organisms. Cells do not work alone in living things. They co-operate with other similar cells. Groups of similar cells combine together to co-operate with each other, as outline below. There are organisms formed by only a cell (singlecelled organism) and organisms formed by more than one cell (pluricellular organisms). Pluricellular organisms could have thallus structure (cells are practically the same and are not specialised in a concrete function) or tissue organisation (cells of different types, each type is specialised in an activity). Tissues: Plants and animals contain many different types of cells. For example, the cells on the inside of your mouth are very different from muscular cells or red blood cells. The cells on the outside of a root of a plant are very different from the green cells in a leaf. Each of these types of tissue contains cells that are similar in size, colour, structure and shape and each type also carries out a specific function. For example, red blood cells carry oxygen. We can define a tissue as a group of similar cells which carry out the same function. Organs: Very often several tissues are found working together in a particular structure in a plant or animal. These structures are called organs. For example, heart, lungs, liver or flowers are organs. Organs are the structural and functional units of animals and plants. Systems and apparatus: Organs which work together form a system or an apparatus: the eyes, ears, skin, nose and tongue are organs that join together to form the sensory system. Organisms: an organism is a living thing, e.g. a human, a dog or a tree. Each organism is composed of a number of systems and apparatus that carries out their function together to permit the organism to work properly and stay alive. 2. - THE CELLS. In 1665, Robert Hooke used a microscope to look at many living things. One of the things he looked at was cork, a type of tree bark. He saw that it was formed by many tiny boxes and he called these them “cells”. Cells are the unit of life: like bricks that make up a house, cells are the building blocks that make up all living things. They are very small, so we need microscopes to see inside them and to examine their structure. There are organisms, such as bacteria that are unicellular (formed by a single cell). Other organisms are pluricellular (Formed by millions of cells. Humans have an estimated 100 trillion or 1014 cells). We can find basically two kinds of cells: prokaryotic (smaller and without a nuclear envelope to separate the DNA from the cytoplasm) and eukaryotic cells (with nuclear membrane). Human cells are eukaryotic. There are two different kinds of eukaryotic cells: animal and vegetal cells. The shape and size of cells can vary greatly, depending on the job they do. Nerve cells, for example, are different from muscle cells, because they do different jobs. We say that these cells are specialised, because they have special features for doing their biological functions. Plant cells also show differences. Respecting to the size, a typical eukaryotic cell size is 10 µm. The largest known cell is an ostrich egg. 2.1. - STRUCTURE OF HUMAN CELLS. Human cells are eukaryotic: the nucleus is separated from the rest of the cell. Image from http://www.geocities.com/redeagle_pt/imagens/eucariotica.jpg We can make out three different parts in a eukaryotic cell: the membrane, the cytoplasm and the nucleus. 2.1.1. - THE CELLULAR MEMBRANE. The cellular membrane surrounds, protects and separates the cell from the exterior. It also regulates the transport of substances between the interior and the exterior of the cell. It is made up by a double layer or lipids. Embedded within this membrane is a variety of proteins. Image from www.ncnr.nist.gov/.../biology/cell_membrane.html 2.1.2. - CYTOPLASM The cytoplasm is the space between the membrane and de nuclear envelope. It consists of a liquid medium that contains the cellular organelles: ribosome, mitochondria, vacuole, lysosome, smooth and rough endoplasmic reticulum, Golgi apparatus, vesicles, cytoskeleton and centrioles. These organelles carry out the cellular functions. The cytoskeleton consists of microtubules and microfilaments of proteins and acts to organize and maintain the cell's shape; anchors organelles in place and moves parts of the cell. The ribosomes are made up of proteins and RNA and their function is to synthesize proteins. The endoplasmic reticulum (ER) is a set of membranes with form of saccules and tubes. There are two types, the rough (covered with ribosomes) and the smooth (without ribosomes). The function of the smooth ER is to make and transport lipids through the cell, and the rough ER stores and transports the proteins synthesized by the ribosomes. The mitochondria are responsible for the cellular respiration, a metabolic path of the cell to obtain energy. The Golgi apparatus is a set of flat saccules which store and transport substances included in vesicles through the cell and to the exterior. The lysosomes are vesicles that store the digestive enzymes that are responsible of the cellular digestion. Vacuoles are saccules of membrane that store different substances. The centrosome is made of microtubules and is related to the shape and movement of the cell and its organelles. This organelle is not present in vegetal cells. 2.1.3. - THE NUCLEUS The nucleus has spherical shape and is surrounded by a double membrane: the nuclear envelope, which has nuclear pores to allow the transport of substances between the nucleus and the cytoplasm. chromatin Image modified from www-personal.umich.edu/.../pictures/nulcleus.htm In the interior we can found the chromatin (Molecules of DNA that carry the genetic information and are responsible of the regulation of the cell functions). When the cell is going to divide by mitosis, the chromatin forms the chromosomes. Other structure present in the nucleus is the nucleoli, which function is to produce ribosomes. 3. - HUMAN TISSUES. Multicellular organisms function more efficiently if cells become specialized for specific functions. A tissue is composed of cells with a similar structure that function together in a specialized activity. Image from danus-sebastian.blogspot.com/2007_10_01_archi... There are four types of tissues found in animals: epithelial, connective, nerve, and muscle tissue. 3.1. EPITHELIAL Epithelial tissue is made of closely-packed cells arranged in flat sheets. Epithelia form the surface of the skin and line cavities and tubes of the body. The function of this tissue is to cover and protect surfaces. For example, the epithelium of the skin protects the underlying tissues from mechanical damage, ultraviolet light, dehydration or invasion by bacteria. Other type or epithelial tissues is the glandular tissue that forms glands like the thyroid. Glandular tissue is specialised in secreting substances. 3.2.- MUSCULAR TISSUE Muscular tissue is responsible for movement. Muscular cells have in their cytoplasm proteins fibbers of actin and myosin. These fibbers are responsible of the muscle movement. Three kinds of muscle are found in vertebrates: Skeletal muscle is made of long and striated fibbers whose contraction is rapid and permits the locomotion and other voluntary body movements. Smooth muscle lines the walls of the hollow structures of the body (for example intestine, urinary bladder, uterus, and blood vessels). Its contraction is slow and involuntary. The heart is made of cardiac muscle, made of long and striated fibbers whose contraction is rapid and involuntary. 3.3. CONNECTING TISSUES The cells of connective tissue are embedded in a great amount of extracellular material. This matrix is secreted by the cells that form de tissue and it consists of protein fibbers surrounded by an amorphous mixture of protein-polysaccharide molecules. There are five main kinds of connective tissues: Cartilaginous tissue has a support function. Example: the outer ear, the inter-vertebrae disc, etc. Bone tissue that forms de bones and has skeletical function. Made of cells (osteocites) surrounded by matrix. The matrix of bone contains collagen fibbers and mineral deposits (calcium phosphate, although magnesium, carbonate, and fluoride ions are also present). Conjunctive tissues, which join other tissues together, like ligament, and tendons. Ligaments attach one bone to another and they contain both collagen and also the protein elastin. Elastin permits ligaments to be stretched. Tendons connect muscle to bone. The matrix is principally collagen, and the fibbers are all oriented parallel to each other. Tendons are strong but not elastic. Adipose tissue is fibrous connective tissue in which the cells stored fats and serves as a thermal insulator and protector. The fat is confined within membrane-bound droplets. The cells of adipose tissue are called adipocytes. Blood tissue. Blood is a very special connecting tissue. It is a liquid tissue made of cells that float in the plasma. 3.4. NERVE TISSUE Nerve tissue has the function of detect variations in the external an internal medium and transmit information and orders from one part to another of the body. It is composed of nerve cells called neurons and glial cells and forms the brain, the spinal chord and the nerves. Neurons are cells specialized in the conduction of nerve impulses. A typical neuron consists of a cell body which contains the nucleus, a number of short fibbers (dendrites) extending from the cell body, and a single long fibre, the axon. The nerve impulse is conducted along the axon. Glial cells surround neurons. They give support for neurons and there are various types. 3.5.- SANTIAGO RAMÓN Y CAJAL AND THE NERVOUS TISSUE. Santiago Ramón y Cajal (1 May 1852 – 17 October 1934) was a Spanish histologist, physician, pathologist and Nobel laureate. His investigations of the microscopic structure of the brain were so original that he is considered by many to be the greatest neuroscientist of all time. He was born of Aragonese parents in Petilla de Aragón, Navarra. He attended the medical school of Zaragoza, from which he graduated. After, he served as a medical officer in the Spanish Army. He took part in an expedition to Cuba in 1874-75, where he contracted malaria and tuberculosis. In 1883 he received his Doctor of Medicine degree. In his investigation, Cajal used a histological staining technique developed by his contemporary Camillo Golgi. This allowed Cajal to resolve in detail the structure of individual neurons and led him to conclude that nervous tissue was composed of individual, autonomous cells, instead of a continuous web. 4.- HUMAN ORGANS, SYSTEMS AND APPARATUS. In biology, an organ is a group of tissues that carries out a specific function. Common human organs are the heart, lungs, brain, pancreas, kidneys, liver, intestines, skin, etc. Image from: http://www.williamsclass.com/SeventhScienceWork/CellsOrganization.htm A group of related organs is an organ system or apparatus. The organs forming a system are similar while in an apparatus organs are different. Organs within a system or an apparatus work together to develop more complex functions. For example the urinary system is comprised of organs that work together to produce, store, and carry urine. In addition, it is frequent that several apparatus were implicated in a superior function. For instance, the nervous and endocrine systems both operate via a shared organ, the hypothalamus, to coordinate the actions of all the organs, systems and apparatus of the body. The same is true for the musculoskeletal system, which is responsible of the movement and of the support of the body. The digestive, urinary, circulatory and breathing systems are involved in the function of nutrition. Examples of several human systems and apparatus: Image from: http://www.northstar.k12.ak.us/schools/ryn/projects/body/reproductive/markey/webpag e.html Image from: http://commons.wikimedia.org/wiki/File:Female_reproductive_system_lateral.png Image from: http://www.cartage.org.lb/en/themes/Sciences/LifeScience/GeneralBiology/Phys iology/RespiratorySystem/HumanRespiratory/HumanRespiratory.htm Circulatory system. Image from: http://www.williamsclass.com/SeventhScienceWork/CellsOrganization.htm Image from danus-sebastian.blogspot.com/2007_10_01_archi... ACTIVITIES: 1.- What are the organs and apparatus responsible for the three vital functions in living things? 2.- Are all the organs and apparatus of our body related? How? 3.- Complete the table with the next words: Ligament, sodium, water, erythrocyte, phosphorous, tendon, protein, neuron, heart, nervous system, skeleton, bone, muscle, blood, eye. ATOMIC LEVEL MOLECULAR LEVEL CELLULAR LEVEL TISSUE LEVEL ORGAN LEVEL SYSTEM AND APPARATUS LEVEL 4.- What mineral salts are for in living beings? 5.- Look for information in internet about prokaryotic and eukaryotic cells. Make a diagram of these two types of cells and summarize the differences between them. 6.- Look for information in internet about animal and vegetal cells. Make a diagram of these two types of cells and summarize the differences between them. In base of the different structure of both cells, explain why vegetal cells have autotroph nutrition and why they can not to move. 7.- Explain the difference between thallus and tissue. A fungus, has thallus structure or tissue structure? 8.- Make a summary about the following terms: a) cellular organelles b) tissue 9.- Explain de difference between: a) mineral salt and lipids b) prokaryotic and eukaryotic cells c) organ and system c) system bio-molecules BIBLIOGRAFY: - Science 3. Biology and Geology. Richmond publishing. (2003). Ed. Santillana. (Varios autores) Ciencias de la Naturaleza. Biología y Geología 3 ESO. Proyecto la casa del saber. (2007). Ed. Santillana. (Varios autores) Wikipedia, the free encyclopaedia