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Shanghai Model United Nations 2015 | Research Reports Forum: General Assembly Issue: Ensuring the suppression and eradication of international pandemics Student Officer: Jackson Chen Position: Chair Introduction Diseases have been a major cause of concern since the dawn of human civilization. Improper knowledge and prevention of epidemics and pandemics have cost millions of lives, and sometimes even the downfall of entire civilizations. The Bubonic Plague, for instance, wiped out an estimated 30 percent of medieval Europe’s population in just a few years. In contemporary times, technology and medicine are more advanced than ever, and various vaccines and cures have been developed to combat diseases that at one point literally plagued the world. In fact, the internationally community’s united efforts caused the deadly smallpox disease to be successfully eradicated altogether. Organizations and laboratories have new strains of potentially dangerous viruses and bacteria constantly under watch for mutations. In addition, research is continuing in hopes of finding efficient answers to unresolved diseases, such as the AntiImmunodeficiency Syndrome (AIDS). A man suffering from smallpox. Despite the progress that scientific research has made recently, new outbreaks of epidemics are constantly threatening the world, and whether the international community can efficiently respond is a question that cannot and must not be left unanswered. Definition of Key Terms Infectious Disease An infectious disease is an illness that can be spread from person to person. Infectious diseases have many diverse ways of spreading, including by air, by water, by animals, and by people themselves. The most common infectious diseases, such as the common cold and the flu, involve the human respiratory system: diseases are spread by air and are inhaled by the lungs. This leads to an infection of the nose, throat, and / or lungs. Also, the disease agent can sometimes stay inactive within the host (the infected organism or human) for a period of time and then become active, as in the case with HIV (Human Immunodeficiency Virus). Epidemic An epidemic is an infectious disease that has rapidly infected many people in a brief period of time. Epidemics usually refer to outbreaks of a relatively “rare” disease, such as the H1N1 influenza virus in 2009, instead of more common diseases like the common cold. An epidemic is generally localized, or limited to a single region. If many cases in other regions begin to arise, an epidemic may be reclassified as a pandemic. Pandemic A pandemic is an epidemic that spreads to many other countries and regions and crosses borders. Pandemics do not have to be global; epidemics within several countries can be Ensuring the suppression and eradication of international pandemics | Page 1 of 10 Shanghai Model United Nations 2015 | Research Reports classified as a pandemic. Like epidemics, pandemics are infectious. Some examples of pandemics are the smallpox pandemic, the “Spanish Flu”, and the 2009 flu pandemic (or H1N1 influenza). Diseases and syndromes that are not infectious, such as cancer, are not pandemics even if they affect many people over a widespread area. Antibiotics and Antiviruses Antibiotics and antiviruses are essentially cures for a disease. Antibiotics target bacteria-related diseases, while antiviruses, or anti-viral drugs, target virus-related diseases. To be cured, each disease requires its own antibiotic or antivirus to be developed from research, which often takes a relatively long time. Some strains of bacteria and viruses have developed resistance to their respective cures, making some cases of traditionally curable diseases difficult to treat. For example, according to the World Health Organization, 50 million people are currently infected with multidrug-resistant tuberculosis (MDR-TB), with 79% of these cases resilient to three or more types of antibiotics. In the future, antibiotic-resistant diseases could become major epidemics Vaccine A vaccine is a method of disease prevention usually administered in the form of syringe shots. A vaccine is not a cure for a disease; they only help safeguard the human body against diseases prior to being infected. People who have been vaccinated against a certain disease usually have a much better chance at withstanding the disease than non-vaccinated people do; however, even vaccinated people are not guaranteed to be safe from the disease. Biologically speaking, a vaccine contains harmless viruses or bacteria that are similar to the infectious and more dangerous counterpart. When white blood cells in the human body destroy these harmless viruses or bacteria, the immune system “remembers” their DNA patterns so that they can react more efficiently if a second infection of similar but more threatening viruses or bacteria occurs. Vaccines allow the human immune system a much better chance at defending against viruses or bacteria. Like antibiotics and antiviruses, vaccines must be developed first before being administered to the general population. Furthermore, vaccines cannot be made for non-existent viruses or bacteria, which is why mutations and new strains of diseases can infect numerous people before vaccines are issued. Background Information Diseases can be spread in many different ways. Many diseases have more than a single method of spreading, and it is difficult to pinpoint the source and way of spreading. Epidemics and pandemics spread very quickly, and limiting the spread is a crucial step in resolving them. The spreading of diseases Diseases can be spread in many ways, including but not limited to by air (airborne transmission), by water (waterborne transmission), by direct contact (direct contact transmission), by blood (bloodborne Ensuring the suppression and eradication of international pandemics | Page 2 of 10 Shanghai Model United Nations 2015 | Research Reports transmission), and by people. Diseases that are spread by animals, such as birds (avian transmission) or insects (arthropod transmission), are classified as spreading through vector transmission. Airborne transmission Diseases spread by air are fairly common. Major epidemics, including influenza and smallpox, are spread by air; so are other illnesses, such as the common cold. Sneezing and coughing are signs of infection by airborne diseases. Facial masks can help slow down transmission. In addition, limiting contact with crowded places and people who show symptoms of sickness can help reduce the chance of spreading. Waterborne transmission Waterborne diseases are diseases that are spread due to drinking or using contaminated water. They are generally more common in lesser developed countries that have unclean water supplies and inadequate sanitation systems. An example of a waterborne disease is cholera, which is spread by contaminated drinking water. Direct contact transmission Any disease that can be contracted through contact with contaminated surfaces is able to spread by direct contact transmission. Many airborne and waterborne diseases, for instance, can spread in this manner. Sanitizing commonly used surfaces, such as doorknobs and railings, can reduce the likelihood of disease spreading. Encouraging people to actively wash their hands and avoid touching parts of the face, such as the mouth and nose, can also help. Bloodborne transmission Any disease that circulates within the human circulatory system can be spread to other people if they come into contact with contaminated fluids. Bloodborne diseases can be spread through contaminated blood transfusions, which is why blood donations should be carefully checked and received from healthy patients. Additionally, sharing syringes is one of the ways that diseases like HIV are spread. To limit bloodborne transmission is not a simple task, especially in lesser developed countries where medical supplies and facilities are inadequate. Sharing syringes is commonplace in certain African and Asian countries where even a needle is relatively expensive. Vector transmission Many diseases involve or infect other organisms instead of just humans. A familiar example would be malaria, which is caused by Plasmodium protozoans. When female mosquitoes that carry the disease-causing protozoans bite humans, they cause an infection. Diseases like malaria are widespread in areas like Africa, South America, and Asia, where treatment and prevention are less widely available. Another example of vector transmission would be influenza. Influenza, or the flu, usually originates from an avian (or bird) virus or a pig virus, which are sometimes called bird flu and swine flu, respectively. These strains of influenza viruses spread among species of animals. Poultry workers, who work closely with domestic animals, may contract the disease. New influenza strains that can infect humans can have several different causes. Some involve original strains mutating to be able to infect humans. Others involve original strains combining with a less severe human influenza virus to form a new strain that is much more severe. Globalization and disease Globalization refers to the process of exchanging goods, people, technology, ideas, and resources across national borders. Both globalization and trade in general have brought about commercial prosperity in participating countries, but they have also helped the spread of infectious Ensuring the suppression and eradication of international pandemics | Page 3 of 10 Shanghai Model United Nations 2015 | Research Reports diseases. For instance, the Black Death or bubonic plague in Europe originated from Asia. The disease was most likely first spread to Europe by Italian merchants. Europeans could not identify the source, which was likely infected fleas that lived rats, making attempts to slow the spreading of the disease ineffective, which thus allowed it to spread rapidly. Diseases that are new to a region are called introduced diseases. Introduced diseases often wipe out a significant portion of the native population. Generally, the introducers of a disease have been in contact with it for many years and have developed some amount of immunity to it. The native peoples who have had no contact with it, however, are quickly overwhelmed. The Columbian Exchange The Columbian Exchange is the mass trading of goods, people, ideas, and diseases between Afro-Eurasia (Africa, Europe, and Asia) and the Americas in the 1400s and 1500s. The term is named after explorer Christopher Columbus, who first discovered the North American continent in 1492. New agricultural crops and domestic animals were introduced to both sides, which diversified food supplies and increased the population. Slaves were also traded. However, diseases were exchanged as well. The effect was particularly devastating for the Native Americans living in the Americas, as diseases such as measles, smallpox, and influenza wiped out as much as 90 percent of their population. In addition, Europeans carried syphilis from the Americas back to Europe, and the disease caused widespread deaths during the Renaissance. Globalization and the current situation The world today is more interconnected than ever. Transportation is now extremely fast and efficient; people can easily fly from one side of the Earth to the other in less than a day. Unfortunately, this also means that infectious diseases can access more parts of the world simultaneously and spread rapidly, making them harder to control. However, stopping globalization altogether is both a ridiculous and an impossible notion. Trade and commerce across borders is essential for countries to prosper and people to live healthier and longer lives. The sharing of ideas and technologies is also needed to facilitate general development. Thus, limiting the spread of diseases requires a different approach. Conditions in different countries Developed countries, such as the United States, Canada, and the United Kingdom, have access to a wide variety of technologies to combat diseases. These countries have advanced healthcare, vaccines, antibiotics and antiviruses, and sometimes medical aid for the poor. They also have research facilities, reachable media systems, sanitation and waste disposal systems, and usually well-educated and hygienic citizens. Thus, relatively speaking, developed countries have a good chance at withstanding A typical modern clinic in a developed country. outbreaks of diseases. In contrast, lesser developed countries, including many African and Asian countries, sometimes do not even have access to basic necessities, such as clean water supplies and sanitation systems, let alone to advanced medical supplies and healthcare. These countries are particularly vulnerable to disease outbreaks and thus require special international aid and attention. A Malaria clinic in Tanzania. Major Epidemics and Pandemics throughout History Date Description of event 430 to 426 B.C. The Plague of Athens wipes out 25 percent of the population Ensuring the suppression and eradication of international pandemics | Page 4 of 10 Shanghai Model United Nations 2015 | Research Reports in just four years. 165 to 180 A.D. The Antonine Plague kills 30 percent of the population in Europe and nearby regions. The Plague of Justinian, or the first outbreak of the bubonic 571 to 750 A.D. plague, wipes out half of Europe’s population and 25 to 50 percent of the world’s population. The Black Death, or the second outbreak of the bubonic plague, causes 75 million deaths worldwide. It wipes out a 1347 to 1453 third of Europe’s population in a period of six years. In the one hundred years that follow, over a hundred outbreaks of plague epidemics occur in Europe. Typhus first strikes in Spain; in a conflict in Granada, approximately 3,000 soldiers die of war and 20,000 die of 1489 typhus. In the 400 years that follow and right before the first World War, more soldiers are killed from typhus than from military action. The recorded first influenza pandemic takes place, with 1580 outbreaks reoccurring every 10 to 30 years. 1629 to 1631 1816 to 1966 1889 to 1890 An Italian plague claims 280,000 lives. A total of seven cholera pandemics kill tens of millions of people throughout the world. The 1889‒1890 Flu Pandemic wipes out a million people worldwide. Ensuring the suppression and eradication of international pandemics | Page 5 of 10 Shanghai Model United Nations 2015 | Research Reports The “Spanish Flu”, or the 1918 flu pandemic, infects a third of the world’s population (around 500 million people at that time). An estimated 50 to 100 million people 1918 to 1919 were killed, making this pandemic the most serious in history. The flu was likely caused by a strain of H1N1 virus, which was the same virus responsible for the 2009 flu pandemic. 1957 to 1958 1960 to present 1968 to 1969 1976 A microscopic view of the H1N1 influenza virus. The “Asian Flu”, caused by an H2N2 virus, kills 2 million people in the world. The HIV / AIDS pandemic starts in Africa. It currently affects millions of people globally. The “Hong Kong Flu”, caused by an H3N2 virus, kills 1 million people worldwide. First outbreak of the Ebola virus. October 26, 1977 Last diagnosis of naturally-occurring smallpox is recorded. December 9, 1979 The World Health Organization declares that smallpox has been successfully eradicated. The SARS (Severe Acute Respiratory Syndrome) epidemic November 2002 begins in Guangdong, China. By 2004, over 8,000 cases and 774 deaths occurred. The 2009 pandemic, commonly known as the H1N1 2009 influenza or swine flu, kills an estimated 284,500 people worldwide. August 10, 2010 December 2013 to present The Director-General of the World Health Organization officially announces the end of the 2009 Flu Pandemic. The Ebola virus epidemic, the 26th Ebola disease outbreak, begins in Guinea. It later spreads to Liberia and Sierra Leone. A total of 21,724 cases and 8,641 deaths have been Ensuring the suppression and eradication of international pandemics | Page 6 of 10 Shanghai Model United Nations 2015 | Research Reports reported; however, the World Health Organization believes that these statistics are much less than the actual numbers. Major Countries and Organizations Involved World Health Organization (WHO) The World Health Organization is an agency within the United Nations. As its name suggests, the WHO focuses on public health. Some of the WHO’s main goals include fighting diseases, food nutrition, and other aspects of health. In terms of diseases, the WHO focuses mainly on malaria, HIV / AIDS, and tuberculosis, as well as Ebola during recent times. Policies and practices advocated by the WHO have saved millions of lives and assisted even more. In the past, the WHO has played a leading role in fighting disease outbreaks and has played key roles during times of major epidemics and pandemics. During the smallpox pandemic, for instance, the WHO closely collaborated with numerous nations to eradicate the disease altogether. In other epidemics and pandemics, the WHO has helped developing nations by limiting the spreading process. In the current Ebola crisis, the WHO is coordinating efforts to develop vaccines and therapies to combat Ebola in Western African countries. Centers for Disease Control and Prevention (CDC) The Centers for Disease Control and Prevention is one of the largest health organizations in the United States. As a government organization, CDC focuses on public health and the control and prevention of diseases. The organization helps in the cause of fighting diseases and conducts research on various strains of new diseases. CDC also sponsors education and public awareness campaigns. It focuses its efforts on major diseases such as influenza and Ebola. Relevant UN Treaties and Events 1. Application of the International Health Regulations, 26 May 2006 (WHA59.2) Made in 1989 by the CDC, this is a poster that shows the threat of AIDS related to drug use. 2. Security Council resolution 2177, 18 September 2014 3. Measures to contain and combat the recent Ebola outbreak in West Africa, 19 September 2014 (A/RES/69/1) Previous Attempts to solve the Issue Only in recent years have scientists gained a more comprehensive idea of how to solve the problem posed by infectious diseases. Vaccines for deadly diseases, such as smallpox and several strains of influenza, have been developed. Antibiotics and antiviruses for certain diseases are widely available in developed countries, but the supply in lesser developed countries is often inadequate. Ensuring the suppression and eradication of international pandemics | Page 7 of 10 Shanghai Model United Nations 2015 | Research Reports After experiencing pandemics such as the smallpox pandemic and the 2009 influenza pandemic, the world is more prepared for future outbreaks than ever. Research facilities around the world are watching potentially dangerous viruses and bacteria in the event of a malicious mutation. Most countries are now fully aware of the threats posed by disease outbreaks, and many have sponsored public education programs to alert the public of safety measures. Possible Solutions The most dangerous aspect of epidemics and pandemics is that they spread extremely rapidly and on a large scale, often to several countries at once. It is, then, essential that the international community can react quickly, calmly, and efficiently to outbreaks when they occur. While finding the cure to an epidemic is arguably the “best” solution, it is usually not the easiest and fastest solution as cure research is an arduously long process. The process of preventing the disease from further spreading should be one of the first priorities when combatting epidemics. On a basic level, methods like face mask distribution can be used for respiratory diseases. Vaccines, once developed, can be used to US President Barack Obama receiving a vaccination for H1N1 influenza. slow down the process of further infections in the population. Also, depending on the severity of the epidemic, countries may choose to implement stricter border control, customs, and quarantine inspections. In addition, education and public awareness, while seemingly trite and inefficient solutions, can help to decrease the infection rate by making the population aware of the threats posed by epidemics. In Africa, for example, HIV infection rates have decreased in countries that have sponsored education programs about safer sexual practices. Education can also encourage more hygienic practices, such as frequent hand washing. Furthermore, full government transparency is one of the most important aspects of a cooperative, united international community. The collaboration of countries for case reporting and investigating is essential for early detection of potential epidemics. To illustrate the risks of not using transparency policy, during the SARS epidemic, the Chinese government delayed both reporting the outbreak to the international community and allowing the assistance of foreign medical experts. This resulted in the outbreak becoming out of control and turning into an epidemic. The issue of lesser developed countries is yet another concern. When outbreaks occur in these countries, they often rapidly spread with little resistance. Lesser developed countries generally lack the technologies for early detection, disease spreading prevention, and vaccine and cure research. Assistance from the international community has often proved to be ineffective, as in the case with the recent Ebola virus epidemic (see section “Noteworthy Current Events”, subsection “The Ebola virus epidemic”). Ensuring the suppression and eradication of international pandemics | Page 8 of 10 Shanghai Model United Nations 2015 | Research Reports Noteworthy Current Events The AIDS pandemic The human immunodeficiency virus (HIV) originated in Africa in 1960 and has since then spread throughout the world. As of 2013, there are around 35 million people in the world living with HIV / AIDS. AIDS, or the conditions related to HIV, has killed an estimated 36 million people in the world. Although there are antiviral therapies and other management methods associated with HIV / AIDS, no permanent and effective cure has been developed yet. This makes HIV / AIDS a serious issue that is still unresolved. HIV can be spread through ways such as blood transfusion, needle sharing, and unprotected sexual contact. A person infected with HIV may show initial The red ribbon, a symbol for AIDS. symptoms related to those of influenza. Later, these symptoms disappear for a long period of time. If the disease goes untreated, however, the human body will experience serious immune system issues. The HIV virus prevents white blood cells in the human body from properly functioning, causing reduced immunity to other diseases. The infected person usually dies from a disease other than AIDS, such as tuberculosis. The Ebola virus epidemic The Ebola Virus Epidemic in West Africa is an ongoing issue that has yet to be resolved. The Ebola Virus Epidemic in West Africa is actually the 26th outbreak in a series of outbreaks in Africa, which started in 1976. Ebola began in Guinea and is currently affecting the African countries of Guinea, Liberia, and Sierra Leone. Despite the fact that Ebola is not affecting a large area, the main threat it poses is the high fatality rate. So far, a total of 21,724 cases and 8,641 deaths have been reported; however, the World Health Organization believes that these statistics are much less than the actual numbers. This is actually the first Ebola outbreak to be classified as an epidemic. A wide range of factors caused the outbreak to become out of control, including inadequate medical facilities, unresponsive governments, and the crowded situation in densely populated cities. Additionally, the World Health Organization was criticized for its slow response to the outbreak, and the Ebola virus epidemic is still continuing. The current situation of the Ebola virus epidemic. 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