Download Consulta: creatorFacets:"Arunava Goswami" Registros recuperados

Consulta: creatorFacets:"Arunava Goswami"
Registros recuperados: 9
Data/hora: 09/06/2017 10:09:12
Quadruple context-free L-System mathematical tools as origin of biological evolution
Provedor de dados: 17
Autores: Arunava Goswami; Pabitra Pal Choudhury; Rajneesh Singh; Sk. Sarif Hassan.
It is well known that A, T, G, C annealed together early in evolution and the long stretch of DNA was found which ultimately
resulted into chromosomes of different organisms. But it is unclear till date how exons, introns, conserved protein domains was
formed. Using the DNA sequences of the largest known gene-family present in human genome, i.e., olfactory receptors and
simplest possible quadruple context-free L-Systems, we show that conserved protein domains and intergenic regions which lies at
the heart of the biological evolution started with a sixteen base-pairs stretch of DNA.
Tipo: Manuscript
Palavras-chave: Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2010
URL: http://precedings.nature.com/documents/4851/version/1
Underlying Mathematics in Diversification of Human Olfactory Receptors in Different Loci
Provedor de dados: 17
Autores: Sk. Sarif Hassan; Pabitra Pal Choudhury; Arunava Goswami.
As per conservative estimate, approximately (51-105) Olfactory Receptors (ORs) loci are present in human genome occurring in
clusters. These clusters are apparently unevenly spread as mosaics over 21 pair of human chromosomes. Olfactory Receptor (OR)
gene families which are thought to have expanded for the need to provide recognition capability for huge number of pure and
complex odorants. ORs form the largest known multi-gene family in the human genome. Recent studies have shown that 388 full
length and 414 OR pseudo-genes are present in these OR genomic clusters. In this paper, the authors report a classification
method for all human ORs based on their sequential quantitative information like presence of poly strings of nucleotides bases,
long range...
Tipo: Manuscript
Palavras-chave: Biotechnology; Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2010
URL: http://precedings.nature.com/documents/5475/version/1
Understanding Genomic Evolution of Olfactory Receptors through Fractal and Mathematical
Morphology
Provedor de dados: 17
Autores: Sk. Sarif Hassan; Pabitra Pal Choudhury; B. S. Dayasagar; Shantanav Chakraborty; Ranita Guha; Arunava Goswami.
Fractals and Mathematical Morphology are immensely used to study many problems in different branches of science and
technology including the domain of Biology. There are many more unrevealed facts and figures of genes and genome in
Computational Biology. In this paper, our objective is to explore how the evolutionary network is associated among Human,
Chimpanzee and Mouse with regards to their genomic information. We are about to explore their genomic evolution through the
quantitative measures of fractals and morphology. We have considered olfactory receptors for our case study. These olfactory
receptors do function in different species with subtle differences in the structures of DNA sequences. Those subtle differences can
be exposed through intricate...
Tipo: Manuscript
Palavras-chave: Biotechnology; Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2011
URL: http://precedings.nature.com/documents/5674/version/1
Protein and DNA evolution: Statistics and combinatorics are the rules of the game
Provedor de dados: 17
Autores: Arunava Goswami; Srimoyee Duttagupta; Chirantan Chakraborty; Amita Pal; Pabitra Pal Choudhury; Sk Sarif Hassan.
Let us assume AVMAYDRYVAIC or MAYDRYVAICCP, most important signature domain of
olfactory
receptor (OR) gene family assembled in evolution following simplest possible laws of statistics which says the addition of V after
A in AVMAYDRYVAIC or addition of A after M are independent events. There are 20 amino acids present in nature so the
probability
of
joint
occurrence
of
such
events
is
1/400.
Therefore
for
making
a
contiguous
string
of
AVMAYDRYVAIC or MAYDRYVAICCP, the probability would be 1 out of 2012. Over millions of
years of evolution this has certainly happened and that is why we see such a signature sequence in OR1D2, OR1D subfamily
member 2 as per "HORDE...
Tipo: Manuscript
Palavras-chave: Biotechnology; Genetics & Genomics; Molecular Cell Biology; Bioinformatics.
Ano: 2010
URL: http://precedings.nature.com/documents/4859/version/1
DNA Sequence Evolution through Integral Value Transformations
Provedor de dados: 17
Autores: Sk Sarif Hassan; Pabitra Pal Choudhury; Ranita Guha; Shantanav Chakraborty; Arunava Goswami.
In deciphering the DNA structures, evolutions and functions, Cellular Automata (CA) do have a significant role. DNA can be
thought of as a one-dimensional multi-state CA, more precisely four states of CA namely A, T, C, and G which can be taken as
numerals 0, 1, 2 and 3. Earlier, G.Ch. Sirakoulis et al reported the DNA structure, evolution and function through quaternary logic
one dimensional CA and the authors have found the simulation results of DNA evolutions with the help of only four linear CA
rules. The DNA sequences which are produced through the CA evolutions, however, are seen by our research team not to exist in
the established databases of various genomes although the initial seed (initial global state of CA) was taken from the database.
This...
Tipo: Manuscript
Palavras-chave: Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2011
URL: http://precedings.nature.com/documents/5729/version/1
Antiviral activity of (E)-cinnamaldehyde revisited with nanoscience tools
Provedor de dados: 17
Autores: Arunava Goswami; Ayesha Rahman.
Contradictory results have been reported regarding the anti-viral activity of (E)-cinnamaldehyde, a major constituent (~69%) of
cinnamon. Here we show that (E)-cinnamaldehyde alone has very low antiviral property contrary to the belief of commoners.
There are early sporadic reports in ancient medicinal practices that fine sand was used for increasing the efficacy of antiviral
drugs. Can we increase the efficacy of (E)-cinnamaldehyde marginally by using one of the major constituents of sand like silica?
Yes, when nanosilica is used as a carrier during (E)-cinnamaldehyde administration, the antiviral efficacy of the resultant cocktail
increases marginally. Therefore, (E)-cinnamaldehyde consumed for centuries in tribal therapy as well as in alternative...
Tipo: Manuscript
Palavras-chave: Biotechnology; Pharmacology.
Ano: 2010
URL: http://precedings.nature.com/documents/5043/version/1
A novel mathematical tool for generating highly conserved protein domain via different organismal
genomic landscapes
Provedor de dados: 17
Autores: Arunava Goswami; Pabitra Pal Choudhury; Rajneesh Singh; Sk. Sarif Hassan.
Darwinian evolution hypothesizes that a short stretch of DNA was first constructed and then it expanded to give rise to a long
strand. This long strand then produced a mix of exons, introns and repetitive DNA sequence. The order of production of above
three kinds of DNA sequence is unknown. Reshuffling of stretches of DNA like above within organisms has given rise to different
chromosomes. Till date it is not known how this process is governed. In this paper we show that starting with a sixteen base-pair
human olfactory DNA sequence one can form a highly conserved protein domain. Once this domain is formed repetitive DNA
sequences of a particular kind starts generating which signifies that this particular conserved protein domain will be unique in
nature....
Tipo: Manuscript
Palavras-chave: Biotechnology; Genetics & Genomics; Molecular Cell Biology; Bioinformatics.
Ano: 2010
URL: http://precedings.nature.com/documents/4850/version/1
Designing L-Systems for making three and six open reading frames from the leading strand of a single
DNA molecule
Provedor de dados: 17
Autores: Arunava Goswami; Rajneesh Singh; Pabitra Choudhury; Sk. Sarif Hassan Hassan.
Current molecular biology dogma (except alternative splicing) suggests that leading strand of DNA produces mRNA and usually
the leading strand gives one ORF (ORF) among the available six ORFs. We attempted to break this rule where three and six ORFs
from the leading strand will be formed by designing L-Systems, originally proposed to study symmetry of biological world. We
thought this would revolutionize the world of synthetic biology. While doing so, we found L-System containing
A→T, T→G, C→A, and G→C, i.e., single nucleotide production rule will stop
growing after one nucleotide. L-System containing either (a) A→TG, T→GC, C→GA,
G→TC or (b) A→CTG,...
Tipo: Manuscript
Palavras-chave: Biotechnology; Genetics & Genomics; Molecular Cell Biology.
Ano: 2010
URL: http://precedings.nature.com/documents/4844/version/1
An attempt to understand Barstar, Barnase and Olfactory receptor protein folding problems using
mathematical biological approach
Provedor de dados: 17
Autores: Arunava Goswami; Sk Sarif Hassan; Pabitra Pal Choudhury.
Protein folding problem as attracted structural biologists immensely (1). Till date, correlation between X-ray crystallographic and
NMR data are considered to be the best methods for determining structure of intra-cellular proteins. Generating crystals and
finding correct experimental conditions for NMR are largly a gamble and resultant data processing highly time consuming. Even
if, a large number of laboratories around the world and India make crystals of protein but majority of them fail to generate
crystallographic data less than or equal to 10A resolution with currently available instruments. This means that X-ray
crystallographic data have been generated from protein crystals with non-uniform lattices. We believe that a large portion of
(chain of...
Tipo: Manuscript
Palavras-chave: Biotechnology; Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2010
URL: http://precedings.nature.com/documents/4891/version/1