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Kee & Hayes: Pharmacology: A Nursing Process Approach, 4th edition Content Updates Recent FDA-Approved Drugs New Drugs 2001-2002 FDA new drug approval list is available weekly by CDER's Division of Data Management and Services on www.fda.gov/cder/da/da.htm. colesevelam (Welchol) This is a bile acid sequentrant that lowers LDL and cholesterol. It is prescribed for clients/patients who can not tolerate statin drugs. It is used as adjunctive therapy to diet and exercise. desloratadine (Clarinex) A non-sedating antihistamine for treatment of seasonal allergic rhinitis. norelgestromin/ethinyl estradiol (Ortho Evra) Ortho Evra is a birth control patch (transdermal system) with hormones similar to those in birth control pills. The contraceptive patch delivers norelgestromin 150 ug and ethinyl estradiol 20 ug daily to the systemic circulation. A prescription is required. The patch works by suppressing ovulation. Ovulation usually returns within 6 weeks of stopping the use of the patch. This patch is 99% effective in preventing pregnancy when used correctly. Dosing schedule for the contraceptive patch is 4 weeks (28 days). The woman applies a new patch each week for the first 3 weeks; followed by a patch-free week, completing the 4 week cycle. Hormones continue to be released after 7 days; thus back up contraception is not needed if one forgets to change the contraceptive patch for up to 48 hours. Withdrawal bleeding is expected to begin during week 4 of no patch use. Apply contraceptive patch to the abdomen, buttock, upper outer arm or upper torso (not breasts). Apply patch to a new location on skin. Bathing, exercising, showering, swimming, and humidity should not affect your contraceptive patch. To remove the patch, lift up at comer and peel back. Fold in half so it sticks to itself before discarding (patch still has active hormones). The most frequent side effects are: breast symptoms, headache, application site reactions, nausea, cramps, and abdominal pain. Potentially life threatening effects are: blood clots, stroke or heart attack. Cigarette smoking increases risk of serious cardiovascular side effects especially in women >35 years. Copyright © 2003, Elsevier, Inc. All rights reserved. Content Updates 2 tazarotene (Tazorac) Topical acetylinic retinoid for treatment of acne. It is available as a 0.1% gel and cream. May cause erythema, dryness, scaling, burning, and pruritus. triptorelin pamoate (Trelstar) An agonist analog of human luteinizing hormone-releasing hormone (LHRH) for parenteral treatment of advanced prostate cancer. Copyright © 2003, Elsevier, Inc. All rights reserved.