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Diseases and Disorders of the Special Senses Module 2 Brenda K. Keller, MD Geriatrics and Gerontology University of Nebraska Medical Center PROCESS Series of 3 modules and questions on 1. Sensory Changes of Aging 2. Diseases and Disorders of the special senses 3. Treatments for vision and hearing impairment Step #1 Power point module with voice overlay Step #2 Case-based question and answer Step #3 Proceed to additional modules or take a break Objectives for Module 2 Recognize the functional impact of disease of the special senses Vision Refractive Error Cataracts Age related macular degeneration Diabetic Retinopathy Glaucoma Dry Eyes Lid abnormalities Herpes Zoster Hearing Sensorineural Conductive Refractive Error Leading cause of visual impairment Treatment: eyeglasses, contact lenses, laser refractive surgery 92% of people over age 70 wear glasses Ametropia Myopia (nearsightedness) Hyperopia (farsightedness) Astigmatism (visual distortion) Presbyopia ( ability to focus at near objects) Begins after age 40 Caused by gradual hardening of the lens and decreased muscular effectiveness of the ciliary body Cataracts Symptoms include 50% glare contrast sensitivity visual acuity 20% Risk factors: - vitamin intake, -light (ultraviolet B) exposure, -smoking, >65 years >75 years -alcohol use, Percentage of population with cataracts -long-term corticosteroid use, -diabetes mellitus Age-Related Macular Degeneration Most common cause of blindness among older adults in developed world Classic symptom is loss of central vision Risk factors: age, genetics, smoking, hypertension, fair skin Diagnosis: presence (dry) of drusen and (wet) of choroidal neovascularization Monitor with dilated eye exams, Amsler grid Glaucoma Defined as characteristic optic nerve head damage and visual field loss- generally loss of peripheral vision. Elevated intraocular pressure is a major risk factor Affects >2.25 million Americans aged >40 years Second most common cause of blindness worldwide; most common cause among African Americans $1 billion for glaucoma-related Medicare and Medicaid payments and disability Glaucoma Primary open-angle glaucoma is most common Slow aqueous drainage leads to chronically elevated intraocular pressure Patients are asymptomatic and may suffer substantial visual field loss before consulting a physician Causes are multifactorial and polygenic Requires monitoring of visual fields and intraocular pressure Diabetic Retinopathy Epidemiology: Among persons who have had type 2 diabetes at least 10 years: 70% show retinopathy Nearly 10% show proliferative disease. Most important risk factors: Duration of disease and control of blood sugar Prevention: Tight glucose control (A1C < 7 %) and BP control (≤140/80) Visual loss spotty, occurring in areas of edema and hemorrhage Keratitis Sicca (Dry Eyes) Tear production decreases with age Characteristics: redness, foreign body sensation, and reflex tearing Management: replacement of tears (artificial tears during daytime and ointment at bedtime) Temporary or permanent punctal plugs may retard tear egress in severe cases Eye Lid Abnormalities Common among older adults Gradual loss of elasticity and tensile strength that develops with age Blepharochalasis (drooping of the brow) and blepharoptosis (drooping of the eyelid) may cause cosmetic deformity and, if severe, impair vision Lid ectropion (eversion) or entropion (inversion) may cause discomfort Treatment: surgery Herpes Zoster Ophthalmicus Painful reactivation of varicella zoster virus Dermatomal distribution of weeping vesicles affecting the ophthalmic division of the trigeminal nerve Hutchinson’s sign: lesions on the tip of the nose Oral acyclovir may shorten the course Post-herpetic neuralgia may be debilitating; treat with local ointments (capsaicin, lidocaine) or systemic medications (corticosteroids, tricyclic antidepressants) Common Hearing Impairments Conductive Hearing Loss Sensory Hearing Loss Sensorineural Hearing Loss Due to cochlear or retrocochlear pathology Pure tone audiograms show decreased thresholds for both air and bone conduction Presbycusis the most common type in elders Other etiologies: ototoxic meds; infection, trauma ,vascular events or tumors of 8th nerve; Meniere’s disease Sensorineural Hearing Loss Conductive Hearing Loss 2nd most common cause of hearing loss Sound transmission to inner ear is impaired On audiogram bone conduction much better than air conduction Conductive Hearing Loss Causes: External ear pathology Ceruminosis- a factor in 80% of cases Foreign body Skin diseases Middle-ear pathology Otosclerosis Paget’s disease Cholesteatoma Tympanic membrane perforation Middle ear effusion Conductive Loss Audiogram Summary Acknowledgments Slides adapted with permission from the American Geriatrics Society, Geriatric Review Syllabus teaching slide set. Permission granted 1-10-07 Post-test question 1 A 70-year-old black American man notes gradually decreasing vision in the right eye. He has a 10-year history of non-insulin-dependent diabetes mellitus and a 3-year history of hypertension. Current medications are two oral hypoglycemic agents, a diuretic, and an angiotensinconverting enzyme inhibitor. He checks his blood glucose weekly and does not follow a strict diet. Cardiopulmonary, abdominal, and musculoskeletal findings are normal except for obesity. Neurologic examination shows decreased touch sensation in the fingertips. Urinalysis shows mild proteinuria. Fingerstick blood glucose level is greater than 200 mg/dL. Hgb A1c is 10.2%. Which of the following is the least likely cause of the vision loss? A.Cataract B.Vitreous hemorrhage C.Macular edema D.Macular ischemia E.Age-related macular degeneration Correct Answer: E. Age-related macular degeneration Age-related macular degeneration is the most common cause of vision loss in the elderly white population but is rare in black persons, who may be protected by their pigmentation. The most likely cause is longstanding, poorly controlled diabetes. Cataract is more prevalent among diabetic persons, in whom typical senile lenticular changes may develop earlier than in the nondiabetic persons. Caution must be exercised with cataract extraction in diabetic patients, who are more prone to develop visually debilitating macular edema. Vitreous hemorrhage may cause severe visual loss in diabetic patients with proliferative retinopathy. Used with permission from: Murphy JB, et. Al. Case Based Geriatrics Review: 500 Questions and Critiques from the Geriatric Review Syllabus. AGS 2002 New York, NY. Panretinal photocoagulation or laser destruction of the peripheral retina will inhibit the stimulus for growth of new blood vessels (neovascularization). Vitrectomy may be indicated for a dense, nonclearing hemorrhage that has been present longer than 3 months. Macular edema is a common cause of moderate visual loss in diabetic patients. Argon laser therapy is beneficial in stabilizing or improving visual acuity. Macular ischemia may result from capillary nonperfusion and is not directly amenable to therapeutic intervention. Argon laser therapy also is indicated for ischemia associated with macular edema, although the prognosis for visual improvement is poor. Post-test question 2 69-year-old woman presents for a pre-employment physical examination for work in a child-care center. Her general health is good; an occasional "water pill" for dependent edema is her only medication. She mentions worsening hearing when around her preschool grandchildren, although conversational hearing with her husband at home appears less affected. There is no family history of hearing loss. Physical examination of the external ear canals reveals no wax accumulation. On handheld audiometric screening she misses the 2000 and 4000 Hz frequencies at 40 dB of amplification bilaterally. Subsequent audiology testing shows bilateral upper-frequency hearing loss along with significant speech discrimination difficulties. Which of the following conditions most likely underlies this woman's hearing loss? A. Meniere's disease B. Eighth cranial nerve damage C. Presbycusis D. Ototoxic medication effect Correct Answer: C. Presbycusis Bilateral higher-frequency hearing loss with poor speech discrimination is characteristic of presbycusis. The higher pitch of children's voices and the greater degree of background noise often make child-care settings particularly difficult for persons with presbycusis. Meniere's disease is a cause of lower-frequency hearing loss and is often unilateral. It is often accompanied by disabling vertigo and tinnitus. Though the latter symptoms often improve with time and treatment, the hearing losses may not improve and are a major source of chronic disability. Damage to the eighth cranial nerve from either ototoxic medication or from trauma causes a clinical picture of sensory neural hearing loss. This hearing loss is often of abrupt onset and affects a broad range of frequencies. Loop diuretic agents are among the most common offending medications causing sensorineural hearing loss when used routinely. End Vision Acknowledgments Co-Editors: Karen Blackstone, MD Elizabeth L. Cobbs, MD GRS6 Chapter Authors: David Sarraf, MD Anne L. Coleman, MD, PhD GRS6 Question Writer: Gwen K. Sterns, MD Medical Writer: Barbara B. Reitt, PhD, ELS (D) Managing Editor: Andrea N. Sherman, MS © American Geriatrics Society Hearing Acknowledgments Co-Editors: Karen Blackstone, MD Elizabeth L. Cobbs, MD GRS6 Chapter Author: GRS6 Question Writer: Priscilla Faith Bade, MD, MS Barbara E. Weinstein, PhD Medical Writer: Barbara B. Reitt, PhD, ELS (D) Managing Editor: Andrea N. Sherman, MS © American Geriatrics Society