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Biochemistry WebQuest
In Biology we study the biochemical structure of living things. In this webquest you will learn some basic
chemistry and then you will learn about the four macromolecules all living things are made of: carbohydrates,
proteins, lipids, and nucleic acids!
PART I Basic Chemical Concepts
To review atomic structure go to:
https://www.youtube.com/watch?v=FSyAehMdpyI
 ______________ - the smallest unit of an element that can combine chemically with other elements.
o Structure
 Proton: __________________ charged
 Neutron: __________________ charged
 Electron: __________________ charged
 Electrons exist in distinct __________ clouds
 Protons and neutrons are the same _____________ and make up the nucleus
o Identification
 ________________ _______________: the number of protons
 Atomic mass number: number of ______________ + neutrons
 Atoms are organized into ______________ in the periodic table
Now go to http://www.ptable.com to fill in the blanks


http://www.phschool.com/science/biology_place/biocoach/biokit/chnops.html What are the six most
common elements in living things?
What is the acronym to help us remember these elements?
Isotopes
Google the term Isotope and fill in the blanks:
 Two atoms with the same ____________ number but different atomic mass numbers. Differ only in the
number of ______________. Some are ____________ (radioisotopes).
o E.g. isotopes of hydrogen:
 H-1 has a mass number of 1 and no neutrons
 H-2 has a mass number of 2 and only one neutron
 H-3 has a mass number of 3 and two neutrons
 Go to http://www.youtube.com/watch?v=w3eGLevyIGE and identify the following isotopes. How many
neutrons are found in each isotope?
o C-12
o C-14
Compounds
Go to
http://ths.talawanda.org/~bramblen/classroom/Chemistry/Notes/Section%203A/LewisDotDiagrams.htm to
learn about Lewis Dot Diagrams and bonding. Fill in the blanks:
 Lewis dot structures are used to show how the atoms of a compound _________ together.
 Bonding occurs between ___________ electrons, electrons in the ___________ level of an atom.
 Draw the Lewis dot structure for sodium (Na)

Draw the Lewis dot structure for selenium (Se)

Summarize the octet rule:
Use your bonding video notes to fill in the following:
 Compound – a combination of two or more ______________ that are joined chemically
 Ionic bond: when an atom will either give or take an ______________ from another atom
o _____________: a positive ion
o Anion: a ______________ ion
o ________________ forces hold the atoms together
Go back to
http://ths.talawanda.org/~bramblen/classroom/Chemistry/Notes/Section%203A/LewisDotDiagrams.htm
 Draw the ionic bond between Na and Cl (table salt)



Covalent bond: when atoms _____________ electrons
o Form single, ______________, or triple bonds
o Sharing of ______________ holds the atoms together
Draw the Lewis dot diagram for water, carbon dioxide, and nitrogen gas (you might have to google
them!)
Polar and non-polar covalent bonds: Go to
https://manoa.hawaii.edu/exploringourfluidearth/chemical/properties-water/types-covalent-bondspolar-and-nonpolar
o Some covalently bonded molecules like hydrogen fluoride gas (HF) do not share electrons
equally. One of the atoms pulls harder on the shared electrons. Covalent molecules with this
type of uneven charge distribution are called _______________ bonds.
o Molecules with polar covalent bonds have a positive and a _____________ side.
o Click on the dog analogies to watch the three types of bonds!
PART II Macromolecules
Carbohydrates Tutorial
Click on the link provided and read the tutorial about carbohydrates. You may need to scroll up and down on
the small screen at the top of the tutorial for more information. When you finish go to Step 2 Lipids.
Internet Links: Carbohydrates http://www.wisc-online.com/objects/index_tj.asp?objid=AP13104
1. Carbohydrates provide the raw fuel for ______________ ___________ ________________.
2. Give 3 examples of monosaccharides.
a.
b.
c.
3.
4.
5.
6.
7.
_____________ is the 6 carbon sugar found in blood.
_____________ is the sugar that sweetens fruit.
_____________ is the sugar found in milk.
Glucose can have a straight line of carbon atoms or form a _________ structure.
The 5 carbon sugars called pentose are used in nucleic acid synthesis are ___________________ and
__________________.
8. Give 3 examples of disaccharides.
a.
b.
c.
9. Polysaccharides include _________________, _____________, and
___________.
10. ________________ is the storage molecule made from glucose by plants.
11. ________________ is made by plants for cell wall construction.
12. Glycogen is the carbohydrate storage molecule found in ______________ and _____________.
Lipids Tutorial
Click on the link below and answer the questions on your sheet about lipids. When you finish the lipid portion
on your worksheet go to Step 3 to view Protein tutorial. Answer the questions on your sheet about Proteins.
Internet Links: Lipid http://www.wisc-online.com/objects/index_tj.asp?objid=AP13204
Lipid Tutorial
1. Lipids are organic molecules that are ___________________ in water.
2. Give 3 examples of lipids.
a.
b.
c
3. Neutral fats are also called ________________________ because they have 3
fatty acids.
4. Neutral fats 3 functions:
a.
b.
c
5. The building blocks of neutral fat molecules are ____________ and __________________.
6. ___________________ fatty acids originate form animal sources and are ___________ at room
temperature.
7. ____________________ fats originate from plants and are _______________ at room temperature.
8. _____________________________ are the chief components of all cell membranes.
9. _____________________ helps to stabilize cell membranes and is used by the body to break down
steroids.
Protein Synthesis
Click on the Protein link below to view the Protein tutorial. Answer the questions on your Biochemistry
worksheet while viewing tutorial. After you have finished go to the Step 4 link on Nucleic Acids (DNA).
Internet Links: http://www.wisc-online.com/objects/index_tj.asp?objid=AP13304
Protein Tutorial
1. Proteins make up ________ % to ________ % of cell mass.
2. Examples of proteins in an organism.
a.
b.
c.
d.
3. Proteins are built from ________ common building blocks called ____________________.
4. The primary structure of protein is determined by the sequence of _____________________ connected
by ___________________ bonds.
Nucleic Acids
DNA Tutorial
Internet Links: http://www.teacherweb.com/MS/Rosascott/BiochemistryWebquest/Nucleicacids2.ppt
Intro
1. DNA comes with a complete set of __________________ to make an entire organism.
2. Using only _____ letters the DNA molecule builds everything from a bug to a human.
Role of DNA
3. While you are growing you need DNA to produce more _____________.
4. As an adult you also need DNA to :
a.
b.
c.
The Cell
5. DNA directs the entire operation by issuing instructions to make things you need such as ___________.
6. DNA allows organisms to make _______________ of themselves which is a requisite of life.
Chromosomes
7. Inside the nucleus you find DNA packaged into _______________________.
8. You get 1 set of chromosomes from your ________ and 1 set of chromosomes from your ___________.
9. Each cell has _________ chromosomes arranged into __________ pairs.
Watson and Crick
10. What are the 4 nitrogen bases found in DNA?
a.
b.
c.
d.
11. What is the shape of DNA? ________________
12. Now use Google to find three differences between DNA and RNA:
a.
b.
c.
Summary
Go to https://www.youtube.com/watch?v=PYH63o10iTE
Draw the structure of the following molecules:
 Carbohydrate
 Lipid
 Protein
 Nucleic acid (DNA)