Download 2nd Semester 428/1429 H

King Saud University
2nd Semester
College of Pharmacy
428/1429 H
PHL 542
(Part of Medicinal Chemistry
Comperhensive Exam for Phd students)
Dr. Nawal Al-Rasheed
Dr Nayira Abdelbaky
Question 1: Multiple Choice Questions: Choose the best answer:
1- All of the following characteristics about oxytocin are true EXCEPT:
a) It regulates myometrial activity.
b) Its release is stimulated by cervical dilatation.
c) Oestrogen inhibits its synthesis and its receptors sensitivity.
d) It contracts myoepithelial cells in the mammary gland.
e) It has a weak antidiuretic action.
2- Prostaglandin I2 exhibits all of the following properites EXCEPT:
a) It is a vasodilator.
b) It is a bronchodilator.
c) It inhibits platelet aggregation.
d) It promotes thromboxane A2 production.
e) It inhibits gastric secretions.
3- All of the following statments about endothelin are true EXCEPT:
a) It stimulates release of various vasoactive substances
b) Bradykinin stimulates its production.
c) Acetylcholine inhibits its production.
d) It is a potent vasoconstrictor peptide.
e) It is released from endothelial cells.
4- All of the following staments about dinoprostone are true EXCEPT:
a) It is used for theraputic abortion
b) It is a synthetic analogeous of PGF2α
c) It can be given as vaginal gel
d) It used for cervical ripening
e) It promotes coordinated contractions of pregnant uterus
5- All of the following staments about minoxidil are true EXCEPT:
a) Causes marked reflex tachycardia.
b) Causes marked fluid retention .
c) Is used as a monotherapy of mild hypertension.
d) Is added as a third drug to a beta blocker and diuretic.
e) Can be used for treatment of alopecia.
6- All of the following about ramipril are incorrect EXCEPT:
a) It stimulats angiotensin converting enzyme
b) It is indicated for low renin hypertensive individuals.
c) It is contraindicated in diabetic hypertensive patients.
d) It decreases plasma potassium level.
e) It is useful for hypertensive patients with concomitant heart failure.
7- Nifedipine produces all of the following EXCEPT:
a) Negative inotropic effect.
b) Selectively acting on vascular smooth muscle.
c) Decrease the concentration of free intracellular Ca2+.
d) Reflex tachycardia.
e) Decrease total peripheral resistance.
8- Which of the following statements about angiotensin II is correct:
a) It causes a profound fall in blood pressure resulting in shock.
b) It constricts blood vessels.
c) It is responsible for the inactivation of bradykinin.
d) It inhibits release of aldosterone.
e) It inhibits cell growth of the heart and arteries.
9- Nicorandil:
a) Acts on M2 receptors and causes vasodilation
b) Acts on  &  receptors and is useful in treating shock
c) Causes vasodilatation by decreasing nitric oxide.
d) Acts on -receptors and is useful in patients with heart block.
e) Acts as potassium channel activator and causes arterial vasodilatation
10- Vascular Relaxation may occur by all these mechanisms EXCEPT:
a) Agonists that lead to decreased intracellular Ca2+ .
b) Activation of atrial natriuretic peptides.
c) Increased intracellular cAMP or cGMP concentration.
d) Potassium Channel blockers.
e) Agonist that increase total peripheral resistance.
Question 2: Indicate if the following statements are TRUE or FALSE and correct the
false:
( ) Most blood vessels in the body do not have parasympathetic innervations.
---------------------------------------------------------------------------------------------------------------------( ) Clonidine is a centrally acting α2-adrenoceptors antagonist.
---------------------------------------------------------------------------------------------------------------------( ) Salbutamol stimulates spontaneous and oxytocin-induced contractions of the pregnant
uterus.
---------------------------------------------------------------------------------------------------------------------( ) NSAIDs are used to treat spasmodic dysmenorrhea
---------------------------------------------------------------------------------------------------------------------( ) The predominant contractile innervations of airway smooth muscle is parasympathetic
and cholinergic in nature.
---------------------------------------------------------------------------------------------------------------------( ) Sildenafil is a PDE inhibitor that inhibits breakdown of cGMP in vascular smooth
muscles leading to vasodilatation.
----------------------------------------------------------------------------------------------------------------------( ) Thiocyanate toxicity is an adverse effect associated with treatment with hydralazin.
----------------------------------------------------------------------------------------------------------------------( ) Anaritide is a recombinant natriuretic peptide that increases cGMP in vascular smooth
muscles and used in treatment of acute renal faliure.
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( ) Beta-adrenergic stimulation increases mucus gland secretion and mast cell releases of
mediators in respiratory system.
----------------------------------------------------------------------------------------------------------------------( ) Cough is a reflex response caused by irritation of afferent C –fibers which consequntly
stimulats sympathatic nerve leading to bronchoconstriction.
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Best Wishes