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Post doctoral position for protein crystallographer University of Texas We are looking for a trained protein crystallographer. The main project is the identification of inhibitors for the A chain of the cytotoxin called ricin. The project is reasonably well advanced with several modest inhibitors now known from virtual screening and high throughput screening of diversity libraries. Future work will focus on improvement of inhibitors with the collaboration of a synthetic team and cell and animal testing team. Structural analysis of new inhibitors is important to the inhibitor design cycles. The structural biologists will be working with the organic synthesis group to help design efficacious inhibitors as drug leads. Applicants should have experience with X-ray data collection, reduction, and analysis, and model building and refinement. In addition, experience with protein purification, elementary molecular cloning, and kinetic assays is desirable. There are several other structural projects in the laboratory, including two other drug design project. In additon, we are engaged in an experimental Freshman research project, dealing with in silico virtual screening, which may offer teaching opportunities to candidates who are so inclined. Send resume and list of at least referees to: Dr. Jon Robertus EM: [email protected] Subject line should state: post doctoral applicant