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Title Code Level Credit rating Pre-requisites Type of module Aims Learning outcomes/objectives Content Molecular Cell Biology 2 BY237 5 10 BY236 Extensive; semester 2 To provide a theoretical understanding of the molecular processes which control protein synthesis and trafficking, membrane transport and cell signalling. Also to give an understanding of the structure and functions of the cytoskeleton and the extracellular matrix. A practical introduction to selected methodologies used to investigate cell signalling and animal cell culture will be provided. At the end of the module the student should be able to: (1) give an account of the molecular events which underlie the translation; post-translational modifications; quality control and transport of proteins within the cell (2) explain the molecular events which underlie membrane transport of small molecules by passive and facilitated diffusion, ion channels and active transport (3) discuss the interactions between cell signalling molecules and their receptors, and the principal pathways of intracellular signal transduction (4) summarise the structure and fuctions of the cytoskeleton (5) explain the structure and functions of the ECM and its role in cell-cell communications. (6) analyze experimental data to demonstrate an understanding of cell signalling processes (7) be able to perform basic manipulations associated with animal cell culture. The following topics will be considered: Protein synthesis in terms of mechanisms of translation; post translational modification and protein trafficking. Vesicle absorption and secretion. Types of hormone receptor; mechanism of action of steroid hormones and cell surface receptors; principal second messenger systems Normal membrane transport processes in both epithelia and in single membranes. The proteins of, and the assembly and structure of the cytoskeleton, its importance in cell shape and movement, and methods of study. The structure of the extracellular matrix and its role in cell-cell interactions and wound repair. The basic techniques used in animal cell culture, sterile techniques, passaging, growth conditions; culture media. Teaching and learning strategies It is envisaged that the 100 hours study time allocated to this module consists of approximately: 24 hours lecture contact 6 hours practical class contact 70 hours personal study The personal study time should be divided between the directed and independent reading and revision for assessments Learning support Current editions: Cooper GM and Hausman RE, The Cell: a molecular approach, ASM Press Hancock JT, Cell Signalling, Harlow Longman Assessment tasks Exam (50%) LO 1, LO 2, LO 3 LO 4 LO 5; Coursework (50%) practical reports, (LO 6,7) Brief description of module This module develops an understanding of the molecular events content and/or aims and processes underpinning cell protein synthesis and (maximum 80 words) expression, the structure and function of the cytoskeleton and the extracellular matrix; cell signalling and ion and water transport. Area examination board to Biology which module relates Module team/authors/ Liz James (module leader), Mike Lethem, Katrin Jennert-Burston coordinator Semester offered, where 2 appropriate Date of first approval 2002 Date of last revision 2005 Date of approval of this 2007 version Version number 3 Replacement for previous N/A module Field for which module is Biology; optional acceptable and status in that field Course(s) for which Biomedical Sciences; compulsory module is acceptable and Biological Sciences; optional status in course School home School of Pharmacy and Biomolecular Sciences External examiner Dr P Nicholls