Download 武汉大学生命科学学院

yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

Document related concepts

Hepatitis C wikipedia, lookup

Hepatitis B wikipedia, lookup

Marburg virus disease wikipedia, lookup

Orthohantavirus wikipedia, lookup

Henipavirus wikipedia, lookup

Plant virus wikipedia, lookup

Influenza A virus wikipedia, lookup

Human cytomegalovirus wikipedia, lookup

Swine influenza wikipedia, lookup

Canine parvovirus wikipedia, lookup

Canine distemper wikipedia, lookup

Avian influenza wikipedia, lookup

Elsayed Elsayed Wagih wikipedia, lookup

Taura syndrome wikipedia, lookup

2006-2007 学年度第二学期期末考试
《病毒学》B 试卷
60 分)
Are the following statements true or false?
( )1. Ribosomal frameshifting allows viruses to produce a polyprotein from an
( )2. Ribosomal frameshifting allows viruses to produce varying amounts of
different proteins from an mRNA.
( )3. Suppression of termination codons allows some viruses to produce multiple
proteins from a polycistronic mRNA.
( )4. Viruses with non-segmented minus-sense genomes produce monocistronic
( ) 5. Viruses with minus-sense genomes always contain a virus-specific
transcriptase/replicase within the virus nucleocapsid.
( )6. Viruses with non-segmented miuns-sense genomes are translated to produce
a single long polyprotein.
( )7. Retrovirused are the only RNA viruses whose genomes are transcribed by
cellular RNA polymersase.
( )8. Hepadnavirus and Caulimovirus genomes contain a number of overlapping
reading frames.
( )9. Treatment of virus infections with drugs is cost effective compared with
( )10. Any of the stages of virus replication can be potential target for antiviral
( )11. The majority of antiviral drugs in use are nucleoside/nucleotide analogues.
( )12. Ribavirin is only active against influenza virus.
( )13. Viruses may become resistant to antiviral drugs.
( )14. Subunit vaccines are generally the most effective and least expensive virus
( )15. The hepatitis B virus vaccine currently in use is produced by genetic
( )16. Inactivated virus vaccines are sometimes not as effective as 'live' virus
vaccines because they fail to stimulate mucosal and cell-mediated
( )17. The majority of successful virus vaccines are currently based on attenuated
( )18. Retroviruses have been successfully used as vectors for gene therapy.
( )19. Most disease states are multi-factorial.
( )20. Inflammation, fever, headaches and skin rashes are frequently not caused by
virus replication, but the immune response to virus infection.
( )21. The vast majority of virus infections do not result in disease.
Viruse with plus-sense RNA genome (true or false?):
( )22. are largely independent of cellular mechanisms for control of gene
( )23. are always expressed as subgenomic RNAs.
( )24. are always translated to produce a single long polyprotein.
( )25. can produce varying ratios of the polypeptides they encode by mechanisms
such as alternative cleavages of polyproteins and variable translation
efficiency of subgenomic RNAs.
Transformed cells may display(true or false?)
( )26. loss of anchorage dependence.
( )27. loss of contact inhibition.
( )28. colony formation in semi-solid media.
( )29. Decreased requirements for growth factors.
( )30. increased requirements for growth factors.
( )31. Increased expression of p53.
PrPc(true or false?)
( )32. is a 254 amino acid protein.
( )33. is encoded by a cellular gene.
( )34. is converted by PrPSc to a protease-resistant form.
( )35. consists of 30percent alpha-helix and 43 percent beta-sheet.
( )36. is resistant to short-wave ultraviolet radiation and to ionizing radiation.
(13). Do the following virus groups possess lipid envelopes (true or false?)
( )37. Populations of virus genomes consisting of mixtures of molecular variants
are known as quasispecies.
( ) 38. Site-specific molecular biological methods are commonly used to
mutagenize virus genomes.
About retroviruses (true or false?):
) 39. Reverse transcriptase is also expressed by hepadnaviruses and
) 40. Are the only RNA viruses whose genome is produced by cellular
transcriptional machinery.
)41. Are the only plus-sense RNA viruses whose genome does not serve directly
as mRNA immediately after infection.
)42. Have low mutation rates, due to the high fidelity of reverse transcriptase
)43. Have a high rate of recombination, due to reverse transcription.
Are the following statements true or false?
( )44. Virus penetration of cells is an energy-dependent process.
( )45. influenza haemagglutinin is a virus fusion protein.
( )46. Uncoating only occurs in the nucleus of the host cell.
( )47. The product of uncoating is usually a complex of nucleic acids and virus
( )48. Nucleoproteins associated with virus genomes are responsible for cell
( )49. Virus receptor molecules are always proteins.
( )50. Most viruses have more than one receptor molecular.
( )51. No known plant virus used a cellular receptor.
( )52. Sialic acid is the influenza virus receptor.
( )53. The expression of receptors on the surface of cells is the major factor which
determines the tropism of viruses.
( )54. Adenoviruses encode their own DNA polymerase.
( )55. Poxviruses encode their own DNA polymerase and are independent of
cellular enzymes for genome replication.
( )56. Reovirus genomes are transcribed by a virus enzyme present in the particle.
( )57. All RNA virus genomes are replicated in the nucleus of the host cell.
( )58. Retrovirus genomes are transcribed by cellular RNA polymerase.
( )59. Reovirus transcription occurs inside virus core particles.
( )60. Segmented virus genomes are usually transcribed to produce polycistronic
1.逆转录病毒与 DNA 肿瘤病毒都可以引起细胞转化,请比较两类病毒引起细
胞转化的机制有何不同。(10 分)
(10 分)
4.根据病毒基因组以及复制方式的不同,病毒可分为几大类? (10 分)