Clinical effects of cardiac contractility modulation (CCM) as a
... previous literature showing that electromagnetic fields can impact on protein–protein interaction and gene expression20 and considering that the CCM-induced increases in contractility were not associated with an increase in MVO2, CCM signals may have a direct impact on cellular physiology beyond typ ...
... previous literature showing that electromagnetic fields can impact on protein–protein interaction and gene expression20 and considering that the CCM-induced increases in contractility were not associated with an increase in MVO2, CCM signals may have a direct impact on cellular physiology beyond typ ...
at different heart rates - IFM
... from the tip) was inserted in the hole and advanced to the sinus venosus (15–20·mm) before secured tightly in place. The cannula was secured twice on the skin, once adjacent to the bubble on top of the cleithrum bone and once close to the dorsal fin. The position of the catheter tip was verified pos ...
... from the tip) was inserted in the hole and advanced to the sinus venosus (15–20·mm) before secured tightly in place. The cannula was secured twice on the skin, once adjacent to the bubble on top of the cleithrum bone and once close to the dorsal fin. The position of the catheter tip was verified pos ...
Estrogen Receptor Я Protects the Murine Heart Against Left
... treatment for ER␣⫺/⫺ as well as ER⫺/⫺), the UW/BW and UW/tibia length (TL) ratios showed a significant difference between placebo and E2-treated mice (Table). In E2-treated WT and ER⫺/⫺ mice, the UW/BW ratios are significantly higher than that of E2-treated ER␣⫺/⫺ mice (Table). Together, we were a ...
... treatment for ER␣⫺/⫺ as well as ER⫺/⫺), the UW/BW and UW/tibia length (TL) ratios showed a significant difference between placebo and E2-treated mice (Table). In E2-treated WT and ER⫺/⫺ mice, the UW/BW ratios are significantly higher than that of E2-treated ER␣⫺/⫺ mice (Table). Together, we were a ...
Anesthesia for non-cardiac surgery in patients with heart failure
... at a rate commensurate with the requirements of the metabolising tissues, despite normal filling pressures (or only at the expense of increased filling pressures).4 Clinically, HF is defined as a syndrome in which patients have typical symptoms (e.g. breathlessness, ankle swelling, and fatigue) and ...
... at a rate commensurate with the requirements of the metabolising tissues, despite normal filling pressures (or only at the expense of increased filling pressures).4 Clinically, HF is defined as a syndrome in which patients have typical symptoms (e.g. breathlessness, ankle swelling, and fatigue) and ...
World Heart Corporation (WHRT)
... are of prime concern for all LVAD patients, and particularly those indicated for Destination Therapy (predicted to be the vast majority of the LVAD market). We also find it plausible that the Levacor may have better blood handling and device durability than other existing LVADs. On the other hand, h ...
... are of prime concern for all LVAD patients, and particularly those indicated for Destination Therapy (predicted to be the vast majority of the LVAD market). We also find it plausible that the Levacor may have better blood handling and device durability than other existing LVADs. On the other hand, h ...
- American Journal of Kidney Diseases
... note that while this calculation includes glucose and serum urea nitrogen, both these substances permeate readily across most cell membranes and are ineffective osmoles. Therefore, the most abundant extracellular cation, sodium, greatly affects water homeostasis. Control over serum osmolality is mai ...
... note that while this calculation includes glucose and serum urea nitrogen, both these substances permeate readily across most cell membranes and are ineffective osmoles. Therefore, the most abundant extracellular cation, sodium, greatly affects water homeostasis. Control over serum osmolality is mai ...
Evaluation of left ventricular function in patients with chronic
... septum shift into the left ventricular cavity and this may result in the limitation of left ventricular cavity dimensions, its contractility and compliance and in consequence in the rise of the left ventricular diastolic pressure [3-5]. This phenomenon has been described in detail with respect to pa ...
... septum shift into the left ventricular cavity and this may result in the limitation of left ventricular cavity dimensions, its contractility and compliance and in consequence in the rise of the left ventricular diastolic pressure [3-5]. This phenomenon has been described in detail with respect to pa ...
Tunica Externa
... 21-1 Structure and Function of Capillaries • Angiogenesis • Formation of new blood vessels • Vascular endothelial growth factor (VEGF) • Occurs in the embryo as tissues and organs develop • Occurs in response to factors released by cells that are hypoxic, or oxygen-starved • Most important in cardi ...
... 21-1 Structure and Function of Capillaries • Angiogenesis • Formation of new blood vessels • Vascular endothelial growth factor (VEGF) • Occurs in the embryo as tissues and organs develop • Occurs in response to factors released by cells that are hypoxic, or oxygen-starved • Most important in cardi ...
Improvement of Cardiac Function During Enzyme
... weight of recombinant ␣-Gal A (agalsidase , Fabrazyme) were followed up for 12 months. Myocardial function was quantified by ultrasonic strain rate imaging to assess radial and longitudinal myocardial deformation. End-diastolic thickness of the left ventricular posterior wall and myocardial mass (a ...
... weight of recombinant ␣-Gal A (agalsidase , Fabrazyme) were followed up for 12 months. Myocardial function was quantified by ultrasonic strain rate imaging to assess radial and longitudinal myocardial deformation. End-diastolic thickness of the left ventricular posterior wall and myocardial mass (a ...
Relaxin Is an Independent Risk Factor Predicting Death in Male
... and 29 of chronic heart failure. The highest relaxin concentrations were seen in patients who died later of myocardial infarction. However, the differences in this subgroup as compared with survivors were not significant, most probably because of the low number of cases. (data not shown). Infectious ...
... and 29 of chronic heart failure. The highest relaxin concentrations were seen in patients who died later of myocardial infarction. However, the differences in this subgroup as compared with survivors were not significant, most probably because of the low number of cases. (data not shown). Infectious ...
Heart Failure and Transplantation
... 19) Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. The SOLVD Investigattors. N Engl J Med. 1992;327:685-91. 20) Bradley TD, Logan AG, Kimoff RJ, et al. Continuous positive airway pressure for central sl ...
... 19) Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. The SOLVD Investigattors. N Engl J Med. 1992;327:685-91. 20) Bradley TD, Logan AG, Kimoff RJ, et al. Continuous positive airway pressure for central sl ...
Impact of obstructive sleep apnoea on left ¨ zkurt ¨ . Kuru*,
... complications of OSAS [2]. These complications include heart failure [3], acute myocardial infarction [4], nocturnal arrhythmias [5], stroke [6], systemic [7, 8] and pulmonary hypertension [9]. All these cardiovascular complications increase morbidity and mortality of OSAS. Currently, sleep apnoea i ...
... complications of OSAS [2]. These complications include heart failure [3], acute myocardial infarction [4], nocturnal arrhythmias [5], stroke [6], systemic [7, 8] and pulmonary hypertension [9]. All these cardiovascular complications increase morbidity and mortality of OSAS. Currently, sleep apnoea i ...
Final Protocol - Medical Services Advisory Committee
... dramatically since the late 1960s, by around 68 per cent. These declines appear to have been largely driven by improvements in some risk factor levels, great increases in the use of drugs to lower blood pressure and to treat and prevent blood clots, and other advances in treatment. Despite these dec ...
... dramatically since the late 1960s, by around 68 per cent. These declines appear to have been largely driven by improvements in some risk factor levels, great increases in the use of drugs to lower blood pressure and to treat and prevent blood clots, and other advances in treatment. Despite these dec ...
EN-RAGE - Arteriosclerosis, Thrombosis, and Vascular Biology
... To address the question whether our results were driven by a certain subgroup, we analyzed the data excluding participants with chronic kidney disease, type 2 diabetes mellitus, and antihypertensive use in the sensitivity analyses. Across all these analyses, there was a consistent effect of EN-RAGE ...
... To address the question whether our results were driven by a certain subgroup, we analyzed the data excluding participants with chronic kidney disease, type 2 diabetes mellitus, and antihypertensive use in the sensitivity analyses. Across all these analyses, there was a consistent effect of EN-RAGE ...
Slide 1
... revascularization, – In 2001, 2 years after the guidelines were published, only 41% of patients with cardiogenic shock complicating AMI were treated with primary PTCA and only 3.1% underwent early CABG. ...
... revascularization, – In 2001, 2 years after the guidelines were published, only 41% of patients with cardiogenic shock complicating AMI were treated with primary PTCA and only 3.1% underwent early CABG. ...
Oxygen Consumption of the Nonworking and Potassium Chloride
... coronary flow was displayed, together with pressure and ECG traces on a Gould Brush 480 pen recorder. In five experiments, the nonworking heart was paced at different rates by means of a Digitimer Mark IV stimulator via electrodes sutured into the right ventricle. Prior to pacing, atrioventricular d ...
... coronary flow was displayed, together with pressure and ECG traces on a Gould Brush 480 pen recorder. In five experiments, the nonworking heart was paced at different rates by means of a Digitimer Mark IV stimulator via electrodes sutured into the right ventricle. Prior to pacing, atrioventricular d ...
- UEA Digital Repository
... a middle-aged general population.[6] One possible explanation for the difference in the findings is that for this study there was a much higher event rate compared to the average among the studies (mortality 56% vs 38%, heart failure 16% vs 14%, atrial fibrillation 15% vs 4%). This study made an int ...
... a middle-aged general population.[6] One possible explanation for the difference in the findings is that for this study there was a much higher event rate compared to the average among the studies (mortality 56% vs 38%, heart failure 16% vs 14%, atrial fibrillation 15% vs 4%). This study made an int ...
Role of cardiac structural and functional abnormalities in the
... contractile function, has been documented to be significantly lowered in cirrhotic rats [8]. In another study, cirrhotic rats have also been found to have abnormalities in cardiac β-adrenergic receptors and conduction pathways [9]. These findings suggest that cirrhotic cardiomyopathy does occur. Thi ...
... contractile function, has been documented to be significantly lowered in cirrhotic rats [8]. In another study, cirrhotic rats have also been found to have abnormalities in cardiac β-adrenergic receptors and conduction pathways [9]. These findings suggest that cirrhotic cardiomyopathy does occur. Thi ...
Multiple Coronary Artery-Left Ventricular Fistulas Associated With
... problem without cardiac surgery, clinicians need to look carefully for its presence. Coronary artery compression is rarely considered in these patients, but its detection and treatment may be lifesaving. ...
... problem without cardiac surgery, clinicians need to look carefully for its presence. Coronary artery compression is rarely considered in these patients, but its detection and treatment may be lifesaving. ...
Investigating stable chest pain of suspected cardiac origin
... What is the next investigation? Cardiovascular disease is a leading cause of death in the United Kingdom1; however, most first presentations with chest pain to primary care have a non-cardiac cause.2 It is important to establish which patients’ symptoms are caused by obstructive coronary artery dise ...
... What is the next investigation? Cardiovascular disease is a leading cause of death in the United Kingdom1; however, most first presentations with chest pain to primary care have a non-cardiac cause.2 It is important to establish which patients’ symptoms are caused by obstructive coronary artery dise ...
Determinants of Hemodynamic Compromise
... concern that fluid-filled catheters may not permit quantitation, particularly of subtle abnormalities, only clearly apparent qualitative distinctions have been emphasized. The statistics reported have been used only as descriptors of these qualitative observations. Furthermore, because our patient p ...
... concern that fluid-filled catheters may not permit quantitation, particularly of subtle abnormalities, only clearly apparent qualitative distinctions have been emphasized. The statistics reported have been used only as descriptors of these qualitative observations. Furthermore, because our patient p ...
QT prolongation: risks and assessment
... – Asymptomatic prolongation of the QT interval has been shown in healthy volunteers receiving trazodone, and occasionally after drug overdose. In contrast, there is no evidence that fluoxetine could modify the QT interval. ...
... – Asymptomatic prolongation of the QT interval has been shown in healthy volunteers receiving trazodone, and occasionally after drug overdose. In contrast, there is no evidence that fluoxetine could modify the QT interval. ...
Use of Sildenafil for Safe Improvement of Erectile Function
... the first report on the safety and efficacy of this commonly used drug in a population with moderately severe CHF. It is also one of few studies to examine the potentially beneficial effect of treating ED in patients with advanced cardiovascular disease. Although the use of sildenafil in patients wi ...
... the first report on the safety and efficacy of this commonly used drug in a population with moderately severe CHF. It is also one of few studies to examine the potentially beneficial effect of treating ED in patients with advanced cardiovascular disease. Although the use of sildenafil in patients wi ...
Article Peripheral Edema, Central Venous Pressure, and Risk of AKI
... heart rate, and temperature as independent continuous variables. Admission creatinine, defined as the first available creatinine 24 hours prior to, or 6 hours after, ICU admission was used as a determinant of “baseline” kidney function. We used NLP searches of prehospital medication lists to identify ...
... heart rate, and temperature as independent continuous variables. Admission creatinine, defined as the first available creatinine 24 hours prior to, or 6 hours after, ICU admission was used as a determinant of “baseline” kidney function. We used NLP searches of prehospital medication lists to identify ...
Risk factors for atrial fibrillation
... 1.18–1.49, and 1.24; 95% CI 1.11–1.40, respectively) The results of the above mentioned study indicate that the inflammatory process may be considered as a cause rather than a result of AF. Nevertheless, this hypothesis should be treated with caution as it has not yet been confirmed by other studies ...
... 1.18–1.49, and 1.24; 95% CI 1.11–1.40, respectively) The results of the above mentioned study indicate that the inflammatory process may be considered as a cause rather than a result of AF. Nevertheless, this hypothesis should be treated with caution as it has not yet been confirmed by other studies ...
Antihypertensive drug
Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.