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Stroke: Effective Strategies for Secondary Prevention
Stroke: Effective Strategies for Secondary Prevention

... Data on the use of antihypertensives in patients following stroke or TIA are limited compared with primary prevention, in part because potential deleterious effects of acute blood pressure lowering in ischemic stroke have raised concerns about the use of antihypertensive agents at all in these patie ...
Does QRS Voltage Correction by Body Mass Index Improve the
Does QRS Voltage Correction by Body Mass Index Improve the

... Left ventricular (LV) hypertrophy (LVH), either detected by electrocardiography or echocardiography, has been shown to be an independent predictor of nonfatal and fatal cardiovascular (CV) events as well as all-cause death in a variety of clinical settings including general population-based samples1 ...
ICD-10-CM: Myocardial Infarction
ICD-10-CM: Myocardial Infarction

... - - - inferior (diaphragmatic) (inferolateral) (inferoposterior) (wall) NEC I21.19 - - - - subsequent I22.1 ...
Thrombosis in one coronary artery causes
Thrombosis in one coronary artery causes

... is determined post-mortem using quantities of fluorescent microspheres which, if given during life, would cause pathological damage ; such examination is not therefore repeatable in order to determine change in bed size with thrombosis. There is an indeterminate aspect to this because some areas do ...
Amiodarone Infusion Guideline
Amiodarone Infusion Guideline

... • Continuous cardiac monitoring is required with daily ECG and QT interval checks. • BP and heart rate hourly for the first 4 hours, then 4 hourly until confusion complete. If hypotension occurs, slowing or stopping the infusion temporarily is usually adequate. • Doctors must chart acceptable clinic ...
Cardiac involvement in adult and juvenile idiopathic
Cardiac involvement in adult and juvenile idiopathic

... (DM), inclusion body myositis (IBM) and juvenile DM ( JDM). The mentioned subgroups are characterised by inflammation of skeletal muscles leading to muscle weakness and other organs can also be affected as well. Even though clinically significant heart involvement is uncommon, heart disease is one o ...
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE

Relationship between Myocardial Performance Index and Severity
Relationship between Myocardial Performance Index and Severity

... Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide, and its incidence has been gradually increasing. CAD is a progressive inflammatory disease in which atherosclerosis plays a major role in its etiology [1]. The SYNTAX score (SS) is a lesion-based angiographic scor ...
Current Perceptions of the Epidemiology of Atrial Fibrillation
Current Perceptions of the Epidemiology of Atrial Fibrillation

... or Metoprolol European Trial (COMET), there was no difference in all-cause mortality in subjects with AF at entry, but mortality increased in those who developed AF during follow-up.35 In the Valsartan Heart Failure Trial of patients with chronic heart failure, development of AF was associated with ...
Congenital Heart Disease
Congenital Heart Disease

Heart worms - Urban Animal
Heart worms - Urban Animal

... mass of intertwined and tangled worms causes a blockage to the flow of blood to and from the right side of the heart. At the same time, the migrating larvae cause a lot of damage and inflammation to the lung tissue. The signs your pet develops are a consequence of both the damage the worm causes to ...
The association between apelin
The association between apelin

... and the other 44 of them had atrioventricular tachyarrhythmias, including AVNRT or atrioventricular reentrant tachycardia (AVRT). All participants provided written informed consent. The protocol was approved by the local ethics committee. Individuals were considered eligible for enrollment if they h ...
Assessment of the pressure–volume relationship of the single
Assessment of the pressure–volume relationship of the single

... volume data was then used to generate PV loops. Heart rate (fH), maximum pressure (Pmax), minimum pressure (Pmin), change in pressure (⌬P), maximum area (Amax), minimum area (Amin) and change in area (⌬A) were determined by independently analyzing the pressure and video output from LabView (National ...
B-type natriuretic peptide in the management of heart failure
B-type natriuretic peptide in the management of heart failure

... as much as in heart failure.6 In patients with chronic tool obstructive pulmonary disease or asthma, a level of A number of factors have been associated with lower than 100 pg/mL has a negative predictive value increased mortality in patients with heart failure, of 97.7%, which makes BNP useful to e ...
Outcome of pulmonary endarterectomy in symptomatic chronic thromboembolic disease
Outcome of pulmonary endarterectomy in symptomatic chronic thromboembolic disease

... remodelling causing persistent elevation of pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) leading to right ventricular failure [1]. This is a progressive disease, usually fatal when left untreated and mortality correlates with mean PAP at diagnosis. Historical data, prece ...
The relationship of fibroblast growth factors 21 and 23
The relationship of fibroblast growth factors 21 and 23

... assess the expression of β-Klotho, which may act as a coreceptor for FGF21 signaling. In summary, cardiac patients with higher serum FGF23 and lower FGF21 levels had high MPV, and presumably increased platelet activity, and this relationship was independent of sex, age, fasting glucose, triglyceride ...
Boundless Study Slides
Boundless Study Slides

... Boundless is an innovative technology company making education more affordable and accessible for students everywhere. The company creates the world’s best open educational content in 20+ subjects that align to more than 1,000 popular college textbooks. Boundless integrates learning technology into ...
Sildenafil attenuates pulmonary arterial pressure but - UvA-DARE
Sildenafil attenuates pulmonary arterial pressure but - UvA-DARE

... patients were excluded: three were treated with another PDE inhibitor (enoximone), three had contraindications to enteral medications, and one patient suffered from pulmonary hemorrhage and was excluded for safety reasons. In three patients, consent was not provided. One patient was excluded after e ...
Characteristics, Treatments, and Outcomes of Hospitalized Heart
Characteristics, Treatments, and Outcomes of Hospitalized Heart

... OBJECTIVES The authors sought to describe characteristics, treatments, and in-hospital outcomes of hospitalized heart failure (HF) patients stratified by etiology. BACKGROUND Whether characteristics and outcomes of HF patients differ by cardiomyopathy etiology is unknown. METHODS The authors analyzed ...
Exercise Test Review Article
Exercise Test Review Article

... complex, and a Dutch group have proposed a score based on composite changes in the Q, R, and S waves in two leads (aVF, V5). These investigators reported a sensitivity of 88·2% and a specificity of 84·8% for coronary artery disease, compared with values for ST depression of 54·9% and 83%, respective ...
RR interval variation, the QT interval index and risk of primary
RR interval variation, the QT interval index and risk of primary

... of controls and reading of electrocardiograms. We estimated risk before and after adjustment for clinical predictors of primary cardiac arrest. Where appropriate, we added squared terms to models based on significance of the log likelihood statistic. On the same basis, we added the product term QTI ...
Cardiac Arrhythmias: The Quest for a Cure
Cardiac Arrhythmias: The Quest for a Cure

... understanding of cardiac arrhythmias and their treatment. This was again demonstrated when Josephson et al. (24,25) showed in patients with ventricular tachycardias that accurate localization of the area of abnormal impulse formation could be followed by cure from the arrhythmia when the abnormal ar ...
Death or Q-wave MI - Clinical Trial Results
Death or Q-wave MI - Clinical Trial Results

... If confirmed in systematic long-term follow-up studies, our findings have potentially serious clinical implications.” McFadden EP et al, Lancet 2004; 364: 1519–21 ...
Heart Surgery and Dissection
Heart Surgery and Dissection

... If there is a long-term demand on the heart to pump more blood – for example during exercise or in pregnancy – the body responds by making the heart cells larger. Conditions like high blood pressure also cause the heart to grow, but in this case increased size does not improve the heart’s pumping ca ...
Physiology and Anatomy of the Heart - An
Physiology and Anatomy of the Heart - An

... aortic and pulmonary valves—about 80 mm Hg in the aorta and 10 mm Hg in the pulmonary trunk. ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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