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heart and blood vessel basics
heart and blood vessel basics

... Arteries carry blood rich in oxygen from your heart to the tissues and organs in your body, like your brain, kidneys, and liver. Because arteries carry oxygen, they appear red. Artery walls are thick and flexible. And they need to be. The heart pumps with enough force, or pressure, to deliver blood ...
Physiology and Anatomy of the Heart - An
Physiology and Anatomy of the Heart - An

... aortic and pulmonary valves—about 80 mm Hg in the aorta and 10 mm Hg in the pulmonary trunk. ...
Indices of Myocardial Contractility
Indices of Myocardial Contractility

... Contractility may be defined also as the velocity of myocardial fiber shortening or change in ventricular dimension during contraction when the fiber shortens or the ventricle contracts against no load. In the clinic; however, myocardial contractility may be estimated by some parameters of systolic ...
Week 5 – Electrocardiography and Blood pressure Objectives
Week 5 – Electrocardiography and Blood pressure Objectives

... the blood through the circulatory system. Blood returning from the body is sent to the right side of the heart and then to the lungs to pick up oxygen and release carbon dioxide. This oxygenated blood is sent to the left side of the heart and back to the body, where oxygen is released and carbon dio ...
Congestive Heart Failure Complicated with Chylothorax as the
Congestive Heart Failure Complicated with Chylothorax as the

... condition, there was non-adherence to his antithyroid therapy. On admission, he presented with symptomatic congestive heart failure and bilateral pleural effusion. Thoracocentesis revealed a high triglyceride level in the pleural effusion, consistent with chylothorax. Survey for other common causes ...
Week 5 – Electrocardiography and Blood pressure Objectives
Week 5 – Electrocardiography and Blood pressure Objectives

... the blood through the circulatory system. Blood returning from the body is sent to the right side of the heart and then to the lungs to pick up oxygen and release carbon dioxide. This oxygenated blood is sent to the left side of the heart and back to the body, where oxygen is released and carbon dio ...
Effects of Flecainide and Propafenone on Systolic
Effects of Flecainide and Propafenone on Systolic

... hand, similar findings patient with dysfunction. the presence ...
Empirical estimates of mean aortic pressure
Empirical estimates of mean aortic pressure

... is added to the diastolic pressure [3,4]. This empirical formula implies that MAP is twice as sensitive to diastolic as it is to systolic pressure (MAP l 2\3 idiastolic pressurej1\3isystolic pressure). Increased MAP is an important component of vascular overload and cardiovascular risk, and the redu ...
publication
publication

... sympathetic activity and withdrawal of parasympathetic control. This autonomic imbalance has long been recognized as an important mediator of increased mortality and morbidity in myocardial infarction and HF (1, 2). Results from the Autonomic Tone and Reflexes after Myocardial Infarction Study (ATRA ...
Determinants of stroke volume and systolic and
Determinants of stroke volume and systolic and

Two preventive multivessel stenting strategy with zotarolimus eluting
Two preventive multivessel stenting strategy with zotarolimus eluting

... There is no doubt when compare with literature data. According to published trials, one-year incidence of adverse cardiovascular events (MACE) in STEMI MVCAD patients of general cohort with bare metal stents and DES ranged from 23.9 to 28%, re-MI from 1.6 to 8.8%, death from 3.3 to 6.3%, ST from 1.8 ...
Articles Primary prevention of cardiovascular disease with
Articles Primary prevention of cardiovascular disease with

... pravastatin group than in the diet alone group (66 events vs 101 events; HR 0·67, 95% CI 0·49–0·91; p=0·01). There was no difference in the incidence of malignant neoplasms or other serious adverse events between the two groups. Interpretation Treatment with a low dose of pravastatin reduces the risk ...
Response of myocardial oxygenation to breathing manoeuvres and
Response of myocardial oxygenation to breathing manoeuvres and

... including chest pain, palpitations, dyspnoea, light-headedness, flushing, sweating, nausea, headache, and anxiety, and recently the US food and drug administration released a warning due to adenosine as a rare, but serious risk of heart attack and death.3 Adenosine infusion can cause arrhythmia, esp ...
Influence of ejection fraction on outcomes and efficacy of
Influence of ejection fraction on outcomes and efficacy of

... less likely to have a history of myocardial infarction, and more likely to have a history of hypertension and diabetes. Both heart rate and BMI were slightly higher in those with higher ejection fraction. NYHA functional class did not differ by EF. Patients with higher EF were more likely to have re ...
Article PDF
Article PDF

... one epicardial coronary artery (ECA). Scores of 0, 1, 2, and 3 was given for normal (no CAD group), significant CAD in one ECA, two ECA and all three ECA respectively. 17 patients had normal ECA, 15 patients had score 1, 13 patients had score 2, and 11 patients had score 3. By noninvasive method, th ...
Toward a Non-invasive Measurement of Cardiac Output
Toward a Non-invasive Measurement of Cardiac Output

... the two-second-averaged data can be analyzed by these algorithms. The program is ...
Obstructive Sleep Apnea - UM Anesthesiology
Obstructive Sleep Apnea - UM Anesthesiology

... • The incidence of unanticipated early postoperative intubation (UEPI) was 0.83-0.9% ...
Title: Blood circulation in the tunicate Corella inflata
Title: Blood circulation in the tunicate Corella inflata

... The transparency of C. inflata makes it easy to see internal structure, but only if the structure is not itself transparent. Optimal observation is thus aided by a dye to create contrast. The dye neutral red is most commonly used in tissue culture as a stain specific for living cells, where it is tr ...
chemokine rantes is increased at early stages of coronary artery
chemokine rantes is increased at early stages of coronary artery

... atherosclerosis is confirmed, and recent research focuses on its gene polimorphisms and their predictive role as a risk factor of coronary artery disease (27, 28). Similar role of severity predictor would play increased mRNA expression of catecholamine-synthesizing enzymes in heart failure (29). Acc ...
11 Adrenergic Drugs - New Age International
11 Adrenergic Drugs - New Age International

... 8. The response of non-catecholamines is largely determined by their ability to release NE, thus their effects are mainly on α and β1 9. Phenylethylamines lacking both aromatic —OH groups and the β-OH on the ethyl chain produce almost all of their effects by NA release. Catecholamines have only a br ...
REFLEX CONTROL OF THE VEINS IN CARDIOVASCULAR
REFLEX CONTROL OF THE VEINS IN CARDIOVASCULAR

... the capacity vessels maximally with norepinephrine or block all activity with hexamethonium (4). From these data (Fig. 91, we concluded that the maximum range of smooth muscle control was of the order of 15 ml/kg body weight at a mean circulatory filling pressure of about 10 mmHg. The effect of gang ...
Angina Pectoris (2)
Angina Pectoris (2)

... Nifedipine, nicardipine, felodipine, amlodipine, isradipine and bepridil are calcium channel blockers that are available for use in the United States. These agents differ in mode of action and clinical effect. However, they are all effective for the treatment of coronary artery spasm via the influx ...
Prevention of stroke and systemic embolization in atrial fibrillation: a
Prevention of stroke and systemic embolization in atrial fibrillation: a

... patients control of the atrial arrhythmia, and in most patients therapy to prevent thromboembo‑ lism. Major advances in the understanding about the risk of thromboembolism and new oral antico‑ agulants (OACs) for its prevention have prompt‑ ed the present review. Risk of stroke  Stroke and non‑centr ...
PDF Article
PDF Article

... tial increases in parasympathetic activity with long-term administl-ation of this drug to normal subjects. Sympathetic activity, as determined from measurement of plasma norepinephrine Icvel;, was significantly reduced by long-term digoxin therapy in these patients. Previousstudies of short-term adm ...
Coronary Revascularization in Patients with Stable
Coronary Revascularization in Patients with Stable

... rapid tachyarrhythmias, or extreme hypertension. The pain is transient, lasting between 2 and 20 minutes. It is relieved by cessation of the event that increased myocardial oxygen demand or by administration of sublingual nitroglycerin. Some patients do not manifest typical symptoms of angina. Rathe ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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