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Tight Glycemic Control Reduces Heart Inflammation and
Tight Glycemic Control Reduces Heart Inflammation and

... strict glycemic control contributes to improve the early outcome of AMI in hyperglycemic patients has been recently debated (4). In this context, our study evaluates whether tight glycemic control during AMI would reduce myocardial levels of peroxynitrite, TNF-␣, and apoptosis in myocardial biopsies ...
Yoga and Heart Disease - ScholarSpace @ JCCC
Yoga and Heart Disease - ScholarSpace @ JCCC

... cardiovascular disease, does not include the peripheral or systemic blood vessels. Exercise affects both cardiovascular disease and heart disease. The heart is a ...
pdf 12 MB - Cardio Symposium 2011
pdf 12 MB - Cardio Symposium 2011

... heart failure would produce any benefits. Barr et al5 showed that spironolactone had beneficial cardiac effects (on sympathetic activity and on ventricular arrhythmias) when added to an ACE inhibitor in human heart failure. Aldosterone blockade was then shown clearly to reduce total mortality in bot ...
JEPonline Physiological Responses to Dangling and Standing in
JEPonline Physiological Responses to Dangling and Standing in

... with the legs hanging over the edge of the bed (35). It is a common nursing intervention used to assess and promote a patient’s physiologic tolerance to getting out of the bed (22,28,33). The patient may dangle or more typically, stand, pivot, and sit in a chair. Despite nurses' routine use of dangl ...
Left ventricular diastolic reserve in patients with
Left ventricular diastolic reserve in patients with

... with DM. This method is more powerful than logistic regression as it directly models the risk of E/e0 ≥15 on the logit scale without dichotomising. BRCO takes into account the fact that values that lie further away from the cut-off bring more information than values that are close, and hence there i ...
Clinical Slide Set. Atrial Fibrillation
Clinical Slide Set. Atrial Fibrillation

...  Other class I drugs are used infrequently because of noncardiac side effects and concern for proarrhythmia  Class III drugs, such as sotalol and dofetilide, can prolong the QT interval and cause torsades de pointes  Amiodarone: permanent liver and lung toxicity is doseand duration-dependent  Dr ...
Chapter 15 Hydrocephalus: New Theories and New Shunts?
Chapter 15 Hydrocephalus: New Theories and New Shunts?

... One approach to minimize large capillary pulse pressures would be to place a damper on the system (analogous to a shock absorber used in automobiles). Dampers, however, absorb energy and, therefore, reduce the efficiency of energy transfer. In effect, vascular autoregulation is a feedback-controlled ...
Form and Function in Reptilian Circulations1
Form and Function in Reptilian Circulations1

... arterial tree lies proximal to the lung parenchyma (Burggren, 1976, 1977a). The major pulmonary artery leading to each lung of the turtle is approximately equally divided into a highly compliant, poorly muscularized proximal segment and a relatively non-compliant, highly muscularized distal segment ...
Heart Failure: Causes and Nursing Management
Heart Failure: Causes and Nursing Management

... Therefore, health care providers’ knowledge about current heart failure management guidelines and strategies are the cornerstone in the management of patients with heart failure. Emphasis on lifestyle modification, including weight management and knowledge on nutrition, are as important as medicatio ...
31 hypoxia and cyanosis
31 hypoxia and cyanosis

... present and clubbing of the fingers may occur. However, in many types of chronic pulmonary disease with fibrosis and obliteration of the capillary vascular bed, cyanosis does not occur because there is relatively little perfusion of underventilated areas. Another cause of reduced SaO is shunting of ...
Giant left anterior descending artery aneurysm resulting in sudden
Giant left anterior descending artery aneurysm resulting in sudden

... might be related to thrombosis after CAG or, albeit rare and unpredictable, coronary aneurismal rupture. Because of the rarity of CAA, its management is not yet well established. Although simple observation may be sufficient for small, asymptomatic aneurysms, surgery should be considered for larger, ...
Left ventricular dysfunction following rewarming from experimental
Left ventricular dysfunction following rewarming from experimental

... moderate hypothermia (4, 30). In more intact animal preparations, marked depressed left ventricular (LV) function has been reported even at mild (34°C) levels of hypothermia (15). In a report using excised crosscirculated dog hearts, the efficiency of myocardial LV contractile function could not be ...
Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With
Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With

... bradycardia pacing was overtly required in only 4% of the patients. Despite a paucity of evidence for need or benefit, most currently implanted ICDs are dual-chamber devices.9 Treatment of CHF has been improved by the routine administration of angiotensin-converting enzyme (ACE) inhibitors and ␤-adr ...
Autonomic control of the heart in Boa constrictor
Autonomic control of the heart in Boa constrictor

... quantified using specific antagonists to the cholinergic and adrenergic effectors on the heart. Materials and methods Animals, surgery and measurements of blood pressure and heart rate Nineteen specimens of Boa constrictor (L.) were bred and reared in captivity for approximately 2 years at the Jacar ...
Pulmonary Hypertension and Cardiovascular Sequelae in 54 Dogs
Pulmonary Hypertension and Cardiovascular Sequelae in 54 Dogs

... ventricular enlargement. A large main pulmonary artery was noted in one dog, and pleural effusion was observed in another. Fifteen dogs in the moderate category had radiographs available for review. Ten had an abnormal pulmonary parenchymal/ vascular pattern. Eleven dogs had generalized cardiomegaly ...
Heritability of the Function and Structure of the Arterial Wall Findings
Heritability of the Function and Structure of the Arterial Wall Findings

... During the cardiovascular assessment, carotid–femoral PWV was measured by means of an automatic Complior SP device with the subjects in a supine position. The time delay between the rapid upstroke from the base point of simultaneously recorded pulse wave curves in the carotid and the femoral arterie ...
Vectorcardiographic Detection of Early Hemodynamic Abnormalities
Vectorcardiographic Detection of Early Hemodynamic Abnormalities

... The rightward terminal QRS force was calculated by using a plastic grid to measure the percentage area in both the right posterior quadrant in the horizontal loop and in the right inferior quadrant in the frontal loop ( s h a d e d areas, Fig I B ) . The rightward terminal QRS force was defined as t ...
Current Status of Primary Prevention of Sudden Cardiac Death With
Current Status of Primary Prevention of Sudden Cardiac Death With

... of FAE was 16.1%, 8.9% and 1.9%, respectively; the use of prophylactic ICD among those with FAE, however, was only 44%, 9% and 6%, respectively. In the groups A and B combined, chronic atrial fibrillation (cAF) and left ventricular end-diastolic dimension (LVDd) ≥65 mm were independent predictors of ...
Seminars in Cardiothoracic and Vascular Anesthesia
Seminars in Cardiothoracic and Vascular Anesthesia

... challenge. Anesthesia is associated with depression of sympathetic activity, on which many patients with diminished cardiac reserve rely. In addition to this indirect effect, anesthetics interfere with cardiovascular performance, either by a direct myocardial depression or by modifying cardiovascula ...
Body height and arterial pressure in seated and supine young males
Body height and arterial pressure in seated and supine young males

... venous return and unload the carotid baroreceptors. It is, therefore, possible that the hydrostatic pressure gradient from the heart to the head in upright subjects is a determinant of arterial pressure at heart level. Tall individuals might, therefore, be endowed with a higher arterial pressure tha ...
Fluid Management Strategies in Heart Failure Cover Article
Fluid Management Strategies in Heart Failure Cover Article

... heart failure and cardiac resynchronization therapies are first-line strategies for managing hypervolemia because the interventions attenuate neurohormonal activation and prevent progression, or promote reversal, of left ventricular remodeling that can worsen congestion.1,28 Unless contraindicated, ...
Implantable Cardioverter Defibrillator (ICD)
Implantable Cardioverter Defibrillator (ICD)

... primary prevention of sudden cardiac death in patients with: A. Ischemic cardiomyopathy with New York Heart Association (NYHA) functional class II or class III symptoms with a history of myocardial infarction at least 40 days prior to implantation and left ventricular ejection fraction of 35% or les ...
Co-morbidities in Patients with Heart Failure: An Analysis of the
Co-morbidities in Patients with Heart Failure: An Analysis of the

Acute Heart Failure Syndromes in Patients With Coronary Artery
Acute Heart Failure Syndromes in Patients With Coronary Artery

... presenting with AHFS have coronary artery disease (CAD). These patients may present in 1 of 2 ways: acute coronary syndromes (ACS) complicated by HF or AHFS with underlying CAD. The role of CAD in AHFS has not been well studied in clinical trials. Therapies that have shown to significantly improve m ...
prognostic value of serum uric acid level in patients with acute
prognostic value of serum uric acid level in patients with acute

... Elevated SUA is also associated with hypertension and renal disease. It is present in >75% of patients with malignant hypertension (24,25). This elevation in these settings may be the result of decreased renal blood flow and resultant increased urate reabsorption, although this relationship is not c ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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