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The Meaning of Central Venous Pressure (CVP) relative to Fluid
The Meaning of Central Venous Pressure (CVP) relative to Fluid

... valve of the heart by the Venous Stressed Volume. Preload is not motivated unilaterally by the Blood Volume, but by the combination of Venous Elastance and Venous Blood Volume which is regulating Figure  2   ...
CARDIOVASCULAR SYSTEM
CARDIOVASCULAR SYSTEM

...  Most murmurs diminish with standing due to reduced preload. However, the murmur of HCM becomes louder, and the murmur of MVP lengthens and often is intensified. Similarly, most murmurs become louder with prompt squatting (or usually passive leg raising), while the murmurs of HCM and MVP typically ...
Making the "Case": Challenging Scenarios in Mental Health
Making the "Case": Challenging Scenarios in Mental Health

... • Doses above 40 mg not recommended • Doses above 20 mg not recommended in patients • >60 years of age • Hepatic impairment • Poor CYP2C19 metabolizers or concomitant potent CYP2C19 inhibitors ...
ACS .CHF. PE - Medical Groupf2
ACS .CHF. PE - Medical Groupf2

... • Advancing age ...
The Cardiovascular System
The Cardiovascular System

... walls of ventricles. • R ventricle pumps blood through pulmonary artery to lungs. • Pulmonary valve leads into artery. ...
pharm 23 [4-20
pharm 23 [4-20

... 10. What extra activity do type IA antiarrhythmics have? What are the three drugs?  K+ blocking in ventricles => slow repolarization and longer plateau  Quinidine, procainamide, and disopyramide [QUeeN DISO’s PYRAMID of coCAINe] 11. What is special about quinidine, or rather, especially bad (4 thi ...
Managing Atrial Fibrillation in Primary care
Managing Atrial Fibrillation in Primary care

... Different types of AF. The arrhythmia tends to progress from paroxysmal (self-terminating, usually <48 hours) to persistent (non-self-terminating or requiring cardioversion), long-standing persistent (lasting longer than 1 year) and eventually to permanent (accepted) AF. First-onset AF may be the fi ...
Toward Better Treatment for Heart Failurewith Preserved Ejection
Toward Better Treatment for Heart Failurewith Preserved Ejection

... to secondary HFpEF is vital, Sharma says. A handful of patients, for example, have cardiac amyloidosis, which can often manifest as HFpEF. On the flip side, nephrologists and pulmonologists refer many patients who initially present with kidney disease or pulmonary hypertension, all of which makes in ...
Lecture 15 CVregulation
Lecture 15 CVregulation

...  Excitatory interneurons onto the cardioinhibitory area: increased mean arterial pressure  baroreceptors  NTS neurons stimulate the cardioinhibitory area  bradycardia  Inhibitory interneurons onto the cardioacceleratory area: increased mean arterial pressure  baroreceptors  NTS neurons inhibi ...
Circulatory System
Circulatory System

Early Diagnosis, Prompt Treatment - ScholarlyCommons
Early Diagnosis, Prompt Treatment - ScholarlyCommons

... For use as chronic therapy, each of these three agents is supported by either extensive clinical anectodal experience (furosemide) or clinical trial data (pimobendan5 and ACE inhibitor6,7). In addition, 2010 data supported use of spironolactone in dogs with heart failure due to MVD, finding improved ...
PAthoPhySIology of hEARt fAIluRE - The Association of Physicians
PAthoPhySIology of hEARt fAIluRE - The Association of Physicians

... decrease of venous pressures (preload) with diuretics to relieve the symptoms and improve the exercise capacity. How much diuretic to give? The therapeutic goal is to give diuretics to improve the exercise capacity to maximal. If compensatory mechanisms fail to raise venous pressures adequately, suc ...
Chapter 6 Cerebrovascular Disease and Stroke
Chapter 6 Cerebrovascular Disease and Stroke

CH 22: The Cardiovascular System: Vessels & Circulation
CH 22: The Cardiovascular System: Vessels & Circulation

... and spleen Superior mesenteric– to pancreas and duodenum, small intestine and colon Paired suprarenal - to adrenal glands Paired renal – to kidneys Paired gonadal – to testes or ...
Travel Brochure of the Body Systems
Travel Brochure of the Body Systems

... 5 sections will cover the information listed below, and the cover will be the remaining section. The key feature is to give an overall sense of the organization and function of each aspect of this system. You may use drawings, computer graphics, and photographs of actual organs, pictures from magazi ...
Circulatory System
Circulatory System

... With the nervous system: – Sensory neurons at several places in the body detect blood pressure and send impulses to brain stem (medulla oblongata) – When too high, the autonomic nervous system releases neurotransmitters that cause the smooth muscles around blood vessels to relax, lowering blood pres ...
Eisenmenger Syndrome and Pregnancy
Eisenmenger Syndrome and Pregnancy

... pregnancy. In addition, a fixed pulmonary vascular resistance with a resulting inability to increase pulmonary blood flow may not accommodate an increase in cardiac output. Similarly, large fluctuations in blood volume both pre and post partum may not be tolerated by an already compromised cardiovas ...
Treatment of heart failure with preserved Karen Hogg, John J.V. McMurray*
Treatment of heart failure with preserved Karen Hogg, John J.V. McMurray*

... The importance of heart failure with preserved systolic function (HF-PSF) has been increasingly recognised during the last decade. However, until recently there were no large, randomised, controlled clinical outcome trials in patients with this condition. Indeed, the best evidence of symptom improve ...
What is Congestive Heart Failure?
What is Congestive Heart Failure?

... If you have congestive heart failure, you’re not alone. About 5.0 million Americans are living with it today. In fact, it’s one of the most common reasons people 65 and older go into the hospital. It can take years for heart failure to develop. So if you don’t yet have it but are at risk for it, you ...
Standard of Care for Heart Failure Management
Standard of Care for Heart Failure Management

... therapy. Placement of an ICD in any patient with EF between 30% and 35% is reasonable who are class II or III and on maximal medical therapy. Hydralazine/nitrate combination may be considered in patients who can not be given ACEI or ARBS. The addition of an ARB may be considered in persistently symp ...
differential diagnosis of coronary pains in chest. particularity of the
differential diagnosis of coronary pains in chest. particularity of the

... systolic and / or diastolic function of the heart. IBS is one of the most common diseases of the cardiovascular system in all developed countries. According to data from prospective studies, IBS affects approximately 5-8% of men aged 20 to 44 years and 18-24,5% - aged 45 to 69 years. The prevalence ...
differential diagnosis of coronary pains in chest. particularity of the
differential diagnosis of coronary pains in chest. particularity of the

... systolic and / or diastolic function of the heart. IBS is one of the most common diseases of the cardiovascular system in all developed countries. According to data from prospective studies, IBS affects approximately 5-8% of men aged 20 to 44 years and 18-24,5% - aged 45 to 69 years. The prevalence ...
What is Congestive Heart Failure?
What is Congestive Heart Failure?

... If you have congestive heart failure, you’re not alone. About 5.0 million Americans are living with it today. In fact, it’s one of the most common reasons people 65 and older go into the hospital. It can take years for heart failure to develop. So if you don’t yet have it but are at risk for it, you ...
End-systolic pressure-volume relation and ventricular
End-systolic pressure-volume relation and ventricular

... difficult or impossible to obtain with resting echo ...
11_Skarvan_The aging heart: what can echocardiography tells us
11_Skarvan_The aging heart: what can echocardiography tells us

... concentric remodeling, increased LV intraventricular velocities may be found in systole by CW Doppler. The presence of mild tricuspid and pulmonic valve regurgitation allows the estimation of the systolic and diastolic pulmonary artery pressures that should be normal. The calculation of the stroke v ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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