Brugada Syndrome - Department of Medicine | Columbia University
... Fig 3. Examples of 2 different mutations in SCN5A leading to a loss of function of the sodium (Na) channel. A, Mutation I1660V, producing a trafficking defect of the Na channel, and thus a decrease of Na channels present in the sarcolemma. Mutant and WT Na channels have been expressed in TSA201 cell ...
... Fig 3. Examples of 2 different mutations in SCN5A leading to a loss of function of the sodium (Na) channel. A, Mutation I1660V, producing a trafficking defect of the Na channel, and thus a decrease of Na channels present in the sarcolemma. Mutant and WT Na channels have been expressed in TSA201 cell ...
Congenital abnormalities of aortic artery. Assessment in neonates
... Fig. 5. a) Female patient, with 5 days of life. Respiratory distress. Cardiogenic shock. Aortic interruption type B. 3D reconstruction. There is a dissociation between ascending and descending aorta, which has a continuity with the trunk of pulmonary artery. The interruption is between carotid arter ...
... Fig. 5. a) Female patient, with 5 days of life. Respiratory distress. Cardiogenic shock. Aortic interruption type B. 3D reconstruction. There is a dissociation between ascending and descending aorta, which has a continuity with the trunk of pulmonary artery. The interruption is between carotid arter ...
Part II: Chapter 8
... and macrovascular complications. The arterial vessel wall reveals structural changes in patients with DM which results in stiffening of the arterial vasculature, including the aortic wall.1 This stiffening occurs early in the diseases process in Type 1 DM (DM1) and is even evident at a young age.2 I ...
... and macrovascular complications. The arterial vessel wall reveals structural changes in patients with DM which results in stiffening of the arterial vasculature, including the aortic wall.1 This stiffening occurs early in the diseases process in Type 1 DM (DM1) and is even evident at a young age.2 I ...
Echogenic Intracardiac Focus: A Sonographic Sign for
... on this finite group of patients. Although we are unable to comment on the true meaning of an echogenic intracardiac focus in a low-risk population, we can extrapolate from our data as follows: The positive predictive value of an echogenic intracardiac focus for the detection of Down syndrome in a f ...
... on this finite group of patients. Although we are unable to comment on the true meaning of an echogenic intracardiac focus in a low-risk population, we can extrapolate from our data as follows: The positive predictive value of an echogenic intracardiac focus for the detection of Down syndrome in a f ...
Cardiovascular magnetic resonance assessment of the aortic valve
... Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany Full list of author information is available at the end of the article ...
... Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany Full list of author information is available at the end of the article ...
case report - Maja Guldborg
... litters of small size, only one puppy in the litter is affected, and that puppy is usually overweight. Lots of breeders and veterinarians have made the observation that the affected puppy is nursing with the head to the same side most of the time. The puppy remains in sternal recumbency. It is unabl ...
... litters of small size, only one puppy in the litter is affected, and that puppy is usually overweight. Lots of breeders and veterinarians have made the observation that the affected puppy is nursing with the head to the same side most of the time. The puppy remains in sternal recumbency. It is unabl ...
Asymptomatic Aortic Stenosis-Prognosis, Risk Stratification and
... Asymptomatic Aortic Stenosis - Prognosis, Risk Stratification and Follow-Up Paoli Ursula and Dichtl Wolfgang ...
... Asymptomatic Aortic Stenosis - Prognosis, Risk Stratification and Follow-Up Paoli Ursula and Dichtl Wolfgang ...
Atsuyoshi Takao
... laboratory for molecular biology were to investigate the aetiology of conotruncal anomaly face syndrome. Be that as it may, in the mid 1970s, Dr. Takao wanted to evaluate the characteristics of the face and fingerprints of this syndrome. Akiko Kinouchi measured the length of various parts of the fa ...
... laboratory for molecular biology were to investigate the aetiology of conotruncal anomaly face syndrome. Be that as it may, in the mid 1970s, Dr. Takao wanted to evaluate the characteristics of the face and fingerprints of this syndrome. Akiko Kinouchi measured the length of various parts of the fa ...
Point of View Maladies Attributed to Myxomatous Mitral
... absence of severe mitral regurgitation and left ventricular dysfunction, the risk of sudden death in young people without ventricular dysrhythmias, syncope, or presyncope is so remote that patients should not be told of the possibility. Mitral Valve Prolapse Syndrome a When diagnosis of MVP is made ...
... absence of severe mitral regurgitation and left ventricular dysfunction, the risk of sudden death in young people without ventricular dysrhythmias, syncope, or presyncope is so remote that patients should not be told of the possibility. Mitral Valve Prolapse Syndrome a When diagnosis of MVP is made ...
Straight Back Syndrome - bangkokmedjournal.com
... Resonance Imaging (MRI) may be used as optional techniques. Other investigations such as electrocardiography, echocardiography may be used as supporting tools for SBS assessment. The manifestation of twelve lead ECG in cases of SBS is usually in a normal pattern or ...
... Resonance Imaging (MRI) may be used as optional techniques. Other investigations such as electrocardiography, echocardiography may be used as supporting tools for SBS assessment. The manifestation of twelve lead ECG in cases of SBS is usually in a normal pattern or ...
TRANSCATHETER AORTIC VALVE IMPLANTATION: REVIEW AND
... Since the introduction of transcatheter aortic valve implantation (TAVI) 12 years ago, the treatment options for severe, symptomatic aortic valve stenosis in high-risk patients have significantly increased. Because of the growing implementation of TAVI in clinical practice, knowledge of the outstand ...
... Since the introduction of transcatheter aortic valve implantation (TAVI) 12 years ago, the treatment options for severe, symptomatic aortic valve stenosis in high-risk patients have significantly increased. Because of the growing implementation of TAVI in clinical practice, knowledge of the outstand ...
Management of Paradoxical Low-Flow, Low
... is of prognostic importance as a marker for reduced cardiac pump function and worse outcomes, whereas gradient is of diagnostic importance because a LG with a small AVA raises uncertainty about stenosis severity, and thus, about the indication for AVR. Consequently, several studies (8,15) and guidel ...
... is of prognostic importance as a marker for reduced cardiac pump function and worse outcomes, whereas gradient is of diagnostic importance because a LG with a small AVA raises uncertainty about stenosis severity, and thus, about the indication for AVR. Consequently, several studies (8,15) and guidel ...
Translating Novel Imaging Technologies Into Clinical Applications
... that we can develop novel biomarkers and therapeutic targets for this common condition. There is considerable interest in novel imaging techniques that can provide key insights into the pathogenesis of aortic ...
... that we can develop novel biomarkers and therapeutic targets for this common condition. There is considerable interest in novel imaging techniques that can provide key insights into the pathogenesis of aortic ...
Transcatheter Aortic Valve Replacement With Early
... study was supported by a grant from the CardioVascular Research Foundation, Seoul, Republic of Korea. The Department of Cardiology at the Leiden University Medical Center received research grants from Edwards Lifesciences, Biotronik, Medtronic, and Boston Scientific. Drs. Lefèvre, Tay, and Yong have ...
... study was supported by a grant from the CardioVascular Research Foundation, Seoul, Republic of Korea. The Department of Cardiology at the Leiden University Medical Center received research grants from Edwards Lifesciences, Biotronik, Medtronic, and Boston Scientific. Drs. Lefèvre, Tay, and Yong have ...
Ichthyosis follicularis, alopecia and photophobia syndrome (IFAP):
... possible X-linked mode of inheritance. The patient presented with ocular findings of photophobia, corneal scarring and erosions, superficial and deep corneal vascularization and myopia. He was treated with artificial tears and punctal occlusion with small improvement of photophobia. After three mont ...
... possible X-linked mode of inheritance. The patient presented with ocular findings of photophobia, corneal scarring and erosions, superficial and deep corneal vascularization and myopia. He was treated with artificial tears and punctal occlusion with small improvement of photophobia. After three mont ...
Fig. 11 - JACC: Cardiovascular Imaging
... TAVR ⴝ transcatheter aortic valve replacement TEE ⴝ transesophageal echocardiography ...
... TAVR ⴝ transcatheter aortic valve replacement TEE ⴝ transesophageal echocardiography ...
Degenerative changes in cornea
... The role of inheritance are not clear,offsprings are affected in about 10% of the cases AS. Transmission are proposed Association Systemic disorder,: down ,ehler danlos,marfan syndroms,osteogenesis imperfecta and mitral valve prolapse Ocular association: vernal keratocongectivitis,aniridia,ectopia l ...
... The role of inheritance are not clear,offsprings are affected in about 10% of the cases AS. Transmission are proposed Association Systemic disorder,: down ,ehler danlos,marfan syndroms,osteogenesis imperfecta and mitral valve prolapse Ocular association: vernal keratocongectivitis,aniridia,ectopia l ...
Imaging for Transcatheter Aortic Valve Replacement
... area (AVA) <1.0 cm2 (or <0.6 cm2/m2 body surface area), mean aortic valve pressure gradient >40 mm Hg, or an aortic jet velocity >4 m/s [2]. Two-dimensional transthoracic echocardiography (TTE) is the standard for diagnosis and severity assessment through Doppler quantification of maximum jet veloci ...
... area (AVA) <1.0 cm2 (or <0.6 cm2/m2 body surface area), mean aortic valve pressure gradient >40 mm Hg, or an aortic jet velocity >4 m/s [2]. Two-dimensional transthoracic echocardiography (TTE) is the standard for diagnosis and severity assessment through Doppler quantification of maximum jet veloci ...
Aortic Stenosis: Diagnosis and Treatment
... Aortic stenosis is the most important cardiac valve disease in developed countries, affecting 3 percent of persons older than 65 years. Although the survival rate in asymptomatic patients with aortic stenosis is comparable to that in age- and sex-matched control patients, the average overall surviva ...
... Aortic stenosis is the most important cardiac valve disease in developed countries, affecting 3 percent of persons older than 65 years. Although the survival rate in asymptomatic patients with aortic stenosis is comparable to that in age- and sex-matched control patients, the average overall surviva ...
Heart Sounds
... the pulmonic valve. The right ventricle has increased filling as blood is shunted from the left atrium to the right atrium and finally into the right ventricle. There is fixed splitting of S2 because of continued delay in the closure of the pulmonic valve. ...
... the pulmonic valve. The right ventricle has increased filling as blood is shunted from the left atrium to the right atrium and finally into the right ventricle. There is fixed splitting of S2 because of continued delay in the closure of the pulmonic valve. ...
Arterial Stiffness in the Young: Assessment
... inhibition102) appear to reduce aortic stiffness, which may, in turn, slow aortic dilation and delay aortic root replacement.102) Despite a biological basis for abnormal elastic fibres, results of studies exploring arterial elastic properties in patients with Williams syndrome are controversial.103- ...
... inhibition102) appear to reduce aortic stiffness, which may, in turn, slow aortic dilation and delay aortic root replacement.102) Despite a biological basis for abnormal elastic fibres, results of studies exploring arterial elastic properties in patients with Williams syndrome are controversial.103- ...
Instantaneous pressure gradient across the aortic valve
... Aortic stenosis is the most frequent valvular heart disease. The mean systolic value of the transvalvular pressure gradient (TPG) is commonly utilized during clinical examination to evaluate its severity and it can be determined either by cardiac catheterization or by Doppler echocardiography. TPG i ...
... Aortic stenosis is the most frequent valvular heart disease. The mean systolic value of the transvalvular pressure gradient (TPG) is commonly utilized during clinical examination to evaluate its severity and it can be determined either by cardiac catheterization or by Doppler echocardiography. TPG i ...
echocardiography in cardiac surgery
... TEE is useful for the evaluation of patients with limiting body habitus, such as obesity or emphysema, who are not optimally imaged by the transthoracic approach. In addition, certain structures that are not well visualized by transtracheal echo (TTE) [such as the left atrial (LA) appendage, thoraci ...
... TEE is useful for the evaluation of patients with limiting body habitus, such as obesity or emphysema, who are not optimally imaged by the transthoracic approach. In addition, certain structures that are not well visualized by transtracheal echo (TTE) [such as the left atrial (LA) appendage, thoraci ...
Prospective and Retrospective ECG Gating for Thoracic CT
... Fig. 1—Diagrams show injection/acquisition technique retrospective and prospective gating for thoracic CT angiography. Cephalocaudad coverage is 25 cm. A, Schematic diagram illustrates injection acquisition technique for thoracic CT angiography using retrospective gating. Time in seconds is indicate ...
... Fig. 1—Diagrams show injection/acquisition technique retrospective and prospective gating for thoracic CT angiography. Cephalocaudad coverage is 25 cm. A, Schematic diagram illustrates injection acquisition technique for thoracic CT angiography using retrospective gating. Time in seconds is indicate ...
Marfan syndrome
Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed. The syndrome also may affect the lungs, eyes, dural sac surrounding the spinal cord, the skeleton, and the hard palate. People with Marfan syndrome tend to be unusually tall, with long limbs and long, thin fingers and toes.The syndrome is caused by the misfolding of fibrillin-1, a glycoprotein which forms elastic fibers in connective tissue and contributes to cell signaling activity by binding to and sequestering transforming growth factor beta (TGF-β). The mutated fibrillin binds poorly to TGF-β, which results in an accumulation of excess TGF-β in the lungs, heart valves, and aorta. This in turn causes abnormal structure and function of vascular smooth muscle and reduced integrity of the extracellular matrix, which weaken the tissues and cause the features of Marfan syndrome.Named after Antoine Marfan, the French pediatrician who first described the condition in 1896, the disease is an autosomal dominant disorder. Management often includes the use of angiotensin II receptor antagonists (ARBs) and beta blockers.