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A Large Pseudoautosomal Region on the Sex Chromosomes of the
A Large Pseudoautosomal Region on the Sex Chromosomes of the

... sex chromosome divergence resulting from suppressed recombination and involves the loss of coding regions, the accumulation of repetitive regions, and structural changes such as insertions, deletions, and inversions on the sex-specific chromosome (the Y or W). Thus, degenerate sex chromosomes have d ...
interPopula: a Python API to access the HapMap Project dataset
interPopula: a Python API to access the HapMap Project dataset

... The HapMap project [1] (http://hapmap.ncbi.nlm.nih. gov/) is an effort to identify and catalogue genetic similarities and differences in humans. The project makes information available on single nucleotide polymorphisms (SNPs), and it more recently added information on copy number variation (CNV). H ...
Slides
Slides

...  cURL module for integration of 3rd Party tools into a Drupal site.  Under development at Washington State University  Will allow seamless integration with other GMOD tools into the site (e.g. Gbrowse, CMAP) ...
Physical mapping shows that the unstable oxytetracycline gene
Physical mapping shows that the unstable oxytetracycline gene

... The agarose containing the 300 kb AseI-J band was excised from a gel. DNA was eluted, partially digested with MboI and used to construct a cosmid bank in sCos-1. Forty clones were obtained and were ordered by cross-hybridization. This yielded a contig in fragment AseI-J which was spanned by 9 cosmid ...
RECOMBINANT DNA TECHNOLOGY AND BIOTECHNOLOGY
RECOMBINANT DNA TECHNOLOGY AND BIOTECHNOLOGY

... addition to this particular methylase, individual bacterial strains also contain accompanying specific endonuclease activity. In late 1960s, Stewart Linn and Werner Arber isolated two types of enzymes responsible for this observed phage restriction phenomenon. Later on, in 1978, Smith, Nathans and ...
Evidence for autosomal recessive inheritance in SPG3A
Evidence for autosomal recessive inheritance in SPG3A

... Genomic DNA was extracted from peripheral blood. The ambiguous mode of inheritance and the genetic heterogeneity in HSP prompted us to perform whole-exome sequencing conducted on DNA from two affected individuals (III:3 and IV:2). DNA was sonicated (Covaris S2, Covaris, Inc., Woburn, MA, USA) and fr ...
Article The Landscape of Realized Homologous
Article The Landscape of Realized Homologous

... (Perez-Losada et al. 2006; Vos 2009), ranging from clonal species (Smith et al. 2006) to those that exchange 10% or more of their DNA within a single 4-year human infection (Cao et al. 2014). This variation presents specific challenges for effective comparison between species. We recently developed ...
Structure and functions of lampbrush chromosomes
Structure and functions of lampbrush chromosomes

... LBCs’ activity abates. Nevertheless, this is not associated with morphological changes. At that time of the year, each transcription unit contains approximately 10 RNP (ribonucleoproteinic) filaments, while in the summer, this number is twice as high, the change corresponding with morphological tran ...
PPT - Larry Smarr
PPT - Larry Smarr

... Led to Calit2 Discussions with Craig Venter Coastal Zone Data Assimilation Surface, Subsurface, and Ocean Floor Observatories Ocean Environmental Metagenomics ...
Chromatin Structure Is a Focus for Regulation 30.2
Chromatin Structure Is a Focus for Regulation 30.2

... nucleosomes that occurs in conjunction with activation of genes for transcription. ...
Agilent Whole Human Genome Oligo Microarray Kit
Agilent Whole Human Genome Oligo Microarray Kit

... Figures A & B depict Agilent’s proven process for ‘superclustering’ and choosing multiple probes within a GeneBin (gene and associated transcripts). In many cases, more than one consensus region will be selected for a given GeneBin. Figure A demonstrates the selection of consensus regions and probes ...
iGenetics: A Molecular Approach, 3e (Russell/Bose)
iGenetics: A Molecular Approach, 3e (Russell/Bose)

... Answer: To be a good genetic model, an organism has to have a well-known genetic history, a short life cycle, produce many offspring, be easy to handle, and have genetic variability among the individuals in a population. Skill: Factual recall 47) Why are genetic databases so important to the study o ...
Kreitman review on positive selection
Kreitman review on positive selection

... just a transient phase of molecular evolution” (57). Kimura did even more in this paper. He also deduced a major role for selection by showing that the rate of amino acid substitution in hemoglobin was far lower than that predicted from reasonable estimates of the nucleotide mutation rate. He argued ...
genetics - Gene In The Title
genetics - Gene In The Title

... At least in some cases, condition may not be mental or emotional http://www.msnbc.msn.com/id/35336470/ns/healthmore_health_news/ # there have been some ‘stutter’ stories in the past few weeks – here is another . . . from an unexpected source --- ...
Supplemental File S3. Homologous Chromosomes
Supplemental File S3. Homologous Chromosomes

PDF - The Journal of General Physiology
PDF - The Journal of General Physiology

... size extended from 7.4 to 15.4 rays per star. The average of these determinations for the average number of p~2 atoms per phage particle, No, is 127 4- 10. This number combined with the constant a/Vo found from the inactivation by suicide, gives a value for the efficiency of killing, a, of 0.11 4- 0 ...
Comparison of three molecular methods for typing Aeromonas
Comparison of three molecular methods for typing Aeromonas

... was simpler, cheaper, and quicker to perform, and consequently more suitable for epidemiological studies (Talon et al. 1998). Recently, restriction fragment length polymorphism (RFLP) of the 16S-23S intergenic spacer region (ISR) has been used success´ fully for typing Aeromonas veronii strains (Mar ...
Advances in maize genomics: the emergence of positional cloning
Advances in maize genomics: the emergence of positional cloning

... that a 0.1 cM distance is contained on 1–2 BACs. If no BAC or BAC contig is available for a particular marker, or if one wishes to assemble a contig, a BAC library needs to be screened. The most widely used BAC library, ZMMBBb, consists of 247 680 clones, with an average insert size of 137 kb, that ...
A novel mutation of the Keratin 12 gene responsible for a severe
A novel mutation of the Keratin 12 gene responsible for a severe

... form of Meesmann’s corneal dystrophy. Methods: A family with clinically identified Meesmann’s corneal dystrophy was recruited and studied. Electron microscopy was performed on scrapings of corneal epithelial cells from the proband. Mutations in the KRT12 gene were sought using direct genomic sequenc ...
Transgenic Plastids in Basic Research and Plant Biotechnology
Transgenic Plastids in Basic Research and Plant Biotechnology

... to effective inhibition of plastid protein biosynthesis by spectinomycin (an aminoglycoside antibiotic speci®cally blocking translation on prokaryotic-type 70 S ribosomes). A successfully transformed chloroplast expresses the spectinomycin-resistance gene, aadA, thus allowing for continued cell and ...
Final Exam Review Part B - Hudson City School District
Final Exam Review Part B - Hudson City School District

... • B. same structures, different functions, same origins • C. different structures, same functions, same origins • D. different structures, same functions, different origins • ANSWER: B ...
Methods for detection of point mutations
Methods for detection of point mutations

... for screening purposes, relatively few systematic studies on the fraction of mutations detectable have been published. The detection of mutations is mainly dependent on the position of the mismatch within the DNA fragment and the type of mismatch. White et al. [27] described the detection of eight o ...
Printable version - Chromosome 18 Registry and Research Society
Printable version - Chromosome 18 Registry and Research Society

... also determines if any bands are missing, added or rearranged. However, in each one of these chromosomes there are hundreds of genes. There are over 300 genes on chromosome 18. So what would appear to be a small change in the karyotype could ...
Lesson Overview - Dr. Thornton`s Courses
Lesson Overview - Dr. Thornton`s Courses

... With cell membranes unable to transport chloride ions, tissues throughout the body malfunction. Children with CF have serious digestive problems and produce thick, heavy mucus that clogs their lungs and breathing passageways. ...
Analysis of Protein Geometry, Particularly Related to Packing at the
Analysis of Protein Geometry, Particularly Related to Packing at the

... terms of overlap? ...
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Genomics

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism). Advances in genomics have triggered a revolution in discovery-based research to understand even the most complex biological systems such as the brain. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.
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