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Leading The Way in Genetic Fertility Screening
Leading The Way in Genetic Fertility Screening

... the internal characteristics and potential quality of the embryo (Perkel et al., 2015). If changes can be detected and compared, there exists substantial potential for the development of a minimally-invasive diagnostic tool, in which the spent culture media is analyzed. This concept is not novel, ho ...
Functional Genomics
Functional Genomics

... Several of the articles in this Insight discuss new technologies that are being developed to understand function on a genome-wide scale. Are these approaches conceptually different from what biologists have been doing for many years, or is it just the scale on which experiments can be done that is d ...
Antigenic diversity of Theileria major piroplasm surface protein gene
Antigenic diversity of Theileria major piroplasm surface protein gene

... isolates were type I, and the cattle exhibited severe symptoms [5]. In our study, type I was rare (6 of 35); most of the isolates were types C (20 of 35) and B (17 of 35), and all cattle were normal clinically and on hematological examination. In this study, we used PCR-RLFP to subclassify type B, a ...
Molecular cloning and evolutionary analysis of captive forest musk
Molecular cloning and evolutionary analysis of captive forest musk

... genes also form a multi-gene family and display high sequence similarity (Conte et al., 2002; Shi et al., 2003). Coding regions of T2Rs contain an average of 300 codons, and they are not interrupted by introns, rendering them easy to be detected in whole-genome sequences. Genomic analyses using comp ...
A SNP in the ABCC11 gene is the determinant of human earwax type
A SNP in the ABCC11 gene is the determinant of human earwax type

... 1Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. 2Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology, Kawaguchi, Japan. 3Department of Biological Sciences, Graduate School of Science, University of Tok ...
Adaptive evolution drives divergence of a hybrid inviability gene
Adaptive evolution drives divergence of a hybrid inviability gene

View Tutorial
View Tutorial

... aminoacylated. The enzyme protects the ester linkage between the tRNA and is cognate amino acid en route to the ribosome. The EF-Tu:tRNA complex then associates with the ribosome, allowing the anticodon region of the tRNA to associate with the codon of the mRNA in the A-site of the ribosome. If the ...
Ends-out, or replacement, gene targeting in Drosophila
Ends-out, or replacement, gene targeting in Drosophila

... joined the two ends. We also estimated the approximate proportion of donor with a DSB at each site. A cut at the left site will generate a 6.3-kb fragment; a cut at the right site will generate a 1.7-kb fragment. At the peak of cutting, about 4 h after heat shock, ⬇30% of the donor exhibited a DSB a ...
PubMed Advanced: Linking PubMed to NCBI Genetics Databases
PubMed Advanced: Linking PubMed to NCBI Genetics Databases

... Practice Opportunity Find all the sequences that these articles are linked to in RefSeq Find sequences that one particular article links to ...
PDF - American Society of Mammalogists
PDF - American Society of Mammalogists

... exceptions (e.g., the XY females of the transcaucasian mole vole [Ellobius lutescens]), most Y-linked genes will affect only males and be passed only to other males (Just et al. 2002). The parental effects on mammalian X chromosomes are more subtle. The best known are those in which recessive X-link ...
Ribosomal RNA Secondary Structure
Ribosomal RNA Secondary Structure

... composite of Drosophila melanogaster (Insecta) and Lampetra aepyptera (Petromyzontiformes) sequences as an outgroup. Their DNA sequences were aligned against the Mus sequence by the alignment subroutines of Pustell and Kafatos ( 1986), with adjustments made manually to increase similarity. Nucleotid ...
METADOMAIN: A PROFILE HMM-BASED PROTEIN DOMAIN
METADOMAIN: A PROFILE HMM-BASED PROTEIN DOMAIN

... the position distribution of read alignments. The position distribution of read alignments on a truly encoded domain is expected to be more uniform than a domain that incurs random read alignments.15,16 Figure 3 shows the schematic representations of three types of distributions of read alignments a ...
Supporting Information Parfenov et al. 10.1073/pnas.1416074111
Supporting Information Parfenov et al. 10.1073/pnas.1416074111

... S5). For graphical representation of exon expression levels, we mean-centered the RPKM values and divided by their SD for each exon. The lengths of the composite exons were transformed using the square root of the length. DNA Methylation and mRNA Expression Analysis. The Infinium HM450k array was us ...
Somatic MEN1 gene mutation does not contribute
Somatic MEN1 gene mutation does not contribute

... with LOH for MEN1 in a sample of 39 sporadic tumours (9). Prezant et al. using dideoxy fingerprinting analysis (which is more sensitive) studied 45 sporadic tumours but failed to reveal any mutations in the coding sequence of MEN1 (10). Recently, in a sample of 31 sporadic tumours, Tanaka et al. det ...
Practice exam
Practice exam

Mapping the histone code at hMLH1. - JScholarship
Mapping the histone code at hMLH1. - JScholarship

... al., 2001; Noma et al., 2001; Peters et al., 2002). The existence of these histone modifications has been known for many years, but for some of these modifications, their functional significance is just being discovered. The idea that combinations of modifications on the histone tails can determine ...
Variations on a theme: Genomics of sex
Variations on a theme: Genomics of sex

... XX-XY sex-determining system, sequences present on the Y but absent from the X chromosome should have sequence coverage only in males, whereas sequences in an X-limited region should be twice as frequent in XX females compared to XY males. In contrast, sequences in pseudo-autosomal regions (PARs), s ...
$doc.title

... for  SimpleStrand,   should   be  O(1)  rather   than  O(S)for   a   splicee   strand   with   S   characters/base-­‐pairs.   In   your   new   implementation,   the   complexity   ofcreating  the   recombinant   strand   will   be  O(B)  where ...
D. melanogaster - GEP Community Server
D. melanogaster - GEP Community Server

Conservation and Variation in Human and Common Chimpanzee
Conservation and Variation in Human and Common Chimpanzee

... The presence of CD94 and NKG2 genes was typed by PCR amplification of genomic DNA isolated from a panel of higher primates using genespecific oligonucleotide primers. Because these amplification primers were based on human and chimpanzee sequences, negative results in other species should not be int ...
PowerPoint Presentation - No Slide Title
PowerPoint Presentation - No Slide Title

... Sanguinetti, 2012 ...
Chromosomal breakpoint positions suggest a direct role for radiation
Chromosomal breakpoint positions suggest a direct role for radiation

... was not always linear, leading to a model of chromatin arrangement in ¯exible loops of several Mbp arranged along the chromosomal backbone (Yokota et al., 1995). Thus, although two chromosomal loci are located at a considerable linear distance from each other (such as the ELE1 and RET genes), they m ...
Slide 1
Slide 1

... Use either this parameter or blastResult_url parameter as input but not both together. blastResult_url: url of the blast result. .[BLAST_report]. oldRefFile_direct_data: old blast result file..[BLAST_report]. Use either this parameter or oldblastResult_url as input but not both together. oldRefFile_ ...
RAPD markers for identifying oil palm (Elaeis guineensis Jacq
RAPD markers for identifying oil palm (Elaeis guineensis Jacq

... Random amplification of polymorphic DNA (RAPD) analysis was done by arbitrary primers for determining the DNA polymorphism among the oil palm (Elaeis guineensis) varieties dura, pisifera and tenera, and monitoring the specificity of the primers for identifying each genotype. The three varieties were ...
The eukaryotic genome: a system regulated at different hierarchical
The eukaryotic genome: a system regulated at different hierarchical

... The genome sequences of an increasing number of organisms are now known. Within the draft sequence of the human genome (McPherson et al., 2001; Venter et al., 2001), most protein-coding genes and a limited number of RNA genes have been identified: together close to 35,000 genes. This number will inc ...
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Genomics

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism). Advances in genomics have triggered a revolution in discovery-based research to understand even the most complex biological systems such as the brain. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.
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