innovative development strategies and applications for bispecific
... the bispecific antibody can block two signaling pathways involved in cancer cell proliferation and the inflammatory response. This multi-targeted approach is highly effective in destroying tumor cells. Bispecific antibodies can also be engineered to guide immune effector cells such as Natural Killer ...
... the bispecific antibody can block two signaling pathways involved in cancer cell proliferation and the inflammatory response. This multi-targeted approach is highly effective in destroying tumor cells. Bispecific antibodies can also be engineered to guide immune effector cells such as Natural Killer ...
M261 MHC class I antigen presentation April 17, 2000
... Proteolysis for MHC class II antigen presentation occurs in endocytic vesicles by proteases that are active at low pH. Cysteine proteases such as the cathepsins degrade proteins into short peptides for MHC class II presentation. Invariant chain is also degraded by cathepsins into CLIP. ...
... Proteolysis for MHC class II antigen presentation occurs in endocytic vesicles by proteases that are active at low pH. Cysteine proteases such as the cathepsins degrade proteins into short peptides for MHC class II presentation. Invariant chain is also degraded by cathepsins into CLIP. ...
Introduction to Immunoassays
... • Immunoassays are tests that use antibody and antigen complexes (also called immunocomplexes) to measure the presence of a specific analyte in a sample. • Antibodies are proteins that are normally produced by the immune system in response to a foreign substance. • Antigens are the molecules that an ...
... • Immunoassays are tests that use antibody and antigen complexes (also called immunocomplexes) to measure the presence of a specific analyte in a sample. • Antibodies are proteins that are normally produced by the immune system in response to a foreign substance. • Antigens are the molecules that an ...
Review IL-23 and IL-27
... IFN-γ or IL-4, provided the first evidence of a unique role for IL-23 in the regulation of a T cell effector function (14, 15). This discovery suggested that there is indeed an additional T cell subset that has unique functions, and it led to geneexpression studies that revealed that the IL23-depende ...
... IFN-γ or IL-4, provided the first evidence of a unique role for IL-23 in the regulation of a T cell effector function (14, 15). This discovery suggested that there is indeed an additional T cell subset that has unique functions, and it led to geneexpression studies that revealed that the IL23-depende ...
Complex splicing in the human T-cell leukemia virus (HTLV) family
... cytoplasmic inactive NFAT (Nuclear factor of activated T-cells) which migrates within the nucleus to induce IL-2 gene expression. (3) Furthermore, within the ER, p12 interacts with the heavy α chain of MHC-I molecules preventing its association with the β2 microglobulin (β2 m) and leads to its degra ...
... cytoplasmic inactive NFAT (Nuclear factor of activated T-cells) which migrates within the nucleus to induce IL-2 gene expression. (3) Furthermore, within the ER, p12 interacts with the heavy α chain of MHC-I molecules preventing its association with the β2 microglobulin (β2 m) and leads to its degra ...
Document
... Response: was corrected to: development Whereas, there were no hairy roots formed from control explants. When cotyledon explants were also infected and co-cultured with Agrobacterium, no hairy roots induced on these explants. Response: the statement was changed to: , whereas no adventitious roots fo ...
... Response: was corrected to: development Whereas, there were no hairy roots formed from control explants. When cotyledon explants were also infected and co-cultured with Agrobacterium, no hairy roots induced on these explants. Response: the statement was changed to: , whereas no adventitious roots fo ...
Answer
... A. only through a lipid bilayer membrane B. from an area of low concentration to an area of high concentration C. only in liquids D. from an area of high concentration to an area of low concentration ...
... A. only through a lipid bilayer membrane B. from an area of low concentration to an area of high concentration C. only in liquids D. from an area of high concentration to an area of low concentration ...
Thesis of Rownok_12376001
... Amena Akhter, Md. Shahidul Islam, Md. Arifur Rahman, Mrs. Rehana and other members of the immunology Laboratory who have contributed in various ways during this work. Getting through my dissertation required more than academic support, and I have many, many people to thank for listening to and, at t ...
... Amena Akhter, Md. Shahidul Islam, Md. Arifur Rahman, Mrs. Rehana and other members of the immunology Laboratory who have contributed in various ways during this work. Getting through my dissertation required more than academic support, and I have many, many people to thank for listening to and, at t ...
Lecture 35 Transgenic animals
... The impact of transgenesis is emphasized by the huge number of research groups and corporations that utilized the transgenic technology to study important fields of embryonic and adult physiology. The transgenic technology also became an excellent tool in basic research for understanding the functio ...
... The impact of transgenesis is emphasized by the huge number of research groups and corporations that utilized the transgenic technology to study important fields of embryonic and adult physiology. The transgenic technology also became an excellent tool in basic research for understanding the functio ...
Synapsis-Mediated Fusion of Free DNA Ends Forms Inverted Dimer Plasmids in Yeast.
... The presence of carrier DNA results in a new population of transformants, most of which harbor a circular inverted (head-to-head) dimer of the original linearized plasmid. The role of fragmented carrier DNA in forming these products is not clear. It could be to induce an additionalDNA repair pathway ...
... The presence of carrier DNA results in a new population of transformants, most of which harbor a circular inverted (head-to-head) dimer of the original linearized plasmid. The role of fragmented carrier DNA in forming these products is not clear. It could be to induce an additionalDNA repair pathway ...
20Sexual Reproduction, Meiosis, and Genetic Recombination
... Organisms vary greatly in the relative prominence of the haploid and diploid phases of their life cycles, as shown for some representative groups in Figure 20-4. Some fungi are examples of sexually reproducing organisms whose life cycles are primarily haploid but include a brief diploid phase that b ...
... Organisms vary greatly in the relative prominence of the haploid and diploid phases of their life cycles, as shown for some representative groups in Figure 20-4. Some fungi are examples of sexually reproducing organisms whose life cycles are primarily haploid but include a brief diploid phase that b ...
RECEPTOR TYROSINE KINASES AND THE REGULATION OF
... differentiation under polarizing conditions in vitro (Wilson and Correll, submitted). In vivo, STK-deficient mice exhibit increased inflammation in a Th1-mediated delayed-type hypersensitivity (DTH) response[31, 33]. Furthermore, macrophages and dendritic cells from triple-mutant mice for the RTKs T ...
... differentiation under polarizing conditions in vitro (Wilson and Correll, submitted). In vivo, STK-deficient mice exhibit increased inflammation in a Th1-mediated delayed-type hypersensitivity (DTH) response[31, 33]. Furthermore, macrophages and dendritic cells from triple-mutant mice for the RTKs T ...
Identification and characterization of the Plasmodium vivax
... analysis of the P. falciparum proteome [9,10] have promoted studies aimed at identifying proteins involved in parasite invasion to host cells, such as proteins of the secretory apical organelles and surface proteins of bloodstage parasites. Based on this large body of available data, recent research ...
... analysis of the P. falciparum proteome [9,10] have promoted studies aimed at identifying proteins involved in parasite invasion to host cells, such as proteins of the secretory apical organelles and surface proteins of bloodstage parasites. Based on this large body of available data, recent research ...
Tissue Engineering for In Vitro Analysis of Matrix Metalloproteinases
... Effect of Decorin on Keloid Fibroblasts in the Matrigel ModelLetters indicate statistical significance from HS27 at corresponding time point (P < .01b); plus signs, statistical significance from day 7 of same cell type (P < .001a). A, DNA quantification normalized to respective dry weights indicated ...
... Effect of Decorin on Keloid Fibroblasts in the Matrigel ModelLetters indicate statistical significance from HS27 at corresponding time point (P < .01b); plus signs, statistical significance from day 7 of same cell type (P < .001a). A, DNA quantification normalized to respective dry weights indicated ...
Evidence for allelism of the recessive insertional
... Characterization of certain phenotypes in Drosophila melanogaster provides a molecular explanation for dominant mutations. One of the most extensive studies has' been performed with the act 88 F gene, which encodes actin III of the indirect flight muscles. A dominant mutation called KM88 is describe ...
... Characterization of certain phenotypes in Drosophila melanogaster provides a molecular explanation for dominant mutations. One of the most extensive studies has' been performed with the act 88 F gene, which encodes actin III of the indirect flight muscles. A dominant mutation called KM88 is describe ...
EliSpot and CD57+
... Lyme Borreliosis does not only show humoral immune responses by antibodies, but can activate T-lymphocytes at the same time. Once Borrelia burgdorferi is not active anymore, the T-cellular immune response should cease. It is not possible to test the treatment success by Borrelia antibodies, because ...
... Lyme Borreliosis does not only show humoral immune responses by antibodies, but can activate T-lymphocytes at the same time. Once Borrelia burgdorferi is not active anymore, the T-cellular immune response should cease. It is not possible to test the treatment success by Borrelia antibodies, because ...
Trawling DNA Databases for Partial Matches: What is the FBI Afraid
... trawls have led police to serial rapists and murderers who have long eluded detection. 4 Indeed, even dead men have been "accused" through this technology. 5 In addition, database trawls have considerable potential to solve common property crimes. 6 In one case, an observant police inspector in Finl ...
... trawls have led police to serial rapists and murderers who have long eluded detection. 4 Indeed, even dead men have been "accused" through this technology. 5 In addition, database trawls have considerable potential to solve common property crimes. 6 In one case, an observant police inspector in Finl ...
Nucleotide sequences from tomato leaf curl viruses from different
... DNA-A. Moreover, the nucleotide sequences of the different isolates, although related, are no more similar to one another than to the sequences of WTGs from other plant species. Evidence of antigenic differences, which parallel these genomic differences, was provided by the results of tests in which ...
... DNA-A. Moreover, the nucleotide sequences of the different isolates, although related, are no more similar to one another than to the sequences of WTGs from other plant species. Evidence of antigenic differences, which parallel these genomic differences, was provided by the results of tests in which ...
Seed specific polycomb group gene and methods of use for same
... mother cell, and 3) adventitious embryony-embryo develops directly from a somatic cell. In most forms of apomixis, pseudogamy or fertiliZation of the polar nuclei to produce endosperm is necessary for seed viability. These types of apomixis have economic potential because they can cause any genotype ...
... mother cell, and 3) adventitious embryony-embryo develops directly from a somatic cell. In most forms of apomixis, pseudogamy or fertiliZation of the polar nuclei to produce endosperm is necessary for seed viability. These types of apomixis have economic potential because they can cause any genotype ...
maturation of humoral immune responses
... In this complex, the TCR chains are responsible for recognition of antigen (peptide+ MHC class I/II) while the intracellular signaling is conveyed by the CD3 subunits [reviewed in Alarcon et al 2003]. The emerging T cells can further be divided into subsets based on the expression of the CD4 or CD8 ...
... In this complex, the TCR chains are responsible for recognition of antigen (peptide+ MHC class I/II) while the intracellular signaling is conveyed by the CD3 subunits [reviewed in Alarcon et al 2003]. The emerging T cells can further be divided into subsets based on the expression of the CD4 or CD8 ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.