Immunity against Mucosal Pathogens?
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Erp, an extracellular protein family specific to
... and in M. bovis BCG resulted in a marked attenuation of virulence, as judged from survival and multiplication in mouse lungs, spleen, or in bone marrow derived macrophages. However, no differences in growth characteristics were observed in axenic media between wild-type, mutant and complemented H37R ...
... and in M. bovis BCG resulted in a marked attenuation of virulence, as judged from survival and multiplication in mouse lungs, spleen, or in bone marrow derived macrophages. However, no differences in growth characteristics were observed in axenic media between wild-type, mutant and complemented H37R ...
Journal of Autoimmunity
... significant proportion of T2D patients exhibited T-cell proliferation when exposed to human islet preparations [20]. To analyze our data more stringently, we assessed cytokine production against the DR4-restricted epitopes (PIC19eA3 & IA-2752e þ 775) in only DR4 subjects (T1D n ¼ 19, T2D n ¼ 4). As w ...
... significant proportion of T2D patients exhibited T-cell proliferation when exposed to human islet preparations [20]. To analyze our data more stringently, we assessed cytokine production against the DR4-restricted epitopes (PIC19eA3 & IA-2752e þ 775) in only DR4 subjects (T1D n ¼ 19, T2D n ¼ 4). As w ...
Richness and diversity of mammalian fungal communities shape
... which plays a crucial role in the induction of IFN-γ, are also more susceptible to disseminated candidiasis [37]. Th1 also appears to be protective in the host defense against Aspergillus. Cells producing IFN-γ are induced by Aspergillus in immunocompetent mice. Live conidia, which undergo swelling ...
... which plays a crucial role in the induction of IFN-γ, are also more susceptible to disseminated candidiasis [37]. Th1 also appears to be protective in the host defense against Aspergillus. Cells producing IFN-γ are induced by Aspergillus in immunocompetent mice. Live conidia, which undergo swelling ...
Original Article:
... So far very few studies have focused on this issue. In one study by Cespedes et al. the authors have shown that in nasal carriage less than 10% are colonized by more than one strain. Their approach, cultivation of three colonies from each sample, is time consuming, and will only reveal the major clo ...
... So far very few studies have focused on this issue. In one study by Cespedes et al. the authors have shown that in nasal carriage less than 10% are colonized by more than one strain. Their approach, cultivation of three colonies from each sample, is time consuming, and will only reveal the major clo ...
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... in developing embryonic tissues, (2) whether the expression of H-2 antigens is restricted to certain cell types, and (3) whether there are specific patterns of H-2 localization in time and space that can be elucidated in situ in embryonic tissues. Virtually all of the work reported has been confined ...
... in developing embryonic tissues, (2) whether the expression of H-2 antigens is restricted to certain cell types, and (3) whether there are specific patterns of H-2 localization in time and space that can be elucidated in situ in embryonic tissues. Virtually all of the work reported has been confined ...
Marwa Yahia Ahmed_o
... significantly higher in healthy 79-year-olds than in healthy 39-year-olds. The significance of this observation to the decline in immunity with increasing age remains to be evaluated. Interestingly, levels of IL-1Ra in amniotic fluids and urine of newborns were also shown to be significantly higher ...
... significantly higher in healthy 79-year-olds than in healthy 39-year-olds. The significance of this observation to the decline in immunity with increasing age remains to be evaluated. Interestingly, levels of IL-1Ra in amniotic fluids and urine of newborns were also shown to be significantly higher ...
Severe Perinatal Thrombosis in Double and Triple Heterozygous
... protein S (PROS) gene is located on chromosome 3, comprises 15 exons, and is closely linked to a highly homologous pseudogene.lo Hereditary deficiencies of both protein C and protein S are well-documented, and both are associated with an increased risk of venous thrombosis.” Together they account fo ...
... protein S (PROS) gene is located on chromosome 3, comprises 15 exons, and is closely linked to a highly homologous pseudogene.lo Hereditary deficiencies of both protein C and protein S are well-documented, and both are associated with an increased risk of venous thrombosis.” Together they account fo ...
The coiled-coil of the human Rad50 DNA repair protein contains
... globular ATPase domain made up from the N and C termini of the protein separated by an extensive central region predicted to form a coiled-coil (2). Accumulated recent evidence reveals that Rad50 and other SMC proteins are arranged as intramolecular coiled-coils bringing together the N and C termini ...
... globular ATPase domain made up from the N and C termini of the protein separated by an extensive central region predicted to form a coiled-coil (2). Accumulated recent evidence reveals that Rad50 and other SMC proteins are arranged as intramolecular coiled-coils bringing together the N and C termini ...
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... synthesis, a slight stimulation of protein synthesis, and no increase in DNA synthesis. More direct evidence concerning the relative importance of these metabolic activities in hypostome determination is reported in this paper. The experimental approach made use of the transplantation test of Webste ...
... synthesis, a slight stimulation of protein synthesis, and no increase in DNA synthesis. More direct evidence concerning the relative importance of these metabolic activities in hypostome determination is reported in this paper. The experimental approach made use of the transplantation test of Webste ...
Slide 1
... enabling knowledge sharing” (Gruber, 1993) But then, one also finds descriptions like: “Shallow ontologies comprise relatively few unchanging terms that organize very large amounts of data—for example, terms such as customer, account number, and overdraft…” (Shadbolt, 2006) ...
... enabling knowledge sharing” (Gruber, 1993) But then, one also finds descriptions like: “Shallow ontologies comprise relatively few unchanging terms that organize very large amounts of data—for example, terms such as customer, account number, and overdraft…” (Shadbolt, 2006) ...
Immunology for physicists - Laboratoire de Physique Statistique
... the chemistry more phenomenological laws that govern the growth and differentiation (or maturation) of lymphocytes into cells with specialized functions, such as plasma cells that secrete antibody at very high rates. We also look at a phenomenon, known as affinity maturation, by which the immune sys ...
... the chemistry more phenomenological laws that govern the growth and differentiation (or maturation) of lymphocytes into cells with specialized functions, such as plasma cells that secrete antibody at very high rates. We also look at a phenomenon, known as affinity maturation, by which the immune sys ...
Review Molecular Biology in Arteriosclerosis Research
... have seen the techniques of molecular biology applied to an increasingly wider range of problems directly or indirectly related to arteriosclerosis. The first focus of research in this area has been the isolation and characterization of complementary DNA (cDNA) clones for the major apolipoproteins o ...
... have seen the techniques of molecular biology applied to an increasingly wider range of problems directly or indirectly related to arteriosclerosis. The first focus of research in this area has been the isolation and characterization of complementary DNA (cDNA) clones for the major apolipoproteins o ...
Transcriptional Repression of the
... distinguish the a-subunit promoter from other promoters negatively regulated by AR, suggesting that transcriptional repression by AR can occur through multiple mechanisms that depend on promoter context. As far as we know, this is the first example of steroid receptor-dependent negative regulation b ...
... distinguish the a-subunit promoter from other promoters negatively regulated by AR, suggesting that transcriptional repression by AR can occur through multiple mechanisms that depend on promoter context. As far as we know, this is the first example of steroid receptor-dependent negative regulation b ...
chapter 5 complement
... The final outcome following introduction of a pathogen into an organism will depend on many factors, including its susceptibility to complement dependent lysis and opsonization and its ability to trigger the alternate pathway of complement, as well as on the nature of the adaptive immune response w ...
... The final outcome following introduction of a pathogen into an organism will depend on many factors, including its susceptibility to complement dependent lysis and opsonization and its ability to trigger the alternate pathway of complement, as well as on the nature of the adaptive immune response w ...
Nucleotide Sequence and Organization of the Rat Heme Oxygenase
... Features of Intron Sequences-The lengths of four introns are 1900, 826, 1508,and 1039 bp in the 5‘ to 3’ direction. All FIG. 3. S1 nuclease-mappinganalysis of the 5’ end of heme the exon/intron boundaries follow the GT/AG rule (36) and oxygenase mRNA. The S1 probe was hybridizedto spleen RNA or are ...
... Features of Intron Sequences-The lengths of four introns are 1900, 826, 1508,and 1039 bp in the 5‘ to 3’ direction. All FIG. 3. S1 nuclease-mappinganalysis of the 5’ end of heme the exon/intron boundaries follow the GT/AG rule (36) and oxygenase mRNA. The S1 probe was hybridizedto spleen RNA or are ...
Document
... presents the same structural organization and is located on chromosome 3 [47]. The proximal promoters of both human and murine PTX3 genes share numerous potential enhancerbinding elements, including Pu1, AP-1, NF-κB, SP1, and NF-IL-6 sites [47, 48]. It has been shown that the NF-κB binding site is e ...
... presents the same structural organization and is located on chromosome 3 [47]. The proximal promoters of both human and murine PTX3 genes share numerous potential enhancerbinding elements, including Pu1, AP-1, NF-κB, SP1, and NF-IL-6 sites [47, 48]. It has been shown that the NF-κB binding site is e ...
Review Article Viral Bacterial Artificial - diss.fu
... cloned into mini-F vectors [38, 39]. All in all, BAC systems are available for at least 27 herpesvirus species that infect hosts as diverse as fish, birds, and humans (Table 1). For many of these herpesviruses, several strains have been cloned as BACs, allowing the maintenance and manipulation of la ...
... cloned into mini-F vectors [38, 39]. All in all, BAC systems are available for at least 27 herpesvirus species that infect hosts as diverse as fish, birds, and humans (Table 1). For many of these herpesviruses, several strains have been cloned as BACs, allowing the maintenance and manipulation of la ...
B.2 Specific Aims. The term `epigenetics` literally means `above the
... phenomena, and indicates the covalent transfer of a methyl group to the carbon at position 5 of cytosine residues,[2] usually within regions of DNA in which cytosine occurs next to a guanine nucleotide (CpG sites). DNA methylation is linked to the regulation of gene expression and transcriptional si ...
... phenomena, and indicates the covalent transfer of a methyl group to the carbon at position 5 of cytosine residues,[2] usually within regions of DNA in which cytosine occurs next to a guanine nucleotide (CpG sites). DNA methylation is linked to the regulation of gene expression and transcriptional si ...
Using the Wolbachia Bacterial Symbiont to Teach Inquiry
... nematodes, terrestrial crustaceans (isopods), mites, scorpions, and spi(2) provide curriculum, protocols, and training to enhance teachers’ ability to lead ders. Wolbachia infections play an important role in filarial nematodes students through the project; and (3) increase students’ understanding o ...
... nematodes, terrestrial crustaceans (isopods), mites, scorpions, and spi(2) provide curriculum, protocols, and training to enhance teachers’ ability to lead ders. Wolbachia infections play an important role in filarial nematodes students through the project; and (3) increase students’ understanding o ...
Hemolin development and its effect on malaria parasites
... flavus, Leptothorax melas, Atta cephalotes, have life spans of over ten years [13] and Lasius niger even more than 28 years [14]. It would be interesting to study if such long-lived insects posses adaptive immunity. ...
... flavus, Leptothorax melas, Atta cephalotes, have life spans of over ten years [13] and Lasius niger even more than 28 years [14]. It would be interesting to study if such long-lived insects posses adaptive immunity. ...
The Trojan exosome hypothesis - Gene
... detect and kill infected cells, amplify the antiviral immune response, and provide immunological memory (2, 64). In healthy individuals, these mechanisms are usually sufficient to either clear viruses from the body or drive viruses into latent states where replication occurs only infrequently. Furth ...
... detect and kill infected cells, amplify the antiviral immune response, and provide immunological memory (2, 64). In healthy individuals, these mechanisms are usually sufficient to either clear viruses from the body or drive viruses into latent states where replication occurs only infrequently. Furth ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.