Chemokines as Drug Targets in Type 1 Diabetes
... THE RIP-LCMV MODEL FOR TYPE 1 DIABETES One possible mechanism of how pathogens can initiate autoimmunity is molecular mimicry. This hypothesis involves breaking existing self-tolerance due to an inherent structural similarity of pathogen molecules to self-components [20-25]. The concept of molecular ...
... THE RIP-LCMV MODEL FOR TYPE 1 DIABETES One possible mechanism of how pathogens can initiate autoimmunity is molecular mimicry. This hypothesis involves breaking existing self-tolerance due to an inherent structural similarity of pathogen molecules to self-components [20-25]. The concept of molecular ...
The response regulator 2 mediates ethylene signalling and
... ARR2 also functions in ethylene signalling We investigated in detail whether the arr2 knockout mutant affects hormone signalling by analyzing the hypocotyl growth response in seedlings. As shown in Figure 1B, ACC- and cytokinin-treated arr2 seedlings displayed a reduced response compared to wild typ ...
... ARR2 also functions in ethylene signalling We investigated in detail whether the arr2 knockout mutant affects hormone signalling by analyzing the hypocotyl growth response in seedlings. As shown in Figure 1B, ACC- and cytokinin-treated arr2 seedlings displayed a reduced response compared to wild typ ...
Bee Propolis: Ancient Cure for Today`s Ailments
... James, J.S. (1987, July 31). Bee Propolis for Thrush, Fungus or Leukoplakia? AIDS Treatment News, 1(37), Retrieved September 19, 2005, from the World Wide Web: http://www.aids.org/atn/a-037-01.html Kulinčevića, J. & Gačića, R. (1991). Propolis. Retrieved November 14, 2005, from the World Wide Web: h ...
... James, J.S. (1987, July 31). Bee Propolis for Thrush, Fungus or Leukoplakia? AIDS Treatment News, 1(37), Retrieved September 19, 2005, from the World Wide Web: http://www.aids.org/atn/a-037-01.html Kulinčevića, J. & Gačića, R. (1991). Propolis. Retrieved November 14, 2005, from the World Wide Web: h ...
Our focus is on vaccines
... • Chimigen® HIV Vaccine is immunogenic; most of the animals responded • Chimigen® HIV Vaccine is capable of inducing antibody response • Response is specific for the vaccine component antigens • Moderate to significant response following the third immunization • Higher antigen-specific IgG2a antibod ...
... • Chimigen® HIV Vaccine is immunogenic; most of the animals responded • Chimigen® HIV Vaccine is capable of inducing antibody response • Response is specific for the vaccine component antigens • Moderate to significant response following the third immunization • Higher antigen-specific IgG2a antibod ...
Developmental Validation of the Quantifiler Real-Time
... amplify target loci, allowing accurate genotype information to be gathered from as little as picogram amounts of genomic DNA (1). Yet, ancillary methods for the quantification of forensic DNA samples, an official requirement for STR analysis of casework samples (2), have until recently relied on old ...
... amplify target loci, allowing accurate genotype information to be gathered from as little as picogram amounts of genomic DNA (1). Yet, ancillary methods for the quantification of forensic DNA samples, an official requirement for STR analysis of casework samples (2), have until recently relied on old ...
Review Article Thyroid dysfunction: an autoimmune aspect
... al. demonstrated the noticeable association between thyroid auto-antibodies (TPO, Tg) and increased risk of miscarriage or preterm delivery [27]. In various studies presence of TPO antibodies without overt thyroid dysfunction was significantly associated with a 3- to 5-fold increase in miscarriage r ...
... al. demonstrated the noticeable association between thyroid auto-antibodies (TPO, Tg) and increased risk of miscarriage or preterm delivery [27]. In various studies presence of TPO antibodies without overt thyroid dysfunction was significantly associated with a 3- to 5-fold increase in miscarriage r ...
Unusual mutations in high functioning fragile X males
... markedly reduced in the presence of more than 200 CGGs, probably because of an impediment of the linear migration of the 40S ribosomal subunit along the 5' untranslated mRNA sequence by trinucleotide expansion. 1 Another mutational class identified in fragile X families is premutations which are sma ...
... markedly reduced in the presence of more than 200 CGGs, probably because of an impediment of the linear migration of the 40S ribosomal subunit along the 5' untranslated mRNA sequence by trinucleotide expansion. 1 Another mutational class identified in fragile X families is premutations which are sma ...
Why Compare sequences?
... (20 aa and a terminator), the information is sharpened up considerably. The 'wrongframe' information is discarded, and third-base degeneracies are consolidated. All in all, the signal-to-noise ratio is greatly improved for the specific purpose of identifying protein relatives. It is accepted that co ...
... (20 aa and a terminator), the information is sharpened up considerably. The 'wrongframe' information is discarded, and third-base degeneracies are consolidated. All in all, the signal-to-noise ratio is greatly improved for the specific purpose of identifying protein relatives. It is accepted that co ...
as a PDF
... IFN induction are becoming elucidated. While there are still many questions regarding the signaling mechanisms leading to type I IFN induction, future studies will fill in the remaining gaps in these signaling pathways. Furthermore, we still have a lot to learn regarding the function of various cell ...
... IFN induction are becoming elucidated. While there are still many questions regarding the signaling mechanisms leading to type I IFN induction, future studies will fill in the remaining gaps in these signaling pathways. Furthermore, we still have a lot to learn regarding the function of various cell ...
Adrenocorticotropic hormone: a molecule for all seasons
... radioimmunoassays in different tissue of various species examined (Table 1). Moreover, in situ hybridization experiments using a bovine ACTH receptor cDNA probe evidenced that M. galloprovincialis immunocytes express an mRNA encoding for a molecule similar to ACTH receptor (Ottaviani et al., 1998). ...
... radioimmunoassays in different tissue of various species examined (Table 1). Moreover, in situ hybridization experiments using a bovine ACTH receptor cDNA probe evidenced that M. galloprovincialis immunocytes express an mRNA encoding for a molecule similar to ACTH receptor (Ottaviani et al., 1998). ...
DNA methylation controls histone H3 lysine 9 methylation
... been studied at the molecular level for speci®c DNA sequences. Integrated genetic, molecular and cytological approaches can provide new insights into chromatin remodeling. For example, genome-wide H4 acetylation appeared to be tightly linked to DNA replication and possibly with post-replicative proc ...
... been studied at the molecular level for speci®c DNA sequences. Integrated genetic, molecular and cytological approaches can provide new insights into chromatin remodeling. For example, genome-wide H4 acetylation appeared to be tightly linked to DNA replication and possibly with post-replicative proc ...
22 It`s hard to name a thinker more important to shaping
... them. As Burnet would have predicted, there was a tremendous increase in the number of cells making antibodies—an expansion of clones. Aaron Stock, a bacteriologist, suggested staining the plaques with benzidine. Jerne proclaimed that the view was like taking in the stars in the heavens. The group w ...
... them. As Burnet would have predicted, there was a tremendous increase in the number of cells making antibodies—an expansion of clones. Aaron Stock, a bacteriologist, suggested staining the plaques with benzidine. Jerne proclaimed that the view was like taking in the stars in the heavens. The group w ...
Oncogenic herpesviruses: viral mechanisms and modified immune
... since viruses are, unlike other microbes, incapable of growing in pure virus culture they cannot adhere to Koch’s postulates. In addition some viruses, for example HIV, are unable to infect anim ...
... since viruses are, unlike other microbes, incapable of growing in pure virus culture they cannot adhere to Koch’s postulates. In addition some viruses, for example HIV, are unable to infect anim ...
Alterations of cell-mediated immunity following cardiac operations
... following cardiac operation. In contrast, IL-10 and transforming growth factor-ß essential to TH2-mediated humoral or anti-inflammatory immune response, are upregulated. In vivo tests, e.g., delayed type hypersensitivity skin reaction and tetanus antibody production, confirm the polarization of the ...
... following cardiac operation. In contrast, IL-10 and transforming growth factor-ß essential to TH2-mediated humoral or anti-inflammatory immune response, are upregulated. In vivo tests, e.g., delayed type hypersensitivity skin reaction and tetanus antibody production, confirm the polarization of the ...
Full-Text PDF
... into the cytosol and the initiation of the replication process. The entire VSV lifecycle occurs in the cytoplasm. Despite the ability of VSV to infect a wide range of host cells, replication is limited to cells that are defective in their antiviral interferon signaling pathways, allowing for an inhe ...
... into the cytosol and the initiation of the replication process. The entire VSV lifecycle occurs in the cytoplasm. Despite the ability of VSV to infect a wide range of host cells, replication is limited to cells that are defective in their antiviral interferon signaling pathways, allowing for an inhe ...
Tesi unita 08 - Padua@Research
... Little is know about how T. pallidum causes the syphilis, and in particular how T. pallidum survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In the present study, we investigated the role of a T. pallidum protein, called antigen 4D or ...
... Little is know about how T. pallidum causes the syphilis, and in particular how T. pallidum survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In the present study, we investigated the role of a T. pallidum protein, called antigen 4D or ...
Aberrant replication timing induces defective chromosome
... The origin recognition complex (ORC) is composed of six subunits, ORC1–6 [1]. ORCs have been identified in yeast, flies, frogs, mice and humans [2], and several of the homologous subunits or even whole complexes are functionally interchangeable between species, suggesting a high degree of conservati ...
... The origin recognition complex (ORC) is composed of six subunits, ORC1–6 [1]. ORCs have been identified in yeast, flies, frogs, mice and humans [2], and several of the homologous subunits or even whole complexes are functionally interchangeable between species, suggesting a high degree of conservati ...
Diphtheria, Tetanus and Acellular Pertussis
... which leads to vomiting. The cough may cause breathing to stop for a short period of time. The cough can last for weeks and can make it hard to eat, drink or even breathe. Pertussis is most severe in babies and young children. Serious complications happen most often in babies. Pneumonia can occur in ...
... which leads to vomiting. The cough may cause breathing to stop for a short period of time. The cough can last for weeks and can make it hard to eat, drink or even breathe. Pertussis is most severe in babies and young children. Serious complications happen most often in babies. Pneumonia can occur in ...
A review on transfer factor an immune modulator
... been reported so far with transfer factor,35 and valuable when administered orally as well as by injection.17,36 Long-term oral administration is convenient,37 safe38,39 and easily accepted37 by infants, elderly people who are at the risk for numerous infections. Dresseler and Rosenfield40 reported, ...
... been reported so far with transfer factor,35 and valuable when administered orally as well as by injection.17,36 Long-term oral administration is convenient,37 safe38,39 and easily accepted37 by infants, elderly people who are at the risk for numerous infections. Dresseler and Rosenfield40 reported, ...
Insertional inactivation studies of the csmA and csmC genes of the
... additional HindIII sites as indicated in Fig. 1A. For all transformants tested, the hybridization pattern showed the presence of both the 1.57-kb HindIII fragment wild-type fragment as well as the two smaller HindIII fragments of 0.85-kb and 0.72-kb that arise from the introduced HindIII sites that ...
... additional HindIII sites as indicated in Fig. 1A. For all transformants tested, the hybridization pattern showed the presence of both the 1.57-kb HindIII fragment wild-type fragment as well as the two smaller HindIII fragments of 0.85-kb and 0.72-kb that arise from the introduced HindIII sites that ...
Harnessing Local Immunity for an Effective Universal Swine
... heterosubtypic protection with the LAIV vaccine carrying the elastase cleavage site was observed when the vaccine was administered in a prime/boost regime and challenged either intratracheally [50] or intranasally [46]. As in other studies with LAIV vaccines, cross reactive IgG in serum and IgA in B ...
... heterosubtypic protection with the LAIV vaccine carrying the elastase cleavage site was observed when the vaccine was administered in a prime/boost regime and challenged either intratracheally [50] or intranasally [46]. As in other studies with LAIV vaccines, cross reactive IgG in serum and IgA in B ...
University of Birmingham Antibody response to vaccination and
... quality of antigen-specific antibody present at different times after immunisation by modulating a variety of processes within the immune response. Stress might affect the primary immune response in a number of broad areas, including 1) T-lymphocyte clonal expansion and maturation to T-helper-2 (Th2 ...
... quality of antigen-specific antibody present at different times after immunisation by modulating a variety of processes within the immune response. Stress might affect the primary immune response in a number of broad areas, including 1) T-lymphocyte clonal expansion and maturation to T-helper-2 (Th2 ...
BMC Genomics Antigen stimulation of peripheral blood mononuclear cells from expression program
... Background: Bovine tuberculosis (BTB) caused by Mycobacterium bovis continues to cause substantial losses to global agriculture and has significant repercussions for human health. The advent of high throughput genomics has facilitated large scale gene expression analyses that present a novel opportu ...
... Background: Bovine tuberculosis (BTB) caused by Mycobacterium bovis continues to cause substantial losses to global agriculture and has significant repercussions for human health. The advent of high throughput genomics has facilitated large scale gene expression analyses that present a novel opportu ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.