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Regulation of Stage I1 of Sporulation in Bacillus subtilis
Regulation of Stage I1 of Sporulation in Bacillus subtilis

... The finding that the expression of sporulation operons is strikingly different in strains carrying two different mutations, apparently in spoOJ, will be considered later (Discussion). Eflects of mutations in spoIIA on spore formation, sporulation phenotype, the formation of alkaline phosphatase and ...
Regulation of Stage I1 of Sporulation in Bacillus subtilis
Regulation of Stage I1 of Sporulation in Bacillus subtilis

... The finding that the expression of sporulation operons is strikingly different in strains carrying two different mutations, apparently in spoOJ, will be considered later (Discussion). Eflects of mutations in spoIIA on spore formation, sporulation phenotype, the formation of alkaline phosphatase and ...
Role of tumor necrosis factor alpha gene polymorphism in childhood
Role of tumor necrosis factor alpha gene polymorphism in childhood

... Bronchial asthma is a common disease with multiple determinants that include genetic variation, environmental exposures, and gene–environment interactions. Tumor necrosis factor alpha (TNF-α) has a role in asthma and wheezing pathophysiology. Single nucleotide gene polymorphisms, may be important as ...
Case report - HAL
Case report - HAL

... surrounding liver, but not encapsulated. It was soft, yellow with no hemorraghe or necrosis (Figure 1A). Light microscopy observation revealed that it was composed of benign appearing hepatocytes arranged in two-cell thick plates separated by sinusoids and intermingled with numerous thin-walled vess ...
Deletion of a conserved noncoding sequence in Plzf intron leads to
Deletion of a conserved noncoding sequence in Plzf intron leads to

... we identified 70 sequence variants (Fig. 4A and Supp. Table S1). There are 47 substitutions or SNPs in strict sense; 22 small indels (insertions and deletions up to 14 bp), from which 12 appear to be in a single base “run” and 5 in more complex ...
Distinct functions of two olfactory marker protein genes derived from
Distinct functions of two olfactory marker protein genes derived from

... new functions (neofunctionalization) [2, 3]. Alternatively, subfunctionalization is observed especially as a result of WGD. In subfunctionalization, both paralogs are functional, but each paralog undergoes a complementary reduction and specialization in its expression pattern because of the mutation ...
ppt - University of Illinois at Chicago
ppt - University of Illinois at Chicago

... Experience of using UMLS 2. Some candidate targets are variants of the entities in the documents. A sample relevant passage: “In patients with cad, several small clinical trials suggest that cognitive-behavioural therapy successfully reduced anxiety and depression, and thus facilitated the modifica ...
Finding Eukaryotic Open reading frames.
Finding Eukaryotic Open reading frames.

... • The CDS sequence of genes are generally highly: Hypothesis why this is the case? • Like prokaryotic DNA the CDS sequence is highly conserved so database searches can facilitate determining exons and thus ORF. • By extracting a possible exon region. It can be submitted to a search for similar seque ...
Determination of obesity associated gene variants related
Determination of obesity associated gene variants related

... all tissues. The expression of TMEM18 in the brain of humans and mice (Almen et al., 2010), particularly in the hypothalamus, has pointed to a function in regulation of homeostasis. Moreover, correlation between prefrontal cortex genetic expression of TMEM18 with body weight in rats has suggested a ...
A series of vectors for fungal transformation
A series of vectors for fungal transformation

... modified polylinker in pBluescript II and pBC (pCB1519 and pCB1520, respectively) where the XhoI site is flanked on both sides by SmaI sites. Second, the selectable markers were cloned into common cloning vectors outside the polylinker, thus leaving the lacZ gene intact. Most of the restriction enzy ...
Molecular Genetics of Autosomal-Dominant Demyelinating Charcot
Molecular Genetics of Autosomal-Dominant Demyelinating Charcot

... normal when the expression was switched off throughout life. When expression was switched off in adult mice, demyelination could be largely corrected within a few months, although Schwann cells were still sensitive to subsequent overexpression; this also supports the dosage hypothesis (Perea et al., ...
A Major Species of Mouse μ-opioid Receptor mRNA and Its
A Major Species of Mouse μ-opioid Receptor mRNA and Its

... and 11.5 kb, respectively, with a similar intensity. Although five MOR splice variants have been reported to use exon 11 instead of exon 1 (Pan et al., 2001), they are not likely to represent the 3.7-kb species because the expression levels of these alternative transcripts are much lower than that o ...
The human Y chromosome: the biological role of a “functional
The human Y chromosome: the biological role of a “functional

... of these STS’s on a large set of patients with a wide range of Y anomalies subdivided the euchromatic into 43 ordered intervals, all defined by naturally occurring chromosomal breakpoints. These 43 deletion intervals further refined the seveninterval map of Vergnaud et al. [7]. This collection of orde ...
article in press - MRC
article in press - MRC

... I. Tosi et al. / Atherosclerosis xxx (2006) xxx–xxx ...
Interfering RNA
Interfering RNA

... • showing of antisense targets across mRNA may be sufficient, but not all antisense targets are open to siRNA • intron targets may not be active for siRNA but may be for antisense – identify all elements claimed and their support in the description – identify species explicitly or implicitly disclos ...
Divergent Evolutionary and Expression Patterns between Lineage
Divergent Evolutionary and Expression Patterns between Lineage

... genome wide syntenic regions between two genomes by reading the headline of ‘axt’ format output. Overall, we used both genomes as query/hit, and hit/query, respectively, to construct reciprocal syntenic relationships between the A. thaliana genome and the other three species. To identify orthologs, ...
Functional and ecological impacts of horizontal gene transfer in
Functional and ecological impacts of horizontal gene transfer in

... relatively recently, during the evolution of vertebrates. However, this claim was almost immediately disputed. In many cases incompletely sequenced eukaryotic genomes were found to contain genes more closely related to the vertebrate homologues than were the bacterial counterparts [60,61]. This case ...
Gene list - Bioinformatics.ca
Gene list - Bioinformatics.ca

... Corrected P-value = M x original P-value ...
Cloning and expression analysis of follicle
Cloning and expression analysis of follicle

... (Sambroni et al. 2007). Many studies demonstrated that in salmonids, FSH secreted earlier and plays a major regulatory role during early stages of gonadal development that was considered to stimulate early development of ovarian follicle and spermatogenesis in the testes; LH, rising later, triggers ...
Etude Annotation
Etude Annotation

... BLAST  data:  If  I  click  on  the  BLAST  tab  (see  below),  I  can  see  that  the  genes  in  GenBank  that   align  well  with  my  gene.  Our  top  hit  is  (as  expected  from  our  Phamerator  view)  to  LeBron   gene ...
Estonian HumanGenesResearchAct.
Estonian HumanGenesResearchAct.

... “tissue sample” means cells, intercellular substance and body fluids taken from a human being for the purposes of genetic research; ...
Comparative analysis of peanut NBS‐LRR gene clusters suggests
Comparative analysis of peanut NBS‐LRR gene clusters suggests

... roles in defense against pathogens. Scarcity of genetic polymorphism makes peanut (Arachis hypogaea) especially vulnerable to a wide variety of pathogens. • Here, we isolated and characterized peanut bacterial artificial chromosomes (BACs) containing a high density of R genes. Analysis of two genomi ...
Forward to the special issue on Hox/Tale transcription factors in
Forward to the special issue on Hox/Tale transcription factors in

... additional levels of control, and recent evidence also suggests that ribosomal proteins may contribute to Hox gene expression. This idea is explored by Soshnikova (this issue) in a review of the mechanisms by which dynamic histone marks along the clusters and higher-order chromatin structure determi ...
An S Receptor Kinase Gene in Self-Compatible
An S Receptor Kinase Gene in Self-Compatible

... in the resulting self-incompatible plants from the cross involving W1 (Figure 1, lanes 6 to 11). Thus, in theW1 line, the A10 allele does not segregate with self-incompatibility. ...
Polycomb Group silencers collaborate with Notch pathway to cause
Polycomb Group silencers collaborate with Notch pathway to cause

... HpaII will not cut at its recognition sequence if it contains a methylated cytosine (mCCGG), both MspI and HpaII digestion will be blocked if both cytosines are methylated (mCmCGG). ...
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Epigenetics of diabetes Type 2

In recent years it has become apparent that the environment and underlying mechanisms affect gene expression and the genome outside of the central dogma of biology. It has been found that many Epigenetic mechanisms are involved in the regulation and expression of genes such as DNA methylation and chromatin remodeling. These epigenetic mechanisms are believed to be a contributing factor to pathological diseases such as Diabetes type II. An understanding of the epigenome of Diabetes patients may help to elucidate otherwise hidden causes of this disease.
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