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Hemolytic anemias - Hemoglobinopathies
Hemolytic anemias - Hemoglobinopathies

... Alpha () thalassemia The disease is manifested immediately at birth  There are normally four alpha chains, so there is a great variety in the severity of the disease.  At birth there are excess  chains and later there are excess  chains. These form stable, nonfunctional tetramers that precipita ...
Characterization of the Human Gene for a Newly Discovered
Characterization of the Human Gene for a Newly Discovered

... reading frame, bounded by consensus acceptor and donor splice sites, that predicted an amino acid sequence which was 56, 65, and 52% identical to the corresponding regions of the human CA I, CA II, and CA III proteins, respectively. This region of the carbonic anhydrases is precisely encoded by exon ...
Principal Components Analysis
Principal Components Analysis

... As mentioned in the introduction, Principal Components Analysis is a covariance analysis between different factors. Covariance is always measured between two factors. So with three factors, covariance is measured between factor x and y; y and z, and x and z. When more than 2 factors are involved, co ...
GENE-CBR - Indiana University School of Informatics
GENE-CBR - Indiana University School of Informatics

... CBR systems (Case-Based Reasoning) Kolodner (1983a, 1983b). Problem solving paradigm in AI. It can be viewed as a methodology for reasoning and learning “reasoning by re-using past cases is a powerful and frequently applied way to solve problems for humans” Joh (1997) ...
The PTC Gene - Wilbur World of Science
The PTC Gene - Wilbur World of Science

... Although PTC is not found in nature, the ability to taste it correlates strongly with the ability to taste other bitter substances that do occur naturally, many of which are toxins. Plants produce a variety of toxic compounds in order to protect themselves from being eaten. The ability to discern bi ...
Cheapest Lasix - Yes, our med prices are exactly THIS low!
Cheapest Lasix - Yes, our med prices are exactly THIS low!

... Yes, our med prices are exactly THIS low! ...
Intrinsic and extrinsic contributions to stochasticity in gene expression
Intrinsic and extrinsic contributions to stochasticity in gene expression

... has little effect on the properties of a system. However, stochastic fluctuations can become significant in smaller systems. In living cells, many components are present at very low copy numbers, [e.g., of order one for DNA loci and of order tens for transcription factors (1)]. Therefore, stochastic ...
Genetic risk factors for chronic obstructive pulmonary disease
Genetic risk factors for chronic obstructive pulmonary disease

... Genes, including those for α1-antichymotrypsin, α2-macroglobulin, vitamin Dbinding protein and blood group antigens, have also been associated with the development of COPD. Variants of the cystic fibrosis transmembrane regulator gene have been identified as risk factors for disseminated bronchiectas ...
the contribution of gene movement to the two rules of speciation
the contribution of gene movement to the two rules of speciation

... contribute to hybrid dysfunction and the Large X-effect depends upon the specific mechanism of gene movement and on details of developmental and reproductive biology of the X. We briefly introduce these mechanisms below, returning to the evidence for each in the next section. There are three mechani ...
A systemic gene silencing method suitable for high throughput
A systemic gene silencing method suitable for high throughput

... nurtures the young embryo. We have used the homosporous fern Ceratopteris richardii as a model system for studying gametophyte development because Ceratopteris gametophytes are autotrophic, small (~1 mm) and develop rapidly [1]. They can also be manipulated to develop as males or hermaphrodites by t ...
not a plastid specific promoter but is also capable of
not a plastid specific promoter but is also capable of

... To identify plastid sequences important for gene regulation at DNA and/or RNA level, it is essential to study the expression of modified plastid genes in vivo. To this purpose the use of T-DNA transfer techniques to transform plastids was investigated (6). T-DNA cassettes were constructed that carri ...
Cluster Analysis in DNA Microarray Experiments
Cluster Analysis in DNA Microarray Experiments

... Cluster analysis Clustering is in some sense a more difficult problem than classification. In general, all the issues that must be addressed for classification must also be addressed for clustering. In addition, with clustering, • there is no learning set of labeled observations; • the number of groups ...
Phylogenetic ANOVA: The Expression Variance and
Phylogenetic ANOVA: The Expression Variance and

... investigation of evolutionary modality (drift, stabilizing selection, adaptive shift, etc.). In ...
Dentinogenesis imperfecta type II
Dentinogenesis imperfecta type II

... Types of dentinogenesis imperfecta with similar dental formalities usually an autosomal dominant trait with variable expressivity but can be recessive if the associated osteogenesis imperfecta is of recessive type. This is type l. Type II : Occurs in people without other inherited disorders (i.e. Os ...
Involvement of respiratory chain in biofilm formation in - HAL
Involvement of respiratory chain in biofilm formation in - HAL

... by RT-PCR and there was no polar effect on genes lanking the mutation. The mutations had no effect on bacterial growth in anaerobic condition as expected. However, these genes may be involved in bacterial growth under variable nutrients or in the presence of few quantity of oxygen. Thus future exper ...
Effects of domestication related genes on behaviour, Anna-Carin Karlsson
Effects of domestication related genes on behaviour, Anna-Carin Karlsson

... when he described it as “that process by which a population of animals becomes adapted to man and the captive environment by some combination of genetic changes occurring over generations and environmentally induced developmental events reoccurring during each generation” (Price, 1984). When human s ...
Negative regulation of defense responses in Arabidopsis by two
Negative regulation of defense responses in Arabidopsis by two

... *For correspondence (fax þ86 10 807 28646; e-mail [email protected]). ...
Wk12-DeanApop
Wk12-DeanApop

... Further research? Other factors may be involved in HBx/FasL • Nuclear factors of activated T-cells (NFAT): evidence for FasL regulatory role • Interferon response factor (IGF): binds FasL promoter • Nur77: regulates FasL expression in presence of HBx (even though it doesn’t seem to interact with Fa ...
Cluster Analysis in DNA Microarray Experiments
Cluster Analysis in DNA Microarray Experiments

... Cluster analysis Clustering is in some sense a more difficult problem than classification. In general, all the issues that must be addressed for classification must also be addressed for clustering. In addition, with clustering, • there is no learning set of labeled observations; • the number of gr ...
Construction of transformation vectors and plant
Construction of transformation vectors and plant

... small and isolated blue spots on the outermost layer of calli were observed. However, the GUS staining patterns in calli cultured during 7 days after the bombardment were different, depending on the promoter used to drive the GUS expression. Callus tissues transformed with A9 promoter showed large a ...
1Department of Hematology, 2Department of Dermatology, Leiden
1Department of Hematology, 2Department of Dermatology, Leiden

... bone marrow samples from treatment naïve B-ALL, chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and hairy cell leukemia (HCL) patients and healthy donors by flow cytometry with a fluorescently labeled GPI-specific aerolysin FLAER and CD52 and CD19 ...
Pre-made tetracycline regulator (TetR) expression lentiviral
Pre-made tetracycline regulator (TetR) expression lentiviral

... TetR is used in tetracycline inducible expression. It binds to any inducible promoters that have incorporated Tet binding sequence to repress target expression. Target expression is induced once tetracycline is added. The added tetracycline binds to TetR, which releases TetR from target's promoter, ...
Activation of Silent Genes by Transposons Tn5 and TnlO
Activation of Silent Genes by Transposons Tn5 and TnlO

... scored for inheritance of resistance to kanamycin (for revertants arising in the presence of a T n 5 element) or tetracycline (for those arising in the presence of Tn10). This permitted identification of the 11 revertants caused by insertion of complete T n 5 elements and the 2 revertants caused by ...
IlllllllllllllIlllllllIllllllllllllllIlllllllllllllllllllllllllllllllllllll
IlllllllllllllIlllllllIllllllllllllllIlllllllllllllllllllllllllllllllllllll

... presence or absence of IPTG or lactose, a new protein the sequence of pTJS260 or of the 3' ?anking sequences band corresponding to the mass of B-galactosidase is of the toxin genes are available, hence some restriction sites are approximated in FIGS. 3, 4, 5 and 6. 45 apparent on SDS-PAGE and the cl ...
What is the Gene Trying to Do?
What is the Gene Trying to Do?

... of secondary importance, or because inclusion of these features would preclude a useful mathematical treatment. It is therefore appropriate, in considering the validity of the FTNS as a theorem, to consider the assumptions upon which it is based. These are either explicit or implicit in the developm ...
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Epigenetics of diabetes Type 2

In recent years it has become apparent that the environment and underlying mechanisms affect gene expression and the genome outside of the central dogma of biology. It has been found that many Epigenetic mechanisms are involved in the regulation and expression of genes such as DNA methylation and chromatin remodeling. These epigenetic mechanisms are believed to be a contributing factor to pathological diseases such as Diabetes type II. An understanding of the epigenome of Diabetes patients may help to elucidate otherwise hidden causes of this disease.
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