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... HTRA1 gene promoter region for adaptor related protein complex 2α (AP2α) and serum response factor (SRF) (15). Increased HTRA1 expression can contribute to pathogenesis and augment AMD injuries by increasing the cell death signals through serine protease pathways (40). AMD patients bearing an allele ...
... HTRA1 gene promoter region for adaptor related protein complex 2α (AP2α) and serum response factor (SRF) (15). Increased HTRA1 expression can contribute to pathogenesis and augment AMD injuries by increasing the cell death signals through serine protease pathways (40). AMD patients bearing an allele ...
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... there is a slight decrease in miR-184 expression compared with wild type (46). Regulation of miRNA expression provides an alternative means by which MeCP2-mediated epigenetic regulation could ultimately influence protein expression and phenotype. Rather than directly influencing the expression of mR ...
... there is a slight decrease in miR-184 expression compared with wild type (46). Regulation of miRNA expression provides an alternative means by which MeCP2-mediated epigenetic regulation could ultimately influence protein expression and phenotype. Rather than directly influencing the expression of mR ...
effect of metformin on thyroid stimulating hormone in euthyroid type
... and those not on metformin (p=0.23).Further, there was no correlation between metformin dose and serum TSH levels (p=0.36). CONCLUSIONS: Metformin use did not affect serum TSH levels in euthyroid patients with T2DM. KEYWORDS: Metformin Thyroid Stimulating Hormone Type 2 Diabetes Thyroid dysfunction. ...
... and those not on metformin (p=0.23).Further, there was no correlation between metformin dose and serum TSH levels (p=0.36). CONCLUSIONS: Metformin use did not affect serum TSH levels in euthyroid patients with T2DM. KEYWORDS: Metformin Thyroid Stimulating Hormone Type 2 Diabetes Thyroid dysfunction. ...
Systematic analysis of gene properties influencing organ system
... yeast and mice have illustrated that the phenotypic responses occurring after single gene perturbations are greatly variable. While perturbations of essential genes cause lethal effects, other gene alterations show undetectable, subtle or environment-dependent phenotypes (Hillenmeyer et al., 2008; N ...
... yeast and mice have illustrated that the phenotypic responses occurring after single gene perturbations are greatly variable. While perturbations of essential genes cause lethal effects, other gene alterations show undetectable, subtle or environment-dependent phenotypes (Hillenmeyer et al., 2008; N ...
Dissecting Gene Expression Changes Accompanying a Ploidy
... the particular pattern of chromosome (and hence gene) copy number change. With sufficiently strong selective pressure, the benefits of the specific effects can sometimes outweigh the general costs of aneuploidy, giving aneuploids a selective advantage (PAVELKA et al. 2010; SHELTZER AND AMON 2011). I ...
... the particular pattern of chromosome (and hence gene) copy number change. With sufficiently strong selective pressure, the benefits of the specific effects can sometimes outweigh the general costs of aneuploidy, giving aneuploids a selective advantage (PAVELKA et al. 2010; SHELTZER AND AMON 2011). I ...
BPA leaflet testing and inheritance
... triggers. (Women are particularly at risk hormone changes can help trigger attacks.) This may not prevent attacks entirely but, if the porphyria is known, an attack can be treated quickly. Delays in treatment can lead to paralysis and sometimes death. Familial PCT (the type caused by a porphyria gen ...
... triggers. (Women are particularly at risk hormone changes can help trigger attacks.) This may not prevent attacks entirely but, if the porphyria is known, an attack can be treated quickly. Delays in treatment can lead to paralysis and sometimes death. Familial PCT (the type caused by a porphyria gen ...
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... genetic risk factors (in cumulative or synergistic ways), may increase or not the risk of the disease. It is known that interactions between genetic and environmental factors are very important in subjects with a high-risk genetic profile (2). Genetic factors have greater contribution to the develop ...
... genetic risk factors (in cumulative or synergistic ways), may increase or not the risk of the disease. It is known that interactions between genetic and environmental factors are very important in subjects with a high-risk genetic profile (2). Genetic factors have greater contribution to the develop ...
Centipede Hox genes - Development
... development by comparing the mechanisms of development in different species. The extensive work in Drosophila developmental genetics facilitates this, as it provides some basis for speculating about the developmental processes of other arthropods. The body plan of Drosophila is encoded in part by th ...
... development by comparing the mechanisms of development in different species. The extensive work in Drosophila developmental genetics facilitates this, as it provides some basis for speculating about the developmental processes of other arthropods. The body plan of Drosophila is encoded in part by th ...
Recent advances in the molecular genetics of congenital
... due to the presence of concurrent type 1 diabetes and/or antibody evidence of pancreatic b-cell autoimmunity (which are associated with DR4 carrying haplotypes). However, a recent study showed a signi®cant increase in the frequency of transmission of the HLA-DR4 haplotype (DRB1*0404, DQ8) from paren ...
... due to the presence of concurrent type 1 diabetes and/or antibody evidence of pancreatic b-cell autoimmunity (which are associated with DR4 carrying haplotypes). However, a recent study showed a signi®cant increase in the frequency of transmission of the HLA-DR4 haplotype (DRB1*0404, DQ8) from paren ...
Expression of the six chromate ion transporter
... universal primers. DNA fragments containing the chr genes were obtained by digestions with HindIII/XbaI or HindIII/EcoRI endonucleases and subcloned into the corresponding sites of pACYC184 or pUCP20 vectors. E. coli W3110 cells were transformed by electroporation with recombinant plasmids and trans ...
... universal primers. DNA fragments containing the chr genes were obtained by digestions with HindIII/XbaI or HindIII/EcoRI endonucleases and subcloned into the corresponding sites of pACYC184 or pUCP20 vectors. E. coli W3110 cells were transformed by electroporation with recombinant plasmids and trans ...
osteogenesis imperfecta
... disease was more fully recognised and more comprehensive classification systems were adopted. The system in common use today was presented by Sillence et al. (1979) and subdivides patients into four types based on disease severity and progression. However, it is appreciated that in reality the disor ...
... disease was more fully recognised and more comprehensive classification systems were adopted. The system in common use today was presented by Sillence et al. (1979) and subdivides patients into four types based on disease severity and progression. However, it is appreciated that in reality the disor ...
`Candidatus Midichloria mitochondrii`, an endosymbiont of the tick
... generated using MrBayes. The GenBank accession number for each sequence is indicated. Numbers adjacent to each node represent the posterior probability values. Acetobacter aceti (Rhodospirillales) was included as an outgroup. Additional analyses in which other Alphaproteobacteria were included as ou ...
... generated using MrBayes. The GenBank accession number for each sequence is indicated. Numbers adjacent to each node represent the posterior probability values. Acetobacter aceti (Rhodospirillales) was included as an outgroup. Additional analyses in which other Alphaproteobacteria were included as ou ...
The Arabidopsis NAC Transcription Factor VNI2
... influenced by both developmental and environmental cues. Gene expression analysis using the GENEVESTIGATOR database (https://www.genevestigator.com/gv/index.jsp) revealed that VNI2, which is highly expressed in senescing plant tissues, is also induced by environmental stress conditions, suggesting t ...
... influenced by both developmental and environmental cues. Gene expression analysis using the GENEVESTIGATOR database (https://www.genevestigator.com/gv/index.jsp) revealed that VNI2, which is highly expressed in senescing plant tissues, is also induced by environmental stress conditions, suggesting t ...
fliD operon of Salmonella typhimurium
... Gene disruption. The genes on the chromosome were replaced with artificially disrupted genes on the plasmids according to the preligation method developed by Yamada e t al. (1993). The detailed procedure is described in the Results section. Preparation of flagellin monomers and in vitro reconstructi ...
... Gene disruption. The genes on the chromosome were replaced with artificially disrupted genes on the plasmids according to the preligation method developed by Yamada e t al. (1993). The detailed procedure is described in the Results section. Preparation of flagellin monomers and in vitro reconstructi ...
Targeting gene expression to cones with human cone opsin
... genomic deletion or missense mutation of the cone cyclic nucleotide-gated cation channel b-subunit (CNGB3).4 CNGB3 is also mutated in about 50% of human patients with achromatopsia.17 On the other hand, XLPRA is caused by microdeletions in exon ORF15 of RPGR, and the mutation causing a frameshift ha ...
... genomic deletion or missense mutation of the cone cyclic nucleotide-gated cation channel b-subunit (CNGB3).4 CNGB3 is also mutated in about 50% of human patients with achromatopsia.17 On the other hand, XLPRA is caused by microdeletions in exon ORF15 of RPGR, and the mutation causing a frameshift ha ...
Gene Conversion as a Source of Nucleotide Diversity in
... both, all except possibly one are consistent with an origin by gene conversion. This result is supported not only by the identity of the polymorphic nucleotides but also by the significant clustering of polymorphic nucleotides within each gene. Positioning of the polymorphisms within derived three-d ...
... both, all except possibly one are consistent with an origin by gene conversion. This result is supported not only by the identity of the polymorphic nucleotides but also by the significant clustering of polymorphic nucleotides within each gene. Positioning of the polymorphisms within derived three-d ...
SGD: Saccharomyces Genome Database.
... world-wide collaboration, was released to the public (1). In the time since this first release there have been many updates to this ‘systematic sequence.’ It is anticipated that these updates will continue for some time, albeit at a decreased rate. In addition, sequence annotations must be continual ...
... world-wide collaboration, was released to the public (1). In the time since this first release there have been many updates to this ‘systematic sequence.’ It is anticipated that these updates will continue for some time, albeit at a decreased rate. In addition, sequence annotations must be continual ...
MYH Associated Polyposis (MAP)
... We have 23 pairs of chromosomes in most cells of our body. Located on the chromosomes are about 25,000 genes which determine our physical characteristics (such as our hair and eye colour, the shape of our nose, our blood type and the number of fingers and toes we have). We have two copies of most ge ...
... We have 23 pairs of chromosomes in most cells of our body. Located on the chromosomes are about 25,000 genes which determine our physical characteristics (such as our hair and eye colour, the shape of our nose, our blood type and the number of fingers and toes we have). We have two copies of most ge ...
A machine learning approach to gene expression data analysis
... • Gene expression data are usually very high dimensional, and RS ensembles reduce the dimensionality and are effective with high dimensional data (Skurichina and Duin, 2002) • Co-regulated genes show correlated gene expression levels (see e.g. Gasch and Eisen, 2002), and RS ensembles are effective w ...
... • Gene expression data are usually very high dimensional, and RS ensembles reduce the dimensionality and are effective with high dimensional data (Skurichina and Duin, 2002) • Co-regulated genes show correlated gene expression levels (see e.g. Gasch and Eisen, 2002), and RS ensembles are effective w ...
Epigenetic Control of Apomixis
... regions of chromosomes and the repetitive elements are heavily methylated. The level of 5-mC is determined by DNA methylation and demethylation processes. Methylation can be removed from the DNA by active and/or passive mechanisms. Promiscuous methylation requires to be pruned by demethylases to cre ...
... regions of chromosomes and the repetitive elements are heavily methylated. The level of 5-mC is determined by DNA methylation and demethylation processes. Methylation can be removed from the DNA by active and/or passive mechanisms. Promiscuous methylation requires to be pruned by demethylases to cre ...
Notch activity induces Nodal expression and mediates the
... is critical for the establishment of asymmetric gene expression in the left LPM, including that of Nodal (Brennan et al. 2002; Saijoh et al. 2003). Here we identify binding sequences for the Notch pathway effector RBPjk/CBF1/Su(H) in the NDE of the Nodal promoter. We also show that Notch activity is ...
... is critical for the establishment of asymmetric gene expression in the left LPM, including that of Nodal (Brennan et al. 2002; Saijoh et al. 2003). Here we identify binding sequences for the Notch pathway effector RBPjk/CBF1/Su(H) in the NDE of the Nodal promoter. We also show that Notch activity is ...
Identification of Potential Corynebacterium ammoniagenes Purine
... Regulation of purE-lacZ and purF-lacZ Reporters by C. ammoniagenes gDNA Clones in E. coli The dependence of purines in the regulation of purE-lacZ and purF-lacZ was characterized by the candidate C. ammoniagenes gDNA clones involved in pur reporter repression. The 3 candidate clones (“E-7”, “E-32”, ...
... Regulation of purE-lacZ and purF-lacZ Reporters by C. ammoniagenes gDNA Clones in E. coli The dependence of purines in the regulation of purE-lacZ and purF-lacZ was characterized by the candidate C. ammoniagenes gDNA clones involved in pur reporter repression. The 3 candidate clones (“E-7”, “E-32”, ...
Reduced penetrance in human inherited disease
... heritable changes, such as DNA methylation, histone modification and miRNA expression as well as environmental and ...
... heritable changes, such as DNA methylation, histone modification and miRNA expression as well as environmental and ...
A novel C. elegans zinc finger transcription factor, lsy
... ASEL and ASER, but is required specifically in ASEL for the execution of the ASEL fate. Furthermore, we show that lsy-2 exerts its activity by regulating the expression of the lsy-6 miRNA. miRNAs are abundant gene regulatory factors that contribute to the generation of cellular and morphological div ...
... ASEL and ASER, but is required specifically in ASEL for the execution of the ASEL fate. Furthermore, we show that lsy-2 exerts its activity by regulating the expression of the lsy-6 miRNA. miRNAs are abundant gene regulatory factors that contribute to the generation of cellular and morphological div ...
In silico Analysis of Single Nucleotide Polymorphisms (Snps) in
... iron binding, oxidative DNA demethylase activity and oxidative RNA demethylase activity. The gene has 25 physical interactions with other genes (interactors) which they have similar functions and illustrated by using BioGRID and shown in Figure (2) and Table (1). ...
... iron binding, oxidative DNA demethylase activity and oxidative RNA demethylase activity. The gene has 25 physical interactions with other genes (interactors) which they have similar functions and illustrated by using BioGRID and shown in Figure (2) and Table (1). ...