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Cytoplasmic inheritance
Cytoplasmic inheritance

... 5. ORFs (open reading frames) sequences capable of encoding proteins but no product has been identified ...
Gregor Mendel Mendel`s 7 Pea Plant Traits
Gregor Mendel Mendel`s 7 Pea Plant Traits

... Contains Genes GENE - region of DNA that produces a functional protein Eg. The Purple Pigment Protein which give a flower its purple color are “encoded” by a specific set of genes. ...
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... d. RNA polymerase will attach to the promoter, and tryptophan is produced. 25. Which type of mutation is most likely to be the least disruptive in a sequence? a. frameshift c. deletion b. substitution in the first base d. point 26. Cells prefer to use glucose over other energy sources. Therefore, in ...
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RC 2 Student Sheet

... 28. Explain the role of RNA in protein synthesis. _____________________________ 29. Let’s look again at the original DNA Coding strand: ...
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Biology Test Chapters 13 Name and Honor Code: 1. The insertion of

cover letter - Annals of Gastroenterology
cover letter - Annals of Gastroenterology

... Department of Internal Medicine, 982055 Nebraska Medical Center, University of Nebraska Medical Center. Omaha, NE 68198-2055. Phone: (978)-810-5992, E-mail: [email protected] ...
Chapter 6 Microbial Genetics
Chapter 6 Microbial Genetics

... b. missense mutations - single base substitution in 1st or 2nd base nucleotide position. This results in a changed amino acid. A change in one amino acid usually will have little effect depending on where in the polypeptide it occurs. c. nonsense mutations - single base substitutions that yield a s ...
Methylation
Methylation

... Uracil or Methylation Interference Assay. End labeled probe is modified at one site per molecule, and allowed to bind protein. Bound and unbound populations are separated, and strands are cleaved at the modified bases. Bases critical for protein binding will not appear as bands in the bound popula ...
Chapter 04
Chapter 04

... • Two X chromosomes in female cells, one X chromosome in male cells • All eggs get X chromosome • Half of sperm get X chromosome, other half get Y chromosome ...
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Genetic Diagnosis, Birth Defects and Cancer Genetics

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DNA, RNA and Proteins

... Proteins called DNA polymerases catalyze the formation of the DNA molecule. The polymerases add nucleotides that pair with each base to form two new double helixes. DNA polymerases also have a “proofreading” function. During DNA replication, errors sometimes occur, and the wrong nucleotide is added ...
Cancer is Caused by Cumulative Gene Mutations
Cancer is Caused by Cumulative Gene Mutations

... DNA repair genes - become damaged/mutated no repair  damage DNA replicated, mutations may not be repaired and will build up. Proto-oncogenes - Code for growth factors, or signalling proteins (promote growth) o o o o ...
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... 1. Name two breeds of dog mentioned in the first paragraph: ______________________________________ 2. What process resulted in all the different breeds of dogs? ______________________________________ 3. Define hybridization: ___________________________________________________________________ 4. The ...
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Loss of MLH1 expression due to promoter methylation in cases

Powerpoint - Wishart Research Group
Powerpoint - Wishart Research Group

... Performs 330 trillion operations per second A spoonful contains 15,000 trillion “computers”/automatons Energy-efficiency is more than a million times that of a PC Guinness World Records recognized the computer as "the smallest biological computing device" ever constructed DNA acts as software, enzym ...
E. coli
E. coli

... The origins of humans • There are 2 main theories on the origin of modern humans: – Multiregional: early human (Homo erectus) left Africa 1,000,000 Ya and evolved separately into modern humans in many places – Out-of-Africa: populations of Homo erectus around the world were displaced by the ancesto ...
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part 1 genetics notes—ch 10-13

Interest Grabber
Interest Grabber

...  Every cell in your body, with the exception of gametes, or sex cells, contains a complete copy of your DNA. Why, then, are some cells nerve cells with dendrites and axons, while others are red blood cells that have lost their nuclei and are packed with hemoglobin? Why are cells so different in str ...
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... combined immunodeficiency (SCID), a fatal genetic disease whose sufferers have a profoundly weakened immune system. ...
All in the Family Humans and Chimps: No one would mistake you for
All in the Family Humans and Chimps: No one would mistake you for

... to find. Our genes match so closely that we can catch many of the same diseases. Humans can even receive blood transfusions from chimps. If you think there is no one like us, think again. Scientists are thinking twice, too. Svante Pääbo is the director of the Max Planck Institute for Evolutionary An ...
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Ch16EukaryoticGeneControl - Environmental

... differential expression of different beta globin genes ensures important physiological changes during human development ...
Oncogenes, Tumor Suppressors, and the Cell Cycle
Oncogenes, Tumor Suppressors, and the Cell Cycle

... normal processes of cell control • Oncogenes (activated proto-oncogenes) are generalized as drivers of tumor cell division • Tumor Suppressors are generalized as brakes to cellular division • Therefore oncogenic transformation combines activation of proto-oncogenes and loss of tumor suppressors to d ...
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Genetic Changes - Down the Rabbit Hole
Genetic Changes - Down the Rabbit Hole

... Significance of Mutations Most are neutral • Eye color • Birth marks • Some are harmful • Cystic Fibrosis • Down Syndrome • Some are beneficial • Sickle Cell Anemia to Malaria • Immunity to HIV ...
genome
genome

... Genes are expressed at widely varying levels. There may be 105 copies of mRNA for an abundant gene whose protein is the principal product of the cell, 103 copies of each mRNA for <10 moderately abundant messages, and <10 copies of each mRNA for >10,000 scarcely expressed genes. Overlaps between th ...
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Cancer epigenetics



Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.
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