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Lecture 6
Lecture 6

... The expression of pair-rule gene is the first evidence of segmentation; however, the cellular blastoderm embryo is not overtly segmented morphologically. Prepattern. ...
Guide for Bioinformatics Project Module 2 - SGD-Wiki
Guide for Bioinformatics Project Module 2 - SGD-Wiki

... expressed  in  similar  patterns  in  normal  cells  or  in  response  to  some  stimuli  can  be  helpful  in  predicting  function  and  give   us  at  least  TWO  key  pieces  of  information.  1.  Expression  in  similar  patterns ...
Specimens - BioMed Central
Specimens - BioMed Central

... samples showing an alteration at that locus. The extent of the genome assigned to each clone was computed by assigning a genomic distance equal to half the distance to the two neighboring clones or to the end of a chromosome for clones with only one neighbor. The number of copy number transitions wa ...
(Rfg, Rbg), (Gfg, Gbg)
(Rfg, Rbg), (Gfg, Gbg)

... samples on the same slide, or between slides, which do not represent true biological variation between samples for example: 1. Dyes activity 2. Dyes quantity 3. scanning parameters 4. location on the array 5. Air bubbles ...
MHC 2
MHC 2

... Genetic organization in the mouse is similar… continue to think about polygenicity, polymorphism, co-dominance, and linkage disequilibrium ...
Gene Co-expression Networks: Functional Organization of
Gene Co-expression Networks: Functional Organization of

... Then we simply change β in the range from 1 to 20, and calculate p(k) for each gene , and see how linear the log(p(k)) - log(k) plot is (as measured by R-squared) We want the fit to be very close to linear, because scale-free network is p(k) = k-γ ...
Using real time RT-PCR analysis to determine multiple gene
Using real time RT-PCR analysis to determine multiple gene

... New techniques are being applied to identify all the genes involved in mammalian gonad development and differentiation. As this list of genes increases, understanding the potential interactions between these genes will become increasingly difficult. We used a real time reverse transcription PCR (rea ...
nuclear structure (2): the nucleolus
nuclear structure (2): the nucleolus

... of ribosomes. This is the ribosomal RNA (rRNA). The “size” of macromolecules such as proteins and RNA can be determined by how rapidly the molecule moves to the bottom of the centrifuge tube during ultracentrifugation. Actually the “size” determined by this method is a reflection of both the mass an ...
Cell-Specific Expression of Genes of the Lipid Transfer Protein
Cell-Specific Expression of Genes of the Lipid Transfer Protein

... synthase; PAL, phenylalanine ammonia lyase. ...
Gene Identification Lab
Gene Identification Lab

Chromosomal Polymorphism
Chromosomal Polymorphism

... •although X inactivation is usually random, a structurally abnormal X, e.g., an X chromosome bearing a deletion, is preferentially inactivated; •in individuals with X-autosome translocations, it is usually the normal X chromosome that is preferentially inactivated; ...
Looping versus linking: toward a model for long
Looping versus linking: toward a model for long

EXPERIMENTAL DESIGN is - Universitat de Barcelona
EXPERIMENTAL DESIGN is - Universitat de Barcelona

... variation cannot be explicitly accounted for  Usual way to deal with it is to assume some ERROR MODELS (e.g. ei~N(0, s2))  Assuming these error models are true… EXPERIMENTAL DESIGN is (must be) used to control the action of random variation  STATISTICAL INFERENCE is (must be) used to extract conc ...
Supplementary Information (doc 7548K)
Supplementary Information (doc 7548K)

... point mutations in DNMT3A (R882H). Average maximum allele bias seen at heterozygous sites within GATA2 for each sample is noted. Among AML patients, 36 are informative (with heterozygous SNPs, high GATA2 expression or exon coverage above coverage thresholds used) and highlighted in dark. Supplementa ...
The nuclear envelope — a scaffold for silencing?
The nuclear envelope — a scaffold for silencing?

... instance, it is well established in yeast that strong promoters block the spread of heterochromatin [38,39]. Similarly, in human cells, active promoters were often found at the edge of lamin-associated chromosomal domains [6], and in flies it was shown that not all genes respond equally to associa ...
video slide
video slide

... • By default the trp operon is on and the genes for tryptophan synthesis are transcribed • When tryptophan is present, it binds to the trp repressor protein, which turns the operon off • The repressor is active only in the presence of its corepressor tryptophan; thus the trp operon is turned off (re ...
Lecture#6 - Further regulation of the lac operon
Lecture#6 - Further regulation of the lac operon

... Operator mutants - OC mutants - Fig cis-acting locus - a genetic region affecting the activity of genes on that same DNA molecule - Such a locus usually does not code for a protein but instead acts as a binding site for trans-acting proteins. Jacob and Monod proposed the "operator element" in the la ...
LETTER The Preferential Retention of Starch Synthesis Genes
LETTER The Preferential Retention of Starch Synthesis Genes

... between chromosomes 11 and 12 formed by segmental duplication (fig. 1). We expect the gene number and size of each pair of duplicated chromosomal segments to be the same immediately following the WGD and the current gene number and size to be similar if the gene loss was random during the diploidiza ...
classification
classification

... complementation of a well characterized heterologous mutant for the protein. COMMENT-INTERNAL // UNIQUE-ID - |EV-EXP-IEP-COREGULATION| COMMON-NAME - Inferred through co-regulation PERTAINS-TO - |Transcription-Units| COMMENT - Inferred through co-regulation. A transcription unit is inferred because a ...
Nerve activates contraction - Green River Community College
Nerve activates contraction - Green River Community College

... — Presence of substrate activates the transcription (mRNA synthesis) of genes coding for the enzymes needed to breakdown the substrate. — Enzymes are not made unless they are needed ...
What are gene polymorphisms and how can we use them in
What are gene polymorphisms and how can we use them in

DNA sequence of a genome determine phenotype through control of
DNA sequence of a genome determine phenotype through control of

... •RNA polymerase binds strongly to the template strand •a transcription bubble opens as the RNA polymerase creates a single stranded region in the DNA downstream from the promoter (relative to the template strand) •RNA is synthesized according to the base pairing rules of A:U G:C •RNA nucleotides add ...
Assembling and Annotating the Draft Human Genome
Assembling and Annotating the Draft Human Genome

... Idealized promoter for a gene involved in making hair. Proteins that bind to specific DNA sequences in the promoter region together turn a gene on or off. These proteins are themselves regulated by their own promoters leading to a gene regulatory network with many of the same properties as a neural ...
PPT File
PPT File

...  DNA methyltransferases, histone-modification enzymes & their regulatory proteins  play essential roles in germ-cell development • Some are germ-cell-specific genes (such as Dnmt3L and Prdm9) • Numerous intra- and inter-individual differences in DNA methylation in human sperm samples  phenotypic ...
Biology 30 Patterns and Probabilities
Biology 30 Patterns and Probabilities

< 1 ... 92 93 94 95 96 97 98 99 100 ... 207 >

Long non-coding RNA

Long non-coding RNAs (long ncRNAs, lncRNA) are non-protein coding transcripts longer than 200 nucleotides. This somewhat arbitrary limit distinguishes long ncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs.
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