The Pax and large Maf families of genes in mammalian eye development Vertebrate eye development is dependent on the coordinated action of thousands of genes. A specific group of over one hundred of regulatory genes is both responsible for ocular cell
... in which a certain group of its specific target genes do not respond properly to the protein levels that are below a threshold value (Cvekl and Tamm, 2004). Haploinsufficiency of the mouse Pax2 gene results in kidney and retinal defects. Similar human PAX2 mutations cause renal‐coloboma syndrome ...
... in which a certain group of its specific target genes do not respond properly to the protein levels that are below a threshold value (Cvekl and Tamm, 2004). Haploinsufficiency of the mouse Pax2 gene results in kidney and retinal defects. Similar human PAX2 mutations cause renal‐coloboma syndrome ...
Supplementary material
... ESTs for a particular clone. For clones without a cDNA sequence and thus no clear representative sequence, the highest-scoring EST match to the representative gene is chosen as the representative sequence. Close to 1,000 of the clones find multiple potential genes with our method. This often is a r ...
... ESTs for a particular clone. For clones without a cDNA sequence and thus no clear representative sequence, the highest-scoring EST match to the representative gene is chosen as the representative sequence. Close to 1,000 of the clones find multiple potential genes with our method. This often is a r ...
Roles of cell-wall invertases and monosaccharide transporters in the
... galactose, xylose, and mannose, but not fructose. It accounts for the majority of the AtSTP activity in vegetative tissues and its activity is markedly repressed by treatment with exogenous sugars. These observations are consistent with a role in the retrieval of cell-wall-derived sugars, for exampl ...
... galactose, xylose, and mannose, but not fructose. It accounts for the majority of the AtSTP activity in vegetative tissues and its activity is markedly repressed by treatment with exogenous sugars. These observations are consistent with a role in the retrieval of cell-wall-derived sugars, for exampl ...
The Role of nm23-H1 in the Progression of Transitional Cell Bladder
... differential screening of cDNA library from low and high metastatic clones of a murine melanoma cell line (1). Presently, a total of five nm23 family members have been identified, i.e., nm23-H1, nm23-H2, DR-nm23, nm23-H4, and nm23-H5 (2– 6). nm23-H2 was identified as coding for the B subunit of NDP3 ...
... differential screening of cDNA library from low and high metastatic clones of a murine melanoma cell line (1). Presently, a total of five nm23 family members have been identified, i.e., nm23-H1, nm23-H2, DR-nm23, nm23-H4, and nm23-H5 (2– 6). nm23-H2 was identified as coding for the B subunit of NDP3 ...
Document
... more of the chromosomes. Even then, it seems likely that the cDNA data are underrepresenting the larger cDNAs, which are correlated with larger genes. In other words, the true mean gene size may be even larger than we have indicated. Moreover, given all of the ongoing arguments about the gene counts ...
... more of the chromosomes. Even then, it seems likely that the cDNA data are underrepresenting the larger cDNAs, which are correlated with larger genes. In other words, the true mean gene size may be even larger than we have indicated. Moreover, given all of the ongoing arguments about the gene counts ...
Allele- and parent-of-origin-specific effects on expression of the
... In our study, a SNP was used as a marker to distinguish transcripts from each allele in a heterozygous genotype; therefore, each allele acted as an internal control for the other (Lo et al., 2003; Yan and Zhou, 2004; Palacios et al., 2009). We found biallelic expression, which enables the hypothesis ...
... In our study, a SNP was used as a marker to distinguish transcripts from each allele in a heterozygous genotype; therefore, each allele acted as an internal control for the other (Lo et al., 2003; Yan and Zhou, 2004; Palacios et al., 2009). We found biallelic expression, which enables the hypothesis ...
Text S1.
... Several plant virus RNAi suppressors influence the miRNA pathway, thereby inducing strong developmental defects in transgenic plants that express RNAi suppressors during development [1,2]. This effect may be due to convergence of the antiviral RNAi and miRNA pathways on Argonaute-1 (AGO1) in plants. ...
... Several plant virus RNAi suppressors influence the miRNA pathway, thereby inducing strong developmental defects in transgenic plants that express RNAi suppressors during development [1,2]. This effect may be due to convergence of the antiviral RNAi and miRNA pathways on Argonaute-1 (AGO1) in plants. ...
Educational Items Section Immunoglobulin Genes Atlas of Genetics and Cytogenetics
... other, and the mutations of each of the genes have led to some degree of diversity. Many of these duplicated genes are functional ..."). First the DNA is rearranged: this makes it possible to join 1 V and 1 J; the intermediate sequences are then deleted, The pre-messenger RNA is copied (transcriptio ...
... other, and the mutations of each of the genes have led to some degree of diversity. Many of these duplicated genes are functional ..."). First the DNA is rearranged: this makes it possible to join 1 V and 1 J; the intermediate sequences are then deleted, The pre-messenger RNA is copied (transcriptio ...
Homeotic genes
... proteins is the transcription factor Distal-less (Dll). • Dll is required for the formation of legs in thoracic segments, and its expression is negatively regulated in abdominal segments by the actions of Ubx and AbdA they bind to the enhancer and suppress it. ...
... proteins is the transcription factor Distal-less (Dll). • Dll is required for the formation of legs in thoracic segments, and its expression is negatively regulated in abdominal segments by the actions of Ubx and AbdA they bind to the enhancer and suppress it. ...
Automatic annotation of organellar genomes with DOGMA
... gions (IRA and IRB) involve a large inverted repeat. The other two regions are the large and small single-copy regions. In general, gene content and order are highly conserved [9], although in some groups numerous structural rearrangements have been identified [4]. Some genes can contain large intr ...
... gions (IRA and IRB) involve a large inverted repeat. The other two regions are the large and small single-copy regions. In general, gene content and order are highly conserved [9], although in some groups numerous structural rearrangements have been identified [4]. Some genes can contain large intr ...
PDF
... cluster of genes or between clusters? What is the nature of the interaction between genes (e.g does gene A inhibit gene B)? To infer such finer relations from perturbed gene expression profiles we use the framework of Friedman et al. (2000). In this framework, we treat the measured expression leve ...
... cluster of genes or between clusters? What is the nature of the interaction between genes (e.g does gene A inhibit gene B)? To infer such finer relations from perturbed gene expression profiles we use the framework of Friedman et al. (2000). In this framework, we treat the measured expression leve ...
... [2] O. Troyanskaya, M. Cantor, G. Sherlock, P. Brown, T.Hastie, R. Tibshirani, D.Botstein and Russ B. Altman , “ Missing value estimation methods for DNA microarrays,” Bioinformatics, 2001, p.p 520–525. [3] A.Kaur, S.Bir, R.kamel,“Approximation of Missing Values in DNA Microarray Gene Expression Dat ...
The abundance and cell cycle dependent expression of the mRNA
... relative content of HMG-17 mRNA in the two human samples was determined by scanning the autoradiograms and integrating the area under each peak. The data indicates that HeLa RNA contained approximately 6 times more HMG-17 mRNA than the RNA extracted from human livers. Since the levels of HMG-17 RNA ...
... relative content of HMG-17 mRNA in the two human samples was determined by scanning the autoradiograms and integrating the area under each peak. The data indicates that HeLa RNA contained approximately 6 times more HMG-17 mRNA than the RNA extracted from human livers. Since the levels of HMG-17 RNA ...
Leukaemia Section t(8;11)(p11;p15) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH) Published in Atlas Database: March 2005 Online updated version: http://AtlasGeneticsOncology.org/Anomalies/t0811p11p15ID1200.html ...
... Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH) Published in Atlas Database: March 2005 Online updated version: http://AtlasGeneticsOncology.org/Anomalies/t0811p11p15ID1200.html ...
The β-Globin LCR is Not Necessary for an Open Chromatin
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
An in-silico functional genomics resource: Targeted re
... • 1,846 sequences (RIKEN FL-cDNA and some genes of interest) • MySelect capture array (solution based hybridization) • Designed 120-mer probes (60-bp overlap design) ...
... • 1,846 sequences (RIKEN FL-cDNA and some genes of interest) • MySelect capture array (solution based hybridization) • Designed 120-mer probes (60-bp overlap design) ...
Relative Expression of a Dominant Mutated ABCC8
... mRNA quantitative studies. RNA samples (1 mg) extracted from two to three different blood samples of each family member using the Tempus Spin RNA Isolation Kit (Applied Biosystems, Foster City, CA) were reverse transcribed. cDNA samples (and cDNA from normal human b-cells as control) were amplified a ...
... mRNA quantitative studies. RNA samples (1 mg) extracted from two to three different blood samples of each family member using the Tempus Spin RNA Isolation Kit (Applied Biosystems, Foster City, CA) were reverse transcribed. cDNA samples (and cDNA from normal human b-cells as control) were amplified a ...