Identifying regulatory mechanisms using individual variation reveals key role for... modification
... model, compared with the results obtained by Brem and Kruglyak (16). The Geronemo model explains a significantly greater fraction of the variance: explaining ⬎50% PGV for 828 genes, as compared with 238 in the analysis of Brem and Kruglyak (16) of the same data set. Our comparison to three simpler G ...
... model, compared with the results obtained by Brem and Kruglyak (16). The Geronemo model explains a significantly greater fraction of the variance: explaining ⬎50% PGV for 828 genes, as compared with 238 in the analysis of Brem and Kruglyak (16) of the same data set. Our comparison to three simpler G ...
The inversion of the dorsoventral axis in the separation of Bilataria
... development and was confirmed in modern molecular phylogeny by the analysis of the relationship of the genes involved. Conserved groups of genes are responsible for the formation of the body axes. The separation of protostomes and deuterostomes is based on the inversion of the dorsoventral axis. The ...
... development and was confirmed in modern molecular phylogeny by the analysis of the relationship of the genes involved. Conserved groups of genes are responsible for the formation of the body axes. The separation of protostomes and deuterostomes is based on the inversion of the dorsoventral axis. The ...
Uncovering evolutionary patterns of gene expression using
... genome and includes all types of RNA from the cell: mRNAs (with all their spliced forms), tRNAs, rRNAs, and non-coding RNAs involved in RNA-based regulation (antisense RNA, microRNAs, and non-coding RNAs [58]). The transcriptome is dynamic and is time, environment, tissue and cell specific. Transcri ...
... genome and includes all types of RNA from the cell: mRNAs (with all their spliced forms), tRNAs, rRNAs, and non-coding RNAs involved in RNA-based regulation (antisense RNA, microRNAs, and non-coding RNAs [58]). The transcriptome is dynamic and is time, environment, tissue and cell specific. Transcri ...
Duplicative Transfer of a MADS Box Gene to a Plant Y Chromosome
... We have discovered that a MADS box gene has been duplicated onto the Y chromosome of S. latifolia. The MADS box genes encode transcription factors that share a common DNA-binding domain and represent crucial regulatory genes in plant development, perhaps comparable in importance to the HOX homeobox ...
... We have discovered that a MADS box gene has been duplicated onto the Y chromosome of S. latifolia. The MADS box genes encode transcription factors that share a common DNA-binding domain and represent crucial regulatory genes in plant development, perhaps comparable in importance to the HOX homeobox ...
Is targeted modification of cytokinin regulatory gene activity in Rapid
... The cytokinins are rapidly being recognised as having critical and specific roles during seed development. Both seed number and seed size have variously been affected by manipulation of cytokinin levels. We hypothesised that we could identify specific cytokinin regulatory genes as targets for breede ...
... The cytokinins are rapidly being recognised as having critical and specific roles during seed development. Both seed number and seed size have variously been affected by manipulation of cytokinin levels. We hypothesised that we could identify specific cytokinin regulatory genes as targets for breede ...
Supplementary Data Files Transcriptome Analysis on Monocytes
... tested by QPCR. Macula (Mac), Peri (Periphery) and Retina all are listed, as are Body, Neural, and Eye. ...
... tested by QPCR. Macula (Mac), Peri (Periphery) and Retina all are listed, as are Body, Neural, and Eye. ...
Chromosomal assignment of seven genes on canine chromosomes
... These six autosomal genes localized to canine chromosomes are the first autosomal genes to be physically mapped in the dog. We have great confidence in the assignments, based on the idiogram by Stone and associates (1991). There is some discussion of developing an internationally agreed upon karyoty ...
... These six autosomal genes localized to canine chromosomes are the first autosomal genes to be physically mapped in the dog. We have great confidence in the assignments, based on the idiogram by Stone and associates (1991). There is some discussion of developing an internationally agreed upon karyoty ...
Kinetic proofreading of gene activation by chromatin remodeling
... The kinetic proofreading scenario for chromatin remodeling presented here shows that chromatin remodeling based on histone tail modifiers, chromatin remodelers, and transcription factors allows to discriminate right from wrong genes to be activated. While in our example we have distinguished between ...
... The kinetic proofreading scenario for chromatin remodeling presented here shows that chromatin remodeling based on histone tail modifiers, chromatin remodelers, and transcription factors allows to discriminate right from wrong genes to be activated. While in our example we have distinguished between ...
Seed Germination Multiplexed Quantitative Gene Expression
... quantitative PCR (real-time qPCR) is widely used for gene expression, having replaced Northern blots as the preferred method by which gene expression is quantified. Real-time qPCR has proven to be reproducible, sensitive, and linear over approximately seven orders of magnitude (Wong and Medrano 2005 ...
... quantitative PCR (real-time qPCR) is widely used for gene expression, having replaced Northern blots as the preferred method by which gene expression is quantified. Real-time qPCR has proven to be reproducible, sensitive, and linear over approximately seven orders of magnitude (Wong and Medrano 2005 ...
Guo, Ming: Biological Pathways - A pathway to explore diseases mechanism
... The methods abovementioned aim at inferring pathway representation directly from the gene expression data of each gene. All these approaches implicitly assume each gene as target for enrichment. The gene set approach, on the other hand, treats the known functionally related genes together as a group ...
... The methods abovementioned aim at inferring pathway representation directly from the gene expression data of each gene. All these approaches implicitly assume each gene as target for enrichment. The gene set approach, on the other hand, treats the known functionally related genes together as a group ...
Training error
... Think about this in three dimensions There are three genes, two patients with known diagnosis (red and yellow) and Ms. Smith (green) There is always one plane separating red and yellow with Ms. Smith on the yellow side and a second separating plane with Ms. Smith on the red side OK! If all points fa ...
... Think about this in three dimensions There are three genes, two patients with known diagnosis (red and yellow) and Ms. Smith (green) There is always one plane separating red and yellow with Ms. Smith on the yellow side and a second separating plane with Ms. Smith on the red side OK! If all points fa ...
Potential Transcriptional Biomarkers in Human Transplant Renal
... unpaired at two time points were used for validating differentially expressed genes, and identifying potential biomarkers by quantitative RT-PCR (qPCR). Differentially expressed genes were also further correlated with renal function and histology at late time points up to 24 months. Results: The ove ...
... unpaired at two time points were used for validating differentially expressed genes, and identifying potential biomarkers by quantitative RT-PCR (qPCR). Differentially expressed genes were also further correlated with renal function and histology at late time points up to 24 months. Results: The ove ...
The promoter of the Arabidopsis nuclear gene COX5b
... A COX5b-1 EST clone encoding exons two to six (clone 234B12T7; accession no. N65183) was obtained from ABRC. For the isolation of clones containing the COX5b-1 gene, the cDNA probe was used to screen 13105 pfu from an Arabidopsis genomic library (Voytas et al., 1990). Phage DNA was transferred to Hy ...
... A COX5b-1 EST clone encoding exons two to six (clone 234B12T7; accession no. N65183) was obtained from ABRC. For the isolation of clones containing the COX5b-1 gene, the cDNA probe was used to screen 13105 pfu from an Arabidopsis genomic library (Voytas et al., 1990). Phage DNA was transferred to Hy ...
Conclusions Synapsin IIa is expressed in the brain of adult zebrafish
... Figure 4: Comparison of zebrafish and human Synapsin II. Human and zebrafish SynapsinII amino acid sequences were aligned using CLUSTALW. Dashes in sequences allow optimal alignment for amino acid insertions/deletions. Identical amino acids are shown and similar amino acids are highlighted by plus s ...
... Figure 4: Comparison of zebrafish and human Synapsin II. Human and zebrafish SynapsinII amino acid sequences were aligned using CLUSTALW. Dashes in sequences allow optimal alignment for amino acid insertions/deletions. Identical amino acids are shown and similar amino acids are highlighted by plus s ...
Poster - University of British Columbia
... Results: Using Principal Component Analysis, the effect of active smoking was found to be stronger than the effect of budesonide. In current smokers, more Phase 1 enzyme genes were upregulated compared with former smokers. However, Phase 2 enzyme genes were up-regulated in former smokers but down-re ...
... Results: Using Principal Component Analysis, the effect of active smoking was found to be stronger than the effect of budesonide. In current smokers, more Phase 1 enzyme genes were upregulated compared with former smokers. However, Phase 2 enzyme genes were up-regulated in former smokers but down-re ...
The best-studied nuclear compartments are the
... associated with CBs, and that their association was dependent on the transcription activity of those genes. Furthermore, when U2 expression levels were increased by increasing the U2 copy number, their association with CBs was also elevated. This indicates that targeting of CBs to this chromosomal s ...
... associated with CBs, and that their association was dependent on the transcription activity of those genes. Furthermore, when U2 expression levels were increased by increasing the U2 copy number, their association with CBs was also elevated. This indicates that targeting of CBs to this chromosomal s ...
Expression of the Epithelial Mesenchymal Transition Regulator
... predominantly in the chondroid matrix and to a lesser amount in the ductal component. Nuclear expression was especially high at the interphase of both components. These finding suggest that the metaplastic Snail positive cells underwent EMT and acquired a mesenchymal phenotype. Another notable findi ...
... predominantly in the chondroid matrix and to a lesser amount in the ductal component. Nuclear expression was especially high at the interphase of both components. These finding suggest that the metaplastic Snail positive cells underwent EMT and acquired a mesenchymal phenotype. Another notable findi ...
ESTs to genome
... downstream regions: TGCATG (9-fold over expected) Not over-represented downstream to constitutive exons. Binding site for FOX1 (splicing regulatory protein) ...
... downstream regions: TGCATG (9-fold over expected) Not over-represented downstream to constitutive exons. Binding site for FOX1 (splicing regulatory protein) ...
Supplementary Methods.
... 0.0004) evolutionary conservation scores (mean Gumby -log(p value): 67.1) than the negatives (mean -log(p value): 43.5)4, indicating that the degree of conservation between humans and rodents can be used to further prioritize human-fish and ultra-conserved elements for functional activity under this ...
... 0.0004) evolutionary conservation scores (mean Gumby -log(p value): 67.1) than the negatives (mean -log(p value): 43.5)4, indicating that the degree of conservation between humans and rodents can be used to further prioritize human-fish and ultra-conserved elements for functional activity under this ...
Genome Annotation
... sequences that are important components of the genome. These sequences include the ribosomal RNAs and tRNAs that are essential for protein translation. In addition, the small nuclear RNAs important to processes such as RNA splicing are necessarily components of the gneome. These sequences exhibit a ...
... sequences that are important components of the genome. These sequences include the ribosomal RNAs and tRNAs that are essential for protein translation. In addition, the small nuclear RNAs important to processes such as RNA splicing are necessarily components of the gneome. These sequences exhibit a ...