reviews - UO Blogs
... as described in more detail below, either mutant fly or human triplet-repeat genes can be expressed in the fly eye to induce the degeneration of retinal photoreceptor cells. In these studies, proteins with wild-type numbers of triplet repeats have little or no effect when expressed in the eye, where ...
... as described in more detail below, either mutant fly or human triplet-repeat genes can be expressed in the fly eye to induce the degeneration of retinal photoreceptor cells. In these studies, proteins with wild-type numbers of triplet repeats have little or no effect when expressed in the eye, where ...
Special Feature —Manipulating Genes to Understand
... information) with regions of identical sequence on the chromosome. The greatest advantage of this methodology is the ability to specifically mutate (create a null mutation in) a gene located in the host genome. Because the cells are pluripotent, genetically modified ES cells can be reintroduced into ...
... information) with regions of identical sequence on the chromosome. The greatest advantage of this methodology is the ability to specifically mutate (create a null mutation in) a gene located in the host genome. Because the cells are pluripotent, genetically modified ES cells can be reintroduced into ...
View/Open - Cadair - Aberystwyth University
... temporally and spatially coordinated manner. In general, there is a gradual decrease in cell division activity as organogenesis proceeds, and most, if not all, cells eventually stop dividing and differentiate. The scheduled cessation of cell division is critical for the formation of organs with gene ...
... temporally and spatially coordinated manner. In general, there is a gradual decrease in cell division activity as organogenesis proceeds, and most, if not all, cells eventually stop dividing and differentiate. The scheduled cessation of cell division is critical for the formation of organs with gene ...
Growth medium composition-determined regulatory mechanisms
... Transcriptional activation from the pheBA and catBCA promoters is regulated by CatR and the catechol degradation pathway intermediate cis,cis-muconate. Here it is shown that physiological control mechanisms are superimposed on this regulatory system. Transcriptional activation from the pheBA and cat ...
... Transcriptional activation from the pheBA and catBCA promoters is regulated by CatR and the catechol degradation pathway intermediate cis,cis-muconate. Here it is shown that physiological control mechanisms are superimposed on this regulatory system. Transcriptional activation from the pheBA and cat ...
PDF
... the LIM domains on Xlim-1; Ldb1 (also known as NLI and CLIM2) being one such factor (Agulnick et al., 1996; Jurata et al., 1996; Bach et al., 1997). Ldb1 contains a selfdimerization domain and a LIM interaction domain (Jurata and Gill, 1997; Breen et al., 1998), and a dimer of Ldb1 has been shown to ...
... the LIM domains on Xlim-1; Ldb1 (also known as NLI and CLIM2) being one such factor (Agulnick et al., 1996; Jurata et al., 1996; Bach et al., 1997). Ldb1 contains a selfdimerization domain and a LIM interaction domain (Jurata and Gill, 1997; Breen et al., 1998), and a dimer of Ldb1 has been shown to ...
reproduction
... widely studied epigenetic process associated with genomic imprinting, although whether it represents the primary ‘imprint’ distinguishing the parental alleles is currently under debate. Differential methylation arises in specific gene regions known as differentially methylated regions or DMRs. Two t ...
... widely studied epigenetic process associated with genomic imprinting, although whether it represents the primary ‘imprint’ distinguishing the parental alleles is currently under debate. Differential methylation arises in specific gene regions known as differentially methylated regions or DMRs. Two t ...
Cotranscriptional coupling of splicing factor recruitment and
... an earlier step, in which the 5¢ and 3¢ splice sites are recognized by base-pairing interactions between the pre-mRNA and the U1 and U2 snRNAs, respectively11. This early step can be influenced by the activities of non-snRNP splicing factors that enhance or suppress interaction of these snRNPs with ...
... an earlier step, in which the 5¢ and 3¢ splice sites are recognized by base-pairing interactions between the pre-mRNA and the U1 and U2 snRNAs, respectively11. This early step can be influenced by the activities of non-snRNP splicing factors that enhance or suppress interaction of these snRNPs with ...
RNA-Mediated Programming of Developmental
... In this experiment, two highly injected clones showed only a moderate reduction in A gene copy numbers (Fig. 1A). Interestingly, these were the only clones to express the A gene at the time of autogamy, as determined by immunological tests of live cells, suggesting that transgene expression is antag ...
... In this experiment, two highly injected clones showed only a moderate reduction in A gene copy numbers (Fig. 1A). Interestingly, these were the only clones to express the A gene at the time of autogamy, as determined by immunological tests of live cells, suggesting that transgene expression is antag ...
C. Errors and Exceptions in Chromosomal
... One of the two X chromosomes has an active XIST gene (X-inactive specific transcript). This gene produces multiple copies of an RNA molecule that almost cover the X chromosome where they are made. This initiates X inactivation, but the mechanism that connects XIST RNA and DNA methylation is un ...
... One of the two X chromosomes has an active XIST gene (X-inactive specific transcript). This gene produces multiple copies of an RNA molecule that almost cover the X chromosome where they are made. This initiates X inactivation, but the mechanism that connects XIST RNA and DNA methylation is un ...
Characterization of the wheat gene encoding a grain
... a few genes are known to be specifically expressed in the ESR. These are ZmEsr1-3 (Opsahl-Ferstad et al., 1997; Bonello et al., 2000), ZmAE1 and ZmAE3 (Magnard et al., 2000), and ZmESR-6 (Balandin et al., 2005). Identification of these ESR-specific genes confirmed ESR cells as a separate domain of g ...
... a few genes are known to be specifically expressed in the ESR. These are ZmEsr1-3 (Opsahl-Ferstad et al., 1997; Bonello et al., 2000), ZmAE1 and ZmAE3 (Magnard et al., 2000), and ZmESR-6 (Balandin et al., 2005). Identification of these ESR-specific genes confirmed ESR cells as a separate domain of g ...
Molecular Evolution in Nonrecombining Regions of the Drosophila
... 200 new genes that lack crossing-over and employing a novel orthology search among species of the melanogaster subgroup. These genes are located in the heterochromatin of chromosomes other than the dot (fourth) chromosome. Noncrossover regions of the genome all exhibited an elevated level of evoluti ...
... 200 new genes that lack crossing-over and employing a novel orthology search among species of the melanogaster subgroup. These genes are located in the heterochromatin of chromosomes other than the dot (fourth) chromosome. Noncrossover regions of the genome all exhibited an elevated level of evoluti ...
Mendelian or qualitative genetics
... With the presence of multiple alleles it can be difficult at times to determine if the observed variation for a trait is due to two genes or allelic variation at one gene locus. The way to determine if the variation you are observing is allelic is to do a complementation test. example: You have two ...
... With the presence of multiple alleles it can be difficult at times to determine if the observed variation for a trait is due to two genes or allelic variation at one gene locus. The way to determine if the variation you are observing is allelic is to do a complementation test. example: You have two ...
Nonconventional Initiation Complex Assembly by STAT and NF
... Figure 5. Recruitment of RNA Polymerase II to the Nos2 Promoter by L. monocytogenes-Derived Signals Pol II recruitment -> 1. a poised state 2. stimulus of gene activation Which situation applies to the macrophage Nos2 gene? A,B,C : analysis of pol II association by ChIP A. Infection with L. monocyt ...
... Figure 5. Recruitment of RNA Polymerase II to the Nos2 Promoter by L. monocytogenes-Derived Signals Pol II recruitment -> 1. a poised state 2. stimulus of gene activation Which situation applies to the macrophage Nos2 gene? A,B,C : analysis of pol II association by ChIP A. Infection with L. monocyt ...
Genomic imprinting effects on brain development and function
... the spatial expression patterns of individual imprinted genes have accumulated, it has become apparent that, although for many genes the pattern of imprinting corresponds to that seen in the chimaeras, there are several exceptions2. This discrepancy might arise from the ‘few genes, large effects’ ca ...
... the spatial expression patterns of individual imprinted genes have accumulated, it has become apparent that, although for many genes the pattern of imprinting corresponds to that seen in the chimaeras, there are several exceptions2. This discrepancy might arise from the ‘few genes, large effects’ ca ...
The human Y chromosome: the biological role of a “functional
... has been estimated to be similar to that of the AZFa region (1–3 Mb). Five genes have been so far described within this interval; RNA-binding motif (RBM), Chromodomain Y (CDY ), XK Related Y (XKRY ), eukaryotic translation initiation factor 1A (eIF-1A), and Selected Mouse cDNA on the Y (SMCY ). The ...
... has been estimated to be similar to that of the AZFa region (1–3 Mb). Five genes have been so far described within this interval; RNA-binding motif (RBM), Chromodomain Y (CDY ), XK Related Y (XKRY ), eukaryotic translation initiation factor 1A (eIF-1A), and Selected Mouse cDNA on the Y (SMCY ). The ...
lac
... determine whether it is transcribed or not. -Regulatory sequences are primarily ‘operators’ (repressor binding sequences). Can also include activator binding sequences. -Regulatory proteins work with regulatory sequences to control transcription of the operon. -Regulatory proteins act as activators ...
... determine whether it is transcribed or not. -Regulatory sequences are primarily ‘operators’ (repressor binding sequences). Can also include activator binding sequences. -Regulatory proteins work with regulatory sequences to control transcription of the operon. -Regulatory proteins act as activators ...
Tandem and segmental gene duplication and
... also been proposed, emphasizing the importance of interallelic sequence exchange and DIVERSIFYING SELECTION [13] (Box 1). Recently, Baumgarten et al. [10] have suggested that most of the genomic dispersion of NBS-LRR genes originates from duplication and translocation of entire chromosomal segments ...
... also been proposed, emphasizing the importance of interallelic sequence exchange and DIVERSIFYING SELECTION [13] (Box 1). Recently, Baumgarten et al. [10] have suggested that most of the genomic dispersion of NBS-LRR genes originates from duplication and translocation of entire chromosomal segments ...
A Major Species of Mouse μ-opioid Receptor mRNA and Its
... and 11.5 kb, respectively, with a similar intensity. Although five MOR splice variants have been reported to use exon 11 instead of exon 1 (Pan et al., 2001), they are not likely to represent the 3.7-kb species because the expression levels of these alternative transcripts are much lower than that o ...
... and 11.5 kb, respectively, with a similar intensity. Although five MOR splice variants have been reported to use exon 11 instead of exon 1 (Pan et al., 2001), they are not likely to represent the 3.7-kb species because the expression levels of these alternative transcripts are much lower than that o ...
is involved in hair formation and spermatogenesis in mice gene
... projections that are produced by certain epidermal cells in late-stage differentiation; ovo is required for survival and differentiation of female germ cells. We cloned a mouse gene, movo1 encoding a nuclear transcription factor that is highly similar to its fly counterpart in its zinc-finger sequen ...
... projections that are produced by certain epidermal cells in late-stage differentiation; ovo is required for survival and differentiation of female germ cells. We cloned a mouse gene, movo1 encoding a nuclear transcription factor that is highly similar to its fly counterpart in its zinc-finger sequen ...
AtREM1, a Member of a New Family of B3 Domain
... (Franco-Zorrilla et al., 1999), AtREM1 (REM1) also belongs to a gene family in Arabidopsis. Genomic DNA sequences from the Arabidopsis Genome Initiative have revealed the existence of at least 23 sequences characterized by the presence of duplicated REM domains (Table I; Fig. 2). Many of them also h ...
... (Franco-Zorrilla et al., 1999), AtREM1 (REM1) also belongs to a gene family in Arabidopsis. Genomic DNA sequences from the Arabidopsis Genome Initiative have revealed the existence of at least 23 sequences characterized by the presence of duplicated REM domains (Table I; Fig. 2). Many of them also h ...
Table S3. Transcription factor binding sites identified in haplotypes
... Required for the establishment of the posterior and anterior domains of the embryo [34,35]. Its products define the positions of the germ layers primordia and thereby the invagination regions of the blastodermal epithelium [36]. tll functions to drive cells to the optic lobe in the developing embryo ...
... Required for the establishment of the posterior and anterior domains of the embryo [34,35]. Its products define the positions of the germ layers primordia and thereby the invagination regions of the blastodermal epithelium [36]. tll functions to drive cells to the optic lobe in the developing embryo ...
Genomic surveys and expression analysis of bZIP gene family in
... Abstract The basic leucine zipper (bZIP) transcription factors comprise a family of transcriptional regulators present extensively in plants, involved in regulating diverse biological processes such as flower and vascular development, seed maturation, stress signaling and pathogen defense. Castor be ...
... Abstract The basic leucine zipper (bZIP) transcription factors comprise a family of transcriptional regulators present extensively in plants, involved in regulating diverse biological processes such as flower and vascular development, seed maturation, stress signaling and pathogen defense. Castor be ...
the regulation of the differential expression of the human globin
... associated with an unusually high production of haemoglobin F in individuals with sickle cell anaemia or /3 thalassaemia (Wainscoat et al. 1985a). This suggests that there may be a genetic determinant within or linked to the /3 globin gene cluster, which, since these haplotypes are not associated wi ...
... associated with an unusually high production of haemoglobin F in individuals with sickle cell anaemia or /3 thalassaemia (Wainscoat et al. 1985a). This suggests that there may be a genetic determinant within or linked to the /3 globin gene cluster, which, since these haplotypes are not associated wi ...